scholarly journals Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Patrick Adu ◽  
David Larbi Simpong ◽  
Godfred Takyi ◽  
Richard K. D. Ephraim
Keyword(s):  
Enzyme Activity ◽  
Sickle Cell ◽  
Road Traffic ◽  
Sickle Cell Trait ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Severe Anaemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Test Kit

Background.Blood transfusion is a therapeutic procedure usually undertaken in patients with severe anaemia. In Ghana, severe anaemia is mostly due to malaria caused by severePlasmodium falciparuminfection, road traffic accidents, and haemoglobinopathy-induced acute haemolysis.Method.This cross-sectional study evaluated coinheritance of sickle cell haemoglobin variant and G6PD enzymopathy among individuals that donated blood at the Holy Trinity Hospital, Berekum, in the Brong-Ahafo Region, Ghana. Demographic data and other pertinent information were captured using questionnaire. Sickle cell haemoglobin variants were determined using cellulose acetate electrophoresis (pH 8.6). Qualitative G6PD status and quantitative G6PD enzyme activity were determined using methaemoglobin reduction and Trinity Biotech G6PD test kit, respectively.Results.Prevalence of sickle cell trait (SCT) and G6PD enzymopathy coinheritance was 7%. In addition, 19.5% of the donors had 10%–60% of normal G6PD enzyme activity suggesting that these donor units are prone to stressor-induced acute haemolysis when given to recipients. Mild G6PD activity (p=0.03, OR: 2.410 (CI: 1.049–5.534)), commercial (p=0.020, OR: 5.609 (CI: 1.309–24.035)), and voluntary (p=0.034, OR: 2.404 (CI: 1.071–5.397)) donors were significantly associated with SCT.Conclusion.Screening for red cell pathologies must be incorporated into existing protocols for populations with high incidence of haemoglobinopathies to protect high-risk recipients.

scholarly journals Pattern of Hemoglobinopathies: A Cross-sectional Study in North of Morocco

2020 ◽  
Author(s):  
Fatima Zahra Alaoui ◽  
Achraf LAGHMICH ◽  
Naima GHAILANI NOUROUTI ◽  
Amina BARAKAT ◽  
Mohcine BENNANI MECHITA
Keyword(s):  
Sickle Cell ◽  
Geographic Distribution ◽  
Rural Areas ◽  
Sickle Cell Trait ◽  
Genetic Disorders ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Screening Programs ◽  
Thalassemia Trait

Abstract Background: Hemoglobinopathies are the most frequent widely spread genetic disorders. In Morocco, epidemiological and clinical data are scarce. The present study aims to determine the spectrum and geographic distribution of hemoglobinopathies in Larache province, North of Morocco.Methods: A retrospective cross-sectional study was conducted from January 2015 to December 2018 at the provincial hospital of Larache city. All patients’ records having a hemoglobinopathy were analyzed. Background data (age, gender, and origin) of each case were analyzed. Results: Our study showed an overall frequency of hemoglobinopathies of 3.6%. Sickle cell trait was registered to be the most common disorder in our studied population (42.3%), followed by β-thalassemia Trait (20.2%), sickle cell disease (19.8%), major β-thalassemia (9.8%) and sickle/β-thalassemia (8%). The average age of subjects with hemoglobin disorders was 17.5 years. The majority of the patients (66.5%) were less than 20 years old. A disparity in the diseases geographic distribution was observed, 74.6% of patients came from rural areas. Conclusions: The present study is the first of its kind offering comprehensive data on hemoglobinopathies pattern in Northern Morocco. Our work may lay the foundation for screening programs for better prevention and coverage.

scholarly journals Pregnancy outcome in women with sickle cell disease/trait in a tertiary care hospital Nagpur, Maharashtra India: a descriptive cross sectional study

2019 ◽  
Vol 8 (10) ◽  
pp. 3943
Author(s):  
Varsha Kose ◽  
Saurabh Kose
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Cross Sectional Study ◽  
Common Complication ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional ◽  
Disease Trait ◽  
Nicu Admission

Background: Pregnancy in sickle cell women has numerous obstetrical, nonobstetrical and fetal complications. Our objective was to study the pregnancy outcome in women with sickle cell disease/trait.Methods: A descriptive cross sectional study in 2 years study period was conducted. 57 women with sickle cell disease/trait were identified. They were attending the antenatal clinic and were admitted in obstetric ward and followed till 7 days after delivery.Results: Out of total 57 women 49 women (85.96%) were sickle cell trait (AS pattern) and 8 women (14.03%) were sickle cell disease (SS pattern). In women with sickle cell trait Pregnancy induced hypertension was the most common complication. Anaemia and hypothyroidism was the common associated medical problem. 5 babies need NICU admission, 6 babies PBU admission and 33 babies given to mother side just after birth. In women with sickle cell disease severe anaemia, preeclampsia, oligohydramnios and intrauterine growth restriction, lower segment caesarean section for preterm baby was the most common complication. 1 baby required NICU admission, 5 babies require PBU admission and only 2 babies given to mother just after delivery. There were no maternal mortality and neonatal mortality.Conclusions: Maternal morbidity and neonatal morbidity is more in sickle cell disease women. They require early diagnosis, premarital and preconceptional counselling, good multidisciplinary obstetrics and neonatal care and early referral to higher centre.

scholarly journals A cross sectional study to understand socio demographic profile of patients of sickle cell anemia in a Taluka of South Gujarat

2017 ◽  
Vol 4 (6) ◽  
pp. 2167
Author(s):  
Chintan Gamit ◽  
MohamedAnas M. Patni ◽  
Sukesha Gamit
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Sickle Cell Trait ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Demographic Profile ◽  
Economic Class ◽  
Tribal Communities ◽  
Tribal Populations

Background: India has the largest concentration of tribal populations globally. A high prevalence of sickle cell anemia is seen in tribal communities of South Gujarat. The aims and objectives were to study socio- demographic profile of the patients having positive sickle cell status.Methods: It was a cross-sectional study, where Bardoli taluka was selected purposively. All patients of sickle cell anemia registered at all PHCs of Bardoli Taluka during period between June 2010 and May 2011 & aged between 18 to 30 years were taken in study.Results: This study included total 276 cases of which 264 (96%) had sickle cell trait, while 12 (4%) had sickle cell disease. Majority of patients were from Umrakh and Vanskui PHC. More than 90% of patients belonged to ST caste and more than 40% among them were from Rathod sub caste.Conclusions: More than 90% of patients were laborers and majority of them belonged to low socio economic class. Mean age at diagnosis of sickle cell anemia ranged from 21 to 25 years. 

scholarly journals Burden of sickle cell trait and disease in the Uganda Sickle Surveillance Study (US3): a cross-sectional study

2016 ◽  
Vol 4 (3) ◽  
pp. e195-e200 ◽  
Author(s):  
Grace Ndeezi ◽  
Charles Kiyaga ◽  
Arielle G Hernandez ◽  
Deogratias Munube ◽  
Thad A Howard ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Cross Sectional Study ◽  
Surveillance Study ◽  
Sectional Study ◽  
Cross Sectional

Influence of environmental factors on road traffic accidents: Hospital based cross sectional study at Tirupati

2018 ◽  
Vol 7 (1) ◽  
pp. 52
Author(s):  
Bayapa Reddy N. ◽  
Shakeer Kahn P. ◽  
Surendra Babu D. ◽  
Khadervali N. ◽  
Chandrasekhar C. ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Cross Sectional Study ◽  
Road Traffic Accidents ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Hand Hygiene Knowledge, Perception, and Practices among Domestic Visitors to the Prophet’s Mosque in Al Madinah City Amid the COVID-19 Pandemic: A Cross-Sectional Study

2021 ◽  
Vol 18 (2) ◽  
pp. 673
Author(s):  
Hashim A. Mahdi ◽  
Hamza M. Assaggaf ◽  
Mohammad Alfelali ◽  
Omar B. Ahmed ◽  
Radi Alsafi ◽  
...  
Keyword(s):  
Hand Hygiene ◽  
Graduate Education ◽  
Formal Education ◽  
Demographic Data ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional Survey ◽  
Cross Sectional

This study aimed to assess hand hygiene knowledge, perception, and practices of visitors to the Prophet’s Mosque in Al Madinah City, Saudi Arabia. Using a self-administered electronic questionnaire, a cross-sectional survey was conducted among domestic residents, who visited the mosque between 31 July and 3 August 2020. Participants’ demographic data, hand hygiene knowledge, perception, and practices were collected. Four hundred participants aged 18–65 (median 36) years completed the survey, of which 215 (53.8%) were female. The visitors’ mean knowledge score about hand hygiene was 6.4 (± standard deviation (SD) 1.35) of total 12. Most participants (392, 98%) were aware of the role of hand hygiene in preventing Coronavirus Disease 2019 (COVID-19); nevertheless, 384 (96%) said hand hygiene lowers body immunity and 316 (79%) thought <60% alcohol is sufficient for hand disinfection. Males had a higher knowledge score than females (6.46 (±1.41) vs. 6.14 (±1.27), p = 0.02) and, visitors who had no formal education scored higher than those with post-graduate education (6.88 (±1.45) vs 5.73 (±1.12), p = 0.01). Washing hands with soap and water was the predominant method practiced after a meal (365, 91.7%), after toilet visit (354, 88.5%), after touching a surface (262, 65.7%), after waste disposal (332, 83.2%), and when hands were visibly dirty (357, 89.5%). Al Madinah visitors had moderate knowledge about hand hygiene, but demonstrated some knowledge gaps and negligence in practice that are crucial to curb the spread of COVID-19.

scholarly journals Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 360
Author(s):  
Ola Hysaj ◽  
Patricia Marqués-Gallego ◽  
Aline Richard ◽  
Magdeldin Elgizouli ◽  
Alexandra Nieters ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Inflection Point ◽  
Demographic Data ◽  
Late Pregnancy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D ◽  
Maximal Suppression

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.

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