Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis

Cystic fibrosis (CF) is a genetic disease characterized by progressive decline of lung function and chronic airway inflammation. Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes. This study evaluated the levels of adiponectin and leptin in adult healthy subjects, in patients with CF and their correlation with long-term physical activity. CF patients were divided into two groups (sedentary versus active) based on their regular physical activity over 3 years. Anthropometric and serum biochemical profiles of CF patients and controls were evaluated and compared. Total serum adiponectin and leptin levels were measured by ELISA; adiponectin oligomeric profiles were analysed by western blot. Adiponectin levels were significantly higher while leptin levels were lower in patients with CF than in healthy controls. Furthermore, adiponectin was significantly lower in active compared to sedentary CF (p=0.047), while leptin was slightly increased in active compared to sedentary CF. In addition, C-reactive protein levels were significantly lower in active than in sedentary CF patients (p=0.048). Interestingly, only in the active group adiponectin levels were inversely correlated with forced expiratory volume (FEV) 1% decrease/year and FEV1% decrease. Moreover, adiponectin levels negatively correlated with lipid profiles. Our findings indicated that regular, long-term physical activity in CF improves respiratory function, metabolism, and inflammation status. These improvements in patients’ conditions are associated with immunometabolic processes involving adiponectin, leptin, and C-reactive protein. Therefore, we propose that both adipokines may be a useful biomarker in the evaluation of metabolic and inflammatory status in patients with CF.

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Abstract P096: Maternal Serum C-Reactive Protein Levels During Pregnancy and Risk for High C-Reactive Protein 7-13 Years Later

Circulation ◽

10.1161/circ.129.suppl_1.p096 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Bonny Rockette-Wagner ◽

Claudia Holzman ◽

Bertha L Bullen ◽

Andrew D Althouse ◽

Janet M Catov

Keyword(s):

Relative Risk ◽

Weight Change ◽

Elevated Serum ◽

Maternal Serum ◽

Health Study ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Inflammatory Status

Introduction: Elevated serum C-reactive protein (CRP) can be a marker of disease activity involving inflammation, such as pregnancy complications and cardiovascular disease (CVD). Systemically high levels of CRP in women, including during pregnancy, may indicate higher risk for CVD. It is unknown if CRP measured during the pro-inflammatory state of pregnancy correlates with concentrations assessed 7-13 years after delivery. Hypothesis: Concentrations of CRP assessed during pregnancy will be related to CRP measured several years after pregnancy, independent of weight gain. Methods: We studied the first 252 women enrolled in the follow-up of the Pregnancy Outcomes and Community Health Study (POUCHmoms 2011-2013) with complete CRP data for the pregnancy (mean gestational age: 22.36 [2.22] weeks) and POUCHmoms visits (mean follow-up: 10.76 [1.38] years). The relative risk for high hsCRP (≥ 3.39 μg/ml) at the follow-up visit, related to quartiles of CRP during pregnancy, was examined using stepwise regression models. Results: Median (IQR) levels of pregnancy CRP and hsCRP at the follow-up visit were 5.68 [3.08, 9.76] and 3.39 [0.69, 9.73] μg/ml, respectively. Although absolute values of hsCRP at follow-up were generally lower than pregnancy CRP, 56% of women in the top and bottom quartiles of pregnancy CRP (71 of 126) were in the same quartile for hsCRP at follow-up (figure). The relative risk of having high hsCRP (≥ 3.39 μg/ml) at follow-up ranged from 2.7-5.2 for the 2 nd - 4 th quartiles of pregnancy CRP (vs. the 1st quartile). Controlling for pre-pregnancy BMI and follow-up weight change, the relative risk of having high hsCRP at follow-up was significantly higher for the 2 nd (1.15 [1.02-1.30]),3 rd (1.19 [1.05-1.35), and 4 th (1.22 [1.05-1.41]) quartiles of pregnancy CRP. Conclusions: Pregnancy CRP levels are related to hsCRP levels several years later in this cohort of women, even after adjusting for pre-pregnancy BMI and follow-up weight change. CRP assessed in pregnancy may reflect inflammatory status later in life.

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Long-Term Stability of High Sensitivity C Reactive Protein Levels in Healthy Adults

Heart Lung and Circulation ◽

10.1016/j.hlc.2007.06.175 ◽

2007 ◽

Vol 16 ◽

pp. S68

Author(s):

B.M. McQuillan ◽

E. Rossi ◽

J. Hung ◽

P.L. Thompson ◽

J.P. Beilby

Keyword(s):

High Sensitivity ◽

Healthy Adults ◽

C Reactive Protein ◽

Term Stability ◽

Protein Levels ◽

Long Term Stability ◽

Reactive Protein

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Association between percutaneous coronary intervention and long-term C-reactive protein levels in patients with acute coronary syndromes

Journal of Thrombosis and Thrombolysis ◽

10.1007/s11239-010-0463-7 ◽

2010 ◽

Vol 30 (1) ◽

pp. 10-13 ◽

Cited By ~ 3

Author(s):

Kausik K. Ray ◽

Babak Nazer ◽

Richard Cairns ◽

C. Michael Gibson ◽

Christopher P. Cannon

Keyword(s):

Percutaneous Coronary Intervention ◽

Acute Coronary Syndromes ◽

Coronary Intervention ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Percutaneous Coronary ◽

Coronary Syndromes

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C-reactive protein levels are associated with arterial media calcification in nondiabetic patients with end-stage renal disease on long-term hemodialysis

Clinical Nephrology ◽

10.5414/cn107003 ◽

2011 ◽

Vol 76 (12) ◽

pp. 425-434 ◽

Cited By ~ 5

Author(s):

A. Marinelli ◽

L. Orlandi ◽

G. Stivali

Keyword(s):

Renal Disease ◽

End Stage Renal Disease ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Stage Renal Disease ◽

End Stage

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Does atorvastatin influence serum C-reactive protein levels in patients on long-term hemodialysis?

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2003.11.008 ◽

2004 ◽

Vol 43 (3) ◽

pp. 471-478 ◽

Cited By ~ 50

Author(s):

Luigi Vernaglione ◽

Claudio Cristofano ◽

Pietro Muscogiuri ◽

Stefano Chimienti

Keyword(s):

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

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Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study

BMC Nephrology ◽

10.1186/1471-2369-10-10 ◽

2009 ◽

Vol 10 (1) ◽

Cited By ~ 5

Author(s):

Wilfried Karmaus ◽

Plamen Dimitrov ◽

Valeri Simeonov ◽

Svetla Tsolova ◽

Vecihi Batuman

Keyword(s):

Longitudinal Study ◽

Balkan Endemic Nephropathy ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Endemic Nephropathy ◽

Inflammatory Processes

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Effect of Body Mass Index on the Disease Activity of Patients With Rheumatoid Arthritis in a Gender-Specific Manner and the Association of Respective Serum C-Reactive Protein Levels With the Body’s Inflammatory Status

Cureus ◽

10.7759/cureus.9417 ◽

2020 ◽

Author(s):

Shumaila M Iqbal ◽

Linda Burns ◽

Joseph Grisanti

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Disease Activity ◽

Body Mass ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Inflammatory Status ◽

Specific Manner ◽

Gender Specific

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Biomarkers, Inflammation, and Bipolar Disorder: Association Between the Improvement of Bipolar Disorder Severity and the Improvement in C-Reactive Protein Levels After 7 Days of Inpatient Treatment

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.803034 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alessandro Cuomo ◽

Despoina Koukouna ◽

Alessandro Spiti ◽

Giovanni Barillà ◽

Arianna Goracci ◽

...

Keyword(s):

Bipolar Disorder ◽

Inpatient Treatment ◽

Inflammatory Marker ◽

C Reactive Protein ◽

Disease Symptoms ◽

Mortality And Morbidity ◽

Protein Levels ◽

Reactive Protein ◽

Inflammatory Processes ◽

The Relationship

Introduction: Compared to the general population, people with severe mental illness (SMI) have a poorer health status and a higher mortality rate, with a 10–20-year reduction in life expectancy. Excess mortality and morbidity in SMI have been explained by intertwined components. Inflammatory processes could increase the morbidity and mortality risk in patients with bipolar disorder (BD) because of a bidirectional interaction between BD and conditions related to inflammation. This pilot study aimed to evaluate the relationship between C-Reactive-Protein (CRP) and bipolar disorder severity.Methods: A retrospective observational study was conducted on 61 hospitalized patients with bipolar disorder. CRP was measured at admission to inpatient treatment (T0) and after seven days from the admission (T1). Clinical Global Impression for Depression, Mania and Overall Bipolar Illness were recorded at T0 and T1. Comparisons among the recorded CRP values were determined through the paired t-test. Correlations between CRP and CGI scores were determined through Spearman's correlation coefficient at T0 and T1.Results: A statistically significant decrease in CRP values was observed after 7 days of hospitalization (p < 0.001) and positive significant correlations emerged between CRP and CGI scores at T0 and T1.Conclusion: Patients admitted to the inpatient unit reported a statistically significant decrease of CRP values during the first 7 days of treatment. Although the direction of the relationship between BP severity and inflammation status continues to remain unclear, this study showed a relationship between the improvement of bipolar disease symptoms and the improvement of the inflammatory marker CRP.

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