Plasma C-Reactive Protein and Risk of Colorectal Cancer in a Nested Case-Control Study: Japan Public Health Center–Based Prospective Study

Purpose Because they have large variations in consumption, Asian countries are suitable settings for studies of the effect of relatively high-dose isoflavone intake on breast cancer risk. Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake. Patients and Methods A total of 24,226 women ages 40 to 69 years in the Japan Public Health Center–based prospective study who responded to the baseline questionnaire and provided blood in 1990 to 1995 were observed to December 2002. During a mean 10.6 years of follow-up, 144 patients newly diagnosed with breast cancer were identified. Two matched controls for each patient were selected from the cohort. Isoflavone levels were assessed by plasma level and food frequency questionnaire, and the odds ratio of breast cancer according to isoflavone level was estimated using a conditional logistic regression model. Results We found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups. Regarding dietary intake of isoflavones, nonsignificant inverse associations were observed for both genistein and daidzein. Conclusion This nested case-control study found an inverse association between plasma genistein and the risk of breast cancer in Japan.

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Colorectal Cancer and Serum C-reactive Protein Levels: a Case-control Study Nested in the JACC Study

Journal of Epidemiology ◽

10.2188/jea.15.s185 ◽

2005 ◽

Vol 15 (Supplement_II) ◽

pp. S185-S189 ◽

Cited By ~ 41

Author(s):

Yoshinori Ito ◽

Koji Suzuki ◽

Koji Tamakoshi ◽

Kenji Wakai ◽

Masayo Kojima ◽

...

Keyword(s):

Colorectal Cancer ◽

Case Control Study ◽

Case Control ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Control Study

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Serial C reactive protein values predict sensitivity of organisms to empirical antibiotics in neonates: a nested case–control study

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/archdischild-2015-309158 ◽

2016 ◽

Vol 101 (6) ◽

pp. F557-F560 ◽

Cited By ~ 5

Author(s):

Sandeep Patil ◽

Sourabh Dutta ◽

Savita Verma Attri ◽

Pallab Ray ◽

Praveen Kumar

Keyword(s):

Case Control Study ◽

Case Control ◽

C Reactive Protein ◽

Reactive Protein ◽

Empirical Antibiotics ◽

Nested Case Control ◽

Control Study

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Plasma Isoflavones and Subsequent Risk of Prostate Cancer in a Nested Case-Control Study: The Japan Public Health Center

Journal of Clinical Oncology ◽

10.1200/jco.2008.16.8807 ◽

2008 ◽

Vol 26 (36) ◽

pp. 5923-5929 ◽

Cited By ~ 75

Author(s):

Norie Kurahashi ◽

Motoki Iwasaki ◽

Manami Inoue ◽

Shizuka Sasazuki ◽

Shoichiro Tsugane

Keyword(s):

Public Health ◽

Prostate Cancer ◽

Health Center ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Case Control ◽

Conditional Logistic Regression Model ◽

Public Health Center ◽

Nested Case Control ◽

Control Study

PurposeThe incidence of prostate cancer is much lower in Japanese than Western populations. Given the preventive effects of isoflavones on carcinogenesis in the prostate in many nonhuman studies and the high consumption of isoflavones in Japanese, this low incidence may be partly due to the effects of soy.Patients and MethodsWe conducted a nested case-control study within the Japan Public Health Center–based Prospective Study. A total of 14,203 men aged 40 to 69 years who had returned the baseline questionnaire and provided blood samples were observed from 1990 to 2005. During a mean of 12.8 years of follow-up, 201 newly diagnosed prostate cancers were identified. Two matched controls for each case were selected from the cohort. Conditional logistic regression model was used to estimate the odds ratios (ORs) and 95% CIs for prostate cancer in relation to plasma levels of isoflavone.ResultsPlasma genistein level tended to be inversely associated with the risk of total prostate cancer. Although plasma daidzein showed no association, the highest tertile for plasma equol, a metabolite of daidzein, was significantly associated with a decreased risk of total prostate cancer (OR = 0.60; 95% CI, 0.36 to 0.99; Ptrend= .04). These inverse associations were strengthened after analysis was confined to localized cases, with ORs in the highest group of plasma genistein and equol compared with the lowest of 0.54 (95% CI, 0.29 to 1.01; Ptrend= .03) and 0.43 (95% CI, 0.22 to 0.82; Ptrend= .02), respectively. Plasma isoflavone levels were not statistically significantly associated with the risk of advanced prostate cancer.ConclusionIsoflavones may prevent the development of prostate cancer.

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