Abstract 2038: Establishment and analysis of an in vitro model for hemangioblastomas of the central nervous system

2014 ◽  
Author(s):  
Ana Martins Metelo ◽  
Elizabeth Lockerman ◽  
Fred Barker ◽  
Jeffrey Engelman ◽  
Othon Iliopoulos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Vitro Model ◽  
The Central Nervous System ◽  
Vitro Model

Neurospheres: a potential in vitro model for the study of central nervous system disorders

2021 ◽  
Author(s):  
Laura da Silva Siqueira ◽  
Fernanda Majolo ◽  
Ana Paula Bornes da Silva ◽  
Jaderson Costa da Costa ◽  
Daniel Rodrigo Marinowic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Vitro Model ◽  
Central Nervous System Disorders ◽  
Vitro Model

An in vitro model of the inhibition of axon growth in the lesion scar formed after central nervous system injury

2010 ◽  
Vol 43 (2) ◽  
pp. 177-187 ◽  
Author(s):  
Junko Kimura-Kuroda ◽  
Xichuan Teng ◽  
Yukari Komuta ◽  
Nozomu Yoshioka ◽  
Kazunori Sango ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Vitro Model ◽  
Axon Growth ◽  
Central Nervous System Injury ◽  
Vitro Model

Neural Stem Cells to Glial Cells an Important Factor for Brain Injury

2020 ◽  
Author(s):  
Prithiv K R Kumar
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Neural Stem Cells ◽  
Glial Cells ◽  
Brain Injuries ◽  
The Body ◽  
The Central Nervous System ◽  
Near Future

Stem cells have the capacity to differentiate into any type of cell or organ. Stems cell originate from any part of the body, including the brain. Brain cells or rather neural stem cells have the capacitive advantage of differentiating into the central nervous system leading to the formation of neurons and glial cells. Neural stem cells should have a source by editing DNA, or by mixings chemical enzymes of iPSCs. By this method, a limitless number of neuron stem cells can be obtained. Increase in supply of NSCs help in repairing glial cells which in-turn heal the central nervous system. Generally, brain injuries cause motor and sensory deficits leading to stroke. With all trials from novel therapeutic methods to enhanced rehabilitation time, the economy and quality of life is suppressed. Only PSCs have proven effective for grafting cells into NSCs. Neurons derived from stem cells is the only challenge that limits in-vitro usage in the near future.

scholarly journals Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2104 ◽  
Author(s):  
Eleonora Ficiarà ◽  
Shoeb Anwar Ansari ◽  
Monica Argenziano ◽  
Luigi Cangemi ◽  
Chiara Monge ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Ad Hoc ◽  
Superparamagnetic Iron Oxide ◽  
Conventional Radiotherapy ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

Magnetic Oxygen-Loaded Nanobubbles (MOLNBs), manufactured by adding Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on the surface of polymeric nanobubbles, are investigated as theranostic carriers for delivering oxygen and chemotherapy to brain tumors. Physicochemical and cyto-toxicological properties and in vitro internalization by human brain microvascular endothelial cells as well as the motion of MOLNBs in a static magnetic field were investigated. MOLNBs are safe oxygen-loaded vectors able to overcome the brain membranes and drivable through the Central Nervous System (CNS) to deliver their cargoes to specific sites of interest. In addition, MOLNBs are monitorable either via Magnetic Resonance Imaging (MRI) or Ultrasound (US) sonography. MOLNBs can find application in targeting brain tumors since they can enhance conventional radiotherapy and deliver chemotherapy being driven by ad hoc tailored magnetic fields under MRI and/or US monitoring.

Sign in / Sign up

Export Citation Format

Share Document