Cinobufacini Injection Improves the Efficacy of Chemotherapy on Advanced Stage Gastric Cancer: A Systemic Review and Meta-Analysis

Gastric cancer has a high morbidity and mortality. Chemotherapy regimens are routine advanced stage gastric cancer (AGC) treatment protocols, but most of these drugs have side-effects such as myelosuppression and gastrointestinal disorders. Cinobufacini, an extractive from TCM, could suppress cell proliferation and inhibit gastric cancer. In this study, we comprehensively reviewed the literature on the efficacy comparison between Cinobufacini injection combined with chemotherapy and chemotherapy solely used in AGC treatment. We extracted data for from six electronic databases to evaluate the efficacy of Cinobufacini injection on AGC patients. Twelve studies with a total of 853 patients were finally included in our study. The results indicated that Cinobufacini injection could increase response rate and disease control rate of chemotherapy on AGC, improve the life quality of AGC patients, increase leukocytes, improve anemia, improve hand-foot syndrome induced by chemotherapy, and relieve cancer pain. This study has its own limitations that prevented us from drawing a definite conclusion and more well-designed clinical trials of TCM are needed.

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Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study

Cancers ◽

10.3390/cancers13133132 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3132

Author(s):

Anna Pocurull ◽

Cristina Herrera-Pariente ◽

Sabela Carballal ◽

Joan Llach ◽

Ariadna Sánchez ◽

...

Keyword(s):

Gastric Cancer ◽

Germline Mutation ◽

Early Onset ◽

Personal Information ◽

Familial Aggregation ◽

High Morbidity ◽

Advanced Stage ◽

Genetic Characteristics ◽

Clinical Criteria ◽

Large Multicenter Study

Gastric adenocarcinoma (GC) is a common tumor with high morbidity and mortality. Only 7% of patients with GC are diagnosed before age 50 (early onset gastric cancer (EOGC)), and their characteristics have been poorly described. We aimed to describe clinical, molecular, and genetic characteristics of EOGC. A total of 309 patients with EOGC were retrospectively studied in four Spanish centers. Personal information, family history, and tumor information were registered. Germinal genetic analysis was performed in patients who met current criteria of a hereditary syndrome at the time of diagnosis. The median age at diagnosis was 44 years. The majority (73.3%) of tumors were diffuse, and 78.3% were diagnosed in an advanced stage. Familial aggregation of GC was present in 18/117 (15.4%) cases, and 5/117 (4.3%) met criteria for familial GC. MMR-IHC was performed in 126/309 (40.7%) tumors: 4/126 (3.1%) had loss of expression in MLH1/PMS2, without an associated germline mutation. Sixteen germline genetic analyses were performed, detecting a pathogenic variant in four (25%) cases: one in BRCA2, one in TP53, and two in CDH1. Most EOGC are diffuse and diagnosed in an advanced stage. In these patients, DNA MMR system deficiency is uncommon. Although familial aggregation was observed in only 15% of cases, a germline mutation was found in 25% of patients tested with clinical criteria. This demonstrates that EOGC has a marked genetic heterogeneity, reinforcing the importance of an accurate genetic counseling and enhancing the emerging use of multigene panels.

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Mo1171 The Incidence of Lymph Node Metastasis in Early Gastric Cancer According to the Expanded Criteria in Comparison to the Absolute Criteria. A Systemic Review and Meta-Analysis

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2017.03.1042 ◽

2017 ◽

Vol 85 (5) ◽

pp. AB448 ◽

Cited By ~ 1

Author(s):

Mohamed M. Abdelfatah ◽

Mohamed Barakat ◽

Mohamed O. Othman

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Early Gastric Cancer ◽

Meta Analysis ◽

Systemic Review ◽

Node Metastasis ◽

Expanded Criteria ◽

The Absolute

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A systemic review and meta-analysis for prognostic values of pretreatment lymphocyte-to-monocyte ratio on gastric cancer

European Journal of Inflammation ◽

10.1177/2058739219831094 ◽

2019 ◽

Vol 17 ◽

pp. 205873921983109

Author(s):

Zhigui Li ◽

Zhaofen Xu ◽

Yuqian Huang ◽

Yong Wang ◽

Hare Ram Karn ◽

...

Keyword(s):

Gastric Cancer ◽

Clinical Outcomes ◽

Cancer Progression ◽

Meta Analysis ◽

Prognostic Significance ◽

Young Patients ◽

Systemic Review ◽

Cochrane Library ◽

Low Level ◽

Lymphocyte To Monocyte Ratio

The systemic inflammation plays a crucial role in carcinogenesis and cancer progression. Pretreatment lymphocyte-to-monocyte ratio (LMR) has been suggested to be associated with clinical outcomes in various malignancies. To evaluate the prognostic significance of pretreatment LMR on gastric cancer, we conducted a comprehensive literature search in PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov (Prospero Registration No. CRD42018087263). This meta-analysis included all studies evaluating the prognostic significance of pretreatment LMR on gastric cancer. The main outcome measures included overall survival (OS), progression-free survival (PFS), and the relationship between LMR and clinicopathological features. In total, 11 studies (12 cohorts) enrolling 14,262 patients with gastric cancer were included. The pooled estimates showed that elevated pretreatment LMR was significantly associated with better OS (hazard ratio (HR): 0.71, 95% confidence interval (CI): 0.58–0.83) and better PFS (HR: 0.71, 95% CI: 0.44–0.99). The elevated LMR was also significantly associated with young patients, female, low level of carcinoembryonic antigen (CEA), low level of carbohydrate antigen 19-9 (CA19-9), stage I–II, small tumor size, absence of lymph node metastasis, absence of vascular invasion, and absence of perineural invasion. In conclusion, the elevated pretreatment LMR predicted the better clinical outcomes in patients with gastric cancer.

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Systemic Review and Meta-analysis of Impact of Splenectomy for Advanced Gastric Cancer

In Vivo ◽

10.21873/invivo.12145 ◽

2020 ◽

Vol 34 (6) ◽

pp. 3115-3125

Author(s):

CHIKARA KUNISAKI ◽

SHO SATO ◽

NOBUHIRO TSUCHIYA ◽

JUN WATANABE ◽

TSUTOMU SATO ◽

...

Keyword(s):

Gastric Cancer ◽

Advanced Gastric Cancer ◽

Meta Analysis ◽

Systemic Review

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Gastric Cancer Perforation: Experience from a Tertiary Care Hospital

Journal of Nepal Medical Association ◽

10.31729/jnma.2276 ◽

2013 ◽

Vol 52 (191) ◽

Cited By ~ 2

Author(s):

Bishnu Prasad Kandel ◽

Yogendra Singh ◽

Keshav Prasad Singh ◽

Mahesh Khakurel

Keyword(s):

Gastric Cancer ◽

Surgical Procedures ◽

Tertiary Care ◽

Stage Iv ◽

Definitive Treatment ◽

High Morbidity ◽

Diffuse Peritonitis ◽

Care Hospital ◽

Advanced Stage ◽

Simple Closure

Introduction: Gastric cancer perforation can occurs in advanced stage of the disease and is oftenassociated with a high morbidity and mortality. Peritonitis due to perforation needs emergencylaparotomy and different surgical procedures can be performed for definitive treatment. Surgicalprocedures largely depend on the stage of the disease and general condition of the patient. Thisstudy was carried out to evaluate the outcome and role of different surgical procedures in gastriccancer perforation.Methods: Medical record of patients with gastric perforation, who were treated during ten yearsperiod, was reviewed retrospectively. Data regarding clinical presentation, surgical procedures,staging and survival of patients were obtained.Results: Features suggestive of diffuse peritonitis were evident in all cases. The majority of thepatients underwent emergency surgery except one who died during resuscitation. The majority ofpatients were in stage III and stage IV. Surgical procedure includes simple closure and omental patchin five patients, simple closure and gastrojejunostomy in nine patients, gastrectomy in six patientsand Devine’s antral exclusion in one patient. Surgical site infection was the most common (45.5%)postoperative complication. Four patients died within one month of the surgery. Three patients whounderwent gastrectomy survived for one year and one patient survived for five years.Conclusions: Although gastric cancer perforation usually occurs in advanced stage of the disease,curative resection should be considered as far as possible._______________________________________________________________________________________Keywords: gastric cancer; gastrectomy; laparotomy; perforation; peritonitis.

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Partial Versus Total Omentectomy in Patients with Gastric Cancer: A Systemic Review and Meta-Analysis

Cancers ◽

10.3390/cancers13194971 ◽

2021 ◽

Vol 13 (19) ◽

pp. 4971

Author(s):

Shion Wei Chai ◽

Suo-Hsien Wang ◽

Chih-Yuan Wang ◽

Yi-Chan Chen ◽

Ruey-Shyang Soong ◽

...

Keyword(s):

Gastric Cancer ◽

Overall Survival ◽

Meta Analysis ◽

Disease Free Survival ◽

Systemic Review ◽

Cochrane Library ◽

Free Survival ◽

Significant Difference ◽

Hospital Stays ◽

Disease Free

Background: Surgical treatment is the key to cure localized gastric cancer. There is no strong evidence that supports the value of omentectomy. Thus, a meta-analysis was conducted to compare the safety and efficiency of partial and total omentectomy in patients with gastric cancer. Methods: PubMed, Embase, and Cochrane Library databases were searched. All studies that compared total and partial omentectomy as treatments for gastric cancer were included. The primary outcomes were patients’ overall survival and disease-free survival, while the secondary outcomes were perioperative outcome and postoperative complications. Results: A total of nine studies were examined, wherein 1043 patients were included in the partial omentectomy group, and 1995 in the total omentectomy group. The partial omentectomy group was associated with better overall survival (hazard ratio: 0.80, 95% CI: 0.66 to 0.98, p = 0.04, I2 = 0%), shorter operative time, and lesser blood loss than the total omentectomy group. In addition, no statistically significant difference was observed in the number of dissected lymph nodes, length of hospital stays, complication rate, and disease-free survival. Conclusions: Our results show that, compared with total omentectomy in gastric cancer surgery, partial omentectomy had non-inferior oncological outcomes and comparable safety outcomes.

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