scholarly journals Role of tumor-derived exosomes in facilitating pre-metastatic niche formation

2018 ◽  
Vol 26 (23) ◽  
pp. 1390-1395
Author(s):  
Xiao-Xia Xing ◽  
Si-Fan Wu ◽  
Jie-Feng Cui
Keyword(s):  
Metastatic Niche ◽  
Niche Formation

scholarly journals The dynamic behavior of lipid droplets in the pre-metastatic niche

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Chunliang Shang ◽  
Jie Qiao ◽  
Hongyan Guo
Keyword(s):  
Tumor Cells ◽  
Immune Cells ◽  
Stromal Cells ◽  
Lipid Droplets ◽  
Metastatic Tumor ◽  
Current Evidence ◽  
Biological Functions ◽  
Metastatic Niche ◽  
Niche Formation

AbstractThe pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed.

scholarly journals The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis

2020 ◽  
Vol 21 (18) ◽  
pp. 6837 ◽  
Author(s):  
Issraa Shoucair ◽  
Fernanda Weber Mello ◽  
James Jabalee ◽  
Saeideh Maleki ◽  
Cathie Garnis
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Therapy Resistance ◽  
The Other ◽  
Cancer Associated Fibroblasts ◽  
Metastatic Niche ◽  
Niche Formation ◽  
Molecular Aspects

Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.

scholarly journals Tumor Microenvironment in Metastatic Colorectal Cancer: The Arbitrator in Patients’ Outcome

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1130
Author(s):  
Cristina Galindo-Pumariño ◽  
Manuel Collado ◽  
Mercedes Herrera ◽  
Cristina Peña
Keyword(s):  
Colorectal Cancer ◽  
Tumor Microenvironment ◽  
Important Research ◽  
Metastatic Niche ◽  
Predictive Capacity ◽  
Stromal Compartment ◽  
Clinical Strategies ◽  
Metastasis Development ◽  
Niche Formation

Colorectal cancer (CRC) is one of the most common cancers in western countries. Its mortality rate varies greatly, depending on the stage of the disease. The main cause of CRC mortality is metastasis, which most commonly affects the liver. The role of tumor microenvironment in tumor initiation, progression and metastasis development has been widely studied. In this review we summarize the role of the tumor microenvironment in the liver pre-metastatic niche formation, paying attention to the distant cellular crosstalk mediated by exosomes. Moreover, and based on the prognostic and predictive capacity of alterations in the stromal compartment of tumors, we describe the role of tumor microenvironment cells and related liquid biopsy biomarkers in the delivery of precise medication for metastatic CRC. Finally, we evaluate the different clinical strategies to prevent and treat liver metastatic disease, based on the targeting of the tumor microenvironment. Specifically, targeting angiogenesis pathways and regulating immune response are two important research pipelines that are being widely developed and promise great benefits.

A review on the role of CAFs and CAF-derived exosomes in progression and metastasis of digestive system cancers

Tumor Biology ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 141-157
Author(s):  
Bahare Zarin ◽  
Laleh Rafiee ◽  
Parnaz Daneshpajouhnejad ◽  
Shaghayegh Haghjooy Javanmard
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Digestive System ◽  
Clinical Intervention ◽  
Metastatic Niche ◽  
Liver Cancers ◽  
Accelerated Proliferation ◽  
Niche Formation ◽  
Metastatic Sites

Cancers evolve as a result of the accelerated proliferation of cancer cells in a complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are the master regulators of any step of cancer development. The tumor microenvironment is composed of many cellular and noncellular components that contribute to the evolution of cancer cells. Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the TME that implicate in tumor progression and metastasis dissemination through secretion of oncogenic factors which are carried to the secondary metastatic sites through exosomes. In this review, we aimed to assess the role of CAF-derived exosomes in TME construction and pre-metastatic niche formation in different cancers of the digestive system in order to better understand some important mechanisms of metastasis and provide possible targets for clinical intervention. This review article is divided into two thematic parts explaining the general mechanisms of pre-metastatic niche formation and metastasis and the role of CAF-derived exosomes in different digestive system cancers including colorectal, gastric, esophageal, pancreatic, and liver cancers.

Roundabout receptors: new actors in bone metastatic niche formation

2016 ◽  
Author(s):  
Lise Clement-Demange ◽  
Pape Francois Le ◽  
Benedicte Eckel ◽  
Sandra Geraci ◽  
Chantal Diaz-Latoud ◽  
...  
Keyword(s):  
Metastatic Niche ◽  
Niche Formation ◽  
Roundabout Receptors

scholarly journals Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

2012 ◽  
Vol 209 (3) ◽  
pp. 537-549 ◽  
Author(s):  
Anna Mansour ◽  
Grazia Abou-Ezzi ◽  
Ewa Sitnicka ◽  
Sten Eirik W. Jacobsen ◽  
Abdelilah Wakkach ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Endochondral Ossification ◽  
Osteoblastic Differentiation ◽  
Hematopoietic Stem ◽  
Mesenchymal Progenitors ◽  
Hsc Niche ◽  
Niche Formation

Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM. Restoration of OCL activity reversed the defect in HSC niche formation. Our data demonstrate that OBLs are required for establishing HSC niches and that osteoblastic development is induced by OCLs. These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis.

scholarly journals Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

2012 ◽  
Vol 90 (7) ◽  
pp. 803-815 ◽  
Author(s):  
Carmen Chak-Lui Wong ◽  
Huafeng Zhang ◽  
Daniele M. Gilkes ◽  
Jasper Chen ◽  
Hong Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Hypoxia Inducible Factor ◽  
Metastatic Niche ◽  
Hypoxia Inducible Factor 1 ◽  
Niche Formation
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