scholarly journals Redox-Dependent Effects in the Physiopathological Role of Bile Acids

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Josué Orozco-Aguilar ◽  
Felipe Simon ◽  
Claudio Cabello-Verrugio
Keyword(s):  
Oxidative Stress ◽  
Bile Acids ◽  
Biological Membrane ◽  
Cellular Damage ◽  
Oxygen Species ◽  
Metabolic Functions ◽  
Toxic Potential ◽  
Cholestatic Diseases ◽  
And Oxidative Stress

Bile acids (BA) are recognized by their role in nutrient absorption. However, there is growing evidence that BA also have endocrine and metabolic functions. Besides, the steroidal-derived structure gives BA a toxic potential over the biological membrane. Thus, cholestatic disorders, characterized by elevated BA on the liver and serum, are a significant cause of liver transplant and extrahepatic complications, such as skeletal muscle, central nervous system (CNS), heart, and placenta. Further, the BA have an essential role in cellular damage, mediating processes such as membrane disruption, mitochondrial dysfunction, and the generation of reactive oxygen species (ROS) and oxidative stress. The purpose of this review is to describe the BA and their role on hepatic and extrahepatic complications in cholestatic diseases, focusing on the association between BA and the generation of oxidative stress that mediates tissue damage.

scholarly journals The Role of MicroRNAs in Diabetes-Related Oxidative Stress

2019 ◽  
Vol 20 (21) ◽  
pp. 5423 ◽  
Author(s):  
Mirza Muhammad Fahd Qadir ◽  
Dagmar Klein ◽  
Silvia Álvarez-Cubela ◽  
Juan Domínguez-Bendala ◽  
Ricardo Luis Pastori
Keyword(s):  
Oxidative Stress ◽  
Target Gene ◽  
Cellular Stress ◽  
Cellular Damage ◽  
Oxygen Species ◽  
Non Coding Rnas ◽  
And Oxidative Stress

Cellular stress, combined with dysfunctional, inadequate mitochondrial phosphorylation, produces an excessive amount of reactive oxygen species (ROS) and an increased level of ROS in cells, which leads to oxidation and subsequent cellular damage. Because of its cell damaging action, an association between anomalous ROS production and disease such as Type 1 (T1D) and Type 2 (T2D) diabetes, as well as their complications, has been well established. However, there is a lack of understanding about genome-driven responses to ROS-mediated cellular stress. Over the last decade, multiple studies have suggested a link between oxidative stress and microRNAs (miRNAs). The miRNAs are small non-coding RNAs that mostly suppress expression of the target gene by interaction with its 3’untranslated region (3′UTR). In this paper, we review the recent progress in the field, focusing on the association between miRNAs and oxidative stress during the progression of diabetes.

scholarly journals Prospects for the Role of Ferroptosis in Fluorosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yi Zhang ◽  
Jialong Wu ◽  
Lai Jiang ◽  
Chenkang Lu ◽  
Zhengwei Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Cellular Damage ◽  
Oxygen Species ◽  
Membrane Rupture ◽  
High Fluoride ◽  
And Oxidative Stress ◽  
Dependent Type

As a strong oxidant, fluorine can induce oxidative stress resulting in cellular damage. Ferroptosis is an iron-dependent type of cell death caused by unrestricted lipid peroxidation (LPO) and subsequent plasma membrane rupture. This article indicated a relationship between fluorosis and ferroptosis. Evidence of the depletion of glutathione (GSH) and increased oxidized GSH can be found in a variety of organisms in high fluorine environments. Studies have shown that high fluoride levels can reduce the antioxidant capacity of antioxidant enzymes, while increasing the contents of reactive oxygen species (ROS) and malondialdehyde (MDA), resulting in oxidative stress and fluoride-induced oxidative stress, which are related to iron metabolism disorders. Excessive fluorine causes insufficient GSH, glutathione peroxidase (GSH-Px) inhibition, and oxidative stress, resulting in ferroptosis, which may play an important role in the occurrence and development of fluorosis.

scholarly journals Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Yuan Zhou ◽  
Shanshan Zhang ◽  
Xiang Fan
Keyword(s):  
Oxidative Stress ◽  
Ischemic Stroke ◽  
Cause Of Death ◽  
Experimental Studies ◽  
Reactive Oxygen Species Generation ◽  
Oxygen Species ◽  
Potential Therapeutic Target ◽  
Antioxidant Effects ◽  
And Oxidative Stress

Stroke is the second most common cause of death globally and the leading cause of death in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress plays an important role in the fundamental pathologic progression of cerebral damage in ischemic stroke. Previous studies have preliminarily confirmed that oxidative stress should be a potential therapeutic target and antioxidant as a treatment strategy for ischemic stroke. Emerging experimental studies have demonstrated that polyphenols exert the antioxidant potential to play the neuroprotection role after ischemic stroke. This comprehensive review summarizes antioxidant effects of some polyphenols, which have the most inhibition effects on reactive oxygen species generation and oxidative stress after ischemic stroke.

scholarly journals The role of reactive oxygen species and oxidative stress in carbon monoxide toxicity: An in-depth analysis

Redox Report ◽  
2014 ◽  
Vol 19 (5) ◽  
pp. 180-189 ◽  
Author(s):  
Sumeyya Akyol ◽  
Serpil Erdogan ◽  
Nuri Idiz ◽  
Safa Celik ◽  
Mehmet Kaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Carbon Monoxide ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Depth Analysis ◽  
And Oxidative Stress

scholarly journals Oxidative Stress and Epilepsy: Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Carlos Clayton Torres Aguiar ◽  
Anália Barbosa Almeida ◽  
Paulo Victor Pontes Araújo ◽  
Rita Neuma Dantas Cavalcante de Abreu ◽  
Edna Maria Camelo Chaves ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Mitochondrial Dysfunction ◽  
Experimental Studies ◽  
Cellular Damage ◽  
Brain Disorder ◽  
Chronic Oxidative Stress ◽  
Seizure Models ◽  
And Oxidative Stress

Backgrounds. The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy.Objective. A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. The role of oxidative stress in seizure induction and propagation is also discussed.Results/Conclusions. Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures. There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models. Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.

The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development

2010 ◽  
Vol 188 (2) ◽  
pp. 334-339 ◽  
Author(s):  
Dominique Ziech ◽  
Rodrigo Franco ◽  
Alexandros G. Georgakilas ◽  
Stavroula Georgakila ◽  
Vasiliki Malamou-Mitsi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Environmental Carcinogenesis ◽  
And Oxidative Stress

scholarly journals Tryptophan-kynurenine pathway as a novel link between gut microbiota and schizophrenia: A review

2021 ◽  
Vol 18 (4) ◽  
pp. 897-905
Author(s):  
Yaping Wang ◽  
Xiuxia Yuan ◽  
Yulin Kang ◽  
Xueqin Song
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Neuronal Excitability ◽  
Kynurenine Pathway ◽  
Inflammatory Factors ◽  
Biological Processes ◽  
Oxygen Species ◽  
Tryptophan Catabolism ◽  
And Oxidative Stress

Gut microbiota and its metabolite tryptophan play an important role in regulating neurotransmission, immune homeostasis and oxidative stress which are critical for brain development. The kynurenine pathway is the main route of tryptophan catabolism. Kynurenine metabolites regulate many biological processes including host-microbiome communication, immunity and oxidative stress, as well as neuronal excitability. The accumulation of metabolites produced by kynurenine pathway in brain results in the activation of the immune system (increase in the levels of inflammatory factors) and oxidative stress (production of reactive oxygen species, ROS), which are associated with mental disorders, for example schizophrenia. Thus, it was hypothesized that perturbations in kynurenine pathway could cause activation of immunity, and that oxidative stress may be involved in the etiology of schizophrenia. The present work is a review of the latest studies on the possible role of kynurenine pathway in schizophrenia, and mechanism(s) involved.

scholarly journals Immunválasz és oxidatív stressz hepatitis C-vírus-infekcióban

2015 ◽  
Vol 156 (47) ◽  
pp. 1898-1903
Author(s):  
Alajos Pár ◽  
Gabriella Pár
Keyword(s):  
Oxidative Stress ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Current Knowledge ◽  
Oxygen Species ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
And Oxidative Stress

This review summarizes our current knowledge on the innate and adaptive immune responses induced by hepatitis C virus, and on the genetic polymorphisms that may determine the outcome of the disease. In addition, the authors discuss the role of reactive oxygen species and oxidative stress in hepatitis C virus-related pathogenic processess, such as hepatitis, fibrosis, hepatocellular carcinoma, steatosis and insulin resistance. Orv. Hetil., 2015, 156(47), 1898–1903.

scholarly journals Mitophagy and Oxidative Stress: The Role of Aging

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 794
Author(s):  
Anna De Gaetano ◽  
Lara Gibellini ◽  
Giada Zanini ◽  
Milena Nasi ◽  
Andrea Cossarizza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Damage ◽  
Ros Production ◽  
Oxygen Species ◽  
Prime Mover ◽  
Age Related ◽  
Chronic Oxidative Stress ◽  
Parkinson’S Diseases ◽  
And Oxidative Stress

Mitochondrial dysfunction is a hallmark of aging. Dysfunctional mitochondria are recognized and degraded by a selective type of macroautophagy, named mitophagy. One of the main factors contributing to aging is oxidative stress, and one of the early responses to excessive reactive oxygen species (ROS) production is the induction of mitophagy to remove damaged mitochondria. However, mitochondrial damage caused at least in part by chronic oxidative stress can accumulate, and autophagic and mitophagic pathways can become overwhelmed. The imbalance of the delicate equilibrium among mitophagy, ROS production and mitochondrial damage can start, drive, or accelerate the aging process, either in physiological aging, or in pathological age-related conditions, such as Alzheimer’s and Parkinson’s diseases. It remains to be determined which is the prime mover of this imbalance, i.e., whether it is the mitochondrial damage caused by ROS that initiates the dysregulation of mitophagy, thus activating a vicious circle that leads to the reduced ability to remove damaged mitochondria, or an alteration in the regulation of mitophagy leading to the excessive production of ROS by damaged mitochondria.

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