scholarly journals The 482Ser ofPPARGC1Aand 12Pro ofPPARG2Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Mónica Vázquez-Del Mercado ◽  
Milton-Omar Guzmán-Ornelas ◽  
Fernanda-Isadora Corona Meraz ◽  
Clara-Patricia Ríos-Ibarra ◽  
Eduardo-Alejandro Reyes-Serratos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Fat ◽  
The Body ◽  
Metabolic Risk Factors ◽  
Polymorphism Analysis ◽  
Metabolic Risk ◽  
Functional Polymorphisms ◽  
Mexican Mestizos ◽  
Polymerase Chain ◽  
The Relationship

The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser inPPARGC1Aand Pro12Ala inPPARG2with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI). Body dimensions and distribution of body fat were measured. The HOMA-IR and adiposity indexes were calculated. Adipokines and metabolic profile quantification were performed by ELISA and routine methods. Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis. A difference between obese and nonobese subjects in polymorphismPPARGC1Adistribution was observed. Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly− phenotype. Subjects withPPARG2Ala− phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala). We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser inPPARGC1Aand 12Pro inPPARG2represents a reduced metabolic risk profile, even when the adiposity indexes are increased.

The Relationship Between Shift Work and Metabolic Risk Factors

2016 ◽  
Vol 50 (5) ◽  
pp. e147-e157 ◽  
Author(s):  
Karin I. Proper ◽  
Daniëlla van de Langenberg ◽  
Wendy Rodenburg ◽  
Roel C.H. Vermeulen ◽  
Allard J. van der Beek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Shift Work ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Relationship

scholarly journals Effect of Almond Consumption on Metabolic Risk Factors - Glucose, Hyperinsulinemia, Inflammatory Markers: A Randomized Controlled Trial in 16–25 year olds in Mumbai City

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1447-1447
Author(s):  
Jagmeet Madan ◽  
Panchali Moitra ◽  
Sharvari Desai ◽  
Sheryl Salis ◽  
Rekha Battalwar ◽  
...  
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Young Adults ◽  
Body Fat ◽  
Inflammatory Markers ◽  
Metabolic Risk Factors ◽  
Control Group ◽  
Metabolic Risk ◽  
Tnf Α ◽  
Mumbai City

Abstract Objectives A large percentage of Indian population has diabetes or is at risk of pre-diabetes. Almond consumption has shown benefits on cardio metabolic risk factors in adults. The present study explored the effect of almond consumption on determinants of metabolic dysfunction - blood glucose, insulin, selected inflammatory markers and oxidant damage in adolescents and young adults aged 16–25 years from Mumbai city. Daily almond consumption will reduce insulin levels, selected pro-inflammatory markers, improve lipid profile of 16–25 year old persons. Methods This cluster randomized trial was conducted on individuals with impaired levels of glucose (fasting glucose (5.6–6.9 mmol/L), 2 h post-glucose (7.8–11.0 mmol/L) and/or insulin (fasting insulin(≥15 mIU/ml)/glucose challenge insulin(≥80 mIU/ml). 421 individuals were selected after screening 1313 individuals. The almonds group (n = 107) consumed 56gm almonds daily for 90 days and was compared with a control group (n = 112) who consumed an iso-caloric snack for the same period. Blood samples were analysed at baseline, endline for glucose, insulin, HbA1C, LDL, HDL, TC, ox-LDL, TG, hs-CRP, IL-6, TNF-α, adiponectin, leptin. Body fat (%), visceral fat, weight, were measured. HOMA-IR, FG: FI ratio, BMI, WHR, WHtR were calculated. Dietary intakes were assessed at baseline, endline using 24-hour recall. Results Baseline values for all measurements, macronutrient intakes did not differ significantly between the two groups. Changes in anthropometric measurements between baseline and endline were not significantly different in both groups. Percent body fat increased in both groups but was four times more in the control than the almonds group. Almond consumption significantly decreased HbA1C, total cholesterol, LDL-C, IL-6. Stimulated insulin decreased post-intervention in both groups, but was greater in almonds group. FG: FI ratio decreased in almonds group. TNF-α decreased in almonds group while it increased in control group. Conclusions The present study shows the directionality for almond consumption to reduce inflammatory markers, total, LDL cholesterol levels and HbA1C levels in adolescents and young adults who were at risk for developing diabetes. Thus, almonds can be considered as one of the food-based strategies for preventing pre-diabetes. Funding Sources Research grant from Almond Board of California.

The role of menopause on the relationship between metabolic risk factors and periodontal disease via salivary oxidative parameters

2018 ◽  
Vol 89 (3) ◽  
pp. 331-340 ◽  
Author(s):  
Esra Sinem Kemer Doğan ◽  
Fatma Yeşim Kırzıoğlu ◽  
Burak Doğan ◽  
Özlem Fentoğlu ◽  
Banu Kale ◽  
...  
Keyword(s):  
Risk Factors ◽  
Periodontal Disease ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Relationship

scholarly journals MP13-20 THE RELATIONSHIP BETWEEN PAPILLARY GRADING AND METABOLIC RISK FACTORS FOR STONE FORMATION

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Christopher B. Riedinger ◽  
Blake B. Anderson ◽  
Melanie A. Adamsky ◽  
Andrew J. Cohen ◽  
Glenn S. Gerber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Stone Formation ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Relationship

BODY FAT DISTRIBUTION AND CARDIO-METABOLIC RISK FACTORS IN MIXED-ANCESTRY SOUTH AFRICAN WOMEN AND MEN

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e145-e146
Author(s):  
A.P. Kengne ◽  
F.E. Davidson ◽  
T.E. Matsha ◽  
R.T. Erasmus ◽  
J.E. Goedecke
Keyword(s):  
Risk Factors ◽  
South African ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Metabolic Risk Factors ◽  
African Women ◽  
Metabolic Risk ◽  
Mixed Ancestry ◽  
South African Women

scholarly journals Metabolic Syndrome and Physical Performance: The Moderating Role of Cognition among Middle-to-Older-Aged Adults

2020 ◽  
pp. 1-9
Author(s):  
Elisa F. Ogawa ◽  
Elizabeth Leritz ◽  
Regina McGlinchey ◽  
William Milberg ◽  
Jonathan F. Bean
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Executive Function ◽  
Physical Performance ◽  
Explicit Memory ◽  
Gait Speed ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Mobility Performance ◽  
The Relationship

Abstract Objective: Mobility limitation and cognitive decline are related. Metabolic syndrome (MetS), the clustering of three or more cardiovascular risk factors, is associated with decline in both mobility and cognition. However, the interrelationship among MetS, mobility, and cognition is unknown. This study investigated a proposed pathway where cognition moderates the relationship between MetS and Mobility. Method: Adults ages 45–90 years were recruited. MetS risk factors and mobility performance (Short Physical Performance Battery (SPPB) and gait speed) were evaluated. Cognition was assessed using a comprehensive neuropsychological battery. A factor analysis of neuropsychological test scores yielded three factors: executive function, explicit memory, and semantic/contextual memory. Multivariable linear regression models were used to examine the relationship among MetS, mobility, and cognition. Results: Of the 74 participants (average age 61 ± 9 years; 41% female; 69% White), 27 (36%) participants manifested MetS. Mean SPPB score was 10.9 ± 1.2 out of 12 and gait speed was 1.0 ± 0.2 m/s. There were no statistically significant differences in mobility by MetS status. However, increase in any one of the MetS risk factors was associated with decreased mobility performance after adjusting for age and gender (SPPB score: β (SE) -.17 (0.08), p < .05; gait speed: -.03 (.01), p < .01). Further adjusting for cognitive factors (SPPB score: explicit memory .31 (.14), p = .03; executive function 0.45 (0.13), p < .01; gait speed: explicit memory 0.04 (0.02), p = .03; executive function 0.06 (0.02), p < .01) moderated the relationships between number of metabolic risk factors and mobility. Conclusion: The relationship between metabolic risk factors and mobility may be moderated by cognitive performance, specifically through executive function and explicit memory.

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