scholarly journals Elevated Serum Neuropeptide FF Levels Are Associated with Cognitive Decline in Patients with Spinal Cord Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Shifei Sun ◽  
Shilong Sun ◽  
Yan Meng ◽  
Bin Shi ◽  
Yuanzhen Chen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Linear Regression ◽  
Cognitive Decline ◽  
Density Lipoprotein ◽  
Healthy Controls ◽  
Baseline Serum ◽  
Neuropeptide Ff ◽  
Cord Injury ◽  
Laboratory Variables

Background. Spinal cord injury (SCI) has high incidence globally and is frequently accompanied by subsequent cognitive decline. Accurate early risk-categorization of SCI patients for cognitive decline using biomarkers can enable the timely application of appropriate neuroprotective measures and the development of new agents for the management of SCI-associated cognitive decline. Neuropeptide FF is an endogenous neuropeptide with a multitude of functions and is associated with neuroinflammatory processes. This prospective study investigated the predictive value of serum neuropeptide FF levels measured after acute SCI for subsequent cognitive decline. Methods. 88 patients presenting with acute SCI without preexisting neurological injury, brain trauma, or severe systemic illness and 60 healthy controls were recruited. Serum neuropeptide FF levels, clinical, and routine laboratory variables including low-density lipoprotein, high-density lipoprotein, fasting blood glucose, total triiodothyronine (TT3), total thyroxine (TT4), and thyroid-stimulating hormone (TSH) levels collected from all subjects were assessed. Montreal cognitive assessment (MoCA) was performed 3 months after enrollment. SCI patients were grouped according to quartile of serum neuropeptide FF level and MoCA scores were compared using ANOVA. Additionally, multivariate linear regression with clinical and laboratory variables was performed to predict MoCA scores. Results. SCI patients displayed significantly higher baseline serum neuropeptide FF levels than healthy controls ( 38.5 ± 4.1 versus 23.4 ± 2.0   pg / ml , p < 0.001 ∗ ∗ ). SCI patients in higher quartiles of baseline serum neuropeptide FF displayed significantly lower MoCA scores at 3 months. Linear regression analysis indicated serum neuropeptide FF levels as a significant independent predictor of worse MoCA scores after SCI ( r = 0.331 , p = 0.034 ∗ ). Conclusion. Early serum neuropeptide FF levels significantly and independently predicted cognitive decline after acute SCI among patients without preexisting neurological disorders.

scholarly journals A STUDY OF RELATION OF LOWER LIMB SPASTICITY WITH LIPID PROFILE AND FASTING PLASMA GLUCOSE LEVELS IN CHRONIC MOTOR COMPLETE SPINAL CORD INJURY PATIENTS.

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Batra Amit ◽  
Prakash Om ◽  
Jindal Rajeshwari ◽  
Batra Shivra
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Lower Limb ◽  
Density Lipoprotein ◽  
Fasting Plasma ◽  
Cord Injury ◽  
Limb Spasticity ◽  
Lower Limb Spasticity

Background: Most common cause of spinal cord injury in India is fall from height followed by road accidents which may lead to incomplete or complete disruption of neural signal transmission across and below the level of injury. Spasticity is a common but not an inevitable complication following spinal cord injury. Study Objective: The present study tried to explore the correlation between the lower limb spasticity following spinal cord injury and the metabolic markers. Study design: Hospital-based cross-sectional study. Material and Methods: Fifty patients recruited from Department of Physical Medicine and Rehabilitation, Sawai Man Singh Hospital, Jaipur (Raj.), were categorized into mild (16),moderate (11), and severe (23)spastic groups based on assessment of  ankle/knee extensor muscle group spasticity using the modified Ashworth scale. The metabolic profile markers such as Total Cholesterol (TC), Low-density Lipoprotein (LDL), High-Density Lipoprotein (HDL), Triglyceride (TG) and Fasting Plasma Glucose (FPG) were estimated and compared between the three groups. Results: The triglycerides, total cholesterol, low density lipoproteins and the fasting plasma glucose level were significantly negatively correlated with the grading of spasticity in lowerlimbs (P <0.001). The high density lipoproteins level was higher in a severe spastic group as compared to the mild and moderate spastic groups; but this result was statistically non-significant (P=0.14). Conclusion: Spasticity in motor complete SCI may have beneficial effects in preserving glucose homeostasis and defending rise in adiposity, rationalizing the need for its judicious management to maintain the crucial balance between its beneficial and problematic effects. Keywords: Spasticity, Modified Ashworth score, Spinal cord injury, lipid profile, fasting plasma glucose.

Quality of life in persons with spinal cord injury: comparisons with other populations

2012 ◽  
Vol 17 (Suppl1) ◽  
pp. 29-37 ◽  
Author(s):  
Maxwell Boakye ◽  
Barbara C. Leigh ◽  
Andrea C. Skelly
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Normative Data ◽  
Healthy Controls ◽  
Validity And Reliability ◽  
Sf 36 ◽  
Cord Injury ◽  
The Impact

Object The aim of this study was to identify the quality of life (QOL) measures commonly used to assess patients with spinal cord injury (SCI) and to summarize studies using common QOL measures that have been validated in SCI populations to compare scores in persons with SCI with those in a control population. Methods A systematic search of PubMed was conducted to identify studies using common QOL measures in persons with SCI and those comparing scores for QOL measures in an SCI population with scores in other populations. The authors sought comparative studies utilizing QOL measures for which validity and reliability analyses had been done. Results Of 28 QOL measures found, validity and reliability studies had been conducted in patients with SCI for 5 measures. Twelve comparative studies compared QOL in SCI patients with QOL in healthy controls or in patients with other disabilities, or with normative data. The 36-Item Short Form Health Survey (SF-36) and the short version of the WHOQOL (WHOQOL-BREF) were the most widely used QOL instruments. Patients with SCI had a decreased QOL as compared with that in healthy controls or normative data, with the most pronounced deficits in the domains of physical functioning and physical role limitations. In 3 studies, patients with tetraplegia had a lower physical domain QOL than did those with paraplegia. Overall, however, the impact of injury level and injury completeness on QOL after SCI remains unclear due to a lack of longitudinal studies. Conclusions The SF-36 and WHOQOL-BREF are validated instruments that should be considered for use in SCI QOL studies. Future analysis of deficits in QOL among patients with SCI would benefit from the development of a QOL instrument specifically targeted to SCI. Longitudinal studies to assess the impact of injury level and injury completeness on SCI QOL are also needed.

scholarly journals Establishing a threshold to predict risk of cardiovascular disease from the serum triglyceride and high-density lipoprotein concentrations in persons with spinal cord injury

Spinal Cord ◽  
2018 ◽  
Vol 56 (11) ◽  
pp. 1051-1058 ◽  
Author(s):  
Michael F. La Fountaine ◽  
Christopher M. Cirnigliaro ◽  
Joshua C. Hobson ◽  
Trevor A. Dyson-Hudson ◽  
Cristin Mc Kenna ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
High Density ◽  
Cord Injury

scholarly journals Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Hadis Sabour ◽  
Abbas Norouzi Javidan ◽  
Sahar Latifi ◽  
Mohammad Reza Hadian ◽  
Seyed-Hassan Emami Razavi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Femoral Neck ◽  
Bone Formation ◽  
Bone Mineral ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Mineral Density ◽  
Cord Injury

Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI.Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age.Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004,r=0.33). HDL was negatively correlated with osteocalcin (P: 0.017,r=-0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD.Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation.

scholarly journals Wireless Brain-Robot Interface: User Perception and Performance Assessment of Spinal Cord Injury Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Alkinoos Athanasiou ◽  
George Arfaras ◽  
Niki Pandria ◽  
Ioannis Xygonakis ◽  
Nicolas Foroglou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Degrees Of Freedom ◽  
Psychometric Evaluation ◽  
Assistive Robotics ◽  
Healthy Controls ◽  
User Perception ◽  
Cord Injury ◽  
Cervical Injuries ◽  
And Performance

Patients suffering from life-changing disability due to Spinal Cord Injury (SCI) increasingly benefit from assistive robotics technology. The field of brain-computer interfaces (BCIs) has started to develop mature assistive applications for those patients. Nonetheless, noninvasive BCIs still lack accurate control of external devices along several degrees of freedom (DoFs). Unobtrusiveness, portability, and simplicity should not be sacrificed in favor of complex performance and user acceptance should be a key aim among future technological directions. In our study 10 subjects with SCI (one complete) and 10 healthy controls were recruited. In a single session they operated two anthropomorphic 8-DoF robotic arms via wireless commercial BCI, using kinesthetic motor imagery to perform 32 different upper extremity movements. Training skill and BCI control performance were analyzed with regard to demographics, neurological condition, independence, imagery capacity, psychometric evaluation, and user perception. Healthy controls, SCI subgroup with positive neurological outcome, and SCI subgroup with cervical injuries performed better in BCI control. User perception of the robot did not differ between SCI and healthy groups. SCI subgroup with negative outcome rated Anthropomorphism higher. Multi-DoF robotics control is possible by patients through commercial wireless BCI. Multiple sessions and tailored BCI algorithms are needed to improve performance.

scholarly journals Extent of cord pathology in the lumbosacral enlargement in non-traumatic versus traumatic spinal cord injury

2021 ◽  
Author(s):  
Gergely David ◽  
Kevin Vallotton ◽  
Markus Hupp ◽  
Armin Curt ◽  
Patrick Freund ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Similar Degree ◽  
Traumatic Spinal Cord Injury ◽  
Healthy Controls ◽  
Lateral Column ◽  
Cord Injury

Objectives: This study compares remote neurodegenerative changes caudal to a cervical injury in degenerative cervical myelopathy (DCM) (i.e. non-traumatic) and incomplete traumatic spinal cord injury (tSCI) patients, using MRI-based tissue area measurements and diffusion tensor imaging (DTI). Methods: Eighteen mild to moderate DCM patients with sensory impairments (mean mJOA score: 16.2), 14 incomplete tetraplegic tSCI patients (AIS C&D), and 20 healthy controls were recruited. All participants received DTI and T2*-weighted scans in the lumbosacral enlargement (caudal to injury) and at C2/C3 (rostral to injury). MRI readouts included DTI metrics in the white matter (WM) columns and cross-sectional WM and gray matter area. One-way ANOVA with Tukey post-hoc comparison (p<0.05) was used to assess group differences. Results: In the lumbosacral enlargement, compared to DCM, tSCI patients exhibited decreased fractional anisotropy in the lateral (tSCI vs. DCM, -11.9%, p=0.007) and ventral WM column (-8.0%, p=0.021), and showed trend toward lower values in the dorsal column (-8.9%, p=0.068). At C2/C3, no differences in DTI metrics were observed between DCM and tSCI, but compared to controls, fractional anisotropy was lower in both groups in the dorsal (DCM vs. controls, -7.9%, p=0.024; tSCI vs. controls, -10.0%, p=0.007) and in the lateral column (DCM: -6.2%, p=0.039; tSCI: -13.3%, p<0.001). WM areas were not different between patient groups, but were significantly lower compared to healthy controls both in the lumbosacral enlargement (DCM: -16.9%, p<0.001; tSCI, -10.5%, p=0.043) and at C2/C3 (DCM: -16.0%, p<0.001; tSCI: -18.1%, p<0.001). Conclusion: In conclusion, mild to moderate DCM and incomplete tSCI lead to similar degree of degeneration of the dorsal and lateral columns at C2/C3, but tSCI results in more widespread white matter damage in the lumbosacral enlargement. These remote changes are likely to contribute to the impairment and recovery of the patients. Diffusion MRI is a sensitive tool to assess remote pathological changes in DCM and tSCI patients.

Abstract 370: Oxidized Low-density Lipoprotein is Related to Carotid Atherosclerosis in Spinal Cord Injury Subjects

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Roberto Schreiber ◽  
Layde R Paim ◽  
José R Matos-Souza ◽  
Anselmo A Silva ◽  
Luis F Campos ◽  
...  
Keyword(s):  
Physical Activity ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Carotid Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Carotid Imt ◽  
Cord Injury

Objective Physical activity is associated with improved carotid atherosclerosis in spinal cord injury (SCI) subjects independent of variation in hemodynamic, metabolic and inflammatory variables. The present study investigated the role of oxidized low-density lipoprotein (Ox-LDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in this regard. Design and Methods We studied 40 men with chronic (>1 year of injury) SCI and no voluntary motor activity [17 sedentary (47% tetraplegic) and 23 athletes (52% tetraplegic)] by clinical, anthropometric, laboratory (glucose, lipid profile and C-reactive protein), hemodynamic (blood pressure and cardiac output) and carotid ultrasound analysis. All enrolled subjects were normotensive, non-diabetics, non-smokers and normolipemic. Plasmatic Ox-LDL, MMP2, MMP8, MMP9, TIMP1 and TIMP2 were determined by ELISA. Data are presented as mean±SEM. A p-value <0.05 was considered significant. Results Sedentary SCI subjects and SCI athletes presented similar clinical, anthropometric, laboratory and hemodynamic features. Carotid intima-media thickness (IMT) of SCI athletes was lower than that of SCI sedentary individuals (0.54±0.01 vs 0.69±0.02 mm; p<0.001). SCI athletes presented lower Ox-LDL (38.4±2.1 vs 54.1±4.1 U/L; p<0.001) levels in comparison with SCI sedentary individuals. Conversely, MMPs and TIMPs levels as were as MMP8/TIMP1, MMP9/TIMP1 and MMP2/TIMP2 ratios were similar between the SCI groups. Bivariate correlation analysis including all SCI subjects showed that carotid IMT correlated with Ox-LDL (r=0.54; p<0.001), but not with any MMPs or MMP/TIMP ratios. Further linear regression analysis adjusted for the presence or not of physical activity showed that Ox-LDL was still associated with carotid IMT (beta=0.293±0.141; p=0.044) in the whole sample. Conclusions Plasmatic Ox-LDL levels are associated with increased carotid IMT in SCI subjects and are lower in physically active SCI individuals than in sedentary SCI ones. These findings may provide a potential mechanism by which physical activity attenuates SCI-induced atherosclerosis.

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