scholarly journals Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Edyta Dziadkowiak ◽  
Agata Sebastian ◽  
Małgorzata Wieczorek ◽  
Elżbieta Kusińska ◽  
Marta Waliszewska-Prosół ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Mean Amplitude ◽  
Control Group ◽  
Cns Involvement ◽  
Sensory Pathway ◽  
Interpeak Latency ◽  
Chronic Autoimmune Disease ◽  
Head Computed Tomography ◽  
Primary Sjӧgren’S Syndrome

Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS damage and normal head computed tomography scan, somatosensory evoked potentials (SEP) were studied. The results were compared to other clinical parameters of the disease, particularly to immunological status. The control group consisted of 20 healthy volunteers. Mean latency of all components of SEP was considerably prolonged in patients compared to the control group. Mean interpeak latency N20-N13 (duration of central conduction TT) did not differ significantly between the groups. However, in the study group, mean amplitude of N20P22 and N13P16 was significantly higher compared to healthy individuals. In patients with pSS, significant differences in SEP parameters depending on the duration of the disease and presence of SSA and SSB antibodies were noted. The authors confirmed CNS involvement often observed in patients with pSS. They also showed dysfunction of the central sensory neuron as a difference in the amplitude of cortical response, which indicates subclinical damage to the CNS.

scholarly journals A Comparison of Interside Asymmetries of Lower Extremity Somatosensory Evoked Potentials in Anesthetized Patients with Unilateral Lumbosacral Radiculopathy

2017 ◽  
Vol 11 (1) ◽  
pp. 99-104
Author(s):  
Qing Yue ◽  
Tyson Hale ◽  
Aaron Knecht
Keyword(s):  
Lower Extremity ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Sural Nerve ◽  
Tibial Nerve ◽  
Control Group ◽  
Superficial Peroneal Nerve ◽  
Asymmetry Ratio ◽  
Lumbosacral Radiculopathy ◽  
Posterior Tibial

<sec><title>Study Design</title><p>Prospective cohort study.</p></sec><sec><title>Purpose</title><p>This study was to investigate interside asymmetries of three lower extremity somatosensory evoked potentials (SSEPs) in anesthetized patients with unilateral lumbosacral radiculopathy.</p></sec><sec><title>Overview of Literature</title><p>Although interside asymmetry is an established criterion of abnormal SSEP, little is known which of the lower SSEPs is more sensitive in detecting interside asymmetry in anesthetized patients.</p></sec><sec><title>Methods</title><p>Superficial peroneal nerve SSEP (SPN-SSEP), posterior tibial nerve SSEP (PTN-SSEP), and sural nerve SSEP were obtained in 31 lumbosacral surgery patients with unilateral lumbosacral radiculopathy, and compared with a group of 22 control subjects.</p></sec><sec><title>Results</title><p>The lumbosacral group showed significant larger interside asymmetry ratios of P37 latencies in SPN-SSEP and PTN-SSEP, and significant larger interside asymmetry ratio of P37-N45 amplitude in SPN-SSEP, when comparing with the control group. Within the lumbosacral group but not the control group, SPN-SSEP displayed significant larger interside asymmetry ratio in P37 latency. When referencing to the control group, more patients in the lumbosacral group displayed abnormal interside SPN-SSEP latency asymmetrieswhich corroborated the symptom laterality.</p></sec><sec><title>Conclusions</title><p>The data suggested that SPN-SSEP was more sensitive in detecting interside latency asymmetry in anesthetized patients.</p></sec>

Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects

1986 ◽  
Vol 100 (9) ◽  
pp. 1031-1036 ◽  
Author(s):  
Y. Holdstein ◽  
H. Pratt ◽  
M. Goldsher ◽  
G. Rosen ◽  
R. Shenhav ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Auditory Brainstem ◽  
The Other ◽  
Control Group ◽  
Sensitive Detector ◽  
Control Groups ◽  
Stimulus Rate ◽  
Adults And Children ◽  
Interpeak Latency ◽  
Brainstem Evoked Potentials

AbstractAuditory Brainstem Evoked Potentials (ABEP) were recorded from 29 adults and children, accidentally exposed to lead through food until approximately a year prior to this study. ABEP were recorded in response to 75 dBHL click presented at rates of 10/sec. and 55/sec. Average values were calculated for peak latency and for interpeak latency differences. Average values of the effect of increasing stimulus rate were calculated as well. Similar values were calculated for normative child and adult control groups.IPLD (I-III) showed the most significant and recurring results, with longer intervals in lead-exposed children compared with their control group. Increasing stimulus rate, on the other hand, affected the adult lead-exposed subjects more than the children. These results may imply an impairment of the auditory system with azonal and myelin involvement. ABEP is suggested as a sensitive detector of subclinical lead exposure effects on the nervous system.

Dynamic somatosensory evoked potentials to determine electrophysiological effects on the spinal cord during cervical spine extension

2013 ◽  
Vol 19 (3) ◽  
pp. 288-292 ◽  
Author(s):  
Yuichiro Morishita ◽  
Takeshi Maeda ◽  
Takayoshi Ueta ◽  
Masatoshi Naito ◽  
Keiichiro Shiba
Keyword(s):  
Spinal Cord ◽  
Cervical Spine ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Cervical Cord ◽  
Control Group ◽  
Neutral Position ◽  
Healthy Controls ◽  
Median Nerve Stimulation ◽  
Significant Difference

Object The goal of this prospective study was to investigate somatosensory evoked potentials (SSEPs) during dynamic motion of the cervical spine and to evaluate the efficacy of analyzing dynamic SSEPs for predicting dynamic effects on the spinal cord in patients with cervical spondylotic myelopathy (CSM). Methods In total, 40 human subjects (20 CSM patients and 20 healthy volunteers as a control group) were examined prospectively using dynamic SSEPs with median nerve stimulation. The CSM patients showed cervical myelopathy due to cervical cord compression at the C4–5 segment. The SSEPs were examined with the cervical spine in a neutral position and at a 20° extension for 10 and 20 minutes. Changes in the N20 latency and amplitude were determined and analyzed. The authors defined the changes in the N20 latency and N20 amplitude between the neutral and extension positions of the cervical spine as percent latency and amplitude, respectively. Results In the CSM patients, SSEPs tended to deteriorate after cervical spine extension, and a statistically significant deterioration of the N20 amplitude after the extension was observed. Moreover, the percent latency and amplitude progressively increased during cervical spine extension in these patients. In the healthy controls, SSEPs tended to deteriorate with cervical spine extension, but these changes did not result in statistically significant differences. Moreover, in this group the percent latency and amplitude were almost identical during the extension. When the CSM patients and the healthy controls were compared, a significant difference in the percent amplitude was observed between the 2 groups during the cervical spine extension. Conclusions This study suggests the potential of dynamic SSEPs as a useful neurophysiological technique to detect the effect of dynamic factors on the pathogenesis of CSM.

scholarly journals Somatosensory evoked potentials in Hirayama disease: A Brazilian study

2020 ◽  
Vol 11 ◽  
pp. 464
Author(s):  
Otto Hernandez Fustes ◽  
Cláudia Suemi Kamoi Kay ◽  
Paulo José Lorenzoni ◽  
Renata Dal-Prá Ducci ◽  
Lineu Cesar Werneck ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Posterior Wall ◽  
Neuromuscular Disorder ◽  
Control Group ◽  
Dorsal Pathway ◽  
Insidious Onset ◽  
Significant Difference ◽  
Upper And Lower Extremities

Background: Hirayama’s disease (HD) is characterized by an insidious onset asymmetric weakness and atrophy of the forearm and hand. Taking as a premise, the etiopathogenesis of the disease is attributed to forward displacement of posterior wall of lower cervical dural canal in neck flexion causing marked compression and flattening of lower spinal cord. This may result in compression of the posterior column of the spinal cord and seems likely to result in somatosensory evoked potentials (SSEPs) abnormalities. In the present study, we studied the possible involvement of the lemniscal dorsal pathway in patients with HD. Methods: SSEPs in upper and lower extremities were prospectively performed in eight patients with HD. All the patients were recruited from the outpatient clinic of a neuromuscular disorder center from South Brazil. SSEPs were obtained by transcutaneous electrical stimulation of the median and posterior tibial nerves, on both sides. We collected the amplitude and the latency of the different components obtained in each channel. The interpretation was based on Brazilian study standards. Results: We evaluated seven men and one woman (mean age 27). The data obtained were compared to a control group consisting of eight patients with spondylotic cervical myelopathy, 6 men and 2 women with mean age of 59 years. The measurements of obtained by the SSEP were also compared between the groups and no significant difference was found for any of them. Conclusion: SSEP did not turn out to be an electrophysiological marker in our HD patients.

Somatosensory evoked potentials as a measure of experimental cerebral ischemia

1985 ◽  
Vol 62 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Kathleen L. Meyer ◽  
Robert J. Dempsey ◽  
Mark W. Roy ◽  
David L. Donaldson
Keyword(s):  
Cerebral Ischemia ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Right Hemisphere ◽  
Content Type ◽  
Mca Occlusion ◽  
Positive Peak ◽  
Interpeak Latency ◽  
The Right ◽  
Experimental Cerebral Ischemia

✓ Somatosensory evoked potentials (SEP's) reflect the integrity of the central neuronal pathway, and as such may be used to assess function that remains during a variety of cerebral insults. To evaluate the natural history and utility of SEP's during experimental cerebral ischemia and infarction, SEP's were measured in 17 adult cats at 24 hours and 1 hour prior to right middle cerebral artery (MCA) occlusion, and again immediately afterward and at either 6 hours (five cats) or 24 hours (six cats) post-occlusion. Before occlusion of the right MCA, the SEP's were identical in the right and left hemispheres. After occlusion, there was a significant slowing of the interpeak latency of the first positive peak (P1) in the right hemisphere (3.53 ± 0.6 msec before compared to 3.99 ± 0.6 msec after occlusion, p < 0.001). Maximal slowing in right hemisphere P1 latency was seen in those animals in which the stroke extended into the thalamus (4.38 ± 0.1 msec). This was significantly slower than left hemisphere values (3.92 ± 0.32 msec, p < 0.01). The ipsilateral cortical components of the SEP's, the second positive peak (P2), and the major negative deflection (MN) were slowed in all cats immediately after right MCA occlusion compared to preocclusion measurements (p < 0.001). Severe infarcts in the mid-suprasylvian and posterior ectosylvian gyri (including the somatosensory cortex) resulted in a greater slowing of the latency of MN compared to less severe infarcts in that region (20.6 ± 3.9 msec versus 16.4 ± 1.1 msec, p < 0.05). There was a precipitous decrease in the amplitude or voltage of the ipsilateral P2-MN complex immediately after occlusion (5.32 ± 0.4 µV before compared to 0.98 ± 0.3 µV after occlusion, p < 0.001). Therefore, the central latencies and cortical amplitudes of the SEP's are sensitive experimental tools as indicators of the onset and extent of a cerebral ischemic insult.

scholarly journals Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment

2020 ◽  
Vol 10 (10) ◽  
pp. 663
Author(s):  
Imran Amjad ◽  
Imran Khan Niazi ◽  
Hamza Ghazanfar Toor ◽  
Rasmus Bach Nedergaard ◽  
Muhammad Shafique ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Evoked Potentials ◽  
Aerobic Exercise ◽  
Somatosensory Evoked Potentials ◽  
Control Group ◽  
Dominant Hand ◽  
Somatosensory Processing ◽  
Acute Effects ◽  
Aerobic Activity

Mild cognitive impairment (MCI) is becoming a serious problem for developing countries as the lifespan of populations increases. Exercise is known to be clinically beneficial for MCI patients. Somatosensory-evoked potentials (SEPs) may be a potential diagnostic and prognostic marker for this population. The objective of this study was to determine the acute effects of aerobic exercise on SEPs in patients with MCI, to test whether SEPs are sensitive enough to detect improvements in early somatosensory processing. The study had a randomized parallel-group design and included 28 MCI subjects (14 in the experimental group and 14 in the control group). The experimental intervention was 20 min of aerobic exercise using a stationary bicycle. The control intervention involved 20 min of movements and stretches. Subjects were assessed before and after a single intervention session. SEPs were recorded by stimulating the median nerve of the dominant hand. Analysis of normalized SEP peak amplitudes showed that a single session of aerobic activity significantly reduced the N30 peak at the F3 channel (p = 0.03). There were no significant effects of aerobic exercise on SEP peak latencies. The results indicate that 20 min of aerobic exercise has a significant effect on the N30 SEP peak amplitude in MCI patients. The results suggest that aerobic exercise is likely to provide sensory-enriching inputs that enhance sensorimotor integration. Future studies should assess the effects of aerobic exercise on somatosensory processing in progressive stages of Alzheimer’s disease, longer exercise durations, and multiple exercise sessions.

Clinical usefulness of assessing lumbar somatosensory evoked potentials in lumbar spinal stenosis

2009 ◽  
Vol 11 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Xinyu Liu ◽  
Shunsuke Konno ◽  
Masabumi Miyamoto ◽  
Yoshikazu Gembun ◽  
Gen Horiguchi ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Somatosensory Evoked Potentials ◽  
Clinical Usefulness ◽  
Control Group ◽  
Vas Score ◽  
Vas Scores ◽  
The Mean ◽  
Lumbar Spinal

Object The aim of this retrospective study was to evaluate the clinical usefulness of assessing lumbar somatosensory evoked potentials (SSEPs) in central lumbar spinal stenosis (LSS). Methods The latencies of lumbar SSEPs were recorded in 40 patients with central LSS, including 16 men and 24 women. The mean age of the patients was 67.3 ± 7.4 years. The diagnosis was LSS in 23 cases and LSS associated with degenerative spondylolisthesis in 17 cases. The average duration of symptoms was 43.8 ± 51.2 months. Twenty-two cases had bilateral and 18 cases had unilateral leg symptoms. Thirty-seven cases were associated with neurogenic intermittent claudication and the mean walking distance of patients with this condition was 246.8 ± 232.7 m. The mean Japanese Orthopedic Association scale score, as well as the visual analog scale (VAS) scores of low-back pain, leg pain, and numbness, were 16.5 ± 3.5, 6.0 ± 2.5, 6.9 ± 2.1, and 7.8 ± 2.2, respectively. The minimal cross-sectional area of the dural sac on MR imaging was 0.44 ± 0.21 cm2. Thirty-nine cases of cervical spondylotic myelopathy without lumbar and peripheral neuropathy were chosen as the control group. Results The latencies of lumbar SSEPs in patients with LSS and in the control group were 23.0 ± 2.0 ms and 21.6 ± 1.9 ms, respectively. There was a statistically significant difference between the LSS and control groups (p < 0.05). The latency of lumbar SSEPs was significant correlated with the VAS score of leg numbness (p < 0.05). The latency of lumbar SSEPs in LSS was clearly delayed when the VAS score of leg numbness was ≥ 8 (p < 0.05). Conclusions Lumbar SSEPs are able to detect neurological deficit in the lumbar area effectively, and they can reflect part of the subjective severity of sensory disturbance (numbness) in LSS. Both lumbar SSEPs and VAS scores of leg numbness may be useful for clinical evaluation in patients with LSS.

scholarly journals Evoked potentials as biomarkers of hereditary spastic paraplegias: A case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259397
Author(s):  
Samanta Ferraresi Brighente ◽  
Paul Vicuña ◽  
Ana Luiza Rodrigues Louzada ◽  
Gabriela Marchisio Giordani ◽  
Helena Fussiger ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Disease Progression ◽  
Somatosensory Evoked Potentials ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Conduction Time ◽  
Upper Limbs ◽  
Hereditary Spastic Paraplegias ◽  
Control Study

Introduction The Hereditary Spastic Paraplegias (HSP) are a group of genetic diseases that lead to slow deterioration of locomotion. Clinical scales seem to have low sensitivity in detecting disease progression, making the search for additional biomarkers a paramount task. This study aims to evaluate the role of evoked potentials (EPs) as disease biomarkers of HSPs. Methods A single center cross-sectional case-control study was performed, in which 18 individuals with genetic diagnosis of HSP and 21 healthy controls were evaluated. Motor evoked potentials (MEP) obtained with transcranial magnetic stimulation and somatosensory evoked potentials (SSEP) were performed in lower (LL) and upper limbs (UL). Results Central motor conduction time in lower limbs (CMCT-LL) was prolonged in HSP subjects, with marked reductions in MEP-LL amplitudes when compared to the control group (p<0.001 for both comparisons). CMCT-UL was 3.59ms (95% CI: 0.73 to 6.46; p = 0.015) prolonged and MEP-UL amplitudes were reduced (p = 0.008) in the HSP group. SSEP-LL latencies were prolonged in HSP subjects when compared to controls (p<0.001), with no statistically significant differences for upper limbs (p = 0.147). SSEP-UL and SSEP-LL latencies presented moderate to strong correlations with age at onset (Rho = 0.613, p = 0.012) and disease duration (Rho = 0.835, p<0.001), respectively. Similar results were obtained for the SPG4 subgroups of patients. Conclusion Motor and somatosensory evoked potentials can adequately differentiate HSP individuals from controls. MEP were severely affected in HSP subjects and SSEP-LL latencies were prolonged, with longer latencies being related to more severe disease. Future longitudinal studies should address if SSEP is a sensitive disease progression biomarker for HSP.

scholarly journals Effect of Neck Muscle Fatigue on Hand Muscle Motor Performance and Early Somatosensory Evoked Potentials

2021 ◽  
Vol 11 (11) ◽  
pp. 1481
Author(s):  
Mahboobeh Zabihhosseinian ◽  
Paul Yielder ◽  
Rufeyda Wise ◽  
Michael Holmes ◽  
Bernadette Murphy
Keyword(s):  
Evoked Potentials ◽  
Muscle Fatigue ◽  
Skill Acquisition ◽  
Upper Limb ◽  
Somatosensory Evoked Potentials ◽  
Motor Task ◽  
Control Group ◽  
Neck Muscle ◽  
Median Nerve Stimulation ◽  
Neck Muscle Fatigue

Even on pain free days, recurrent neck pain alters sensorimotor integration (SMI) measured via somatosensory evoked potentials (SEPs). Neck muscle fatigue decreases upper limb proprioception, and thus may interfere with upper limb motor task acquisition and SMI. This study aimed to determine the effect of cervical extensor muscle (CEM) fatigue on upper limb motor acquisition and retention; and SMI, measured via early SEPs. Twenty-four healthy right-handed individuals were randomly assigned to control or CEM fatigue. Baseline SEPs were elicited via median nerve stimulation at the wrist. Participants then lay prone on a padded table. The fatigue group supported a 2 kg weight until they could no longer maintain the position. The control group rested their neck in neutral for 5 min. Participants completed pre- and post-motor skill acquisition while seated, SEPs were again collected. Task retention was measured 24 h later. Accuracy improved post acquisition and at retention for both groups (p < 0.001), with controls outperforming the fatigue group (p < 0.05). The fatigue group had significantly greater increases in the N24 (p = 0.017) and N30 (p = 0.007) SEP peaks. CEM fatigue impaired upper limb motor learning outcomes in conjunction with differential changes in SEP peak amplitudes related to SMI.

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