Prolonged Cholestatic Jaundice Associated With Flurbiprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed drugs throughout the world for pain relief. Although the adverse effects of NSAIDs to the liver are well known, flurbiprofen-induced liver cholestasis is extremely rare. Herein, we present a patient with prolonged icterus that is associated with the use of flurbiprofen without causing ductopenia.

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The consequences of using widely available non-steroidal anti-inflammatory drugs (NSAIDs)

Medycyna Rodzinna ◽

10.25121/mr.2018.21.3.281 ◽

2018 ◽

Vol 21 (3) ◽

Author(s):

Joanna Synoweć ◽

Katarzyna Pogorzelczyk ◽

Marlena Robakowska ◽

Daniel Ślęzak ◽

Przemysław Żuratyński ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Chronic Pain ◽

Gastrointestinal Tract ◽

Adverse Effects ◽

Respiratory Diseases ◽

Easy Access ◽

The World ◽

Wide Availability ◽

Inflammatory Drugs ◽

Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world due to their wide availability and a broad range of effects. Patients have easy access to these drugs in pharmacies and cosmetic shops, with the latter ones rarely having personnel qualified to provide advice on dosage. NSAIDs are usually administered to manage pain, fever and inflammation. They are used for conditions such as rheumatoid arthritis, oropharyngeal inflammations or in the treatment of chronic pain. Nevertheless, they are most often used for home treatment of common conditions, such as cold. However, NSAIDs can cause multiple adverse effects. They adversely affect the gastrointestinal tract, contribute to hypertension, show hepatotoxic properties, exacerbate respiratory diseases, induce allergies and haematological complications. Adverse effects may occur both due to overdose, as well as independently of the dose. The aim of this review is to present adverse effects of nonsteroidal anti-inflammatory drugs, the awareness of Poles concerning the use of NSAIDs, as well as measures to be taken in order to limit the adverse health consequences of the use of these drugs.

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Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

Advances in Pharmacological Sciences ◽

10.1155/2019/5324170 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Rebecca S. Y. Wong

Keyword(s):

Pain Relief ◽

Adverse Effects ◽

Musculoskeletal System ◽

First Line ◽

Disease Research ◽

Inflammatory Drugs ◽

Disease Modifying ◽

Anti Inflammatory ◽

Continuous Use

Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.

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Current Perspectives in NSAID-Induced Gastropathy

Mediators of Inflammation ◽

10.1155/2013/258209 ◽

2013 ◽

Vol 2013 ◽

pp. 1-11 ◽

Cited By ~ 50

Author(s):

Mau Sinha ◽

Lovely Gautam ◽

Prakash Kumar Shukla ◽

Punit Kaur ◽

Sujata Sharma ◽

...

Keyword(s):

Side Effects ◽

Adverse Effects ◽

Preventive Measures ◽

Gastrointestinal Complications ◽

Gastrointestinal Injury ◽

Novel Drugs ◽

The World ◽

Inflammatory Drugs ◽

Cox 2 ◽

Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.

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Ibuprofen safety at the golden anniversary. A commentary and recent developments

10.22514/sv.2020.16.0097 ◽

2020 ◽

Keyword(s):

The World ◽

Recent Developments ◽

Inflammatory Drugs ◽

Coronavirus Infection ◽

Interesting Story ◽

Anti Inflammatory ◽

Short Comment ◽

Published Paper

Ibuprofen is a long lasting non-steroidal anti-inflammatory drugs (NSAIDs) and still represents one of the most diffused analgesics around the world. It has an interesting story started over 50 years ago. In this short comment to an already published paper, the authors try to focus some specific important point. On top, they illustrate the recent, confusing and fake assertion on the potentially dangerous influence that ibuprofen could have, increasing the risk of Coronavirus infection. This is also better illustrated in a previously published paper, where the readers could find more clear responses to eventual doubts.

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Are topical non-steroidal anti-inflammatory drugs (NSAIDs) safer than oral NSAIDs? Or are the adverse effects of topical NSAIDs comparable to those of oral NSAIDs?

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2021.08.010 ◽

2021 ◽

Author(s):

K. Toda

Keyword(s):

Adverse Effects ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Topical Nsaids

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Analysis of the use and adverse effects of non-steroidal anti-inflammatory drugs: A pilot study

Vojnosanitetski pregled ◽

10.2298/vsp0603271p ◽

2006 ◽

Vol 63 (3) ◽

pp. 271-277 ◽

Cited By ~ 1

Author(s):

Aneta Peric ◽

Marija Toskic-Radojicic

Keyword(s):

Pilot Study ◽

Adverse Effects ◽

Rheumatic Diseases ◽

Test Results ◽

Stomach Pain ◽

Antiulcer Drugs ◽

Inflammatory Drugs ◽

The Mean ◽

Anti Inflammatory ◽

Number Of Males

Background/Aim. The use and adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in outpatients with rheumatic diseases has not yet been studied enough. The aim of this study was to evaluate the data about the efficacy and safety of NSAIDs obtained from the questionnaires submitted to the outpatients receiving these drugs. Methods. The patients who had been prescribed any of NSAIDs within the period from June to September, 2004 were included in the study. The answers obtained from the questionnaires were statistically analyzed by means of ?2-test. Results. At the time of the study, 150 patients had been prescribed ibuprofen or some other NSAID. Out of the total number of dispensed questionnaires (n = 150), only 45 (30%) were shown to be correctly filled-in. Their analysis showed that 64.4% of the patients had suffered from rheumatic diseases for more than five years, and had regularly used NSAIDs. The average age of these patients was about 70 years, and the number of females was double as high as that of the males. The most frequently used NSAIDs were diclofenac and ibuprofen (46.14%, and 23.24%, respectively). According to the answers given by the patients, the most often adverse reactions were gastric complaints such as nausea (11.1%), and stomach pain (8.9%). Due to this, the majority of the patients (64.4%) used some of the antiulcer drugs, most often ranitidine (31.1%). Conclusion. The results of this pilot study revealed that among the outpatients suffering from rheumatic diseases, the number of females was double as high as the number of males, that these patients were of the mean age of 70 years, and that their diseases lasted longer than five years. Gastric complains such as nausea and gastric pain of mild intensity were the most often adverse effects of NSAIDs reported by our patients. It could be the consequence of the predominant use of diclofenac and ibuprofen, NSAIDs with mild to moderate ulcerogenic potential, as well as the concomitant use of H2-receptor antagonists.

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Peran Kurkumin Sebagai Terapi Pada Osteoartritis

Journal of Health Science and Physiotherapy ◽

10.35893/jhsp.v2i1.36 ◽

2020 ◽

Vol 2 (1) ◽

pp. 106-110

Author(s):

Rilianda Abelira

Keyword(s):

Peptic Ulcer ◽

Side Effects ◽

Old Age ◽

Cyclooxygenase 2 ◽

Tnf Α ◽

The World ◽

Inflammatory Drugs ◽

Digestive Disorders ◽

Cox 2 ◽

Anti Inflammatory

Osteoartritis (OA) merupakan salah satu penyakit penyakit degeneratif atau geriatri yang disebabkan adanya inflamasi yang melibatkan kartilago, lapisan sendi, ligamen, dan tulang yang akibatnya dapat menyebabkan nyeri dan kekakuan pada sendi. Epidemiologi OA di didunia sekitar 15% dengan usia diatas 65-75 dan diperkirakan pada tahun 2020 penderita osteoarthritis akan meningkat 11,6 juta penderita. Kejadian OA di Indonesia dari tahun 1990 hingga 2010 telah mengalami peningkatan sebanyak 44,2% dan berdasarkan usia di Indonesia cukup tinggi dengan 65% pada usia tua (lansia) atau lebih dari 61 tahun. Pengobatan secara farmakologis untuk OA dengan menggunakan Obat Anti Inflamasi Non-Steroid (OAINS) salah satu contohnya adalah meloksikam. Namun, efek samping penggunaan OAINS dapat menimbulkan beberapa masalah seperti timbulnya ulkus peptikum dan gangguan pencernaan. Hal ini menyebabkan sedang dikembangkannya pengobatan herbal untuk OA yang harapannya dapat menjadi pengobatan utama dalam mengatasi OA dengan menggunakan kurkumin. Kurkumin berperan sebagai antiinflamasi dalam kunyit putih dengan menurunkan aktivitas cyclooxygenase 2(COX-2), lipoxygenase dan menghambat produksi sitokin seperti TNF-α, interleukin (IL). Osteoarthritis (OA) is a degenerative or geriatric disease that is caused by inflammation involving cartilages, joint lining, ligaments, and bones which can cause pain and stiffness in the joints. Epidemiology of OA in the world around 15% with ages above 65-75 and it is estimated in 2020, osteoarthritis will increase by 11.6 million. The incidence of OA in Indonesia from 1990 to 2010 has increased by 44.2% and by age in Indonesia is quite high with 65% in old age (elderly) or more than 61 years. Treatment for OA is using non-steroidal anti-inflammatory drugs (NSAIDs), such as meloxicam. However, side effects of NSAID use can cause several problems such as the emergence of peptic ulcer and digestive disorders. This has led to the development of herbal treatments for OA which hopes to become the main treatment in overcoming OA by using curcumin. Curcumin acts as an anti-inflammatory in white turmeric by reducing the activity of cyclooxygenase 2 (COX-2), lipoxygenase and inhibiting the production of cytokines such as TNF-α, interleukin (IL).

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Peripheral Tramadol in Dentistry: A New Use for an Old Drug

Odovtos - International Journal of Dental Sciences ◽

10.15517/ijds.v0i0.23490 ◽

2016 ◽

Vol 18 (2) ◽

pp. 10

Author(s):

Daniel Chavarría DDS, MSc, PhD ◽

Amaury Pozos DDS, MSc, PhD

Keyword(s):

Adverse Effects ◽

Opioid Receptors ◽

Analgesic Effect ◽

Health Sciences ◽

Analgesic Drug ◽

Orofacial Region ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

New Perspective ◽

Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain. Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”.

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