scholarly journals Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Adil Mardinoglu ◽  
P. J. Cregg
Keyword(s):  
Magnetic Field ◽  
Drug Targeting ◽  
Computational Analysis ◽  
Drug Carrier ◽  
Superparamagnetic Iron Oxide ◽  
Clinical Applications ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Interparticle Interactions ◽  
Different Diameters

Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications.

Magnetic nanoparticles for magnetic drug targeting

2015 ◽  
Vol 60 (5) ◽  
Author(s):  
Stefan Lyer ◽  
Raminder Singh ◽  
Rainer Tietze ◽  
Christoph Alexiou
Keyword(s):  
Magnetic Nanoparticles ◽  
Side Effects ◽  
Drug Targeting ◽  
Superparamagnetic Iron Oxide ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Treatment Concept ◽  
Substantial Progress ◽  
New Treatment ◽  
Tumor Area

AbstractNanomedicine and superparamagnetic iron oxide nanoparticles (SPIONs) are thought to have an important impact on medicine in the future. Especially in cancer therapy, SPIONs offer the opportunity of improving the effectivity of the treatment and reduce side effects by magnetic accumulation of SPION-bound chemotherapeutics in the tumor area. Although still some challenges have to be overcome, before the new treatment concept of magnetic drug targeting will reach the patients, substantial progress has been made, and promising results were shown in the last years.

Site-Specific in vivo Targeting of Magnetoliposomes Using Externally Applied Magnetic Field

2000 ◽  
Vol 55 (3-4) ◽  
pp. 278-281 ◽  
Author(s):  
Melánia Babincová ◽  
Veronika Altanerová ◽  
Miloš Lampert ◽  
Čestmír Altaner ◽  
Eva Machová ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Targeting ◽  
Left Kidney ◽  
Clinical Applications ◽  
Magnetic Drug Targeting ◽  
Site Specific ◽  
Magnetite Particles ◽  
The Stability ◽  
The Right

Abstract Human serum albumin labeled with technetium-99m was encapsulated together with magnetite particles into phosphatidylcholine/cholesterol liposomes. In order to investigate the stability of this complex and its ability to be used for magnetic drug targeting, the in-vivo distribution after intravenous administration in rats was estimated. For in-vivo targeting an SmCo permanent magnet with intensity ~ 0.3 5 T was attached near the right kidney. Difference between the relative radioactivity in the magnetically targeted right kidney (25.92±5.84%) and non-targeted left kidney (0.93±0.05%) is sufficiently high for relevant clinical applications.

Magnetic Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy

2016 ◽  
Vol 25 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Bogdan Silviu Ungureanu ◽  
Cristian-Mihail Teodorescu ◽  
Adrian Săftoiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Diagnosis And Treatment ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver, ranking as the second most common cause of death from cancer worldwide. Magnetic nanoparticles (MNPs) have been used so far in tumor diagnosis and treatment, demonstrating great potential and promising results. In principle, three different approaches can be used in the treatment of tumors with superparamagnetic iron oxide nanoparticles: magnetically induced hyperthermia, drug targeting and selective suppression of tumor growth. This review focuses on the use of iron oxide nanoparticles for the diagnosis and treatment of liver cancer and offers a walkthrough from the MNPs imaging applicability to further therapeutic options, including their potential flaws. The MNP unique physical and biochemical properties will be mentioned in close relationship to their subsequent effects on the human body, and, also, their toxic potential will be noted. A presentation of what barriers the MNPs should overcome to be more successful will conclude this review. Abbreviations: AMF: Alternating magnetic field; DOX: Doxorubicin; GD: Gadolinium; HCC: hepatocellular carcinoma; 131I: Iodine 131; MDT: Magnetic drug targeting; ML: Magnetoliposomes; MNP: magnetic nanoparticles; MRI: Magnetic Resonance Imaging; PNIPA: Poly-N-isopropylacrylamide; SPIONS: Superparamagnetic iron oxide nanoparticles; VEGF: Vascular endothelial growth factor.

Visualization and Motion of Curcumin Loaded Iron Oxide Nanoparticles During Magnetic Drug Targeting

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammed Asfer ◽  
Ayodhya Prasad Prajapati ◽  
Arun Kumar ◽  
Pradipta Kumar Panigrahi
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Applied Magnetic Field ◽  
Drug Targeting ◽  
In Vitro Study ◽  
Target Site ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Magnetic drug targeting (MDT) involves the localization of drug loaded iron oxide nanoparticles (IONPs) around the malignant tissue using external magnetic field for therapeutic purposes. The present in vitro study reports the visualization and motion of curcumin loaded IONPs (CU-IONPs) around the target site inside a microcapillary (500 × 500 μm2 square cross section), in the presence of an externally applied magnetic field. Application of magnetic field leads to transportation and aggregation of CU-IONPs toward the target site inside the capillary adjacent to the magnet. The localization/aggregation of CU-IONPs at the target site shows strong dependence on the strength of the applied magnetic field and flow rate of ferrofluid through the capillary. Such an in vitro study offers a viable for optimization and design of MDT systems for in vivo applications.

Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma

2017 ◽  
Vol 6 (5) ◽  
pp. 449-472 ◽  
Author(s):  
Marina Fontes de Paula Aguiar ◽  
Javier Bustamante Mamani ◽  
Taylla Klei Felix ◽  
Rafael Ferreira dos Reis ◽  
Helio Rodrigues da Silva ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Process Efficiency ◽  
Cochrane Library ◽  
Oxide Nanoparticles ◽  
Magnetic Targeting

AbstractThe purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by physicochemical characteristics of SPIONs used, cell types used for tumor induction, characteristics of experimental glioma models, magnetic targeting technical parameters, and analysis method of process efficiency. The study shows the highlights and importance of magnetic targeting to optimize the magnetic targeting process as a therapeutic strategy for gliomas. Regardless of the intensity of the patterned magnetic field, the time of application of the field, and nanoparticle used (commercial or synthesized), all studies showed a vast advantage in the use of magnetic targeting, either alone or in combination with other techniques, for optimized glioma therapy. Therefore, this review elucidates the preclinical and therapeutic applications of magnetic targeting in glioma, an innovative nanobiotechnological method.

scholarly journals In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

2020 ◽  
Vol 6 (3) ◽  
pp. 543-546
Author(s):  
Michael Fink ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert ◽  
Stefan Lyer
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Imaging Technique ◽  
Small Animal ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Medical Procedures ◽  
First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

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