scholarly journals Frequency of different histopathological types of esophageal cancer patients at oncology department of a tertiary care hospital in Karachi

2021 ◽  
Vol 14 (4) ◽  
pp. 161-165
Author(s):  
Zoya Sheikh ◽  
Ghulam Haider ◽  
Khalil Ahmed ◽  
Dr. Bhunisha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Carcinoma Of The Esophagus ◽  
Histopathological Type

Background: Around the globe, carcinoma of the esophagus is the eighth most prevalent cancer with an incidence of 456,000 cases per year and is the sixth cause of cancer mortality. There are two major histological subtypes of carcinoma of the esophagus, esophageal squamous cell carcinoma and adenocarcinoma. The aim of the current study is to evaluate the frequency of different histopathological types of esophageal cancer in patients presenting at the tertiary care hospital of Karachi. Patients and methods: It was a cross-sectional study conducted at the Department of Clinical Oncology, Jinnah Postgraduate Medical Center, Karachi from March 2017 till March 2019. Two hundred and one histologically proven cases of esophageal cancer of in patients of either gender and between 15-80 years of age were included. Patients were interviewed and data regarding age, gender, education, marital status, employment status, addictions like cigarette or huqqa smoking, consumption of pan, betel nut, naswar, or gutka were recorded. Endoscopy and histology and computed tomography scan were performed. Stage, site, grade and type of tumor were noted. SPSS version 23 was used to analyze data. Mean and SD were calculated for quantitative variables. Frequency and percentage were calculated for qualitative variables. A Chi-square test was used to assess the significance between age and gender with type of EC. A p-value≤0.05 was taken as significant. Results: Mean age of the patients was 47.84. The majority of the patients had stage 2 of cancer (42.8%) and lower tumor site (62.2%) Squamous cell carcinoma was the most common histopathological type in 137 patients out of 201 (68%). The age, gender, smoking, consumption of pan, grade, site, and stage of the tumor showed a statistically significant difference when compared with esophageal squamous cell carcinoma and esophageal adenocarcinoma. Conclusion: The burden of esophageal squamous cell carcinoma is dramatically increasing in the Pakistani population and squamous cell carcinoma was the most common histopathological type.

scholarly journals Clinicopathological profile of squamous cell carcinoma presenting in Tertiary Care Hospital, Karachi.

2020 ◽  
Vol 27 (05) ◽  
pp. 939-943
Author(s):  
Sameera Asif ◽  
Summera Kanwal ◽  
Tahera Ayub ◽  
Zafar Abbas ◽  
Batool Vazir ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Stage Iv ◽  
Stage Ii ◽  
Stage Iii ◽  
Care Hospital

Objectives: Oral Squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. The study was done with the aim to determine the clinical pattern of OSCC seen in tertiary care hospital of Karachi, Pakistan. The frequency of neck metastasis in different staging of squamous cell carcinoma was also recorded. Study Design: Retrospective study. Setting: Department of Oral & Maxillofacial Surgery Liaquat College of Medicine and Dentistry. Period: June 2013- July 2016. Material & Methods: It included 35 males and 25 females which presented with different sites and stage of squamous cell carcinoma. Clinically patients were staged as stage I, stage II, stage III and stage IV and comprised of 3, 8, 30 & 19 patients respectively. Patients presented with cancer of buccal mucosa (31 patients), retromolar region (12 patients), maxillary alveolus (8 patients), tongue (2 patients), floor of mouth (4 patients) & lip (3 patients). Right side was most common, 48 patients as compare to left side, 12 patients while lip cancers was in upper lip in all patients including commissure. Results: Total 60 patients were included in the study with the male to female ratio of 1.4:1. No significant association was seen between age and gender of the patient (p-value 0.933). Majority of patients were male involving buccal mucosa (51.67%) as the most frequently involved site followed by retromolar area (20%) and tongue (13.3%). Mean age of patients included in the study was 50.87 ± 5.53. Conclusion: Most of the cases of OSCC were seen in older patients with increased number of cases involving buccal mucosa as their primary site. Majority of the tumors were classified as stage III followed by Stage IV, Stage II and stage 1 respectively.

scholarly journals Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study

2017 ◽  
Vol 5 (4) ◽  
pp. 1405
Author(s):  
Vishal Gupta ◽  
Subash Bhardwaj ◽  
Opinder Kumar Bhagat
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Undifferentiated Carcinoma ◽  
North India ◽  
Histopathological Analysis ◽  
Care Hospital ◽  
Female Ratio

Background: Esophageal cancer is one of the deadliest and eighth most common cancer worldwide. It is the sixth most common cause of cancer related deaths with developing nations making up more than 80% of total cases and deaths. The purpose of this study was to assess the histopathological pattern of esophageal cancer in our region.Methods: In our centre, we analyzed 101 cases of endoscopic esophageal biopsy proven cases of esophageal cancer from January 2014 to June 2016. In most of these cases, dysphagia was the commonest indication of esophageal endoscopy.Results: 65 cases (64.4%) were males and 36 cases (35.6%) were females. Most of the patients were in the age group of 41-60 years. The histopathological analysis revealed squamous cell carcinoma as the most common esophageal cancer (n=61, 60.4%) followed by adenocarcinoma (n=38, 37.6%) and 02 cases of undifferentiated carcinoma (2%).Conclusions: Esophageal cancer is one of the commonest digestive tract malignancy in India. The males are affected more than the females with male to female ratio of 1.8:1. The maximum number of cases being seen in fifth and sixth decade of life. The squamous cell carcinoma is the most common esophageal cancer seen, with middle esophagus being the commonest site. However, the number of cases of adenocarcinoma are on rise.

scholarly journals Retrospective Review of Esophageal Carcinoma: 3-Year Experience from a Tertiary Care Teaching Institute

2021 ◽  
Vol 11 (7) ◽  
pp. 111-118
Author(s):  
Diptajit Paul ◽  
Pawan Kumar ◽  
Anil Kumar Dhull
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Treatment Outcome ◽  
Retrospective Study ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Care Hospital ◽  
Advanced Stage

Introduction: Esophageal carcinoma, one of the common malignancies, generally presented in advanced stage makes these neoplasms less curable and highly lethal. Having such poor prognosis, it is significant to understand various patient and tumor facts related to treatment outcome of esophageal cancer, which varies regions wise. The present retrospective study also seeks to focus on current description of patterns and trends of tumors in esophageal cancer patients attended in a tertiary care hospital in a northern state of India and their treatment outcome. Materials and Methods: Records of esophageal carcinoma patients over a period of 3-years were reviewed retrospectively. These records were analysed for incidence, demographic pattern, different treatment modalities and their response evaluation. Results: A total 439-patients of esophageal carcinoma were identified. The median age at presentation was 47-years and males slightly outnumbered females. Among all the tumors, lower thoracic esophagus involvement was most predominant and most common presentation was dysphagia. Squamous cell carcinoma constituted the predominant histopathological type. Majority of patients presented in advanced stage and treated with combined modalities approach of radiation therapy, chemotherapy and surgery. Overall average survival was 13-months. Clinically, the response at last follow-up was CR in 19%, PR and PD in 33% each. Conclusion: Despite its high prevalence in north India and poor survival rate, less initiative has been taken to increase awareness in preventing these cancers. Understandings of socio-demographic patterns and tumor characteristics may improve treatment outcome in these patients and improve quality of life. Further studies are needed in different regions of India, to get more treatment options which may convert the current scenario of palliative intent in to radical one in patients of esophageal carcinoma. Key words: Esophageal carcinoma, retrospective study, socio-demographic profile, dysphagia, squamous cell carcinoma.

scholarly journals Prevalence of type and etiology of lung cancer among the patients presented to a tertiary care hospital at central Kerala: a descriptive study

2018 ◽  
Vol 6 (3) ◽  
pp. 834
Author(s):  
Vadakkan Devassy Thomas ◽  
Binila Jose ◽  
Davis Kizhakkepeedika Rennis
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Descriptive Study ◽  
Male Dominance ◽  
Care Hospital ◽  
The Right

Background: Lung cancer remains the most common cause of premature mortality in men in developing countries. This study was aimed to evaluate the type and etiological factors of lung cancer in patients presented to a tertiary care hospital of central Kerala.Methods: A retrospective descriptive study was conducted in patients who were diagnosed as lung cancer. The medical records of such patients were reviewed. The data such as age, gender, etiological risk factors and type of lung cancer were collected. Patients with incomplete reports or repeated tests, or histopathological findings were negative for lung cancers were excluded from the study.Results: Total 228 patients were included in the study with age of 64.71± 9.75. The male (198) and female (30) ratio was 6.6:1, indicated the male dominance. Among the histological types, the squamous cell carcinoma was 29% (68/228) found as the most prevalent type which is followed by adenocarcinoma 26 % (61/228). The right side (132/228) lobe was the major segment than the left side (91/228). Similarly, incidence in the central region (128/228) was more than the peripheral region (69/228). Among the right side, the upper lobe was dominant when compared to the lower or middle lobe. The lower left lobe incidence was found in 47/228 cases. Among the total, 188 cases were tobacco smokers while the remaining were nonsmokers.Conclusions: Squamous cell carcinoma with right side upper lobe of lung was prevalent among the lung cancer cases. Tobacco smoking was found to be the major etiological factor.

scholarly journals Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

2017 ◽  
Vol 4 (12) ◽  
pp. 4440 ◽  
Author(s):  
Hamna Gul ◽  
Farhana Asif ◽  
Iqra Ghaffar ◽  
Malik Adeel Anwar ◽  
Muhammad Arslan Tayyab ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Laboratory ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
Tissue Samples

Background: Cancer archives perform a dynamic role in observing the prevalence of these cancers. The present study was carried out to study the epidemiological and pathological trends of oral squamous cell carcinoma (OSCC) in a local tertiary care hospital. Methods: Tissue samples were taken from the adult patients of both genders undergoing surgery for OSCC after an informed consent following the inclusion and exclusion criteria. Socio-demographic information was obtained along with relevant clinical, laboratory findings. Tissue samples were stained with H & E stains and were graded according to Anneroth’s system of histological grading. Data were analysed using SPSS 20.0 and a p value ≤0.05 was taken as significant. Results: The most common site for OSCC was tongue and the most common histological subtype was conventional squamous cell carcinoma, while well differentiated tumours form the largest number in the current study. Conclusions: OSCC is a growing malignancy in Pakistan with significant morbidity and mortality and the findings of the present study will be a valuable addition in the local cancer archives. 

scholarly journals The HABITS AND REASONS OF DELAYED PRESENTATION OF PATIENTS WITH ORAL CANCER AT A TERTIARY CARE HOSPITAL OF A THIRD WORLD COUNTRY

2018 ◽  
Vol 8 (3) ◽  
pp. 165-169
Author(s):  
Zohra Saleem ◽  
Syed Akbar Abbas ◽  
Falak Nadeem ◽  
Muhammad Mansoor Majeed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Occurrence Rate ◽  
Initial Symptom ◽  
Care Hospital ◽  
Delayed Presentation

Background: Oral cancer accounts for nearly one-fifth of all cancers in males and one-tenth in females globally. Squamous cell carcinoma accounts for 90% of the oral cancer. The occurrence rate of oral cancer is higher in Sri Lanka, Bangladesh, Pakistan and India. In South Asia oral cancer constitutes 25% of all new cancer reported among males. The estimated incidence of oral cancer in Pakistan is 14.7%. Methods: A cross sectional observational study was carried out at a tertiary care hospital in Karachi with a sample of 145 patients with pathological diagnosis of squamous cell carcinoma of oral cavity. Patients were characterized into early stage (I and II) and advanced stage (III and IV), according to AJCC classification of tumors (2010). Data entry and analysis was carried out on SPSS 19. Qualitative data was expressed in percentages and results were accessed by Chi squared test. Results: The mean age was recorded 47.87 ± 12.50 years. Males participants were 63.4% and 36.6% females were incorporated in our study. More than half came with the Stage IV. 35.2% of participants became aware of their initial symptom before 6 months before pursuing any doctor. 83% patients presented with noteworthy habit of Tobacco or Chalia chewing. Bulk of the participants stated that they would have presented before if they had knowledge about the disease. 85% thought that increasing awareness of oral cancer through media may decrease the time in seeking help from qualified doctor. Conclusion: The study concludes that most of the participants presented late to the professional because of lack of knowledge about signs and symptoms of oral malignancy.

scholarly journals Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Shirui Chen ◽  
Kai Zhou ◽  
Liguang Yang ◽  
Guohui Ding ◽  
Hong Li
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Racial Differences ◽  
Squamous Cell ◽  
Geographic Location ◽  
Molecular Features ◽  
Genome Wide ◽  
White Patients

The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer.

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