scholarly journals Dental Considerations in Children with Glucose-6-phosphate Dehydrogenase Deficiency (Favism): A Review of the Literature and Case Report

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Daniela Hernández-Pérez ◽  
Claudia Butrón-Téllez Girón ◽  
Socorro Ruiz-Rodríguez ◽  
Arturo Garrocho-Rangel ◽  
Amaury Pozos-Guillén
Keyword(s):  
Case Report ◽  
Infectious Diseases ◽  
Hemolytic Anemia ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Present Report ◽  
Review Of The Literature ◽  
Oxidizing Agents ◽  
Dental Management ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an uncommon inherited enzyme deficiency characterized by hemolytic anemia, caused by the inability of erythrocytes to detoxify oxidizing agents such as drugs, infectious diseases, or fava bean ingestion. In this later case, the disorder is known as favism. The aim of the present report was to present a review of the literature in this disease, to describe a case report concerning an affected 9-year-old male, and to review the main implications and precautions in pediatric dental management.

scholarly journals Dental Management in a Child Patient with Glucose-6-phosphate Dehydrogenase Deficiency : A Case Report

2021 ◽  
Vol 48 (3) ◽  
pp. 359-366
Author(s):  
Jiyoon Jeon ◽  
Sunmi Yang ◽  
Namki Choi ◽  
Seonmi Kim
Keyword(s):  
Case Report ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Pediatric Dentistry ◽  
Accurate Knowledge ◽  
Dental Management ◽  
Child Patient ◽  
Pediatric Dentists ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Appropriate Education

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive disorder and is the most common enzyme deficiency worldwide. Although this disease is rare in Korea, its prevalence may increase due to an increase of multicultural families. Patients with this deficiency are prone to hemolytic anemia provoked by specific drugs commonly used or prescribed in pediatric dentistry. It is necessary for pediatric dentists to have accurate knowledge of a patient's medical history and to consult with a pediatric hematologist to avoid oxidative stress that can lead to hemolysis. The most effective treatment is prevention of exposure to factors that may trigger anemia. Appropriate education regarding risk factors is essential for patients diagnosed with this disease. This case report aimed to discuss the drugs and dental management methods that should be cautious in children with G6PD deficiency.

scholarly journals Acute Hemolytic Anemia Induced by Levofloxacin in A Woman With G6PD Deficiency: A Case Report

2021 ◽  
Author(s):  
Ebrahim Salehifar ◽  
Masoud Aliyali ◽  
Aliyeh Bazi
Keyword(s):  
Case Report ◽  
Hemolytic Anemia ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Drug Induced ◽  
High Prevalence ◽  
Northern Regions ◽  
Alternative Antibiotic ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Possible Cause

Introduction: Glucose 6-Phosphate Dehydrogenase deficiency (G6PD) is an X-linked recessive disorder recognized as the most prevalent enzyme deficiency around the world. G6PD deficiency has a high prevalence in Iran, especially in the northern regions. As we know, hemolysis in G6PD patients was not reported with levofloxacin previously. Case Report: In this report, we introduce a 54-year-old G6PD deficient woman who experienced the symptoms of hemolytic anemia following completion of treatment with levofloxacin. Result: After ruling out other causes of hemolysis, by using the Naranjo scale, levofloxacin was considered as a possible cause of hemolysis. Conclusion: Though the hemolytic anemia induced by levofloxacin is extremely rare in G6PD deficient patients, drug-induced hemolytic anemia should be considered as one of the differential diagnoses. It would be appropriate to use an alternative antibiotic instead of levofloxacin in a G6PD deficient patient.  

scholarly journals General Anesthesia in a Glucose-6-Phosphate Dehydrogenase Deficiency Child: A Case Report

2019 ◽  
Vol 66 (2) ◽  
pp. 94-96
Author(s):  
Takahiro Goi ◽  
Yoshiki Shionoya ◽  
Katsuhisa Sunada ◽  
Kiminari Nakamura
Keyword(s):  
Case Report ◽  
High Risk ◽  
General Anesthesia ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Risk Group ◽  
High Risk Group ◽  
Antioxidant Effect ◽  
Attending Physician ◽  
Glucose 6 Phosphate Dehydrogenase

We performed general anesthesia on a 3-year-old boy with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with G6PD deficiency exhibit jaundice and anemia due to hemolysis caused by a lack of the G6PD enzyme. To maintain anesthesia, we used propofol and remifentanil, which may prevent hemolytic attacks by exerting an antioxidant effect. In addition, because the patient was in a high-risk group for the development of methemoglobinemia, we used mepivacaine as a local anesthetic. We liaised with the patient's attending physician to make sufficient arrangements, such as securing an emergency transfer on the day of anesthesia. The patient did not develop hemolytic attacks during or after the procedure, and he progressed well without problems.

scholarly journals Kernicterus by glucose-6-phosphate dehydrogenase deficiency: a case report and review of the literature

2008 ◽  
Vol 2 (1) ◽  
Author(s):  
Gladys Cossio de Gurrola ◽  
Juan José Araúz ◽  
Elfilda Durán ◽  
Maribel Aguilar-Medina ◽  
Rosalío Ramos-Payán ◽  
...  
Keyword(s):  
Case Report ◽  
Dehydrogenase Deficiency ◽  
Review Of The Literature ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency

2017 ◽  
Vol 22 (6) ◽  
pp. 471-471 ◽  
Author(s):  
Manzilat Akande ◽  
Anthony N. Audino ◽  
Joseph D. Tobias
Keyword(s):  
Hemolytic Anemia ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Tumor Lysis Syndrome ◽  
Turnaround Time ◽  
Lymphoblastic Lymphoma ◽  
Test Results ◽  
Tumor Lysis ◽  
Prevention And Treatment ◽  
Glucose 6 Phosphate Dehydrogenase

Rasburicase, used in the prevention and treatment of tumor lysis syndrome (TLS), may cause hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Although routine screening for G6PD deficiency has been recommended, given the turnaround time for test results and the urgency to treat TLS, such screening may not be feasible. We report a case of rasburicase-induced hemolytic anemia without methemoglobinemia in an adolescent with T-cell lymphoblastic lymphoma, TLS, and previously unrecognized G6PD deficiency. Previous reports of hemolytic anemia with rasburicase are reviewed, mechanisms discussed, and preventative strategies presented.

scholarly journals Anaesthesia for a child with glucose-6-phosphate-dehydrogenase deficiency: a case report

2020 ◽  
Vol 6 (12) ◽  
pp. 526
Author(s):  
Baththirange Malaka Munasinghe ◽  
Srisothinathan Nimalan ◽  
Nishanthan Subramaniam ◽  
Sonali Goonetilleke
Keyword(s):  
Oxidative Stress ◽  
Case Report ◽  
General Anaesthesia ◽  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Perioperative Period ◽  
Postoperative Monitoring ◽  
Successful Case ◽  
Operative Planning ◽  
Glucose 6 Phosphate Dehydrogenase

<p class="abstract">Patients with glucose-6-phosphate-dehydrogenase (G6PD) deficiency are prone to acute haemolytic crisis during perioperative period, precipitated by oxidative stress and certain medications, which are common concurrences during this period. Careful peri-operative planning, judicious use of medication and postoperative monitoring plays a pivotal role in preventing complications in these patients. Here, we report a successful case of general anaesthesia in a child with G6PD deficiency.  </p>

Oxaliplatin-induced immune hemolytic anemia: a case report and review of the literature

2007 ◽  
Vol 18 (8) ◽  
pp. 973-976 ◽  
Author(s):  
Francesc Cobo ◽  
Guillem De Celis ◽  
Arturo Pereira ◽  
Xavier Latorre ◽  
Jaume Pujadas ◽  
...  
Keyword(s):  
Case Report ◽  
Hemolytic Anemia ◽  
Review Of The Literature ◽  
Immune Hemolytic Anemia

scholarly journals A Rare Case of Coexistence of Homozygous β-Thalassaemia and Glucose 6 Phosphate Dehydrogenase Deficiency

2020 ◽  
Author(s):  
Jitendar Mohan Khunger ◽  
Monika Gupta ◽  
Ankur Jain ◽  
Monica Khunger Malhotra
Keyword(s):  
Oxidative Stress ◽  
Blood Cells ◽  
G6pd Deficiency ◽  
Rare Case ◽  
Dehydrogenase Deficiency ◽  
Globin Gene ◽  
Genetic Abnormality ◽  
Wide Range ◽  
Symptomatic Anaemia ◽  
Glucose 6 Phosphate Dehydrogenase

β-thalassaemia is one of the most prevalent autosomal disorders worldwide. Mutations/deletions in globin gene underlie deficiencies in Haemoglobin (Hb) production, which can interfere with oxygen delivery by Hb, resulting in thalassaemias causing anaemias with a wide range of disease severity. Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is a genetic abnormality resulting in inadequate amount of G6PD in the Red Blood Cells (RBCs). In patients with G6PD deficiency, the reduced or absent activity of the enzyme in RBCs causes premature haemolysis and symptomatic anaemia. The marked oxidative stress caused by homozygous β-thalassaemia is apparently incompatible with G6PD deficiency. Here, a rare case of six-month-old male child is described who presented with severe pallor hepato-splenomegaly and these two conditions co-existed in this patient.

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