scholarly journals Exploring the Most Promising Stem Cell Therapy in Liver Failure: A Systematic Review

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Jeanne AdiwinataPawitan
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Liver Failure ◽  
Stem Cell Therapy ◽  
Adult Stem Cells ◽  
Cochrane Library ◽  
Safety And Efficacy ◽  
Alternative Approaches

Background. Alternative approaches to transplantation for liver failure are needed. One of the alternative approaches is stem cell therapy. However, stem cell therapy in liver failure is not standardized yet, as every centre have their own methods. This systematic review is aimed at compiling and analyzing the various studies that use stem cells to treat liver failure, to get an insight into potential protocols in terms of safety and efficacy by comparing them to controls. Methods. This systematic review was done according to PRISMA guidelines and submitted for registration in PROSPERO (registration number CRD42018106119). All published studies in PubMed/MEDLINE and Cochrane Library, using key words: “human” and “stem cell” AND “liver failure” on 16th June 2018, without time restriction. In addition, relevant articles that are found during full-text search were added. Inclusion criteria included all original articles on stem cell use in humans with liver failure. Data collected included study type, treatment and control number, severity of disease, concomitant therapy, type and source of cells, passage of cells, dose, administration route, repeats, and interval between repeats, outcomes, and adverse events compared to controls. Data were analyzed descriptively to determine the possible causes of adverse reactions, and which protocols gave a satisfactory outcome, in terms of safety and efficacy. Results. There were 25 original articles, i.e., eight case studies and 17 studies with controls. Conclusion. Among the various adult stem cells that were used in human studies, MSCs from the bone marrow or umbilical cord performed better compared to other types of adult stem cells, though no study showed a complete and sustainable performance in the outcome measures. Intravenous (IV) route was equal to invasive route. Fresh or cryopreserved, and autologous or allogeneic MSCs were equally beneficial; and giving too many cells via intraportal or the hepatic artery might be counterproductive.

scholarly journals Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research

2018 ◽  
Vol 27 (12) ◽  
pp. 1723-1730 ◽  
Author(s):  
Haiqing Zheng ◽  
Bin Zhang ◽  
Pratik Y. Chhatbar ◽  
Yi Dong ◽  
Ali Alawieh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Studies ◽  
Animal Studies ◽  
Current Evidence ◽  
Human Trials

Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. We conducted a systematic review on published literature using MSCs in both pre-clinical studies and clinical trials between 2008 and 2017 using the public databases PubMed and Ovid Medline, and the clinical trial registry ( www.clinicaltrials.gov ). A total of 78 pre-clinical studies and eight clinical studies were identified. While majority of the pre-clinical and clinical studies demonstrated statistically significant effects, the clinical significance of these findings was still unclear. Effect sizes could not be measured mainly due to reporting issues in pre-clinical studies, thus limiting our ability to compare results across studies quantitatively. The overall quality of both pre-clinical and clinical studies was sub-optimal. By conducting a systematic review of both pre-clinical and clinical studies on MSCs therapy in stroke, we assessed the quality of current evidence and identified several issues and gaps in translating animal studies to human trials. Addressing these issues and incorporating changes into future animal studies and human trials may lead to better success of stem cells-based therapeutics in the near future.

Current understanding of safety and efficacy of stem cell therapy for discogenic pain—A systematic review of human studies

2015 ◽  
Vol 19 (1-2) ◽  
pp. 32-37 ◽  
Author(s):  
Christine L. Hunt ◽  
Stephanie Shen ◽  
Ahmad Nassr ◽  
Andre J. van Wijnen ◽  
A. Noelle Larson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Human Studies ◽  
Current Understanding ◽  
Discogenic Pain ◽  
Safety And Efficacy

scholarly journals Safety and Efficacy of Stem Cell Therapeutics in Wound Healing: A Rapid Review of Available Evidence

2021 ◽  
Author(s):  
Zeinab Shaker ◽  
Zohreh Shaker ◽  
Mohsen Barouni
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Good Alternative ◽  
Rapid Review ◽  
Stem Cell Technology ◽  
Safety And Efficacy ◽  
Cell Technology

Background: Skin and wound injuries are important health problems with great mortality rates. While there are different alternative therapies, there is no agreement on the best therapy for burn wounds and wound complications. Stem cell therapy has an optimistic prospect in many preclinical studies of burn wounds and diabetic wounds. Objectives: In this study, we performed a rapid review to evaluate the efficacy and safety of stem cell therapy in wound treatment. Methods: This rapid review of the evidence aimed to evaluate the potential effects of stem cells on wound healing to create a policy guide for policymakers in the health care system. We searched such databases as PubMed and Scopus on March 13, 2021 using keywords, including “stem cells and wound healing”, “safety”, and “efficacy”. The references of retrieved studies were also checked to ensure the capture of the literature. Studies evaluating the safety and efficacy of stem cells on wound healing published in Persian and English were included. Generally, we used the PICO (population, intervention, control, and outcomes) model for search strategy. Results: Out of a total of 92 retrieved papers, 22 studies were eligible for inclusion. The overall review showed that stem cell therapy improved wounds. Also, studies showed that using stem cell technology in a non-invasive way could be a good alternative. However, the limitations of this technology consisted of the need to improve cell delivery methods, cell sustainability, heterogeneity in the research of mesenchymal stem cells, and wound substrate. Further studies are needed to determine its safety and efficacy. Conclusions: Although the evidence on the safety and efficacy of using stem cells for wound healing was limited, studies showed that stem cell technology is a good alternative to traditional therapies. Future clinical studies should consider the differences in the studies to achieve maximum effectiveness.

scholarly journals Enhanced therapeutic effects of umbilical cord mesenchymal stem cells after prolonged treatment for HBV- related liver failure and liver cirrhosis

2020 ◽  
Author(s):  
Yifan Jia ◽  
Xin Shu ◽  
Xiaoan Yang ◽  
Haixia sun ◽  
Huijuan Cao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Stem Cell ◽  
Cell Therapy ◽  
Liver Failure ◽  
Stem Cell Therapy ◽  
Prolonged Treatment ◽  
Therapeutic Effects ◽  
Failure Group

Abstract Background: This study aimed to investigate the therapeutic effect of umbilical cord mesenchymal stem cells (UCMSCs) on HBV-related liver failure and liver cirrhosis and to compare the different efficacies of UCMSCs after different treatment courses.Methods: This was an observational study that retrospectively considered a three-year period during which 513 patients who received stem cell infusion met the criteria of hepatic failure and liver cirrhosis were identified from databases of the Third Affiliated Hospital of Sun Yat-sen University. Eligible patients were categorized into the liver failure group and liver cirrhosis group. The two groups were divided into different subgroups according to the times of stem cell therapy. In the liver failure group, group A received more than 4 weeks and group B received less than 4 weeks. In the liver cirrhosis group, patients who received more than 4 weeks of stem cell therapy belonged to group C, and group D received less than 4 weeks. The patients were followed up for 24 weeks. The demographics, clinical characteristics, biochemical factors, and MELD scores were recorded and compared among different groups.Results: A total of 64 patients met the criteria of liver failure, and 59 patients met the criteria of liver cirrhosis. After UCMSC treatments, the levels of ALT, AST, and TBIL at all postbaseline time points were significantly lower than those at baseline in the liver failure group and liver cirrhosis group; the PTA and MELD scores only gradually improved in the liver failure group. Four weeks after UCMSC treatment, patients with prolonged treatment with UCMSCs had higher TBIL decline levels than patients who terminated treatment with UCMSCs. After more than 4 weeks of UCMSC treatment, there was no statistically significant difference in the levels of change for ALT, AST, TBIL, PTA value and the MELD score between patients with liver failure with prolonged treatment with UCMSCs and patients with liver cirrhosis with prolonged treatment with UCMSCs at all observation weeks. However, the median decline and cumulative decline in the TBIL level of patients with liver failure with a standard 4-week treatment course were higher than those of patients with liver cirrhosis with a standard 4-week treatment course.Conclusion: Peripheral infusion of UCMSCs showed good therapeutic effects for HBV-related liver failure and liver cirrhosis. Prolonging the treatment course can increase the curative effect of UCMSCs for end-stage liver disease, especially for patients with cirrhosis.

Are stem cells a cure for diabetes?

2009 ◽  
Vol 118 (2) ◽  
pp. 87-97 ◽  
Author(s):  
Michael D. McCall ◽  
Christian Toso ◽  
Emmanuel E. Baetge ◽  
A. M. James Shapiro
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Adult Stem Cells ◽  
Embryonic Stem ◽  
Diabetic Patients ◽  
Insulin Producing Cells ◽  
Early Mouse

With the already heightened demand placed on organ donation, stem cell therapy has become a tantalizing idea to provide glucose-responsive insulin-producing cells to Type 1 diabetic patients as an alternative to islet transplantation. Multiple groups have developed varied approaches to create a population of cells with the appropriate characteristics. Both adult and embryonic stem cells have received an enormous amount of attention as possible sources of insulin-producing cells. Although adult stem cells lack the pluripotent nature of their embryonic counterparts, they appear to avoid the ethical debate that has centred around the latter. This may limit the eventual application of embryonic stem cells, which have already shown promise in early mouse models. One must also consider the potential of stem cells to form teratomas, a complication which would prove devastating in an immunologically compromised transplant recipient. The present review looks at the progress to date in both the adult and embryonic stem cells fields as potential treatments for diabetes. We also consider some of the limitations of stem cell therapy and the potential complications that may develop with their use.

scholarly journals TERAPI SEL PUNCA NEURAL PADA PENYANDANG STROKE

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Venki F. Tangkuman ◽  
Denny J. Ngantung ◽  
Arthur Mawuntu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Adult Stem Cells ◽  
Alternative Therapy ◽  
Neural Cells ◽  
Age Group ◽  
Mature Brain ◽  
Fifth Order

Abstract: Stroke is the second order of deaths for the age group above 60 years and the fifth order for the age group 15-59 years. Although there are many kinds of therapies applied to stroke, none are satisfactory cures. An alternative therapy which is very promising, the neural stem cell therapy, is expected to be able to ameliorate stroke patients better, and therefore, can decrease the morbidity and mortality of stroke cases. There are several kinds of stem cells used in research, inter alia embryonal and adult stem cells. The purpose of this stem cell therapy in neurological disorders is to replace the damaged neural cells or to improve their biological function for enhancing brain function. New neuron cells can be produced from stem cell transplantation. Moreover, the mature brain has the ability, although very limited, to  produce new neuron cells as a response to brain damage due to stroke. Keywords: neural stem cells, stroke, transplantation.     Abstrak: Stroke merupakan penyebab kematian urutan kedua pada kelompok usia di atas 60 tahun dan urutan kelima pada kelompok usia 15-59 tahun. Sampai sekarang ini stroke belum dapat disembuhkan dengan baik walaupun telah banyak jenis pengobatan yang digunakan. Salah satu pengobatan alternatif yang mungkin kelak akan mampu memulihkan pasien stroke secara memuaskan serta menurunkan angka morbiditas dan mortalitas kasus stroke di seluruh dunia khususnya Indonesia yaitu terapi sel punca neuronal. Transplantasi sel punca pada gangguan neurologik termasuk stroke yaitu untuk menggantikan atau memperbaiki fungsi biologik dari sel neuron yang rusak agar dapat mempertahankan atau memulihkan fungsi otak. Sel neuron baru dapat dihasilkan dari transplantasi sel punca. Selain itu, otak dewasa akan terpicu untuk membuat sel neuron baru sebagai respon terhadap kerusakan sehingga akan meningkatkan kualitas penyembuhan pasien stroke. Kata kunci: sel punca neuronal, stroke, transplantasi.

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