Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools

Cancer remains a global health challenge, with high morbidity and mortality, despite the recent advances in diagnosis and treatment. Multiple compounds assessed as novel potential anticancer drugs derive from natural sources, including microorganisms, plants, and animals. Lectins, a group of highly diverse proteins of nonimmune origin with carbohydrate-binding abilities, have been detected in virtually all kingdoms of life. These proteins can interact with free and/or cell surface oligosaccharides and might differentially bind cancer cells, since malignant transformation is tightly associated with altered cell surface glycans. Therefore, lectins could represent a valuable tool for cancer diagnosis and be developed as anticancer therapeutics. Indeed, several plant lectins exert cytotoxic effects mainly by inducing apoptotic and autophagic pathways in malignant cells. This review summarizes the current knowledge regarding the basis for the use of lectins in cancer diagnosis and therapy, providing a few examples of plant-derived carbohydrate-binding proteins with demonstrated antitumor effects.

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Mutant Cell Surface Receptors as Targets for Individualized Cancer Diagnosis and Therapy

Current Cancer Drug Targets ◽

10.2174/1568009013334205 ◽

2001 ◽

Vol 1 (2) ◽

pp. 121-128 ◽

Cited By ~ 5

Author(s):

Karl-Friedrich Becker ◽

Heinz Hofler

Keyword(s):

Cell Surface ◽

Cancer Diagnosis ◽

Mutant Cell ◽

Cell Surface Receptors ◽

Surface Receptors ◽

Diagnosis And Therapy ◽

Cancer Diagnosis And Therapy

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Epigenetic Modifiers and Their Potential Application in Colorectal Cancer Diagnosis and Therapy

Critical Reviews™ in Oncogenesis ◽

10.1615/critrevoncog.2020035066 ◽

2020 ◽

Vol 25 (2) ◽

pp. 95-109

Author(s):

Sapnita Shinde ◽

Saurabh Saxena ◽

Vineeta Dixit ◽

Atul K. Tiwari ◽

Naveen K. Vishvakarma ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Diagnosis ◽

Potential Application ◽

Diagnosis And Therapy ◽

Epigenetic Modifiers ◽

Cancer Diagnosis And Therapy

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Steroid Receptors as Molecular Targets for Cancer Diagnosis and Therapy

Critical Reviews in Therapeutic Drug Carrier Systems ◽

10.1615/critrevtherdrugcarriersyst.v26.i3.10 ◽

2009 ◽

Vol 26 (3) ◽

pp. 207-273 ◽

Cited By ~ 4

Author(s):

Pramod Mishra ◽

Arvind Gulbake ◽

Aviral Jain ◽

Piush Khare ◽

Vandana Soni ◽

...

Keyword(s):

Cancer Diagnosis ◽

Steroid Receptors ◽

Molecular Targets ◽

Diagnosis And Therapy ◽

Cancer Diagnosis And Therapy

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Clinico-bacteriological Profile and Outcome of Empyema Thoracis in Children at a Tertiary Care Hospital of Central Nepal

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v16i3.30661 ◽

2020 ◽

Vol 16 (3) ◽

Author(s):

Atanu Pan ◽

Debarshi Jana

Keyword(s):

Ct Scan ◽

Broad Spectrum ◽

Chest Tube ◽

Chest Tube Drainage ◽

Diagnostic Tools ◽

High Morbidity ◽

Care Hospital ◽

Empyema Thoracis ◽

First Line ◽

Tube Drainage

Background: Empyema thoracis (ET) is a serious infection of the pleural space. Despite the availability of broad spectrum antibacterial, improved vaccination coverage and better diagnostic tools, Empyema Thoracis remains associated with high morbidity worldwide. Delay in early diagnosis, failure to institute appropriate antimicrobial therapy, multidrug resistant organisms, malnutrition, comorbidities, poor health seeking behaviour and high treatment cost burden contribute to increased morbidity in children. The available treatment options include intravenous broad-spectrum antibiotics either alone or in combination with surgical procedure (thoracocentesis, chest tube drainage, fibrinolytic therapy, decortications with video assistedthoracoscopic surgery (VATS) and open drainage. Methods: Fifty Children between 1 month to 16 years admitted in the Pediatrics Ward, PICU of College of Medical Sciences, Bharatpur,Nepal. Data analysis was done by SPSS 24.0. Results: Present study found that according to blood culture, 3(6.0%) patients had enterococcus, 40(80.0%) patients had no growth, 2(4.0%) patients had pseudomonas, 4(8.0%) patients had staphylococcus and 1(2.0%) patients had streptococcus. We found that 20(40.0%) patients had done CT scan thorax, 30(60.0%) patients had not done CT scan thorax and 32(64.0%) patients had Amoxiclav first line antibiotic and 18(36.0%) patients had Ceftriaxone first line antibiotic. Conclusions: Suitable antibiotics and prompt chest tube drainage is an effective method of treatment of childhood empyema, especially in resource-poor settings. Majority of the patients progress on this conservative management and have good recovery on follow up.

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Applications in Cancer Diagnosis and Therapy

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION) ◽

10.3724/sp.j.1096.2011.01451 ◽

2012 ◽

Vol 39 (9) ◽

pp. 1451-1458

Author(s):

Shu-Na LIU ◽

Yun-Qiu TU ◽

Wen LI ◽

Ping WU ◽

Hui ZHANG ◽

...

Keyword(s):

Cancer Diagnosis ◽

Diagnosis And Therapy ◽

Cancer Diagnosis And Therapy

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Use p27KIP1 Degradation for Breast Cancer Diagnosis and Therapy

10.21236/ada396607 ◽

2001 ◽

Author(s):

Hui Zhang

Keyword(s):

Breast Cancer ◽

Cancer Diagnosis ◽

Breast Cancer Diagnosis ◽

Diagnosis And Therapy ◽

Cancer Diagnosis And Therapy

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Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

Current Pharmaceutical Design ◽

10.2174/1381612825666190903154847 ◽

2019 ◽

Vol 25 (37) ◽

pp. 3917-3926

Author(s):

Sajjad Molavipordanjani ◽

Seyed Jalal Hosseinimehr

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Medical Imaging ◽

Cancer Diagnosis ◽

Carbon Nanoparticles ◽

Tumor Targeting ◽

Polymeric Nanoparticles ◽

Inorganic Nanoparticles ◽

Active Targeting ◽

Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

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