The Impact of Artesunate-Amodiaquine on Schistosoma mansoni Infection among Children Infected by Plasmodium in Rural Area of Lemfu, Kongo Central, Democratic Republic of the Congo

Background. Malaria and schistosomiasis remain life-threatening public health problems in sub-Saharan Africa. The infection pattern related to age indicates that preschool and school-age children are at the highest risk of malaria and schistosomiasis. Both parasitic infections, separately or combined, may have negative impacts on the haemoglobin concentration levels. The existing data revealed that artemisinin derivatives commonly used to cure malaria present also in antischistosomal activities. The current study investigated the impact of Artesunate-Amodiaquine (AS-AQ) on schistosomiasis when administered to treat malaria in rural area of Lemfu, DRC. Methodology. A prospective longitudinal study including 171 coinfected children screened for anaemia, Schistosoma mansoni, and Plasmodium falciparum infections. The egg reduction rate and haemoglobin concentration were assessed four weeks after the treatment with AS-AQ, of all coinfected children of this series. Results. One hundred and twenty-five (74.4%) out of 168 coinfected children treated and present during the assessment were found stool negative for S. mansoni eggs. Out of 43 (25.6%) children who remained positives, 37 (22%) showed a partial reduction of eggs amount, and no reduction was noted in 3.6% of coinfected. The mean of haemoglobin concentration and the prevalence of anaemia were, respectively, 10.74±1.5g/dl , 11.2±1.3g/dl, and 64.8%, 51.8%, respectively, before and after treatment, p<0.001. Conclusion. The AS-AQ commonly used against Plasmodium allowed curing S. mansoni in coinfected children and increasing the Hb level. For the future, the randomized and multicentric clinical trials are needed for a better understanding of the effectiveness of AS-AQ against Schistosoma spp. The trial registration number was 3487183.

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Schistosoma haematobium infection morbidity, praziquantel effectiveness and reinfection rate among children and young adults in Gabon

Parasites & Vectors ◽

10.1186/s13071-019-3836-6 ◽

2019 ◽

Vol 12 (1) ◽

Cited By ~ 5

Author(s):

Jean Claude Dejon-Agobé ◽

Jean Ronald Edoa ◽

Yabo Josiane Honkpehedji ◽

Jeannot Fréjus Zinsou ◽

Bayodé Roméo Adégbitè ◽

...

Keyword(s):

Young Adults ◽

High Risk ◽

Reduction Rate ◽

Control Measures ◽

Sub Saharan Africa ◽

Reinfection Rate ◽

Prospective Longitudinal Study ◽

The Third ◽

Children And Young Adults ◽

Prospective Longitudinal

Abstract Background Sub-Saharan Africa carries most of the global burden of schistosomiasis. To optimize disease control and reduce morbidity, precise data are needed for control measures adapted to the local epidemiological situation. The objective of this study is to provide baseline information on schistosomiasis dynamics, including praziquantel (PZQ) treatment outcome in children and young adults living in the vicinity of Lambaréné, Gabon. Methods Eligible volunteers were included into a prospective longitudinal study. Urine filtration technique was used to detect eggs in urine for schistosomiasis diagnosis. Subjects were treated with 60 mg of PZQ once per month for three consecutive months, and the outcome was assessed by cure rate (CR) and egg reduction rate (ERR). Results A total of 328 volunteers were enrolled in the study with a mean (± SD) age of 12.2 ± 4.7 years-old. The female-to-male ratio was 0.99. Out of 258 participants in total, 45% had schistosomiasis during the survey and 43% presented with heavy infections. The incidences of haematuria and schistosomiasis were 0.11 and 0.17 person-years, respectively. After the first and third dose of PZQ, overall ERR of 93% and 95% were found, respectively; while the CR were 78% and 88%, respectively. Both ERR (100 vs 88%) and CR (90 vs 68%) were higher among females than males after the first dose. The CR increased for both groups after the third dose to 95% and 80%, respectively. After the first PZQ dose, ERR was higher for heavy compared to light infections (94 vs 89%), while the CR was higher for light than for heavy infections (87 vs 59%). After the third PZQ dose, ERR increased only for light infections to 99%, while CR increased to 98% and 75% for light and for heavy infections, respectively. The reinfection rate assessed at a mean of 44.6 weeks post-treatment was 25%. Conclusions The prevalence of schistosomiasis is moderate in communities living in the vicinity of Lambaréné, where a subpopulation with a high risk of reinfection bears most of the burden of the disease. To improve schistosomiasis control in this scenario, we suggest education of these high-risk groups to seek themselves a one-year PZQ treatment. Trial registration clinicaltrials.gov Identifier NCT 02769103. Registered 11 May 2016, retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT02769013

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516 Impacts of Chronic Nausea and Vomiting on Daytime Sleepiness and Fatigue

SLEEP ◽

10.1093/sleep/zsab072.515 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A203-A203

Author(s):

Maurice Ohayon ◽

Y J Chen ◽

Marie-Lise Cote

Keyword(s):

Longitudinal Study ◽

Daytime Sleepiness ◽

Nausea And Vomiting ◽

Prospective Longitudinal Study ◽

Logistic Regression Models ◽

Related Quality ◽

Health Related ◽

Chronic Nausea ◽

Prospective Longitudinal ◽

The Impact

Abstract Introduction Chronic nausea and vomiting (CNV), common symptoms in patients with GI disorders like gastroparesis, can be a debilitating health problem with considerable impact on patients’ health-related quality of life during daytime. Yet, little is known about how CNV may impact on sleepiness and fatigue during the daytime. Our aim was to examine the impact of CNV on daytime sleepiness and fatigue based on the data from a longitudinal study. Methods Prospective longitudinal study with two waves: 12,218 subjects interviewed by phone during wave 1 (W1); 10,931 during wave 2 (W2) three years later. The sample was representative of the US general population. Analyses included subjects participating to both waves (N=10,931). CNV was defined as episodes of nausea and vomiting occurring at least twice a month for at least 1 month (outside pregnancy). Logistic regression models were employed to determine whether CNV is a predictive variable for excessive sleepiness or fatigue. Results Out of all W1 participants, 9.8% (95% CI: 9.2%-10.4%) reported nausea only while 3% (95% CI: 2.7%-3.3%) reported CNV. In W2, 7.7% (95% CI: 7.2%-8.2%) reported nausea only and 2.5% (95% CI: 2.2%-2.8%) reported having CNV. Of the subjects who participated in both W1 and W2, 25.7% of them reported CNV in W1. CNV subjects reported more frequently excessive daytime sleepiness (53.5% vs. 25.9%) and being moderately or severely fatigued (38.6% vs, 5.4%) compared with the participants without nausea or vomiting. After controlling for age, sex, BMI, health status, alcohol intake, sleep disorders and psychiatric disorders that might impact on daytime sleepiness or fatigue, it was found that subjects with CNV at both W1 and W2 had a significantly higher relative risk of reporting daytime sleepiness (RR: 2.7 (95% CI:1.9–3.9) p<0.0001) and fatigue (RR: 4.9 (95% CI:3.2–7.5) p<0.0001) at W2, compared with the participants without nausea or vomiting. Conclusion Many factors are likely to influence daytime sleepiness. CNV appears to be an important contributor even after controlling for several factors that can explain the sleepiness. This underlines the extent to which alertness could be disturbed and impacted by chronicity of nausea/vomiting symptoms. Support (if any) This analysis study was funded by Takeda Pharmaceutical Company

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The impact of comorbid anxiety disorders on the course of dysthymic disorder: a 5-year prospective longitudinal study

Journal of Affective Disorders ◽

10.1016/s0165-0327(01)00302-0 ◽

2002 ◽

Vol 70 (2) ◽

pp. 211-217 ◽

Cited By ~ 10

Author(s):

Stewart A Shankman ◽

Daniel N Klein

Keyword(s):

Longitudinal Study ◽

Anxiety Disorders ◽

Dysthymic Disorder ◽

Prospective Longitudinal Study ◽

Comorbid Anxiety ◽

Prospective Longitudinal ◽

The Impact

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Looking after the individual to reduce disease in the flock: A binomial mixed effects model investigating the impact of individual sheep management of footrot and interdigital dermatitis in a prospective longitudinal study on one farm

Preventive Veterinary Medicine ◽

10.1016/j.prevetmed.2006.09.005 ◽

2007 ◽

Vol 78 (2) ◽

pp. 172-178 ◽

Cited By ~ 36

Author(s):

L.E. Green ◽

G.J. Wassink ◽

R. Grogono-Thomas ◽

L.J. Moore ◽

G.F. Medley

Keyword(s):

Longitudinal Study ◽

Mixed Effects ◽

Mixed Effects Model ◽

Prospective Longitudinal Study ◽

The Individual ◽

Prospective Longitudinal ◽

The Impact ◽

Interdigital Dermatitis

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Factors Predicating Loss to Follow-Up With Rescreening in Early Hearing Detection and Intervention Programs

Families in Society The Journal of Contemporary Social Services ◽

10.1177/1044389419828884 ◽

2019 ◽

Vol 100 (2) ◽

pp. 213-223 ◽

Cited By ~ 1

Author(s):

Wendy Zeitlin ◽

Charles Auerbach ◽

Susan Mason ◽

Lynn Spivak ◽

Andrew Erdman

Keyword(s):

Hearing Loss ◽

Maternal Depression ◽

Hospital Discharge ◽

The United States ◽

Prospective Longitudinal Study ◽

Loss To Follow Up ◽

Two Factors ◽

Prospective Longitudinal ◽

The Impact

Most infants born in the United States are screened for hearing loss prior to hospital discharge in Early Hearing Detection and Intervention (EHDI) programs; however, many infants who do not pass their screening do not return for recommended rescreening and are considered lost to follow-up (LTF). This research addresses this by examining factors related to LTF at the point of rescreening. A prospective longitudinal study tracked 166 families whose newborns were referred for additional testing upon hospital discharge. Analysis identified two factors related to being LTF: parents’ perceptions of hearing loss as having the potential to impact their child’s future and maternal depression; however, social support moderated the impact of maternal depression. Specific implications for working with families is discussed.

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A two-group study to evaluate the impact of an educational handbook in the care of patients with head and neck cancer (HNC).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.26_suppl.228 ◽

2016 ◽

Vol 34 (26_suppl) ◽

pp. 228-228

Author(s):

Jessica Ruth Bauman ◽

Areej El-Jawahri ◽

Karen Quinn ◽

Lisa Arcikowski ◽

Gina Chan ◽

...

Keyword(s):

Head And Neck ◽

Illness Perception ◽

Depression Scale ◽

Symptom Burden ◽

Prospective Longitudinal Study ◽

Illness Perception Questionnaire ◽

Group 2 ◽

Prospective Longitudinal ◽

The Impact ◽

Group 1

228 Background: Patients undergoing chemoradiotherapy for HNC have a significant symptom burden, psychological distress, and educational needs. We evaluated the impact of an educational handbook integrated into oncology care on patient outcomes. Methods: We conducted a two group, prospective, longitudinal study. Patients enrolled in group 1 received standard care as a control. Then, patients in group 2 received the intervention of a specialized handbook integrated into weekly visits with oncology clinicians during treatment. To assess preliminary efficacy, we evaluated satisfaction (Information Satisfaction Questionnaire-ISQ), mood (Hospital Anxiety and Depression Scale-HADS), illness perception (Brief Illness Perception Questionnaire-IPQ), and quality of life (QOL) (MD Anderson Symptom Inventory-Head and Neck-MDASI-HN) at baseline and week 3. We compared outcomes using two sample t-tests and measured effect size using Cohen’s D. Results: From 8/2014-5/2015 we enrolled and followed 30 patients in group 1. From 5/2015-12/2015, we enrolled and followed 30 patients in group 2. There were no significant differences in baseline characteristics. There were more missing data from group 2. There were high levels of satisfaction in both groups. 20/23 (87%) reported they would ‘definitely’ recommend the handbook to others. Changes in outcomes are shown in Table 1. Compared to group 1, group 2 reported a less threatening view of illness, lower better symptom burden, and less anxiety, but these were not statistically significant. Conclusions: The specialized handbook for patients with HNC was well received. The sample size was too small to detect differences in mood, QOL, illness perception, or satisfaction. Further development in a larger cohort is warranted. Clinical trial information: NCT02204631. [Table: see text]

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A Longitudinal Study in Adults With Sequential Bilateral Cochlear Implants: Time Course for Individual Ear and Bilateral Performance

Journal of Speech Language and Hearing Research ◽

10.1044/2014_jslhr-h-13-0087 ◽

2014 ◽

Vol 57 (3) ◽

pp. 1108-1126 ◽

Cited By ~ 19

Author(s):

Ruth M. Reeder ◽

Jill B. Firszt ◽

Laura K. Holden ◽

Michael J. Strube

Keyword(s):

Longitudinal Study ◽

Speech Recognition ◽

Cochlear Implant ◽

Cochlear Implants ◽

Time Course ◽

Performance Outcomes ◽

Prospective Longitudinal Study ◽

Early Improvement ◽

Prospective Longitudinal ◽

The Impact

PurposeThe purpose of this study was to examine the rate of progress in the 2nd implanted ear as it relates to the 1st implanted ear and to bilateral performance in adult sequential cochlear implant recipients. In addition, this study aimed to identify factors that contribute to patient outcomes.MethodThe authors performed a prospective longitudinal study in 21 adults who received bilateral sequential cochlear implants. Testing occurred at 6 intervals: prebilateral through 12 months postbilateral implantation. Measures evaluated speech recognition in quiet and noise, localization, and perceived benefit.ResultsSecond ear performance was similar to 1st ear performance by 6 months postbilateral implantation. Bilateral performance was generally superior to either ear alone; however, participants with shorter 2nd ear length of deafness (<20 years) had more rapid early improvement and better overall outcomes than those with longer 2nd ear length of deafness (>30 years). All participants reported bilateral benefit.ConclusionsAdult cochlear implant recipients demonstrated benefit from 2nd ear implantation for speech recognition, localization, and perceived communication function. Because performance outcomes were related to length of deafness, shorter time between surgeries may be warranted to reduce negative length-of-deafness effects. Future study may clarify the impact of other variables, such as preimplant hearing aid use, particularly for individuals with longer periods of deafness.

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A Prospective longitudinal study comparing the impact of external radiation therapy with radical prostatectomy on health related quality of life (HRQOL) in prostate cancer patients

The Prostate ◽

10.1002/pros.10342 ◽

2004 ◽

Vol 58 (4) ◽

pp. 354-365 ◽

Cited By ~ 21

Author(s):

G. van Andel ◽

A.P. Visser ◽

A.H. Zwinderman ◽

M.C.C.M. Hulshof ◽

S. Horenblas ◽

...

Keyword(s):

Quality Of Life ◽

External Radiation ◽

Health Related Quality ◽

Prospective Longitudinal Study ◽

Related Quality ◽

Health Related ◽

External Radiation Therapy ◽

Prospective Longitudinal ◽

The Impact

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A prospective longitudinal study of the impact of early postnatal vs. chronic maternal depressive symptoms on child development

European Psychiatry ◽

10.1016/j.eurpsy.2010.05.004 ◽

2011 ◽

Vol 26 (8) ◽

pp. 484-489 ◽

Cited By ~ 53

Author(s):

A.-L. Sutter-Dallay ◽

L. Murray ◽

L. Dequae-Merchadou ◽

E. Glatigny-Dallay ◽

M.-L. Bourgeois ◽

...

Keyword(s):

Depressive Symptoms ◽

Longitudinal Study ◽

Child Development ◽

Postnatal Depression ◽

Repeated Measures ◽

Maternal Depressive Symptoms ◽

Prospective Longitudinal Study ◽

Postnatal Depressive Symptoms ◽

Prospective Longitudinal ◽

The Impact

AbstractBackgroundFew studies of the effects of postnatal depression on child development have considered the chronicity of depressive symptoms. We investigated whether early postnatal depressive symptoms (PNDS) predicted child developmental outcome independently of later maternal depressive symptoms.MethodsIn a prospective, longitudinal study, mothers and children were followed-up from birth to 2 years; repeated measures of PNDS were made using the Edinburgh Postnatal Depression Scale (EPDS); child development was assessed using the Bayley Scales II. Multilevel modelling techniques were used to examine the association between 6 week PNDS, and child development, taking subsequent depressive symptoms into account.ResultsChildren of mothers with 6 week PNDS were significantly more likely than children of non-symptomatic mothers to have poor cognitive outcome; however, this association was reduced to trend level when adjusted for later maternal depressive symptoms.ConclusionEffects of early PNDS on infant development may be partly explained by subsequent depressive symptoms.

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