scholarly journals The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Fang Liu ◽  
Jiawei Xu ◽  
Linliang Wu ◽  
Tiantian Zheng ◽  
Qi Han ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Great Influence ◽  
Nerve Cells ◽  
Nerve Tissue ◽  
Surface Topology ◽  
Material Surface ◽  
Proliferation And Differentiation ◽  
Surface Topographies ◽  
Topographical Cues

The surface topographies of artificial implants including surface roughness, surface groove size and orientation, and surface pore size and distribution have a great influence on the adhesion, migration, proliferation, and differentiation of nerve cells in the nerve regeneration process. Optimizing the surface topographies of biomaterials can be a key strategy for achieving excellent cell performance in various applications such as nerve tissue engineering. In this review, we offer a comprehensive summary of the surface topographies of nerve implants and their effects on nerve cell behavior. This review also emphasizes the latest work progress of the layered structure of the natural extracellular matrix that can be imitated by the material surface topology. Finally, the future development of surface topographies on nerve regeneration was prospectively remarked.

scholarly journals Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration

2015 ◽  
Vol 15 (6) ◽  
pp. 612-621 ◽  
Author(s):  
Lorena R. Lizarraga-Valderrama ◽  
Rinat Nigmatullin ◽  
Caroline Taylor ◽  
John W. Haycock ◽  
Frederik Claeyssens ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

scholarly journals Effects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration

2017 ◽  
Vol 17 (3) ◽  
pp. 191 ◽  
Author(s):  
Joo-Ryun Chung ◽  
Jong-Won Choi ◽  
Joseph P. Fiorellini ◽  
Kyung-Gyun Hwang ◽  
Chang-Joo Park
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Adhesion Molecules ◽  
Peripheral Nerve Regeneration ◽  
Nerve Cells ◽  
Nerve Conduit

Electrofabrication of flexible and mechanically strong tubular chitosan implants for peripheral nerve regeneration

2021 ◽  
Author(s):  
Hongyu Liu ◽  
Yanan Zhao ◽  
Jun Tong ◽  
Xiaowen Shi ◽  
Yun Chen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering ◽  
New Type

The development of peripheral nerve tissue engineering requires safe and reliable methodology to construct biodegradable conduits. Herein, a new type of chitosan-based nerve-guide hydrogel conduit (CNHC) with enhanced mechanical flexibility...

Preparation and characterization of conductive poly-dl-lactic-acid/tetra-aniline conduit for peripheral nerve regeneration

2018 ◽  
Vol 34 (2) ◽  
pp. 190-208 ◽  
Author(s):  
Xing-Lei Guo ◽  
Hai-Xing Xu ◽  
Qun-Di He ◽  
Yun-Xuan Yu ◽  
Xiao-Fei Ming ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Contact Angles ◽  
Nerve Tissue ◽  
Conductive Composite ◽  
Nerve Tissue Engineering

Defected peripheral nerve regeneration is still a challenge in clinical treatment. Conductive polymers show great potential in nerve tissue engineering because of their electrical property based on bioelectricity in vivo. In this study, conductive composite nerve conduit was synthesized with tetra-aniline and poly-dl-lactic acid. Their properties and the differentiation of rat pheochromocytoma 12 (PC12) cells in vitro stimulated with 200 mV for 1 h were investigated. Different amounts of tetra-aniline (0%, 5%, 10%, and 15%) were used to synthesize the conduits with different conductivities (0, 0.00625, 0.01, and 0.025 s/m, respectively), tensile strengths (2.45, 3.40, 4.45, and 5.50 MPa, respectively), and contact angles (80°, 78.5°, 62.5°, and 61.5°, respectively). The percentage of neurite-bearing cells and the median neurite length increased with an obvious raise of the content of tetra-aniline. In addition, the conduit with subcutaneous implantable experiments in vivo showed less inflammatory response. These promising results illustrated that this poly-dl-lactic acid/tetra-aniline conductive composite conduit had potential for nerve tissue engineering.

scholarly journals Tissue Engineering Strategies for Peripheral Nerve Regeneration

2021 ◽  
Vol 12 ◽  
Author(s):  
Yin Li ◽  
Zhenjiang Ma ◽  
Ya Ren ◽  
Dezhi Lu ◽  
Tao Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Injury ◽  
Peripheral Nerve Regeneration ◽  
Neural Tissue ◽  
Nerve Tissue ◽  
Neural Tissue Engineering ◽  
Clinical Problems

A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. In recent years, many constructive nerve regeneration schemes are proposed at home and abroad. Nerve tissue engineering plays an important role. It develops an ideal nerve substitute called artificial nerve. Given the complexity of nerve regeneration, this review summarizes the pathophysiology and tissue-engineered repairing strategies of the PNI. Moreover, we discussed the scaffolds and seed cells for neural tissue engineering. Furthermore, we have emphasized the role of 3D printing in tissue engineering.

scholarly journals Physical Cues of Matrices Reeducate Nerve Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Yiqian Luo ◽  
Jie Li ◽  
Baoqin Li ◽  
Yuanliang Xia ◽  
Hengyi Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Nerve Regeneration ◽  
Neurite Growth ◽  
Nerve Cells ◽  
Nerve Tissue ◽  
Mechanical Tension ◽  
Biological Scaffolds ◽  
Physical Cues ◽  
Mechanical Transduction

The behavior of nerve cells plays a crucial role in nerve regeneration. The mechanical, topographical, and electrical microenvironment surrounding nerve cells can activate cellular signaling pathways of mechanical transduction to affect the behavior of nerve cells. Recently, biological scaffolds with various physical properties have been developed as extracellular matrix to regulate the behavior conversion of nerve cell, such as neuronal neurite growth and directional differentiation of neural stem cells, providing a robust driving force for nerve regeneration. This review mainly focused on the biological basis of nerve cells in mechanical transduction. In addition, we also highlighted the effect of the physical cues, including stiffness, mechanical tension, two-dimensional terrain, and electrical conductivity, on neurite outgrowth and differentiation of neural stem cells and predicted their potential application in clinical nerve tissue engineering.

scholarly journals Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 41
Author(s):  
Fengshi Zhang ◽  
Meng Zhang ◽  
Songyang Liu ◽  
Ci Li ◽  
Zhentao Ding ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Physical Properties ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Functional Restoration ◽  
Nerve Tissue ◽  
Alternative Methods ◽  
Electrically Conductive ◽  
Conductive Hydrogels

Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the nervous system and the combination of different biomaterials are considered to be encouraging alternative methods for effective tissue regeneration and functional restoration of injured nerves. Considering the inherent presence of an electric field in the nervous system, electrically conductive biomaterials have been used to promote nerve regeneration. Due to their singular physical properties, hydrogels can provide a three-dimensional hydrated network that can be integrated into diverse sizes and shapes and stimulate the natural functions of nerve tissue. Therefore, conductive hydrogels have become the most effective biological material to simulate human nervous tissue’s biological and electrical characteristics. The principal merits of conductive hydrogels include their physical properties and their electrical peculiarities sufficient to effectively transmit electrical signals to cells. This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration.

scholarly journals Polymeric scaffolds for three-dimensional culture of nerve cells: a model of peripheral nerve regeneration

2017 ◽  
Vol 7 (3) ◽  
pp. 391-415 ◽  
Author(s):  
Radamés Ayala-Caminero ◽  
Luis Pinzón-Herrera ◽  
Carol A. Rivera Martinez ◽  
Jorge Almodovar
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Three Dimensional ◽  
Nerve Cells ◽  
Polymeric Scaffolds ◽  
Three Dimensional Culture ◽  
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