The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer.

Download Full-text

Faculty Opinions recommendation of The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717147857.792403058 ◽

2012 ◽

Author(s):

Ajay Chawla

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Stem Cell Niche ◽

Bone Marrow Stem Cell ◽

Cell Niche ◽

Marrow Stem Cell

Download Full-text

Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled

Journal of The Royal Society Interface ◽

10.1098/rsif.2012.0968 ◽

2013 ◽

Vol 10 (81) ◽

pp. 20120968 ◽

Cited By ~ 21

Author(s):

Adam L. MacLean ◽

Cristina Lo Celso ◽

Michael P. H. Stumpf

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Immune Cells ◽

Stem Cell Niche ◽

Haematopoietic Stem Cell ◽

Current Analysis ◽

Oncogenic Potential ◽

Viable Population ◽

Cell Niche ◽

Potential Cancer

Haematopoietic stem cells (HSCs) are responsible for maintaining immune cells, red blood cells and platelets throughout life. HSCs must be located in their ecological niche (the bone marrow) to function correctly, that is, to regenerate themselves and their progeny; the latter eventually exit the bone marrow and enter circulation. We propose that cells with oncogenic potential—cancer/leukaemia stem cells (LSC)—and their progeny will also occupy this niche. Mathematical models, which describe the dynamics of HSCs, LSCs and their progeny allow investigation into the conditions necessary for defeating a malignant invasion of the niche. Two such models are developed and analysed here. To characterize their behaviour, we use an inferential framework that allows us to study regions in parameter space that give rise to desired behaviour together with an assessment of the robustness of the dynamics. Using this approach, we map out conditions under which HSCs can outcompete LSCs. In therapeutic applications, we clearly want to drive haematopoiesis into such regimes and the current analysis provide some guidance as to how we can identify new therapeutic targets. Our results suggest that maintaining a viable population of HSCs and their progenies in the niche may often already be nearly sufficient to eradicate LSCs from the system.

Download Full-text

Stem-Cell Niche Based Comparative Analysis of Chemical and Nano-mechanical Material Properties Impacting Ex Vivo Expansion and Differentiation of Hematopoietic and Mesenchymal Stem Cells

Advanced Healthcare Materials ◽

10.1002/adhm.201200169 ◽

2012 ◽

Vol 2 (1) ◽

pp. 25-42 ◽

Cited By ~ 46

Author(s):

Jinlin Jiang ◽

Eleftherios T. Papoutsakis

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Comparative Analysis ◽

Material Properties ◽

Stem Cell Niche ◽

Ex Vivo ◽

Ex Vivo Expansion ◽

Cell Niche

Download Full-text

Endothelial progenitor cells as a possible component of stem cell niche to promote self-renewal of mesenchymal stem cells

Molecular and Cellular Biochemistry ◽

10.1007/s11010-014-2191-3 ◽

2014 ◽

Vol 397 (1-2) ◽

pp. 235-243 ◽

Cited By ~ 10

Author(s):

Hongwei Zhang ◽

Lingling Xian ◽

Zhiyi Lin ◽

Chaozhe Yang ◽

Meng Zhang ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Progenitor Cells ◽

Endothelial Progenitor Cells ◽

Stem Cell Niche ◽

Endothelial Progenitor ◽

Self Renewal ◽

Cell Niche

Download Full-text

2011 - ENGINEERING A HEMATOPOIETIC STEM CELL NICHE BY REVITALIZING MESENCHYMAL STEM CELLS

Experimental Hematology ◽

10.1016/j.exphem.2019.06.285 ◽

2019 ◽

Vol 76 ◽

pp. S45

Author(s):

Fumio Nakahara ◽

Daniel Borger ◽

Qiaozhi Wei ◽

Sandra Pinho ◽

Maria Maryanovich ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Hematopoietic Stem Cell ◽

Stem Cell Niche ◽

Hematopoietic Stem ◽

Hematopoietic Stem Cell Niche ◽

Cell Niche

Download Full-text

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Bone Marrow Research ◽

10.1155/2011/353878 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 40

Author(s):

Tian Li ◽

Yaojiong Wu

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell Niche ◽

Adult Stem Cells ◽

Bone Marrow Mscs ◽

Hematopoietic Stem ◽

Hematopoietic Stem Cell Niche ◽

Hsc Niche ◽

Cell Niche ◽

Hsc Transplantation

Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are both adult stem cells residing in the bone marrow. MSCs interact with HSCs, they stimulate and enhance the proliferation of HSCs by secreting regulatory molecules and cytokines, providing a specialized microenvironment for controlling the process of hematopoiesis. In this paper we discuss how MSCs contribute to HSC niche, maintain the stemness and proliferation of HSCs, and support HSC transplantation.

Download Full-text