scholarly journals Association of Oxidative Stress on Pregnancy

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Kinga Toboła-Wróbel ◽  
Marek Pietryga ◽  
Piotr Dydowicz ◽  
Marta Napierała ◽  
Jacek Brązert ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
English Language ◽  
Negative Impact ◽  
Relevant Information ◽  
Adverse Pregnancy Outcomes ◽  
Pathophysiological Mechanism ◽  
Search Terms ◽  
Adverse Pregnancy

The pathophysiological mechanism underlying pregnancy complications such as congenital malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known. However, the negative impact of the mother’s body oxidative imbalance on the fetus and the course of gestation is increasingly discussed. This article is an integrative review of some original studies and review papers on the effects of oxidative stress on the adverse pregnancy outcomes mainly birth defects in fetuses. A systematic search for English language articles published from 2010 until 2020 was made, using MEDLINE data. Additionally, we analyzed the Cochrane and Scopus databases, discussions with experts, and a review of bibliography of articles from scientifically relevant and valuable sources. The main purposes are to assess the contribution of the existing literature of associations of oxidative stress on the etiology of the abovementioned conditions and to identify relevant information and outline existing knowledge. Furthermore, the authors aim to find any gaps in the research, thereby providing grounds for our own research. The key search terms were “oxidative stress in pregnancy,” “oxidative stress and congenital malformations,” and “oxidative stress and adverse pregnancy outcomes.” Studies have confirmed that oxidative stress has a significant impact on pregnancy and is involved in the pathomechanism of adverse pregnancy outcomes.

Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-analysis

2020 ◽  
Vol 26 ◽  
Author(s):  
Yang Zhang ◽  
Dandan Li ◽  
Heng Guo ◽  
Weina Wang ◽  
Xingang Li ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Preterm Birth ◽  
Spontaneous Abortion ◽  
Bowel Disease ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Inflammatory Bowel ◽  
Adverse Pregnancy

Background: Conflicting data exist regarding the influence of thiopurines exposure on adverse pregnancy outcomes in female patients with inflammatory bowel disease (IBD). Objective: The aim of this study was to provide an up-to-date and comprehensive assessment of the safety of thiopurines in pregnant IBD women. Methods: All relevant articles reporting pregnancy outcomes in women with IBD received thiopurines during pregnancy were identified from the databases (PubMed, Embase, Cochrane Library, and ClinicalTrials.gov) with the publication data up to April 2020. Data of included studies were extracted to calculate the relative risk (RR) of multiple pregnancy outcomes: congenital malformations, low birth weight (LBW), preterm birth, small for gestational age (SGA), and spontaneous abortion. The meta-analysis was performed using the random-effects model. Results: Eight studies matched with the inclusion criteria and a total of 1201 pregnant IBD women who used thiopurines and 4189 controls comprised of women with IBD received drugs other than thiopurines during pregnancy were included. Statistical analysis results demonstrated that the risk of preterm birth was significantly increased in the thiopurine-exposed group when compared to IBD controls (RR, 1.34; 95% CI, 1.00-1.79; p=0.049; I 2 =41%), while no statistically significant difference was observed in the incidence of other adverse pregnancy outcomes. Conclusion: Thiopurines’ use in women with IBD during pregnancy is not associated with congenital malformations, LBW, SGA, or spontaneous abortion, but appears to have an association with an increased risk of preterm birth.

scholarly journals Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Samprikta Manna ◽  
Cathal McCarthy ◽  
Fergus P. McCarthy
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Pregnancy Outcomes ◽  
Current Knowledge ◽  
Neonatal Morbidity ◽  
Adverse Pregnancy Outcomes ◽  
Premature Ageing ◽  
Dna Mutations ◽  
Critical Organ ◽  
Adverse Pregnancy

Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia remains unclear; however, it is speculated that the various pathologies can be attributed to impaired vascular remodelling and elevated oxidative stress within the placenta. Oxidative stress plays a key role in cell ageing, and the persistent presence of elevated oxidative stress precipitates cellular senescence and mitochondrial dysfunction, resulting in premature ageing of the placenta. Premature ageing of the placenta is associated with placental insufficiency, which reduces the functional capacity of this critical organ and leads to abnormal pregnancy outcomes. The changes brought about by oxidative insults are irreversible and often lead to deleterious modifications in macromolecules such as lipids and proteins, DNA mutations, and alteration of mitochondrial functioning and dynamics. In this review, we have summarized the current knowledge of placental ageing in the aetiology of adverse pregnancy outcomes and discussed the hallmarks of ageing which could be potential markers for preeclampsia and fetal growth restriction.

scholarly journals Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes

2017 ◽  
Vol 77 (5) ◽  
pp. e12653 ◽  
Author(s):  
Zakia Sultana ◽  
Kaushik Maiti ◽  
John Aitken ◽  
Jonathan Morris ◽  
Lee Dedman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy

scholarly journals The possible role of selenium status in adverse pregnancy outcomes

2011 ◽  
Vol 105 (10) ◽  
pp. 1418-1428 ◽  
Author(s):  
Aline B. Mariath ◽  
Denise P. Bergamaschi ◽  
Patrícia H. C. Rondó ◽  
Ana C. D'A. Tanaka ◽  
Patrícia de Fragas Hinnig ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Outcomes ◽  
Stress Studies ◽  
Confounding Variables ◽  
Adverse Pregnancy ◽  
Study Designs ◽  
Se Status

The present study reviews the possible role of Se status during pregnancy regarding adverse pregnancy outcomes, with emphasis on those related to diminished antioxidant activity and increased oxidative stress. Studies have reported that Se could play an important role in adverse outcomes such as miscarriages, neural tube defects, diaphragmatic hernia, premature birth, low birth weight, pre-eclampsia, glucose intolerance and gestational diabetes. Also, low Se status has been associated with adverse outcomes among HIV-infected pregnant women and their offspring. Nevertheless, the function of Se in the aetiology of pregnancy complications is yet to be elucidated. Available evidence presents the following limitations: most study designs do not allow conclusions about causal relationships; study populations, selection of subjects, research setting, procedures for defining sample size and analytical methods are often poorly described; many studies fail to adjust for important confounding variables. In addition, population studies assessing the relationship between Se intake during pregnancy and health outcomes are scarce. Further research is still needed to clarify the role of Se status in adverse pregnancy outcomes, especially those related to augmented oxidative stress.

scholarly journals Dihydroergotamine and triptan use to treat migraine during pregnancy and the risk of adverse pregnancy outcomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anick Bérard ◽  
Shannon Strom ◽  
Jin-Ping Zhao ◽  
Shashi Kori ◽  
Detlef Albrecht
Keyword(s):  
Birth Weight ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Case Control ◽  
Adverse Pregnancy Outcomes ◽  
Spontaneous Abortions ◽  
Estimation Equations ◽  
Adverse Pregnancy ◽  
Major Congenital Malformations ◽  
Nested Case Control

AbstractMigraine is prevalent during pregnancy. Antimigraine medications such as dihydroergotamine (DHE) and triptans have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains. We compared the risk of prematurity, low birth weight (LBW), major congenital malformations (MCM), and spontaneous abortions (SA) associated with gestational use of DHE or triptans. Three cohort and one nested-case–control analyses were conducted within the Quebec Pregnancy Cohort to assess the risk of prematurity, LBW, MCM, and SA. Exposure was defined dichotomously as use of DHE or triptan during pregnancy. Generalized estimation equations were built to quantify the associations, adjusting for potential confounders. 233,900 eligible pregnancies were included in the analyses on prematurity, LBW, and MCM; 29,104 cases of SA were identified. Seventy-eight subjects (0.03%) were exposed to DHE and 526 (0.22%) to triptans. Adjusting for potential confounders, DHE and triptans were associated with increased risks of prematurity, LBW, MCM, and SA but not all estimates were statistically significant. DHE was associated with the risk of prematurity (aRR: 4.12, 95% CI 1.21–13.99); triptans were associated with the risk of SA (aOR: 1.63, 95% CI 1.34–1.98). After considering maternal migraine, all antimigraine specific medications increased the risk of some adverse pregnancy outcomes, but estimates were unstable.

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