scholarly journals Recent Advances in Carbon Nanotubes for Nervous Tissue Regeneration

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Carlos Redondo-Gómez ◽  
Rocío Leandro-Mora ◽  
Daniela Blanch-Bermúdez ◽  
Christopher Espinoza-Araya ◽  
David Hidalgo-Barrantes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Tissue Regeneration ◽  
Nervous Tissue ◽  
Tissue Repair ◽  
Spinal Cord Injuries ◽  
Review Article ◽  
Nerve Tissue ◽  
Recent Advances ◽  
Nerve Tissue Engineering ◽  
Carbon Based Nanomaterials

Regenerative medicine has taken advantage of several nanomaterials for reparation of diseased or damaged tissues in the nervous system involved in memory, cognition, and movement. Electrical, thermal, mechanical, and biocompatibility aspects of carbon-based nanomaterials (nanotubes, graphene, fullerenes, and their derivatives) make them suitable candidates to drive nerve tissue repair and stimulation. This review article focuses on key recent advances on the use of carbon nanotube- (CNT-) based technologies on nerve tissue engineering, outlining how neurons interact with CNT interfaces for promoting neuronal differentiation, growth and network reconstruction. CNTs still represent strong candidates for use in therapies of neurodegenerative pathologies and spinal cord injuries.

scholarly journals Recent Advances in Carbon Nanotubes for Nervous Tissue Regeneration

2019 ◽  
Author(s):  
Carlos Redondo-Gómez ◽  
Rocío Leandro-Mora ◽  
Daniela Blanch-Bermúdez ◽  
Christopher Espinoza-Araya ◽  
David Hidalgo-Barrantes ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Nervous Tissue ◽  
Tissue Repair ◽  
Spinal Cord Injuries ◽  
Review Article ◽  
Nerve Tissue ◽  
Imaging Diagnostics ◽  
Recent Advances ◽  
Nerve Tissue Engineering ◽  
Carbon Based Nanomaterials

Nanomedicine has allowed for emerging advances in imaging, diagnostics and therapeutics. Regenerative Medicine has taken advantage of a number of nanomaterials for reparation of diseased or damaged tissues in the nervous system involved in memory, cognition and movement. Electrical, thermal, mechanical and biocompatibility aspects of carbon-based nanomaterials (nanotubes, graphene, fullerenes and their derivatives) make them suitable candidates to drive nerve tissue repair and stimulation. This review article focuses on recent advances on the use of carbon nanotube (CNT)-based technologies on nerve tissue engineering; outlining how neurons interact with the nanomaterials interface for promoting neuronal differentiation, growth and network reconstruction for their possible use in therapies of neurodegenerative pathologies and spinal cord injuries.

Preparation of Porous Multi-Channeled Chitosan Conduits for Nerve Tissue Engineering

2005 ◽  
Vol 288-289 ◽  
pp. 27-30 ◽  
Author(s):  
Q. Ao ◽  
A.J. Wang ◽  
W.L. Cao ◽  
C. Zhao ◽  
Ya Dong Gong ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stainless Steel ◽  
Spinal Cord Injuries ◽  
Neuroblastoma Cells ◽  
Nerve Tissue ◽  
Tissue Engineering Scaffolds ◽  
Nerve Conduits ◽  
Porous Chitosan ◽  
Nerve Tissue Engineering ◽  
Chitosan Gel

A new method to fabricate porous chitosan nerve conduits with multi-channels was described. A uniquely designed mold was composed of 7-50 stainless steel needles and a set of plastic pedestals. Porous or imperforate chitosan tubes with 2-5mm inner diameter and 0.2-1.0 mm wall thickness were made firstly. The chitosan tubes were injected with 3% chitosan gel. The stainless steel needles longitudinally perforated through the chitosan tubes filled with chitosan gel, and the plastic pedestals were used to fix the needles. Lyophilization was used to finish fabrication. The diameter of channels was 0.2-0.4mm. Swelling property and biodegradability of Multi-channeled chitosan conduits were investigated. Wright’s staining and scanning electron microscope (SEM) were used to observe spread and proliferation of Neuroblastoma cells (N2A, mouse) on the conduits. It is promising that the porous chitosan nerve conduits with multi-channels are used as nerve tissue engineering scaffolds in repair of peripheral nerve and spinal cord injuries.

Recent advances in inorganic nanomaterials for wound-healing applications

2019 ◽  
Vol 7 (7) ◽  
pp. 2652-2674 ◽  
Author(s):  
Susheel Kumar Nethi ◽  
Sourav Das ◽  
Chitta Ranjan Patra ◽  
Sudip Mukherjee
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Clinical Status ◽  
Review Article ◽  
Inorganic Nanoparticles ◽  
Future Directions ◽  
Recent Advances ◽  
Inorganic Nanomaterials

The emergence of inorganic nanoparticles has generated considerable expectation for solving various biomedical issues including wound healing and tissue regeneration. This review article highlights the role and recent advancements of inorganic nanoparticles for wound healing and tissue regeneration along with their advantages, clinical status, challenges and future directions.

Recent advances in strategies for peripheral nerve tissue engineering

2017 ◽  
Vol 4 ◽  
pp. 134-142 ◽  
Author(s):  
Sahba Mobini ◽  
Benjamin S. Spearman ◽  
Christopher S. Lacko ◽  
Christine E. Schmidt
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Tissue ◽  
Recent Advances ◽  
Nerve Tissue Engineering

scholarly journals What to know in Managing Spinal Cord Injury for Anesthesiologists?

2020 ◽  
Vol 2 ◽  
pp. 89-93
Author(s):  
Charles Charles
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Disorders ◽  
Spinal Cord Injuries ◽  
Spinal Nerve ◽  
Cost Of Care ◽  
Nerve Tissue ◽  
Cord Injury ◽  
The Cost ◽  
Very High

Background: Spinal cord injury (SCI) is trauma to the area of the vertebrae resulting in spinal cord lesions resulting in neurological disorders, depending on the location of the spinal nerve damage and the injured nerve tissue. The symptoms of SCI can range from pain and paralysis to incontinence. SCI due to trauma is estimated to occur in 30–40 per million population per year, and about 8000–10,000 sufferers each year, generally, occurs in adolescents and young adults. Although the annual incidence of events is relatively low, the cost of care and rehabilitation for spinal cord injuries is very high, at around US $ 53,000/patient. Methods: This study aims to provide an overview of how to manage SCI. This study reviewed various sources then reviewed as a literature review. Conclusion: Treatment in the hospital includes all systems that may experience complications from SCI, starting from the respiratory, cardiovascular, urological, gastrointestinal, skin, to non-operative. and operative reduction measures.

scholarly journals Elaboration of New Treatment Methods for Spinal Cord Injuries Using Magnetic Nanoparticles in Combination with Electromagnetic Field (Experimental Study)

2016 ◽  
Vol 23 (4) ◽  
pp. 55-60
Author(s):  
S. V Kolesov ◽  
A. A Panteleev ◽  
M. L Sazhnev ◽  
A. I Kaz’min
Keyword(s):  
Magnetic Field ◽  
Spinal Cord ◽  
Experimental Study ◽  
Magnetic Nanoparticles ◽  
Spinal Cord Injuries ◽  
Nerve Tissue ◽  
Experimental Animals ◽  
Tissue Integrity ◽  
Function Loss ◽  
New Treatment

The latest studies on the use of magnetic nanoparticles (MNP) in biological systems prove their high biocompatibility and possibility to interact with various types of cells including the neurons. This may serve as a basis for potential restoration of the neuronal network after nerve tissue integrity damage. The purpose of the study was to determine the influence of MNP on the restoration of hind paws function in experimental animals after spinal cord transection (by 50, 80 and 100%) under the influence of a magnetic field. Magnetic nanoparticles were inserted into the injury zone via plastic catheter. The degree of function loss and its subsequent restoration was assessed by BBB Locomotor Scale and induced potentials on the first postoperative day and then weekly within one month. Statistically significant (p

Recent Advances in Nerve Tissue Engineering

2014 ◽  
Vol 37 (4) ◽  
pp. 277-291 ◽  
Author(s):  
Bill G.X. Zhang ◽  
Anita F. Quigley ◽  
Damian E. Myers ◽  
Gordon G. Wallace ◽  
Robert M.I. Kapsa ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Nerve Tissue ◽  
Recent Advances ◽  
Nerve Tissue Engineering

scholarly journals Recent Progress in the Regeneration of Spinal Cord Injuries by Induced Pluripotent Stem Cells

2019 ◽  
Vol 20 (15) ◽  
pp. 3838 ◽  
Author(s):  
Maria Csobonyeiova ◽  
Stefan Polak ◽  
Radoslav Zamborsky ◽  
Lubos Danisovic
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Spinal Cord Injuries ◽  
Ethical Issues ◽  
Embryonic Stem ◽  
Sensory Function ◽  
Nerve Tissue ◽  
Current Status ◽  
Cell Based Therapy

Regeneration of injuries occurring in the central nervous system, particularly spinal cord injuries (SCIs), is extremely difficult. The complex pathological events following a SCI often restrict regeneration of nervous tissue at the injury site and frequently lead to irreversible loss of motor and sensory function. Neural stem/progenitor cells (NSCs/NPCs) possess neuroregenerative and neuroprotective features, and transplantation of such cells into the site of damaged tissue is a promising stem cell-based therapy for SCI. However, NSC/NPCs have mostly been induced from embryonic stem cells or fetal tissue, leading to ethical concerns. The pioneering work of Yamanaka and colleagues gave rise to the technology to induce pluripotent stem cells (iPSCs) from somatic cells, overcoming these ethical issues. The advent of iPSCs technology has meant significant progress in the therapy of neurodegenerative disease and nerve tissue damage. A number of published studies have described the successful differentiation of NSCs/NPCs from iPSCs and their subsequent engraftment into SCI animal models, followed by functional recovery of injury. The aim of this present review is to summarize various iPSC- NPCs differentiation methods, SCI modelling, and the current status of possible iPSC- NPCs- based therapy of SCI.

Recent advances in regenerative medicine approaches for spinal cord injuries

2017 ◽  
Vol 4 ◽  
pp. 40-49 ◽  
Author(s):  
Marian H. Hettiaratchi ◽  
Tobias Führmann ◽  
Molly S. Shoichet
Keyword(s):  
Spinal Cord ◽  
Regenerative Medicine ◽  
Spinal Cord Injuries ◽  
Recent Advances
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