scholarly journals Electrical Remodeling of Ventricular Repolarization Abnormality after Treatment in Pheochromocytoma: U Wave Finding in a Retrospective Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Giuseppe Di Stolfo ◽  
Sandra Mastroianno ◽  
Angela Maggio ◽  
Giovanni De Luca ◽  
Domenico R. Potenza ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Retrospective Analysis ◽  
Tumor Size ◽  
Systemic Blood Pressure ◽  
Ventricular Repolarization ◽  
P Wave ◽  
Surgical Removal ◽  
Pr Interval ◽  
Before And After ◽  
Qrs Duration

Background. Pheochromocytoma is a rare neuroendocrine tumor, clinically characterized by high blood pressure, palpitations, and headache. It is often associated with abnormalities of the ventricular repolarization phase; the dispersion of ventricular repolarization is the basis for ventricular arrhythmias (torsion de point, ventricular tachycardia or ventricular fibrillation). Objectives. Analysis of abnormal ventricular repolarization focused on the presence and amount of U wave in patients affected by pheochromocytoma and its modification after surgery. Materials and Methods. We reviewed pathology records of 722 patients admitted for adrenal nodule or suspected chromaffin-cell tumor and identified 39 patients affected by pheochromocytoma. Metanephrine, normetanephrine, and 3-methoxytyramine have been assessed by determining concentrations in 24-hour urine collection. Standard 12-lead electrocardiogram records have been reviewed with analysis of heart rate, P wave, PR interval, QRS duration, QTc, and U wave. Then we selected and compared 22 patients of 39 affected by pheochromocytoma, with both clinical and electrocardiographic data before and after surgery. Results. In our cohort of 39 patients affected by pheochromocytoma, we found U wave in ECG, before treatment, in 82.8 percent of patients, while only 37.0 percent after treatment (p<0.001) and we observed a statistically significant correlation between this wave and the urinary metanephrine. After surgery, in the selected 22 patients, we observed a clear significant reduction in systemic blood pressure, fasting glucose, metanephrine, normetanephrine, and 3-methoxytyramine. We found a significant reduction of U wave presence and leads involved in these patients after surgery (90.9% versus 9%). We observed a linear correlation between the amount of U waves in 12-lead electrocardiogram and metanephrine (r2=0.333, p=0.015), 3-methoxytyramine levels (r2=0.458, p=0.006), and tumor size (r2=0.429, p=0.003). Conclusions. In our retrospective analysis, patients affected by pheochromocytoma presented U wave in electrocardiogram. The presence and amount of U wave were associated with the metanephrine levels and the tumor size with significant reduction after surgical removal.

scholarly journals Decreased Size of Mammary Tumors Caused by Preoperative Treatment with Aglepristone in Female Domestic Dogs (Canis familiaris) Do Not Influence the Density of the Benign Neoplastic Tissue Measured Using Shear Wave Elastography Technique

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 527 ◽  
Author(s):  
Barbara Pieczewska ◽  
Kamila Glińska-Suchocka ◽  
Wojciech Niżański ◽  
Michał Dzięcioł
Keyword(s):  
Shear Wave ◽  
Tumor Size ◽  
Histopathological Examination ◽  
Shear Wave Elastography ◽  
Mammary Tumors ◽  
Needle Aspiration ◽  
Surgical Removal ◽  
Preoperative Treatment ◽  
Neoplastic Tissue ◽  
Before And After

Shear wave elastography (SWE) can be useful to discriminate between malignant and benign mammary tumors. In dogs with elevated progesterone levels compared to the baseline and fast-growing tumors, treatment with the use of aglepristone allows for tumor size reduction, which facilitates surgery. This study aimed to evaluate the influence of the preoperative treatment of benign mammary tumors (BMTs), performed with the use of aglepristone, on the density of the tumor tissue measured by SWE. Twelve female dogs with diagnosed BMTs and increased levels of progesterone were treated with aglepristone (Alizine, Virbac, France) at 10 mg/kg s.c. (Subcutaneous injection). twice, with a 24 h interval. The density of the tumor was evaluated by SWE before and after the treatment. The type of tumor was evaluated by fine needle aspiration cytology before treatment, and a histopathological examination was made after surgical removal, performed after the aglepristone treatment. In all the cases, a significant reduction in the mammary tumor’s size was observed following treatment, with no influence on the density of the tumor’s tissue measured by SWE. Similar studies on malignant mammary tumors are warranted to verify if in these cases, density will also be a constant parameter that is not dependent on the tumor size.

Atrioventricular conduction abnormalities and atrioventricular blocks: ECG patterns and diagnosis

2018 ◽  
Author(s):  
S. Serge Barold
Keyword(s):  
P Wave ◽  
Conduction Time ◽  
Type I ◽  
Type Ii ◽  
Av Block ◽  
Ventricular Extrasystoles ◽  
Av Conduction ◽  
Pr Interval ◽  
Before And After ◽  
Second Degree

The diagnosis of first-degree and third-degree atrioventricular (AV) block is straightforward but that of second-degree AV block is more involved. Type I block and type II second-degree AV block are electrocardiographic patterns that refer to the behaviour of the PR intervals (in sinus rhythm) in sequences (with at least two consecutive conducted PR intervals) where a single P wave fails to conduct to the ventricles. Type I second-degree AV block describes visible, differing, and generally decremental AV conduction. Type II second-degree AV block describes what appears to be an all-or-none conduction without visible changes in the AV conduction time before and after the blocked impulse. The diagnosis of type II block requires a stable sinus rate, an important criterion because a vagal surge (generally benign) can cause simultaneous sinus slowing and AV nodal block, which can resemble type II block. The diagnosis of type II block cannot be established if the first post-block P wave is followed by a shortened PR interval or by an undiscernible P wave. A narrow QRS type I block is almost always AV nodal, whereas a type I block with bundle branch block barring acute myocardial infarction is infranodal in 60–70% of cases. All correctly defined type II blocks are infranodal. A 2:1 AV block cannot be classified in terms of type I or type II block, but it can be AV nodal or infranodal. Concealed His bundle or ventricular extrasystoles may mimic both type I or type II block (pseudo-AV block), or both

scholarly journals NONTHERMAL EFFECTS OF MOBILE PHONE RADIATIONS ON HUMAN HEART RATE, BLOOD PRESSURE, AND SUGAR LEVEL

2017 ◽  
Vol 10 (7) ◽  
pp. 142
Author(s):  
Basandrai D ◽  
Dhami A K ◽  
Bedi A K
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Mobile Phone ◽  
Experimental Work ◽  
Cell Phone ◽  
Human Heart ◽  
P Wave ◽  
St Segment ◽  
Before And After ◽  
Cell Phone Radiation

Objective: A single-blinded pilot study has been conducted to investigate the effect of cell phone radiation on the human heart. Methods: Experimental work has been conducted in Jalandhar-based hospital under the supervision of a cardiologist. During experimental work, electrocardiogram (ECG), blood pressure (BP) level, and sugar level have been examined before and after cell phone radiation exposure. For ECG analysis, the parameters such as heart rate, rhythm, mechanism, axis, P wave, PR interval, QRS complex, ST segment, T wave, and QT interval have been examined in the study.Results: No significant variations in the results of above-mentioned parameter has been observed before and after acute exposure of cell phones radiations by placing cell phone closer to heart.Conclusion: The result of this study concludes that mobile phone radiations do not interfere with any electrical activity of the human heart, BP, and sugar level in healthy individuals.

scholarly journals Electrocardiographic Changes during Normal Pregnancy

2017 ◽  
Vol 02 (03) ◽  
pp. 035-038
Author(s):  
Beeram Sumalatha ◽  
Maddury Jyotsna ◽  
Garre Indrani
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Pregnant Women ◽  
Qtc Interval ◽  
Normal Range ◽  
Cardiovascular Changes ◽  
Pr Interval ◽  
Qrs Duration ◽  
The Mean

Background Pregnancy is a physiologic condition which is unique in that it alters the physiology of each organ in the body. Cardiovascular changes during pregnancy are significant and start at 6 to 8 weeks of gestation. Physiologic cardiovascular changes during pregnancy suggest the chance of altered electrocardiographic (ECG) parameters during pregnancy. Study of variations in ECG in normal pregnant women serves as a basis to detect pathologic changes in pregnant women. Material and Methods This is a cross-sectional data of case series of pregnant women across all stages of gestation who attended antenatal clinic of our teaching hospital, on Women's Day (March 8, 2017). A 12-lead ECG was recorded in all the participants in supine position. The parameters noted from the ECG include heart rate, PR interval, QRS duration, QRS axis, corrected QT (QTc) interval, and ST-T changes. Results Total 151 pregnant women were studied. The average age was 23.38 ± 3.49 years. With respect to gestational age, 12 (7.94%), 48 (31.78%), and 91 (60.26%) women were in the first, second, and third trimesters of pregnancy, respectively. With respect to parity, 60 (39.7%) were primigravidae and 91 (60.26%) were multigravidae. The mean ECG heart rate was increased (100.15 ± 12.48 beats/min). The mean systolic blood pressure (109.67 ± 9.34 mm Hg) and the mean diastolic blood pressure (71.32 ± 6.89 mm Hg) were decreased. The mean of ECG intervals and durations (PR, QRS, QTc) were in normal range (0.14 ± 0.01, 0.08 ± 0.008, and 407.83 ± 11.98, respectively). There was no abnormal P-wave dispersion. Even though the QTc was in normal range in 63.56% of pregnant women, this parameter was in upper quadrant of the normal range. General linear regression demonstrated that systolic blood pressure and palpitations were the only variables to independently predict QTc in upper quadrant of normal range (p = 0.05, 0.03, respectively). Conclusion The cardiovascular hemodynamic adaptation to pregnancy is a well-established fact that is also seen in our study. There is shortening of PR interval and QRS duration. Even though QTc is with in normal range, in more than half (63.56%) of pregnant women, it is in the upper quadrant of the normal range.

The effect of nimodipine on intracranial pressure

1987 ◽  
Vol 67 (3) ◽  
pp. 387-393 ◽  
Author(s):  
Mark N. Hadley ◽  
Robert F. Spetzler ◽  
Mary S. Fifield ◽  
William D. Bichard ◽  
John A. Hodak
Keyword(s):  
Blood Pressure ◽  
Intracranial Pressure ◽  
Systemic Blood Pressure ◽  
Artery Occlusion ◽  
Content Type ◽  
Arterial Blood ◽  
Increased Risk ◽  
Before And After ◽  
The Right ◽  
Cerebral Artery Occlusion

✓ Nimodipine was administered by intravenous infusion to six male baboons before, during, and after 6 hours of middle cerebral artery occlusion. Intracranial pressure (ICP) and systemic blood pressure were monitored continuously. An epidural balloon was inflated at regular intervals at three levels of arterial CO2 tension (25, 35, and 50 mm Hg) before and after the administration of nimodipine, and volume-pressure curves were generated. In every case, curves generated after intravenous nimodipine infusion were lower and shifted more to the right than the same set of curves generated before nimodipine administration, regardless of the baseline ICP. The reduction in ICP following nimodipine infusion was not due to a reduction in mean arterial blood pressure and was statistically significant at all three levels of pCO2 (p < 0.01). These results suggest that, in the presence of elevated ICP due to cerebral infarction, there is no increased risk of exacerbating intracranial hypertension with the addition of nimodipine.

Noradrenaline Reactivity in Patients with Phaeochromocytoma before and after Surgical Correction

1981 ◽  
Vol 61 (s7) ◽  
pp. 211s-213s ◽  
Author(s):  
G. Leonetti ◽  
L. Terzoli ◽  
G. Bianchini ◽  
L. Rupoli ◽  
R. Lipira ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Surgical Correction ◽  
Plasma Noradrenaline ◽  
Reactivity Index ◽  
Surgical Removal ◽  
Endogenous Noradrenaline ◽  
Before And After ◽  
Blood Pressures

1. For comparable blood pressures, plasma noradrenaline is disproportionately higher in patients with phaeochromocytoma than in those with essential hypertension. 2. The ‘pressor-dose’ of noradrenaline or its reciprocal, the reactivity index, were abnormal in patients with phaeochromocytoma before surgery and made normal by surgical removal of the phaeochromocytoma. 3. There was a significant correlation between blood pressures and the logarithm of plasma noradrenaline concentrations. 4. The higher dose of exogenous noradrenaline required in patients with phaeochromocytoma for a given rise in blood pressure seems to be the expression of the higher levels of endogenous noradrenaline rather than true decreased reactivity.

scholarly journals The ECG changes in various comorbidities with hypertension and without hypertension

2020 ◽  
Vol 8 (4) ◽  
pp. 1351
Author(s):  
Metta Anil Kumar ◽  
J. Muralikrishna ◽  
Anand Acharya
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
P Wave ◽  
Study Group ◽  
Qtc Interval ◽  
Epidemiologic Transition ◽  
Mortality And Morbidity ◽  
Pr Interval

Background: Hypertension is the commonest cardiovascular disorder posing a challenge to the societies in socioeconomic and epidemiologic transition. In India, Cardiovascular Diseases (CVDs) are estimated to be responsible for 1.5 million deaths annually. Indeed, it is estimated that by 2020, CVDs will be the largest cause of mortality and morbidity in India. To present study is designed to evaluate the variation of blood pressure and ECG wave forms among people hypertension with co morbidities (study group) and controls.Methods: The study included 50 people comorbidities with hypertension and 50 controls, each between ages 30-40 years from general population, and also from Medicine outpatient department, KIMS and RF Amalapuram. Detailed history from subjects, blood pressure (sitting position) and electrocardiogram was recorded during resting state in supine position. The ECG results were evaluated for various parameters like heart rate, P wave, PR interval, QRS complex etc.Results: There was significant increase in heart rate, systolic blood pressure as well as diastolic blood pressure in study group when compared to controls. Decrease in PR interval, decrease in QT interval, decrease in QTc interval, decrease in QRS axis in smokers when compared to controls.Conclusions: There was significant increase in heart rate in study group (smokers, diabetic) when compared to controls. There was significant increase in systolic blood pressure as well as diastolic blood pressure in study group (smokers, diabetics) when compared to controls. There was significant decrease in PR interval in smokers when compared to controls. There was significant decrease in QT and QTc interval in smokers when compared to controls.

scholarly journals Electrocardiographic patterns of Mangalarga Marchador horses before and after implementation of the marcha gait

2016 ◽  
Vol 46 (5) ◽  
pp. 915-920 ◽  
Author(s):  
Clarisse Simões Coelho ◽  
Gabriella Agra de Omena e Silva ◽  
Luiz Antonio Trindade Oliveira Junior ◽  
Vanessa Sartor Moraes ◽  
Laura Monteiro de Castro Conti ◽  
...  
Keyword(s):  
Qt Interval ◽  
P Wave ◽  
Qrs Complex ◽  
Sinus Arrhythmia ◽  
Qt Intervals ◽  
Pr Interval ◽  
Before And After ◽  
Kolmogorov Smirnov ◽  
Electrocardiographic Parameters ◽  
T Waves

ABSTRACT: The aim of this study was to evaluate the electrocardiographic parameters in Mangalarga Marchador horses submitted to marcha exercise. Twenty-four Mangalarga Marchador horses, thirteen females and eleven males, 6.4±2.7 years old with a mean weight of 428.3±24.7kg, were used. Electrocardiograms were recorded in two different moments: rest and immediately after exercise (40 minutes of aerobic exercise, marcha gait). The electrocardiographic variables analyzed were cardiac rhythm, heart rate (HR), duration of P wave, QRS complex, PR and QT intervals, amplitudes of P, R and T waves, and analysis of QT corrected (QTc) according to Bazett's formula (QT/√RR). Variables were analyzed for normality with Kolmogorov-Smirnov test and paired t-test, considering P<0.05. Rhythm analysis revealed 91.7% of sinus rhythm and 8.3% of sinus arrhythmia in rest, with mean HR of 45.7±12.7 beats minute-1, and 100% of sinus tachycardia, with mean HR of 77.3±13.5 beats minute-1 after exercise (P<0.0001). In post-exercise, it was possible to observe decreases in P wave duration (P=0.0121), PR interval (P=0.0007) and QT interval (P<0.0001) and increase of QTc (P=0.0039) and R wave amplitude (P=0.0033). There were no significant differences for amplitude of P and T waves and QRS complex related to atrioventricular enlargement. Although QT interval decreased after exercise, there was an increase on QTc after exercise, indicating changes in ventricular repolarization. It was possible to conclude that the imposed exercise (marcha gait) led to electrocardiographic alterations without causing pathological arrhythmias.

Atrioventricular conduction abnormalities and atrioventricular blocks: ECG patterns and diagnosis

ESC CardioMed ◽  
2018 ◽  
pp. 1958-1961
Author(s):  
S. Serge Barold
Keyword(s):  
P Wave ◽  
Conduction Time ◽  
Type I ◽  
Type Ii ◽  
Av Block ◽  
Ventricular Extrasystoles ◽  
Av Conduction ◽  
Pr Interval ◽  
Before And After ◽  
Second Degree

The diagnosis of first-degree and third-degree atrioventricular (AV) block is straightforward but that of second-degree AV block is more involved. Type I block and type II second-degree AV block are electrocardiographic patterns that refer to the behaviour of the PR intervals (in sinus rhythm) in sequences (with at least two consecutive conducted PR intervals) where a single P wave fails to conduct to the ventricles. Type I second-degree AV block describes visible, differing, and generally decremental AV conduction. Type II second-degree AV block describes what appears to be an all-or-none conduction without visible changes in the AV conduction time before and after the blocked impulse. The diagnosis of type II block requires a stable sinus rate, an important criterion because a vagal surge (generally benign) can cause simultaneous sinus slowing and AV nodal block, which can resemble type II block. The diagnosis of type II block cannot be established if the first post-block P wave is followed by a shortened PR interval or by an undiscernible P wave. A narrow QRS type I block is almost always AV nodal, whereas a type I block with bundle branch block barring acute myocardial infarction is infranodal in 60–70% of cases. All correctly defined type II blocks are infranodal. A 2:1 AV block cannot be classified in terms of type I or type II block, but it can be AV nodal or infranodal. Concealed His bundle or ventricular extrasystoles may mimic both type I or type II block (pseudo-AV block), or both

scholarly journals The Acute Effect of Hemodialysis on Choroidal Thickness

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Osman Çelikay ◽  
Sinan Çalışkan ◽  
Tolga Biçer ◽  
Naciye Kabataş ◽  
Canan Gürdal
Keyword(s):  
Blood Pressure ◽  
Choroidal Thickness ◽  
Linear Regression Analysis ◽  
Systemic Blood Pressure ◽  
Acute Effect ◽  
Multivariate Linear Regression Analysis ◽  
Before And After ◽  
Patients With Diabetes ◽  
The Right ◽  
Stage Renal Disease

Objective. To determine the effect of hemodialysis (HD) on choroidal thickness (CT).Methods. The right eyes of 41 patients with end-stage renal disease (ESRD) undergoing HD were included. All patients underwent an ophthalmic examination, including CT measurement via optical coherence tomography, intraocular pressure (IOP), blood pressure, and body weight measurement immediately before and after a HD session.Results. Mean subfoveal choroidal thickness (SFCT) after HD decreased significantly from 254.59 ± 84.66 µm to 229.34 ± 77.79 µm(p<0.001). CT at the temporal and nasal regions also decreased significantly after HD (bothp<0.001). IOP changes after HD were insignificant(p=0.958). CT difference was insignificant in patients with diabetes mellitus (DM) and without DM before and after HD, respectively (p=0.285andp=0.707). Stepwise multivariate linear regression analysis showed that diastolic blood pressure was the best fitted factor to explain the changes in CT (r=0.327andp=0.040).  Conclusion. CT was decreased in the patients with ESRD following a HD session. This study suggested that the changes in CT may be related to the changes in systemic blood pressure.

Sign in / Sign up

Export Citation Format

Share Document