Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group

Purpose. To assess the risk for capsular rupture during routine phacoemulsification in patients with a history of anti-VEGF injections and other possible risk modifiers such as treatment patterns, type of anti-VEGF agent, and experience of the surgeon, among others. Methods. This study reviewed the medical records of 11,129 patients from 7 different hospitals in 5 countries. The study included 939 patients that underwent routine phacoemulsification and had a history of anti-VEGF therapy. We excluded patients with known risk factors for capsular rupture, as well as patients with a history of other retinal procedures. The study extracted data regarding general demographics, the number of previous injections, type of anti-VEGF agent, details of cataract surgery, and anti-VEGF treatment patterns. Results. Overall prevalence of posterior capsular rupture: 7.45% (95% CI: 5.9–9.32%). The mean number of injections per patient was 3.37 ± 2.8. More than 50% of the patients received their last anti-VEGF injection within three months before cataract surgery. The complication rate during intravitreal injections was 1.07%. In the univariate analysis, the experience of the cataract surgeon (inexperience surgeons; OR: 2.93) and the history of prior anti-VEGF therapy (OR: 1.77) were significant risk indicators for PCR ( p < 0.05 ). However, after controlling for age in the multivariate analysis, the trend did not reach a statistical significance. Conclusion. The risk for capsular rupture is higher in patients with a history of intravitreal anti-VEGF injections.

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Incorrect sleeping position and eye rubbing in patients with unilateral or highly asymmetric keratoconus: a case-control study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-020-04771-z ◽

2020 ◽

Vol 258 (11) ◽

pp. 2431-2439

Author(s):

Adrien Mazharian ◽

Christophe Panthier ◽

Romain Courtin ◽

Camille Jung ◽

Radhika Rampat ◽

...

Keyword(s):

Case Control Study ◽

Statistical Significance ◽

Univariate Analysis ◽

Case Control ◽

Sleeping Position ◽

History Of ◽

Sleeping Habits ◽

Univariate Analyses ◽

Red Eyes ◽

Control Study

Abstract Purpose To evaluate eye rubbing and sleeping position in patients with Unilateral or Highly Asymmetric Keratoconus (UHAKC). Methods Case-control study of consecutive UHAKC patients diagnosed at the Rothschild Foundation. Controls were age- and sex-matched, randomly selected refractive surgery clinic patients. Patients self-administered questionnaires regarding their family history of keratoconus, eye rubbing, and sleeping habits. All the eyes underwent a comprehensive ocular examination. Logistic regression was used to analyze univariate and multivariate data to identify risk factors for keratoconus. Results Thirty-three UHAKC patients and 64 controls were included. Univariate analyses showed that daytime eye rubbing [OR = 172.78], in the morning [OR = 24.3], or in eyes with the steepest keratometry [OR = 21.7] were significantly different between groups. Allergy [OR = 2.94], red eyes in the morning [OR = 6.36], and sleeping on stomach/sides [OR = 14.31] or on the same side as the steepest keratometry [OR = 94.72] were also significantly different. The multivariate model also showed statistical significance for most factors including daytime eye rubbing [OR = 134.96], in the morning [OR = 24.86], in the steepest eye [OR = 27.56], and sleeping on stomach/sides [OR = 65.02] or on the steepest side [OR = 144.02]. A univariate analysis in UHAKC group, comparing the worse and better eye, showed that eye rubbing [OR = 162.14] and sleeping position [OR = 99.74] were significantly (p < 0.001) associated with the worse eye. Conclusion Our data suggests that vigorous eye rubbing and incorrect sleeping position are associated with UHAKC. This is especially true in rubbing the most afflicted eye, and contributory sleep position, including positions placing pressure on the eye with the steepest keratometry.

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Incidence and Risk Factors for Bilateral Nephrolithiasis: A Large Case-retrospective Study

10.21203/rs.3.rs-414196/v1 ◽

2021 ◽

Author(s):

Xiong Yang ◽

Zhi Li ◽

Shiyong Qi ◽

Linguo Xie ◽

Qiduo Shi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Multivariate Analysis ◽

Kidney Stones ◽

Statistical Significance ◽

Univariate Analysis ◽

Renal Stones ◽

Urinary Stones ◽

Preoperative Imaging ◽

History Of

Abstract To determine the incidence and risk factors of bilateral kidney stones. Utilized the retrospective analysis method on demographic characteristics and clinical data of patients with renal stones in the Second Hospital of Tianjin Medical University. Grouped patients into unilateral and bilateral renal stones according to preoperative imaging and ultrasound examination. Univariate and multivariate analysis methods were used to evaluate the factors that may cause bilateral stones. The study included 7587 patients with kidney stones in total, of whom 4983 had unilateral kidney stones (including 2719 left stones and 2264 right stones), and 2604 had bilateral kidney stones (34.3%). By comparing the unilateral stones group with the bilateral stones group, the univariate analysis demonstrated that weight, body mass index (BMI), history of nephrolithiasis, diabetes mellitus (DM), hypertension, gout, and the maximal stone diameter had statistical significance. Binary logistic regression multivariate analysis demonstrated that BMI, history of nephrolithiasis, diabetes mellitus, hypertension, gout, and the maximal stone diameter were independent risk factors for bilateral urinary stones. This study shows that 34.3% of patients with kidney stones were diagnosed as having bilateral kidney stones; BMI and the maximal stone diameter are positively correlated with the incidence of bilateral kidney stones; Patients with a history of nephrolithiasis, diabetes, hypertension, and gout have a significantly higher risk of having bilateral kidney stones.

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Safety of pediatric cerebral angiography

Journal of Neurosurgery Pediatrics ◽

10.3171/2021.8.peds21301 ◽

2021 ◽

pp. 1-8

Author(s):

David C. Lauzier ◽

Joshua W. Osbun ◽

Arindam R. Chatterjee ◽

Christopher J. Moran ◽

Akash P. Kansagra

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Cerebral Angiography ◽

Statistical Significance ◽

Univariate Analysis ◽

Information Criterion ◽

Fisher Exact Test ◽

Femoral Access ◽

Increased Risk ◽

History Of

OBJECTIVE Catheter-based cerebral angiography is commonly used for neurovascular diagnosis in children. In this work, the authors aimed to quantify the complication rate of cerebral angiography in children, characterize these complications, and identify risk factors for complications. METHODS Relevant clinical data were retrospectively obtained for 587 consecutive cerebral angiography procedures performed in 390 children from March 2002 to March 2020. Complications were categorized as neurological or nonneurological, and severity was graded using a standard schema. Incidences of complications were reported as point estimates. Associations between risk factors and complications were characterized in univariate analysis using the two-tailed Fisher exact test and in multivariate analysis using multiple logistic regression with bidirectional elimination based on the Akaike information criterion. In both univariate and multivariate analyses, statistical significance was corrected for multiple comparisons using the Benjamini-Hochberg method. RESULTS Complications occurred in 6.5% of procedures, including neurological complications in 1.9% and nonneurological complications in 4.8%. Permanent deficits occurred in only 0.2% of cases. Overall, 0.5% of procedures resulted in major complications, while 6.0% resulted in minor complications. Female sex and a history of hypertension or ischemic stroke were associated with an increased risk of complications, while femoral artery access was associated with a decreased risk of complications. CONCLUSIONS Pediatric cerebral angiography was shown to have a low rate of major or permanent complications. Children who were female and those with a history of hypertension or ischemic stroke were shown to be at higher risk of complications, while the use of femoral access carried a lower risk of complications.

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HYPERVASCULAR LIVER LESIONS IN RADIOLOGICALLY NORMAL LIVER

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-6720201700010007 ◽

2017 ◽

Vol 30 (1) ◽

pp. 21-26

Author(s):

Enio Campos AMICO ◽

José Roberto ALVES ◽

Dyego Leandro Bezerra de SOUZA ◽

Fellipe Alexandre Macena SALVIANO ◽

Samir Assi JOÃO ◽

...

Keyword(s):

Risk Factors ◽

Univariate Analysis ◽

Significant Risk ◽

Normal Liver ◽

Personal History ◽

Liver Lesions ◽

Diagnostic Challenge ◽

Imaging Characteristics ◽

History Of ◽

History Of Cancer

ABSTRACT Background: The hypervascular liver lesions represent a diagnostic challenge. Aim: To identify risk factors for cancer in patients with non-hemangiomatous hypervascular hepatic lesions in radiologically normal liver. Method: This prospective study included patients with hypervascular liver lesions in radiologically normal liver. The diagnosis was made by biopsy or was presumed on the basis of radiologic stability in follow-up period of one year. Cirrhosis or patients with typical imaging characteristics of haemangioma were excluded. Results: Eighty-eight patients were included. The average age was 42.4. The lesions were unique and were between 2-5 cm in size in most cases. Liver biopsy was performed in approximately 1/3 of cases. The lesions were benign or most likely benign in 81.8%, while cancer was diagnosed in 12.5% of cases. Univariate analysis showed that age >45 years (p< 0.001), personal history of cancer (p=0.020), presence of >3 nodules (p=0.003) and elevated alkaline phosphatase (p=0.013) were significant risk factors for cancer. Conclusion: It is safe to observe hypervascular liver lesions in normal liver in patients up to 45 years, normal alanine aminotransaminase, up to three nodules and no personal history of cancer. Lesion biopsies are safe in patients with atypical lesions and define the treatment to be established for most of these patients.

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The Malaysian Cataract Surgery Registry: risk Indicators for posterior capsular rupture

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2016-309902 ◽

2017 ◽

Vol 101 (11) ◽

pp. 1466-1470 ◽

Cited By ~ 3

Author(s):

Mohamad Aziz Salowi ◽

Fiona L M Chew ◽

Tassha Hilda Adnan ◽

Christopher King ◽

Mariam Ismail ◽

...

Keyword(s):

Cataract Surgery ◽

Risk Indicators ◽

Capsular Rupture

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Risk factors for recurrence of peritonsillar abscess

The Journal of Laryngology & Otology ◽

10.1017/s002221511400259x ◽

2014 ◽

Vol 128 (12) ◽

pp. 1084-1088 ◽

Cited By ~ 7

Author(s):

J H Chung ◽

Y C Lee ◽

S Y Shin ◽

Y G Eun

Keyword(s):

Risk Factors ◽

Computed Tomography ◽

Univariate Analysis ◽

Significant Risk ◽

Peritonsillar Abscess ◽

Hazard Ratio ◽

Recurrent Tonsillitis ◽

Laboratory Findings ◽

History Of ◽

Risk Factors For Recurrence

AbstractBackground:Additional high-quality evidence for predictors of peritonsillar abscess recurrence could lead to better-informed treatment decisions regarding tonsillectomy.Methods:In this study, 172 patients, who had been diagnosed and treated for peritonsillar abscess, were evaluated at follow up. A retrospective review of medical records and a telephone survey were performed. The clinical characteristics analysed included underlying disease, laboratory findings and computed tomography findings. Cox proportional hazard models were used to identify risk factors for peritonsillar abscess recurrence.Results:The recurrence rate of peritonsillar abscess was 13.9 per cent. Univariate analysis indicated that extraperitonsillar spread of the abscess (beyond the peritonsillar area) on computed tomography and a history of recurrent tonsillitis were associated with recurrence. Multivariate analysis also indicated that extraperitonsillar spread (p = 0.007; hazard ratio = 3.399) and recurrent tonsillitis history (p < 0.001; hazard ratio = 11.953) were significant risk factors for recurrence.Conclusion:Our results suggest that tonsillectomy may be indicated as a treatment for peritonsillar abscess in patients with a history of recurrent tonsillitis or extraperitonsillar spread on computed tomography.

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The relationship between contact to cat and the development of asthma in children

Paediatrica Indonesiana ◽

10.14238/pi49.6.2009.379-86 ◽

2009 ◽

Vol 49 (6) ◽

pp. 379

Author(s):

Made Lndah Nastiti Utami Budha ◽

Roni Naning ◽

Ketut Dewi Kumara Wati

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Univariate Analysis ◽

Significant Risk ◽

Significant Risk Factor ◽

Stepwise Logistic Regression ◽

Passive Smoker ◽

History Of ◽

Asthma In Children ◽

The Relationship

Background Data suggesting history of direct or indirect contactto cats are either protective, has no effect or increase risk ofsensitization and asthma development.Objective To determine the relationship between childhoodcontact to cat and the development of asthma in children.Methods A case control study was conducted in Denpasar sinceDecember 2006 until Juli 2008. In this study, subjects withasthma (cases group) were selected for comparisons to a series of healthy subjects without asthma (controls group). Forty-sevensubjects (3-12 years) with asthma were recruited and matched(age and sex) with 4 7 healthy and non asthma controls. Data were collected using two kinds of questionnaires, i.e: ISAAC, ATS 78, and Robertson modification questionnaire from Medical School, University of Indonesia, which had been validated to determine asthma and asthma risk factors questionnaire. Data were analyzed as univariate by using chi-square or Fisher's exact test, and multivariate analysis by stepwise logistic regression model.Results Result of univariate analysis showed that there were seven significant risk factors of asthma. Using multivariate analysis, contact to cat was significant risk factor for asthma [OR: 4.5 (95% CI 1.3 to 16.0), P= 0.020]. Other significant risk factors were; contact to cockroach [OR: 11.7 (95% CI 2.6 to 51.6), P= 0.001], use of kapok mattress [OR: 6.4 (95% CI 1.4 to 29.0), P= 0.015], passive smoker [OR: 4.7 (95% CI 1.3 to 17.0), P= 0.018], and atopic history [OR: 9.2 (95% CI 2.3 to 36.7), P= 0.002].Conclusions There was a relationship between childhood contactto cat and the development of asthma in children. Risk factors that statistically significant were; contact to cockroach, use of kapok mattress, passive smoker, and history of allergy in study subject.

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Identifying the Risk Factors for Hospital-Acquired Methicillin-Resistant Staphylococcus aureus (MRSA) Infection among Patients Colonized with MRSA on Admission

Infection Control and Hospital Epidemiology ◽

10.1086/668420 ◽

2012 ◽

Vol 33 (12) ◽

pp. 1219-1225 ◽

Cited By ~ 24

Author(s):

Yuriko Fukuta ◽

Candace A. Cunningham ◽

Patricia L. Harris ◽

Marilyn M. Wagener ◽

Robert R. Muder

Keyword(s):

Risk Factors ◽

Staphylococcus Aureus ◽

Univariate Analysis ◽

Significant Risk ◽

Prior History ◽

Methicillin Resistant ◽

Control Subjects ◽

History Of ◽

Mrsa Infection ◽

Hospital Acquired

Background.Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen in hospital-acquired infections. MRSA-colonized inpatients who may benefit from undergoing decolonization have not been identified.Objective.To identify risk factors for MRSA infection among patients who are colonized with MRSA at hospital admission.Design.A case-control study.Setting.A 146-bed Veterans Affairs hospital.Participants.Case patients were those patients admitted from January 2003 to August 2011 who were found to be colonized with MRSA on admission and then developed MRSA infection. Control subjects were those patients admitted during the same period who were found to be colonized with MRSA on admission but who did not develop MRSA infection.Methods.A retrospective review.Results.A total of 75 case patients and 150 control subjects were identified. A stay in the intensive care unit (ICU) was the significant risk factor in univariate analysis (P<.001). Prior history of MRSA (P = .03), transfer from a nursing home (P = .002), experiencing respiratory failure (P<.001), and receipt of transfusion (P = .001) remained significant variables in multivariate analysis. Prior history of MRSA colonization or infection (P = .02), difficulty swallowing (P = .04), presence of an open wound (P = .002), and placement of a central line (P = .02) were identified as risk factors for developing MRSA infection for patients in the ICU. Duration of hospitalization, readmission rate, and mortality rate were significantly higher in case patients than in control subjects (P< .001, .001, and <.001, respectively).Conclusions.MRSA-colonized patients admitted to the ICU or admitted from nursing homes have a high risk of developing MRSA infection. These patients may benefit from undergoing decolonization.

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Clinical Outcomes and Risk Factor Analysis of Patients Presenting with Emphysematous Cystitis: A 15-Year Retrospective Multicenter Study

Medicina ◽

10.3390/medicina57060531 ◽

2021 ◽

Vol 57 (6) ◽

pp. 531

Author(s):

Jeonghyouk Choi ◽

Seung-Kwon Choi ◽

Sang-Hyub Lee ◽

Koo-Han Yoo

Keyword(s):

Risk Factors ◽

Univariate Analysis ◽

Significant Risk ◽

Control Group ◽

Emphysematous Pyelonephritis ◽

Acute Cystitis ◽

Emphysematous Cystitis ◽

Patient Status ◽

History Of ◽

Retrospective Multicenter Study

Background and objectives: To investigate the risk factors for emphysematous cystitis (EC) compared to those of acute cystitis (AC) to increase clinicians awareness of the possibility for the aggravation of patient status. Materials and methods: We retrospectively reviewed a total of 54 patients who were hospitalized with a diagnosis of EC by abdominal computed tomography (CT) scan from 2006 to 2020. The control group included 92 patients who were hospitalized for the treatment of AC in the same period. We sought to identify the clinical features and predisposing diseases, such as age, sex, diabetes mellitus (DM), hypertension (HTN), cerebrovascular accident (CVA), chronic kidney disease (CKD), neurogenic bladder (NB), history of urinary tract infection (UTI), and emphysematous pyelonephritis (EPN), that were associated with the development of EC. Results: The median (interquartile range (IQR)) age of the patients with EC was older than that of the patients with AC (78.5 (15.3) years (range: 52–100) vs. 70.0 (26.5) years (range: 28–97 years)). Sepsis and mortality occurred only in the EC group (48.1% and 11.1%, respectively). The univariate analysis of predisposing factors revealed that age, DM, HTN, CVA, CKD, and NB were significantly associated with EC. In the multivariate analysis, DM (OR, 6.251; 95% CI, 2.254–17.250; p < 0.001), CKD (OR, 18.439; 95% CI, 3.421–99.404; p = 0.001), NB (OR, 7.374; 95% CI, 1.993–27.285; p = 0.003) were associated with EC. Conclusions: The results of this study revealed that DM, CKD, and NB were significant risk factors for EC. The tendency toward sepsis and high mortality underscore the need for careful observation while treating patients with EC with the risk noted above.

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EPID-02. HEIGHT AND THE RISK OF MENINGIOMA

Neuro-Oncology ◽

10.1093/neuonc/noz175.302 ◽

2019 ◽

Vol 21 (Supplement_6) ◽

pp. vi74-vi74

Author(s):

Shlomit Yust-Katz ◽

Alexandra Amiel ◽

Ramiz Abu Shkara ◽

Tali Siegal ◽

Gilad Twig

Keyword(s):

Risk Factors ◽

Autoimmune Diseases ◽

Cancer Registry ◽

Large Population ◽

Univariate Analysis ◽

Significant Risk ◽

Female Gender ◽

Total Study Population ◽

Increased Risk ◽

History Of

Abstract BACKGROUND Meningiomas are the most common primary central nervous system tumors. Risk factors for meningiomas including obesity, height, history of allergy/atopy or autoimmune diseases, have been previously assessed with conflicting results. We reviewed a large cohort of Israeli adolescents in order to assess potential risk factors for the development of meningiomas. METHODS This study analyzed a cohort of 2,035,915 Jewish men and women who underwent obligatory physical examination when aged 16 to 19 years, from 1967 to 2011. Meningioma incidence was identified by linkage to the national cancer registry. Cox proportional hazard models were used to estimate the hazard ratios for meningioma according to sex, body mass index (BMI), height, history of allergic and autoimmune disease. RESULTS Linkage of the adolescent military database with the Israeli cancer registry identified 480 cases (152 males and 328 females) of meningioma during a follow up of 40,304,078-person years. The median age at diagnosis of meningioma was 42.1 ± 9.4 (range 17.4–62.6). On univariate analysis, only female gender (p< 0.01) and height (p< 0.01) were associated with risk for meningioma in the total study population. When stratified by gender, height remained a significant risk factor only in men. Spline analysis in the men group showed the minimum risk at a height of 1.62 meters and a statistically significant increase in the risk for meningioma at heights taller than 1.85 meters. BMI, past medical history including asthma, diabetes, and atopic and autoimmune diseases, were not associated with meningioma risk. CONCLUSION in this large population study, we found that sex and taller height in adolescent males was associated with an increased risk of adult meningioma.

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