The Cerebellum Posterior Lobe Associates with the Exophthalmos of Primary Hyperthyroidism: A Resting-State fMRI Study

Background. Exophthalmos occurs in patients with primary hyperthyroidism. There were few studies about the changes of brain functional networks of patients with exophthalmos of primary hyperthyroidism (EOPH). However, differences in spontaneous brain activity in patients with EOPH remain unclear. Objective. This study explored alterations in the brain functional networks of patients with EOPH using a voxel-wise degree centrality (DC) method. Methods. A total of 20 patients with EOPH (8 men and 12 women) were enrolled. In addition, 20 patients with primary hyperthyroidism without exophthalmos, matched in age, sex, and education status, were enrolled as a control group. The Hospital Anxiety and Depression Scale was used to assess the anxiety and depression status of participants. All participants were examined using resting-state functional MRI. Changes in spontaneous brain activity were investigated using the DC method. To distinguish between the DC values of the patients with EOPH and those of the control group, we analyzed the receiver operating characteristic (ROC) curve. The interrelationships between the DC values and clinical variables in the patients with EOPH were evaluated using Pearson’s correlation coefficient. Results. Patients with EOPH exhibited notably lower DC values in the cerebellum posterior lobe than the control group. In addition, there were negative correlations between the anxiety scores (AS) and the depression scores (DS) and DC values of the cerebellum posterior lobe. The ROC curve analysis of the cerebellum posterior lobe demonstrated that the area under the curve method had a high diagnostic accuracy. Conclusions. Our study was the first, to our knowledge, to explore changes in the brains of patients with EOPH using the DC method. The DC value was significantly different in the cerebellum posterior lobe in patients with EOPH, indicating that the cerebellum posterior lobe is associated with EOPH.

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Investigation of changes in activity and function in acute unilateral open globe injury–associated brain regions based on percent amplitude of fluctuation method: a resting-state functional MRI study

Acta Radiologica ◽

10.1177/02841851211034035 ◽

2021 ◽

pp. 028418512110340

Author(s):

Chu-Qi Li ◽

Fan Yao ◽

Chen-Yu Yu ◽

Hui-Ye Shu ◽

Li-Juan Zhang ◽

...

Keyword(s):

Roc Curve ◽

Resting State ◽

Brain Activity ◽

Brain Regions ◽

Anterior Lobe ◽

Anxiety And Depression ◽

Open Globe Injury ◽

Neural Basis ◽

Increased Risk ◽

Open Globe

Background Open globe injury (OGI) is a serious condition that can lead to visual impairment and lifelong sequelae, brain activity of some brain regions would change in patients with OGI. Purpose To evaluate changes in brain activity associated with unilateral OGI by resting-state functional magnetic resonance imaging (rs-fMRI) and analysis of percentage amplitude of fluctuation (PerAF). Material and Methods A total of 22 patients with OGI (12 men, 10 women) and 22 healthy controls (HCs) matched for sex, age, and body weight were enrolled. All patients underwent rs-fMRI scans. Brain activity in the relevant brain regions was assessed with the PerAF method. The ability of PerAF to distinguish patients with OGI from HCs was assessed by receiver operating characteristic (ROC) curve analysis. We also examined the relationship between Hospital Anxiety and Depression Scale (HADS) scores and PerAF signals by Pearson’s correlation analysis. Results PerAF values in amygdala_R and Frontal_Inf_Orb_L/Frontal_Inf_Oper_L were increased whereas that in Cerebellum Anterior Lobe/Cerebelum_8_L was decreased in patients with OGI compared to HCs. The areas under the ROC curve showed that these brain regions could distinguish between patients with OGI and HCs. The PerAF value of amygdala_R was positively correlated with HADS scores. Conclusion Changes in PerAF in the amygdala_R, Frontal_inferior_Orb_L/Frontal_Inf_Oper_L, and Cerebellum Anterior Lobe/Cerebelum_8_L in patients with OGI may be related to an increased risk of developing psychiatric disorders such as anxiety and depression. PerAF can be used to investigate the neural basis of complications associated with OGI and monitor disease progression.

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Abnormal Spontaneous Brain Activity in Left-Onset Parkinson Disease: A Resting-State Functional MRI Study

Frontiers in Neurology ◽

10.3389/fneur.2020.00727 ◽

2020 ◽

Vol 11 ◽

Author(s):

Kai Li ◽

Wen Su ◽

Min Chen ◽

Chun-Mei Li ◽

Xin-Xin Ma ◽

...

Keyword(s):

Parkinson Disease ◽

Functional Mri ◽

Resting State ◽

Brain Activity ◽

Spontaneous Brain Activity ◽

Mri Study

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Jumping over baselines with new methods to predict activation maps from resting-state fMRI

Scientific Reports ◽

10.1038/s41598-021-82681-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Eric Lacosse ◽

Klaus Scheffler ◽

Gabriele Lohmann ◽

Georg Martius

Keyword(s):

Resting State ◽

Brain Activity ◽

Resting State Fmri ◽

Behavioral Differences ◽

Large Variability ◽

Single Vertex ◽

Spontaneous Brain Activity ◽

New Methods ◽

Group Averaging ◽

Proposed Modification

AbstractCognitive fMRI research primarily relies on task-averaged responses over many subjects to describe general principles of brain function. Nonetheless, there exists a large variability between subjects that is also reflected in spontaneous brain activity as measured by resting state fMRI (rsfMRI). Leveraging this fact, several recent studies have therefore aimed at predicting task activation from rsfMRI using various machine learning methods within a growing literature on ‘connectome fingerprinting’. In reviewing these results, we found lack of an evaluation against robust baselines that reliably supports a novelty of predictions for this task. On closer examination to reported methods, we found most underperform against trivial baseline model performances based on massive group averaging when whole-cortex prediction is considered. Here we present a modification to published methods that remedies this problem to large extent. Our proposed modification is based on a single-vertex approach that replaces commonly used brain parcellations. We further provide a summary of this model evaluation by characterizing empirical properties of where prediction for this task appears possible, explaining why some predictions largely fail for certain targets. Finally, with these empirical observations we investigate whether individual prediction scores explain individual behavioral differences in a task.

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Distinct patterns of spontaneous brain activity between children and adults with anisometropic amblyopia: a resting-state fMRI study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-015-3117-9 ◽

2015 ◽

Vol 254 (3) ◽

pp. 569-576 ◽

Cited By ~ 13

Author(s):

Minglong Liang ◽

Bing Xie ◽

Hong Yang ◽

Longhua Yu ◽

Xuntao Yin ◽

...

Keyword(s):

Resting State ◽

Brain Activity ◽

Resting State Fmri ◽

Spontaneous Brain Activity ◽

Anisometropic Amblyopia ◽

Fmri Study

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Disrupted Topological Organization in Whole-Brain Functional Networks of Heroin-Dependent Individuals: A Resting-State fMRI Study

PLoS ONE ◽

10.1371/journal.pone.0082715 ◽

2013 ◽

Vol 8 (12) ◽

pp. e82715 ◽

Cited By ~ 29

Author(s):

Guihua Jiang ◽

Xue Wen ◽

Yingwei Qiu ◽

Ruibin Zhang ◽

Junjing Wang ◽

...

Keyword(s):

Resting State ◽

Resting State Fmri ◽

Functional Networks ◽

Whole Brain ◽

Brain Functional Networks ◽

Fmri Study ◽

Topological Organization

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Differing Spontaneous Brain Activity in Healthy Adults with Two Different Body Constitutions: A Resting-State Functional Magnetic Resonance Imaging Study

Journal of Clinical Medicine ◽

10.3390/jcm8070951 ◽

2019 ◽

Vol 8 (7) ◽

pp. 951

Author(s):

Ching-Hsiung Liu ◽

Yen-Ying Kung ◽

Tzu-Chen Yeh ◽

Pei-Shan Hsu ◽

Ching-Ju Yang ◽

...

Keyword(s):

Quality Of Life ◽

Magnetic Resonance Imaging ◽

Resting State ◽

Brain Activity ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Spontaneous Brain Activity ◽

Body Constitution ◽

Postcentral Gyrus

Traditional Chinese medicine (TCM) practitioners assess body constitution (BC) as a treatment basis for maintaining body homeostasis. We investigated patterns in spontaneous brain activity in different BC groups using resting-state functional magnetic resonance imaging (rsfMRI) and determined the relationship between these patterns and quality of life (QOL). Thirty-two healthy individuals divided into two groups (body constitution questionnaire (BCQ)-gentleness [BCQ-G] and BCQ-deficiency [BCQ-D]) based on the body constitution questionnaire (BCQ) underwent rsfMRI to analyze regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF). The World Health Organization Quality of Life Instruments (brief edition) scale was used to evaluate the QOL. The BCQ-G group (n = 18) had significantly greater ReHo values in the right postcentral gyrus and lower ALFF values in the brainstem than the BCQ-D group (n = 14). In the BCQ-D group, decreased ReHo of the postcentral gyrus correlated with better physiological functioning; increased ALFF in the brainstem correlated with poor QOL. BCQ-subgroup analysis revealed a nonsignificant correlation between ReHo and Yang deficiency/phlegm and stasis (Phl & STA). Nonetheless, the BCQ-D group showed a positive correlation between ALFF and Phl & STA in the parahippocampus. This study identified differences between BCQ-G and BCQ-D types of healthy adults based on the rsfMRI analysis. The different BCQ types with varied brain endophenotypes may elucidate individualized TCM treatment strategies.

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