scholarly journals Hemosiderin-Laden Macrophages in Bronchoalveolar Lavage: Predictive Role for Acute Exacerbation of Idiopathic Interstitial Pneumonias

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Toru Arai ◽  
Tomoko Kagawa ◽  
Yumiko Sasaki ◽  
Reiko Sugawara ◽  
Chikatoshi Sugimoto ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Acute Exacerbation ◽  
Characteristic Curve ◽  
Predictive Ability ◽  
Lavage Fluid ◽  
Rank Test ◽  
Idiopathic Interstitial Pneumonias ◽  
Group 4 ◽  
Blue Stain ◽  
Cox Proportional Hazard Regression

Background. Hemosiderin-laden macrophages (HLMs) have been identified in the bronchoalveolar lavage fluid (BALF) of patients with idiopathic pulmonary fibrosis (IPF). This retrospective study examined the ability of HLMs in BALF to predict the acute exacerbation (AE) of chronic idiopathic interstitial pneumonias (IIPs). Methods. Two hundred and twenty-one patients with IIP diagnosed by bronchoscopy were enrolled in the study (IPF, n = 87; IIPs other than IPF, n = 134). Giemsa stain was used to detect HLMs in BALF specimens. Prussian blue stain was used to quantify HLMs in BALF, and a hemosiderin score (HS) was given to the specimens containing HLMs. Results. Twenty-four patients had a positive HS (range: 7‒132). The receiver-operating characteristic curve analysis identified the cutoff HS value for predicting the AE of IIPs to be 61.5. Seven cases had a higher HS (≥61.5) and 214 had a lower HS. AE occurred significantly earlier in the higher HS group (4/7 cases) than in the lower HS group (41/214 cases) during a median observation period of 1239 days (log-rank test, p  = 0.026). Multivariate Cox proportional hazard regression analysis showed that a higher HS was a significant predictor of AE in addition to IPF, percent predicted forced vital capacity, and modified Medical Research Council score. The C-statistics for the prediction of AE did not significantly improve by all the above parameters with HS as compared without HS. Conclusions. A higher HS was a significant predictor of AE in IIPs but did not significantly improve the predictive ability of other parameters.

scholarly journals Small medullary thyroid carcinoma: post-operative calcitonin rather than tumour size predicts disease persistence and progression

2014 ◽  
Vol 171 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Katerina Saltiki ◽  
Gianna Rentziou ◽  
Kimon Stamatelopoulos ◽  
Georgios Georgiopoulos ◽  
Charalambos Stavrianos ◽  
...  
Keyword(s):  
Disease Progression ◽  
Tumour Size ◽  
Characteristic Curve ◽  
Rank Test ◽  
Medullary Thyroid ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Disease Persistence ◽  
Group 1

ObjectiveRecently, small medullary thyroid carcinomas (smallMTCs; ≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical specimens. Their clinical course varies. We examined tumour size as a predictor of clinical behaviour.DesignA retrospective study.MethodsA total of 128 smallMTC patients (35.2% males and 45% familial) were followed up for 0.9–30.9 years. According to tumour size (cm), patients were classified into four groups: group 1, 0.1–0.5 (n=33); group 2, 0.6–0.8 (n=33); group 3, 0.8–1.0 (n=29) and group 4, 1.1–1.5 (n=33).ResultsPre- and post-operative calcitonin levels were positively associated with the tumour size (P<0.001). Capsular and lymph node invasion were more frequent in groups 3 and 4 (P<0.03); the stage was more advanced and the outcome was less favourable with an increasing tumour size (P<0.001). Groups 1 and 2 patients were more frequently cured (group 1, 87.8%; group 2, 72.7%; group 3, 68.9%; and group 4, 48.5%; P=0.002). The 10-year probability of lack of disease progression according to the tumour size differed between patients with tumour sizes of 0.1–1.0 and 1.1–1.5 cm (96.6%, 81.3%, x2=4.03, P=0.045 for log-rank test). Post-operative calcitonin was the only predictor significantly associated with the 10-year progression of disease. Post-operative calcitonin levels ≥4.65 pg/ml predicted disease persistence (sensitivity 93.8% and specificity 90%) and ≥14.5 pg/ml predicted disease progression (sensitivity 100%, specificity 82%, receiver operating characteristic curve analysis).ConclusionsTumour size may be of clinical importance only in patients with MTCs >1 cm in size. Post-operative calcitonin is a more important predictor than size for disease progression.

scholarly journals Cytokine concentrations in bronchoalveolar lavage fluid (BALF) from children with severe community-acquired pneumonia (SCAP) from Shanghai

2021 ◽  
Author(s):  
bingru yin ◽  
Min Lu ◽  
Guodong Ding ◽  
Na Dong ◽  
Xiaoyan Dong ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Predictive Value ◽  
Bronchoalveolar Lavage Fluid ◽  
Characteristic Curve ◽  
Critical Role ◽  
Lavage Fluid ◽  
Community Acquired Pneumonia ◽  
Tnf Α ◽  
Hospitalization Costs ◽  
Severe Community Acquired Pneumonia

Background: It has been well known that overreaction of host immune systems plays a critical role in severe community-acquired pneumonia (SCAP). However, few of previous studies focused on the association between cytokine concentrations in bronchoalveolar lavage fluid (BALF) and SCAP. Object: We examined cytokine concentrations in BALF from children with SCAP and explored predictive value of cytokine concentrations for SCAP. Method: It was a retrospective study. A total of 100 children with SCAP who underwent parallel bronchoalveolar lavage between July 2017 and June 2019 were enrolled. 100 patients with mild community-acquired pneumonia (MCAP) who were admitted to the hospital were matched based on age and sex during the same time period . Basic clinical information were collected. Flow cytometry was used to determine the cytokine concentrations in BALF. Receiver operating characteristic curve was used to analyze their predictive value for SCAP. Result: A total of 106 males and 94 females were included in this study. The results showed that the CRP, PCT, ESR, LDH, and D-dimer were significantly increased in the SCAP group. The SCAP patients also had longer fever duration, hospitalization stays, and higher hospitalization costs. The IL-5，IL-17A，IL-18，and TnF-α in BALF of SCAP group were significantly higher than those in MCAP group. ROC curve analysis demonstrated AUC of those cytokines were all among 0.5~0.7. Conclusion: The IL-5，IL-17A，IL-18，and TnF-α in BALF of children with SCAP group were highe. However, the efficacy of those cytokines in the clinical diagnosis of SCAP is not excellent to be used as a predictor.

Identification of neutrophil chemotactic factors in bronchoalveolar lavage fluid of asthmatic patients

1997 ◽  
Vol 27 (4) ◽  
pp. 396-405 ◽  
Author(s):  
L. M. TERAN ◽  
M. G. CAMPOS ◽  
B. T. BEGISHVILLI ◽  
J.-M. SCHRODER ◽  
R. DJUKANOVIC ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Asthmatic Patients ◽  
Chemotactic Factors

scholarly journals MicroRNAs-1299, -126-3p and -30e-3p as Potential Diagnostic Biomarkers for Prediabetes

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 949
Author(s):  
Cecil J. Weale ◽  
Don M. Matshazi ◽  
Saarah F. G. Davids ◽  
Shanel Raghubeer ◽  
Rajiv T. Erasmus ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Predictive Ability ◽  
Roc Curves ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Receiver Operating

This cross-sectional study investigated the association of miR-1299, -126-3p and -30e-3p with and their diagnostic capability for dysglycaemia in 1273 (men, n = 345) South Africans, aged >20 years. Glycaemic status was assessed by oral glucose tolerance test (OGTT). Whole blood microRNA (miRNA) expressions were assessed using TaqMan-based reverse transcription quantitative-PCR (RT-qPCR). Receiver operating characteristic (ROC) curves assessed the ability of each miRNA to discriminate dysglycaemia, while multivariable logistic regression analyses linked expression with dysglycaemia. In all, 207 (16.2%) and 94 (7.4%) participants had prediabetes and type 2 diabetes mellitus (T2DM), respectively. All three miRNAs were significantly highly expressed in individuals with prediabetes compared to normotolerant patients, p < 0.001. miR-30e-3p and miR-126-3p were also significantly more expressed in T2DM versus normotolerant patients, p < 0.001. In multivariable logistic regressions, the three miRNAs were consistently and continuously associated with prediabetes, while only miR-126-3p was associated with T2DM. The ROC analysis indicated all three miRNAs had a significant overall predictive ability to diagnose prediabetes, diabetes and the combination of both (dysglycaemia), with the area under the receiver operating characteristic curve (AUC) being significantly higher for miR-126-3p in prediabetes. For prediabetes diagnosis, miR-126-3p (AUC = 0.760) outperformed HbA1c (AUC = 0.695), p = 0.042. These results suggest that miR-1299, -126-3p and -30e-3p are associated with prediabetes, and measuring miR-126-3p could potentially contribute to diabetes risk screening strategies.

Sign in / Sign up

Export Citation Format

Share Document