Safety and Efficacy of Stem Cell Therapeutics in Wound Healing: A Rapid Review of Available Evidence

Background: Skin and wound injuries are important health problems with great mortality rates. While there are different alternative therapies, there is no agreement on the best therapy for burn wounds and wound complications. Stem cell therapy has an optimistic prospect in many preclinical studies of burn wounds and diabetic wounds. Objectives: In this study, we performed a rapid review to evaluate the efficacy and safety of stem cell therapy in wound treatment. Methods: This rapid review of the evidence aimed to evaluate the potential effects of stem cells on wound healing to create a policy guide for policymakers in the health care system. We searched such databases as PubMed and Scopus on March 13, 2021 using keywords, including “stem cells and wound healing”, “safety”, and “efficacy”. The references of retrieved studies were also checked to ensure the capture of the literature. Studies evaluating the safety and efficacy of stem cells on wound healing published in Persian and English were included. Generally, we used the PICO (population, intervention, control, and outcomes) model for search strategy. Results: Out of a total of 92 retrieved papers, 22 studies were eligible for inclusion. The overall review showed that stem cell therapy improved wounds. Also, studies showed that using stem cell technology in a non-invasive way could be a good alternative. However, the limitations of this technology consisted of the need to improve cell delivery methods, cell sustainability, heterogeneity in the research of mesenchymal stem cells, and wound substrate. Further studies are needed to determine its safety and efficacy. Conclusions: Although the evidence on the safety and efficacy of using stem cells for wound healing was limited, studies showed that stem cell technology is a good alternative to traditional therapies. Future clinical studies should consider the differences in the studies to achieve maximum effectiveness.

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Exploring the Most Promising Stem Cell Therapy in Liver Failure: A Systematic Review

Stem Cells International ◽

10.1155/2019/2782548 ◽

2019 ◽

Vol 2019 ◽

pp. 1-15 ◽

Cited By ~ 4

Author(s):

Jeanne AdiwinataPawitan

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Stem Cell ◽

Cell Therapy ◽

Liver Failure ◽

Stem Cell Therapy ◽

Adult Stem Cells ◽

Cochrane Library ◽

Safety And Efficacy ◽

Alternative Approaches

Background. Alternative approaches to transplantation for liver failure are needed. One of the alternative approaches is stem cell therapy. However, stem cell therapy in liver failure is not standardized yet, as every centre have their own methods. This systematic review is aimed at compiling and analyzing the various studies that use stem cells to treat liver failure, to get an insight into potential protocols in terms of safety and efficacy by comparing them to controls. Methods. This systematic review was done according to PRISMA guidelines and submitted for registration in PROSPERO (registration number CRD42018106119). All published studies in PubMed/MEDLINE and Cochrane Library, using key words: “human” and “stem cell” AND “liver failure” on 16th June 2018, without time restriction. In addition, relevant articles that are found during full-text search were added. Inclusion criteria included all original articles on stem cell use in humans with liver failure. Data collected included study type, treatment and control number, severity of disease, concomitant therapy, type and source of cells, passage of cells, dose, administration route, repeats, and interval between repeats, outcomes, and adverse events compared to controls. Data were analyzed descriptively to determine the possible causes of adverse reactions, and which protocols gave a satisfactory outcome, in terms of safety and efficacy. Results. There were 25 original articles, i.e., eight case studies and 17 studies with controls. Conclusion. Among the various adult stem cells that were used in human studies, MSCs from the bone marrow or umbilical cord performed better compared to other types of adult stem cells, though no study showed a complete and sustainable performance in the outcome measures. Intravenous (IV) route was equal to invasive route. Fresh or cryopreserved, and autologous or allogeneic MSCs were equally beneficial; and giving too many cells via intraportal or the hepatic artery might be counterproductive.

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An update review of stem cell applications in burns and wound care

Indian Journal of Plastic Surgery ◽

10.4103/0970-0358.101285 ◽

2012 ◽

Vol 45 (02) ◽

pp. 229-236 ◽

Cited By ~ 21

Author(s):

Lin Huang ◽

Andrew Burd

Keyword(s):

Stem Cells ◽

Wound Healing ◽

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Medical Technology ◽

Wound Care ◽

Therapeutic Strategies ◽

Wound Management

ABSTRACTThe ultimate goal of the treatment of cutaneous burns and wounds is to restore the damaged skin both structurally and functionally to its original state. Recent research advances have shown the great potential of stem cells in improving the rate and quality of wound healing and regenerating the skin and its appendages. Stem cell-based therapeutic strategies offer new prospects in the medical technology for burns and wounds care. This review seeks to give an updated overview of the applications of stem cell therapy in burns and wound management since our previous review of the "stem cell strategies in burns care".

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Induced pluripotent stem cell technology and stem cell therapy for diabetes

Experimental and Therapeutic Medicine ◽

10.3892/etm.2010.173 ◽

2010 ◽

Vol 2 (1) ◽

pp. 3-7 ◽

Cited By ~ 3

Author(s):

ROBERT J. DRUMMOND ◽

TILO KUNATH ◽

P. JOSEPH MEE ◽

JAMES A. ROSS

Keyword(s):

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Pluripotent Stem Cell ◽

Induced Pluripotent Stem Cell ◽

Stem Cell Technology ◽

Cell Technology ◽

Induced Pluripotent

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Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

Polymers ◽

10.3390/polym13101546 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1546

Author(s):

Shaima Maliha Riha ◽

Manira Maarof ◽

Mh Busra Fauzi

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Wound Healing ◽

Stem Cell ◽

Cell Therapy ◽

Synergistic Effect ◽

Stem Cell Therapy ◽

Skin Tissue ◽

Therapeutic Effects ◽

Skin Tissue Engineering

Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.

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Will Nanotechnology Bring New Hope for Stem Cell Therapy?

Cells Tissues Organs ◽

10.1159/000500517 ◽

2018 ◽

Vol 206 (4-5) ◽

pp. 229-241 ◽

Cited By ~ 1

Author(s):

Saeed Farzamfar ◽

Niloofar Nazeri ◽

Majid Salehi ◽

Alireza Valizadeh ◽

Sayed Mahdi Marashi ◽

...

Keyword(s):

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Stem Cell Differentiation ◽

Stem Cell Technology ◽

Cell Therapies ◽

Cell Technology ◽

Quantum Size ◽

Preclinical Trials ◽

The Many

The potential of stem cell therapy has been shown in preclinical trials for the treatment of damage and replacement of organs and degenerative diseases. After many years of research, its clinical application is limited. Currently there is not a single stem cell therapy product or procedure. Nanotechnology is an emerging field in medicine and has huge potential due to its unique characteristics such as its size, surface effects, tunnel effects, and quantum size effect. The importance of application of nanotechnology in stem cell technology and cell-based therapies has been recognized. In particular, the effects of nanotopography on stem cell differentiation, proliferation, and adhesion have become an area of intense research in tissue engineering and regenerative medicine. Despite the many opportunities that nanotechnology can create to change the fate of stem cell technology and cell therapies, it poses several risks since some nanomaterials are cytotoxic and can affect the differentiation program of stem cells and their viability. Here we review some of the advances and the prospects of nanotechnology in stem cell research and cell-based therapies and discuss the issues, obstacles, applications, and approaches with the aim of opening new avenues for further research.

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Stem Cell Therapy in Wound Healing

Journal of Interdisciplinary Medicine ◽

10.1515/jim-2017-0094 ◽

2017 ◽

Vol 2 (s4) ◽

pp. 20-24 ◽

Cited By ~ 2

Author(s):

András Mester ◽

Diana Opincariu ◽

Imre Benedek ◽

István Benedek

Keyword(s):

Stem Cells ◽

Wound Healing ◽

Stem Cell ◽

Growth Factors ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Chronic Wounds ◽

Skin Surface ◽

Skin Substitutes ◽

Recent Trial

AbstractWound healing is a complex restorative process of the altered cutaneous tissue, which is impaired by numerous local and systemic factors, leading to chronic non-healing lesions with few efficient therapeutic options. Stem cells possess the capacity to differentiate into various types of cell lines. Furthermore, stem cells are able to secrete cytokines and growth factors, modulating inflammation and ultimately leading to angiogenesis, fibrogenesis, and epithelization. Because of their paracrine activity, these cells are able to attract other cell types to the base of the wound, improving the formation of new skin layers. Mesenchymal stem cells derived from the adipose tissue, bone marrow, and placenta, offer numerous ways of implementation. The process of harvesting, growing, and administrating stem cells depends on the site and type of the cells, but recent trial results showed improvement of wound healing independent of the administration site. Bioengineered skin substitutes are validated for treatment of chronic wounds with direct application on the skin surface. These offer physical scaffolding for the migrating cells and promote secretion of growth factors, thus facilitating rapid wound healing. Obtaining further clinical data is essential, but stem cell therapy may become a first-line therapeutic choice for the treatment of non-healing chronic wounds.

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