Antioxidant Capacity of “Mexican Arnica”Heterotheca inuloidesCass Natural Products and Some Derivatives: Their Anti-Inflammatory Evaluation and Effect onC. elegansLife Span

It has been suggested that the accumulation of biomolecular damage caused by reactive oxygen species (ROS) contributes to aging. The antioxidant activity is related to the ability of certain compounds to protect against the potentially harmful effect of processes or reactions involving ROS. This ability is associated with the termination of free radical propagation in biological systems. FromHeterotheca inuloidesvarious compounds which have shown to possess antioxidant capacity and scavenging ROS. The aim of this study was to determine the antioxidant capacity of additional natural components isolated fromH. inuloidesand some semisynthetic derivatives, their anti-inflammatory activity and the effect onCaenorhabditis elegansnematode life span. Compounds showed ability to inhibit various biological processes such as lipid peroxidation, scavenge nonbiological important oxidants such as1O2,OH∙, H2O2, and HOCl and scavenge non biological stable free radicals (DPPH). Some cadinane type compounds showed possess antioxidant, ROS scavenging capacity, anti-inflammatory activity, and effect on theC. eleganslife span. Flavonoid type compounds increased the life of the nematode and quercetin was identified as the compound with the greatest activity. The modification of chemical structure led to a change in the antioxidant capacity, the anti-inflammatory activity, and the survival of the worm.

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Comparison of Functional Properties of the Bael Fruit at Various Levels of Maturity

Issue 4 - Journal of Science and Technology ◽

10.46243/jst.2020.v5.i4.pp137-142 ◽

2020 ◽

pp. 137-142

Keyword(s):

Hydrogen Peroxide ◽

Antioxidant Capacity ◽

Functional Properties ◽

Radical Scavenging ◽

Inflammatory Activity ◽

Total Phenolic ◽

Ripe Fruit ◽

Scavenging Capacity ◽

Anti Inflammatory ◽

Hydroxyl Hydrogen

Aegle marmelos fruit is packed with immense medicinal properties. The main objective of the studywas to assess and compare the phytochemical potency, antioxidant capacity and anti-inflammatory activity of unripe, ripe and overripe fruits. The fruit pulp was dried and extract (ripe fruit) was prepared in various solvents. Phytochemical assessment was done and the solvent which exhibited maximum potency was chosen as unripe and ripe fruit solvents. Phytochemical assessment, estimation of phenols (FolinCiocalteau method), antioxidant capacity (Molybdate method), anti-inflammatory activity (membrane stabilization property method) and Free radical scavenging capacity for hydroxyl, hydrogen peroxide and DPPH free radicals were carried out. The phytochemical screening of the ripe fruit showed maximum intensity in hydroethanolic extract. On comparison, ripe fruit extract possessed a greater phytochemical potency, antioxidant capacity and inhibition against hydroxyl, hydrogen peroxide, DPPH radicals. The total phenolic content of the over ripe fruit was high. The anti-inflammatory activity of unripe fruit was slightly higher than ripe fruit. This signifies that phytochemical potency and functional properties of the fruit differs with maturity stages.

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