scholarly journals A Case Study of Stevens–Johnson Syndrome-Toxic Epidermal Necrolysis (SJS-TEN) Overlap in Mycoplasma pneumoniae-Associated Tracheobronchitis

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Ranjit Sah ◽  
Samikshya Neupane ◽  
Shusila Khadka ◽  
Sagar Poudyal ◽  
Hem Raj Paneru ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Mycoplasma Pneumoniae ◽  
Respiratory Tract Infections ◽  
Medical Emergency ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Steven Johnson Syndrome ◽  
Tract Infections ◽  
Simple Bedside

Stevens–Johnson syndrome is a medical emergency which is characterized by skin and mucosal reaction to the use of certain drugs. Atypical Steven–Johnson syndrome can occur due to various microorganisms and Mycoplasma pneumoniae being one of them. We present a clinical course, diagnosis, and successful management of Steven–Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) overlap due to Mycoplasma pneumoniae in a 17-year-old Nepalese female. In the resource-limiting country and hospitals where serology and PCR for M. pneumoniae is not easily accessible, a simple bedside cold agglutination test can be done to increase the suspicion of infectious cause (most common M. pneumoniae ) of SJS-TEN overlap. M. pneumoniae infection should be considered in all cases of mucositis, especially in patients having preceding respiratory tract infections (tracheobronchitis).

scholarly journals DRUG-INDUCED STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS

2016 ◽  
Vol 65 (4) ◽  
pp. 377-381
Author(s):  
Dalia Dop ◽  
◽  
Desdemona Stepan ◽  
Cristian Gheonea ◽  
Elena Carmen Niculescu ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Rare Diseases ◽  
Intravenous Immunoglobulins ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Johnson Syndrome ◽  
Medical Emergencies ◽  
Steven Johnson Syndrome ◽  
Restitutio Ad Integrum

Steven-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare diseases that appear following the administration of risk drugs. Both are severity grades of the same condition and are considered medical emergencies, because they are potentially lethal. They are characterized by mucocutaneous tenderness, erythema, necrosis and bullous detachment similar to extended burns. We report 3 cases of SJS/TEN in which the etiology was probably drug-related (Paracetamol, Atomoxetinum, Sulfamethoxazolum + trimethoprinum), with restitutio ad integrum following the administration of intravenous immunoglobulins.

scholarly journals Stevens-Johnson Syndrome in a Child on Phenytoin, Exacerbated with Cefixime

2019 ◽  
Vol 39 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Yam Bahadur Roka ◽  
Sabrina Shrestha ◽  
Narayani Roka ◽  
Mohan Karki
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Whole Body ◽  
Stevens Johnson Syndrome ◽  
Intravenous Fluids ◽  
Oral Ulceration ◽  
Topical Antibiotics ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
History Of ◽  
Steven Johnson Syndrome

Steven Johnson syndrome and toxic epidermal necrolysis are rare but potentially life threatening muco-cutaneous disorders. Their incidence ranges from 1.2 to six per million patient-years for Steven Johnson syndrome and 0.4 to 1.2 per million patient-years for toxic epidermal necrolysis. Drugs are the primary cause for these syndromes in majority cases. They might also be due to infections with Mycoplasma Pneumoniae or Herpes Simplex. The mortality ranges from five to 40% in these cases. We report a 10-year old girl who presented with history of multiple skin eruptions involving whole body and oral ulceration for five days. She was a known case of seizure disorder on phenytoin and had been prescribed Cefexime for fever. She was managed with intravenous fluids, corticosteroids, opiates, antacids and topical antibiotics. We want to highlight the possibility of Steven Johnson syndrome following the combination of these two drugs.

scholarly journals Pediatric SJS-TEN: Where are we now?

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 982
Author(s):  
Michele Ramien ◽  
Jennifer L. Goldman
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Mycoplasma Pneumoniae ◽  
Adverse Drug Reactions ◽  
Response To Treatment ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Skin Reactions ◽  
Recent Advances ◽  
Johnson Syndrome

Stevens–Johnson syndrome and toxic epidermal necrolysis are rare severe blistering skin reactions triggered by medications or infections. Over the last 5 to 10 years, a number of important publications have advanced understanding of these diseases and their response to treatment. Importantly, a subset of patients with disease triggered by infection has been identified as having Mycoplasma pneumoniae–induced rash and mucositis, suggesting a reconsideration of the diagnostic paradigm. We present an update on pediatric Stevens–Johnson syndrome and toxic epidermal necrolysis in the broader context of cutaneous adverse drug reactions and focus on challenges and recent advances in diagnosis, management, and prevention.

scholarly journals A CASE REPORT ON AMOXICILLIN INDUCED STEVENS- JOHNSON SYNDROME

2021 ◽  
Vol 12 (7) ◽  
pp. 22-24
Author(s):  
Rispa Darabadi ◽  
Karasani Harini
Keyword(s):  
Case Report ◽  
Mucous Membrane ◽  
Case Reports ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Oral Consumption ◽  
Life Threatening ◽  
Steven Johnson Syndrome

Steven-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membrane that is usually a reaction to medication. It usually starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Other symptoms include Fever, sore mouth and throat, Fatigue, burning eyes, extensive skin and mucous membrane lesions (i.e., mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95% of case reports, drugs were identified to be an important cause for the development of SJS. The below is a case report of A 37-year-old male patient hospitalized with rashes over the body and fever, after oral consumption of Amoxicillin drug for cough and sore throat through OTC prescription. The patient has taken three doses of Amoxicillin and due to lack of awareness on Adverse drug reactions, the patient ignored the rashes that were developed after the first dose. This case study discusses the possibility of serious hypersensitivity reactions with Amoxicillin that rarely occur and can be extremely harmful and life threatening, brief knowledge on Stevens-Johnson syndrome and also some of the preventive measures to control the adverse reactions due to drugs.

scholarly journals SJS/TENN: A Mnemonic for Early Clinical Diagnosis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

2021 ◽  
Vol 14 ◽  
pp. 114-115
Author(s):  
Brett Neill ◽  
Edward Seger ◽  
Jessica Ferguson ◽  
Tyler Hooton ◽  
Jace J. Rickstrew ◽  
...  
Keyword(s):  
Primary Care ◽  
Toxic Epidermal Necrolysis ◽  
Clinical Diagnosis ◽  
Clinical Characteristics ◽  
Primary Care Providers ◽  
Initial Diagnosis ◽  
Stevens Johnson Syndrome ◽  
Care Providers ◽  
Johnson Syndrome ◽  
Steven Johnson Syndrome

Steven Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are dermatologic emergencies that are more likely to be encountered by primary care providers rather than dermatologists. Thus, it is essential for all clinicians to be familiar with common signs associated with SJS/TEN, so as not to miss or delay the diagnosis. We designed the simple mnemonic “SJS/TENN” which describes the most frequently seen clinical characteristics in these conditions to aid in the initial diagnosis.

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