scholarly journals Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Yasmen F. Mahran ◽  
Amira M. Badr ◽  
Alhanouf Aldosari ◽  
Raghad Bin-Zaid ◽  
Hind N. Alotaibi
Keyword(s):  
Oxidative Stress ◽  
Cross Talk ◽  
Ovarian Failure ◽  
Radioprotective Effect ◽  
Whole Body ◽  
Nuclear Antigen ◽  
Hormonal Changes ◽  
Tnf Α ◽  
Ovarian Damage ◽  
The Cross

Premature ovarian failure (POF) is a common cause of infertility in premenopausal women who are unavoidably exposed to cytotoxic therapy. Radiotherapy is one of the most effective cytotoxic treatments. However, the radiosensitivity of ovarian tissues limits its therapeutic outcome and results in the depletion of the primordial follicle and loss of fertility. Therefore, the need for an effective radioprotective therapy is evident especially when none of the current clinically used modalities for radioprotection succeeds efficiently. The present study investigated the potential radioprotective effect of carvacrol (CAR) (80 mg) or thymol (80 mg) on gamma- (γ-) irradiation-induced ovarian damage as well as their role in the cross-talk between IGF-1 and TNF-α signaling and antioxidative activity. In immature female Wister rats, a single dose of whole-body irradiation (3.2 Gy, L D 20 ) produced considerable ovarian damage, which was evident by histopathological findings and hormonal changes. Interestingly, pretreatment with CAR or thymol significantly enhanced the follicular development and restored the anti-Mullerian hormone (AMH), E2, and FSH levels. Both essential oils improved the irradiation-mediated oxidative stress and reduction in proliferating cell nuclear antigen (PCNA) expression. Moreover, irradiated rats exhibited an inverse relationship between IGF-1 and TNF-α levels two days post irradiation, which was further inverted by the pretreatment with CAR and thymol and ought to contribute in their radioprotective mechanisms. In conclusion, CAR and thymol showed a radioprotective effect and rescued the ovarian reserve mainly through counteracting oxidative stress and the dysregulated cross-talk between IGF-1 and TNF-α.

scholarly journals Insights into the Protective Mechanisms of Tamoxifen in Radiotherapy-Induced Ovarian Follicular Loss: Impact on Insulin-Like Growth Factor 1

Endocrinology ◽  
2013 ◽  
Vol 154 (10) ◽  
pp. 3888-3899 ◽  
Author(s):  
Yasmen F. Mahran ◽  
Ebtehal El-Demerdash ◽  
Ahmed S. Nada ◽  
Azza A. Ali ◽  
Ashraf B. Abdel-Naim
Keyword(s):  
Oxidative Stress ◽  
Proliferating Cell Nuclear Antigen ◽  
Follicular Development ◽  
Ovarian Failure ◽  
Radioprotective Effect ◽  
Whole Body ◽  
Nuclear Antigen ◽  
Γ Irradiation ◽  
Protective Mechanisms ◽  
Proliferating Cell

Radiotherapy is one of the most common and effective cancer treatments. However, it has a profound impact on ovarian function, leading to premature ovarian failure. With the hope of preserving fertility in cancer survivors, the need for an effective radioprotective therapy is evident. The present study investigated the mechanism of the potential radioprotective effect of tamoxifen (TAM) on γ-irradiation-induced ovarian failure on experimental rats and the impact of the IGF-1 in the underlying protective mechanisms. Female Sprague Dawley rats were either exposed to single whole-body irradiation (3.2 Gy; lethal dose [LD20]) and/or treated with TAM (1 mg/kg). γ-Irradiation caused an array of ovarian dysfunction that was evident by assessment of hormonal changes, follicular development, proliferation marker (proliferating cell nuclear antigen), and oxidative stress as well as apoptotic markers. In addition, IGF-1/IGF-1 receptor axis expression was assessed using real-time RT-PCR and immunolocalization techniques. Furthermore, fertility assessment was performed. TAM significantly enhanced follicular development and restored the anti-Mullerian hormone level. Moreover, it ameliorated the deleterious effects of irradiation on oxidative stress, proliferating cell nuclear antigen expression, and apoptosis. Interestingly, TAM was shown to enhance the ovarian IGF-1 but not IGF-1 receptor, a property that contributed significantly to its radioprotective mechanisms. Finally, TAM regained the fertility that was lost after irradiation. In conclusion, TAM showed a radioprotective effect and saved the ovarian reserve and fertility through increasing anti-Mullerian hormone and the local IGF-1 level and counteracting the oxidative stress-mediated apoptosis.

Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-α and ROS

2016 ◽  
Vol 31 (3) ◽  
pp. e21868 ◽  
Author(s):  
Qian Zhang ◽  
Linlin Zhu ◽  
Gang Wang ◽  
Ye Zhao ◽  
Na Xiong ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cross Talk ◽  
Tnf Α ◽  
The Cross

A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells

2012 ◽  
Vol 393 (1-2) ◽  
pp. 101-106 ◽  
Author(s):  
Vijaya Lakshmi Simhadri ◽  
Hinrich P. Hansen ◽  
Venkateswara R. Simhadri ◽  
Katrin S. Reiners ◽  
Martina Bessler ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Nk Cells ◽  
Natural Killer ◽  
Cross Talk ◽  
Mitogen Activated Protein Kinase ◽  
Tnf Α ◽  
Mitogen Activated Protein ◽  
Ifn Γ ◽  
The Cross

Abstract The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-κB-dependent release of TNF-α/IFN-γ. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.

The cross-talk between oxidative stress and endocannabinoid system in keratinocytes after UV irradiation

2015 ◽  
Vol 86 ◽  
pp. S28
Author(s):  
Agnieszka Gęgotek ◽  
Wojciech Luczaj ◽  
Ewa Ambrozewicz ◽  
Katarzyna Bielawska ◽  
Elzbieta Skrzydlewska
Keyword(s):  
Oxidative Stress ◽  
Uv Irradiation ◽  
Cross Talk ◽  
Endocannabinoid System ◽  
The Cross

scholarly journals Cross-Talk between Mitochondrial Dysfunction-Provoked Oxidative Stress and Aberrant Noncoding RNA Expression in the Pathogenesis and Pathophysiology of SLE

2019 ◽  
Vol 20 (20) ◽  
pp. 5183 ◽  
Author(s):  
Chang-Youh Tsai ◽  
Song-Chou Hsieh ◽  
Cheng-Shiun Lu ◽  
Tsai-Hung Wu ◽  
Hsien-Tzung Liao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Cross Talk ◽  
Noncoding Rna ◽  
Nitrosative Stress ◽  
Noncoding Rnas ◽  
The Body ◽  
Rna Expression ◽  
Epigenetic Regulations ◽  
The Cross

Systemic lupus erythematosus (SLE) is a prototype of systemic autoimmune disease involving almost every organ. Polygenic predisposition and complicated epigenetic regulations are the upstream factors to elicit its development. Mitochondrial dysfunction-provoked oxidative stress may also play a crucial role in it. Classical epigenetic regulations of gene expression may include DNA methylation/acetylation and histone modification. Recent investigations have revealed that intracellular and extracellular (exosomal) noncoding RNAs (ncRNAs), including microRNAs (miRs), and long noncoding RNAs (lncRNAs), are the key molecules for post-transcriptional regulation of messenger (m)RNA expression. Oxidative and nitrosative stresses originating from mitochondrial dysfunctions could become the pathological biosignatures for increased cell apoptosis/necrosis, nonhyperglycemic metabolic syndrome, multiple neoantigen formation, and immune dysregulation in patients with SLE. Recently, many authors noted that the cross-talk between oxidative stress and ncRNAs can trigger and perpetuate autoimmune reactions in patients with SLE. Intracellular interactions between miR and lncRNAs as well as extracellular exosomal ncRNA communication to and fro between remote cells/tissues via plasma or other body fluids also occur in the body. The urinary exosomal ncRNAs can now represent biosignatures for lupus nephritis. Herein, we’ll briefly review and discuss the cross-talk between excessive oxidative/nitrosative stress induced by mitochondrial dysfunction in tissues/cells and ncRNAs, as well as the prospect of antioxidant therapy in patients with SLE.

scholarly journals The Cross-Talk Between the TNF-α and RASSF-Hippo Signalling Pathways

2019 ◽  
Vol 20 (9) ◽  
pp. 2346 ◽  
Author(s):  
Delvac Oceandy ◽  
Bella Amanda ◽  
Faisal Ashari ◽  
Zakiyatul Faizah ◽  
M Aziz ◽  
...  
Keyword(s):  
Cross Talk ◽  
Hippo Pathway ◽  
Signalling Pathways ◽  
Physiological Processes ◽  
Tnf Α ◽  
The Cross ◽  
Factor Α ◽  
Apoptosis Regulation ◽  
The Hippo Pathway ◽  
Hippo Signalling

The regulation of cell death through apoptosis is essential to a number of physiological processes. Defective apoptosis regulation is associated with many abnormalities including anomalies in organ development, altered immune response and the development of cancer. Several signalling pathways are known to regulate apoptosis including the Tumour Necrosis Factor-α (TNF-α) and Hippo signalling pathways. In this paper we review the cross-talk between the TNF-α pathway and the Hippo signalling pathway. Several molecules that tightly regulate the Hippo pathway, such as members of the Ras-association domain family member (RASSF) family proteins, interact and modulate some key proteins within the TNF-α pathway. Meanwhile, TNF-α stimulation also affects the expression and activation of core components of the Hippo pathway. This implies the crucial role of signal integration between these two major pathways in regulating apoptosis.

p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway

2019 ◽  
Vol 53 (7) ◽  
pp. 800-814 ◽  
Author(s):  
Weitang Liao ◽  
Zhiyu Wang ◽  
Zongjie Fu ◽  
Hongkun Ma ◽  
Mengdi Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cross Talk ◽  
Signalling Pathway ◽  
The Cross
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