scholarly journals Genipin Cross-Linked Chitosan-Polyvinylpyrrolidone Hydrogels: Influence of Composition and Postsynthesis Treatment on pH Responsive Behaviour

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Chinyelumndu Jennifer Nwosu ◽  
Glenn Adam Hurst ◽  
Katarina Novakovic
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Mechanical Stability ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Freeze Thaw ◽  
Continuous Freezing

Understanding the factors that influence the pH responsive behaviour of biocompatible cross-linked hydrogel networks is essential when aiming to synthesise a mechanically stable and yet stimuli responsive material suitable for various applications including drug delivery and tissue engineering. In this study the behaviour of intelligent chitosan-polyvinylpyrrolidone-genipin cross-linked hydrogels is examined as a function of their composition and postsynthesis treatment. Hydrogels are synthesised with varying amounts of each component (chitosan, polyvinylpyrrolidone, and genipin) and their response in a pH 2 buffer is measured optically. The influence of postsynthesis treatment on stability and smart characteristics is assessed using selected hydrogel samples synthesised at 30, 40, and 50°C. After synthesis, samples are exposed to either continuous freezing or three freeze-thaw cycles resulting in increased mechanical stability for all samples. Further morphological and mechanical characterisations have aided the understanding of how postsynthesis continual freezing or freeze-thaw manipulation affects network attributes.

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

2021 ◽  
Vol 11 (23) ◽  
pp. 11369
Author(s):  
Ashni Arun ◽  
Pratyusha Malrautu ◽  
Anindita Laha ◽  
Hongrong Luo ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Solubility ◽  
Stimuli Responsive ◽  
Preparation Methods ◽  
Nanoparticle Preparation ◽  
Responsive Behavior ◽  
Reduced Toxicity

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

scholarly journals Thermo- and pH-responsive fibrillization of squid suckerin A1H1 peptide

Nanoscale ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 6307-6317
Author(s):  
Yunxiang Sun ◽  
Feng Ding
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Ph Responsive ◽  
Temperature Dependent ◽  
Aggregation And Disaggregation ◽  
Novel Applications

The aggregation and disaggregation of A1H1 peptides is pH and temperature-dependent. The thermo- and pH-responsive properties of A1H1 aggregates may enable novel applications, such as drug delivery, diagnostics, tissue engineering, and biosensors.

scholarly journals Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (16) ◽  
pp. 7178-7183 ◽  
Author(s):  
Isurika R. Fernando ◽  
Daniel P. Ferris ◽  
Marco Frasconi ◽  
Dmitry Malin ◽  
Elena Strekalova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Amino Ester ◽  
Stimuli Responsive ◽  
Ph Responsive

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved.

scholarly journals Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

2020 ◽  
Vol 21 (13) ◽  
pp. 4724 ◽  
Author(s):  
Sofia Municoy ◽  
María I. Álvarez Echazú ◽  
Pablo E. Antezana ◽  
Juan M. Galdopórpora ◽  
Christian Olivetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Stimuli Response ◽  
Materials Used

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

2015 ◽  
Vol 6 (11) ◽  
pp. 2098-2107 ◽  
Author(s):  
Yang Kang ◽  
Xiao-Mei Zhang ◽  
Sheng Zhang ◽  
Li-Sheng Ding ◽  
Bang-Jing Li
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Polymer Conjugates

pH stimuli-responsive controlled selective release of drugs at the endosomal compartments of the PR-g-DOX supramolecular micelles.

Unconventional and facile production of stimuli-responsive multifunctional system for simultaneous drug delivery and environmental remediation

2021 ◽  
Author(s):  
Narsimha Mamidi ◽  
Ramiro Manuel Velasco Delgadillo ◽  
Javier Villela Castrejón
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Environmental Remediation ◽  
Single Walled Carbon Nanotubes ◽  
Selective Removal ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Single Walled Carbon ◽  
Fiber Membranes ◽  
Walled Carbon Nanotubes

Herein, pH-responsive poly 4-hydroxyphenyl methacrylated single-walled carbon nanotubes (PHPMA-SWCNT = f-CNT)/PE nanocomposite (NCST) fiber membranes were developed for stimuli drug delivery and the selective removal of Pb2+ and Cd2+ from...

Highly stretchable and tough pH-sensitive hydrogels with reversible swelling and recoverable deformation

RSC Advances ◽  
2016 ◽  
Vol 6 (6) ◽  
pp. 4850-4857 ◽  
Author(s):  
Xue Jiao Liu ◽  
Hai Qiang Li ◽  
Bao Yuan Zhang ◽  
Ya Jun Wang ◽  
Xiu Yan Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Stimuli Responsive ◽  
Highly Stretchable ◽  
Mechanical Performances ◽  
Responsive Hydrogels

Stimuli-responsive hydrogels are becoming increasingly important for controlled drug delivery, biosensing, and tissue engineering. It would be much advantageous for intelligent hydrogels if they exhibit superior mechanical performances.

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