Abstract 1190: Comparison of cumulative incidence rates of colorectal cancer among Asians and Pacific Islanders (API) populations in Guam, Hawai'i, and the United States

2020 ◽  
Author(s):  
Grazyna Badowski
Keyword(s):  
Colorectal Cancer ◽  
United States ◽  
Cumulative Incidence ◽  
The United States ◽  
Incidence Rates ◽  
Pacific Islanders

scholarly journals Patterns of Early-Onset Colorectal Cancer Among Nigerians and African Americans

2020 ◽  
pp. 1647-1655
Author(s):  
Andreana N. Holowatyj ◽  
Aishatu Suleiman Maude ◽  
Halimatu Sadiya Musa ◽  
Ahmed Adamu ◽  
Sani Ibrahim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
United States ◽  
African Americans ◽  
Early Onset ◽  
Ethnic Disparities ◽  
Cancer Registries ◽  
The United States ◽  
Incidence Rates ◽  
University Teaching ◽  
Rectal Tumors

PURPOSE Colorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of age (early-onset CRC) globally with causes unknown. Racial/ethnic disparities in early-onset CRC have also grown more pronounced, because Black individuals have higher early-onset CRC incidence and poorer survival compared with White individuals. We describe the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans (AAs) in the United States. PATIENTS AND METHODS We identified Black individuals diagnosed with a first primary CRC ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria (Nigerians), and in the United States (AAs) using the National Institutes of Health/National Cancer Institute’s SEER program of cancer registries. Multivariable logistic regression models were used to investigate clinical and demographic differences between Nigerians and AAs with early-onset CRC, adjusted for age, sex, tumor site, and histology. RESULTS A total of 5,019 Black individuals were diagnosed with early-onset CRC over the study period (379 Nigerians; 4,640 AAs). Overall, approximately one third of young Black patients were diagnosed with rectal tumors (35.8%). Nigerian individuals with early-onset CRC were eight-fold more likely to be diagnosed with rectal tumors (odds ratio [OR], 8.14; 95% CI, 6.23 to 10.62; P < .0001) and more likely to be diagnosed at younger ages (OR, 0.87; 95% CI, 0.86 to 0.89; P < .0001) compared with young African Americans in adjusted models. CONCLUSION Compared with AA individuals diagnosed with early-onset CRC, Nigerian individuals harbor distinct features of early-onset CRC. Additional investigation of the histopathologic and biologic heterogeneity of early-onset CRCs among Black individuals is critical for understanding racial disparities in susceptibility and outcomes, which may have implications for tailored early-onset CRC prevention, detection, and treatment strategies.

scholarly journals Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030

2016 ◽  
Vol 34 (15) ◽  
pp. 1787-1794 ◽  
Author(s):  
Jessica L. Petrick ◽  
Scott P. Kelly ◽  
Sean F. Altekruse ◽  
Katherine A. McGlynn ◽  
Philip S. Rosenberg
Keyword(s):  
United States ◽  
Hepatocellular Carcinoma ◽  
Treatment Strategies ◽  
Population Data ◽  
The United States ◽  
Incidence Rates ◽  
Pacific Islanders ◽  
Birth Cohorts ◽  
Race Ethnicity ◽  
Registry Database

Purpose Hepatocellular carcinoma (HCC) incidence rates have been increasing in the United States for the past 35 years. Because HCC has a poor prognosis, quantitative forecasts could help to inform prevention and treatment strategies to reduce the incidence and burden of HCC. Methods Single-year HCC incident case and population data for the years 2000 to 2012 and ages 35 to 84 years were obtained from the SEER 18 Registry Database. We forecast incident HCC cases through 2030, using novel age-period-cohort models and stratifying by sex, race/ethnicity, and age. Rates are presented because absolute numbers may be influenced by population increases. Results Rates of HCC increased with each successive birth cohort through 1959. However, rates began to decrease with the 1960 to 1969 birth cohorts. Asians/Pacific Islanders (APIs) have had the highest HCC rates in the United States for many years, but the rates have stabilized and begun to decline in recent years. Between 2013 and 2030, rates among APIs are forecast to decline further, with estimated annual percentage changes of −1.59% among men and −2.20% among women. Thus, by 2030, Asians are forecast to have the lowest incidence rates among men, and Hispanics are forecast to have the highest rates among men (age-standardized rate, 44.2). Blacks are forecast to have the highest rate among women (age-standardized rate, 12.82). Conclusion Although liver cancer has long had some of the most rapidly increasing incidence rates, the decreasing rates seen among APIs, individuals younger than 65 years, and cohorts born after 1960 suggest that there will be declines in incidence of HCC in future years. Prevention efforts should be focused on individuals in the 1950 to 1959 birth cohorts, Hispanics, and blacks.

Abstract 3702: Cumulative incidence rates of breast cancer for Filipinos and Chamorros in Guam and the United States

2015 ◽  
Author(s):  
Grazyna Badowski ◽  
Rachael Leon Guerrero ◽  
Brayan Simsiman ◽  
Rachel Novotny ◽  
Lynne Wilkens
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Cumulative Incidence ◽  
The United States ◽  
Incidence Rates

Racial disparities and treatment outcomes among patients admitted with a diagnosis of colorectal cancer: Analysis of the 2014 national inpatient sample database.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 529-529
Author(s):  
Ikponmwosa Enofe ◽  
Manoj P. Rai ◽  
Osamuyimen Osaghae
Keyword(s):  
Colorectal Cancer ◽  
United States ◽  
Cancer Treatment ◽  
Racial Disparities ◽  
The United States ◽  
Pacific Islanders ◽  
National Inpatient Sample ◽  
Asian Pacific Islanders ◽  
Asian Pacific ◽  
Colorectal Cancer Treatment

529 Background: Colorectal cancer is the fourth most common cancer in the United states and the second most common cause of death. Despite universal advocacy for screening colonoscopies and early diagnosis, racial disparities in screening and diagnosis of colorectal cancer exist and affect patients outcomes. In this analysis we determine racial disparities and treatment outcomes for colorectal cancer treatment in the United States. Methods: We performed a retrospective analysis of the National Inpatient Sample 2014 Database (HCUP_NIS) which contains records of all hospital discharges in the United States Patients 18 years and older with a diagnosis of colorectal cancer were identified by their ICD 9 codes along with treatment they had for colorectal cancer. We then used multivariable regression to identify the effect of race on receiving a therapeutic procedure (open surgical, laparoscopic or robotic) during hospitalization and outcomes as it relates to inpatient mortality. We adjusted for patients age, sex, number of comorbidities (elixhauser comorbidity score), insurance type, and hospital level charactertistics (i.e. size, teaching status) and location (urban and rural location). Results: There were 25,749 discharge diagnosis of colorectal cancer in the United States in 2014 of which 19,300 were associated with undergoing a procedure for colorectal cancer treatment. Whites accounted for the majority of colorectal cancer admissions (65%) while blacks 11.4 %, Hispanics 8.0%, Asian/Pacific Islanders 3.2 %, and Native Americans 0.4%. Blacks had the lowest frequency of procedure related admissions and were less likely to undergo a therapeutic procedure relating to colorectal cancer treatment (67.5 vs. 76.6 OR 0.84 CI 0.75 - 0.93) compared to whites. For specific procedures, blacks (OR 0.81, CI 0.72-0.91) and Hispanics (OR 0.85, CI 0.74-0.98) had a significantly lesser odds of undergoing open surgical procedures when compared to whites but were similarly likely (Blacks OR 0.93, CI 0.81-1.05, Hispanics OR 0.84, CI 0.61-1.14) to undergo laparoscopic/robotic surgical procedure. On multivariable analysis, Asian/Pacific Islanders had a significantly higher mortality (OR 1.61 CI 1.01-2.60) for non-procedure related colorectal cancer admissions. However, this increase mortality was not seen in procedure related colorectal cancer admissions. Overall, after adjusting for potential confounders and treatment, there was no significant variation amongst different races for colorectal cancer mortality in patients admitted to the hospital. Conclusions: Among patients with colorectal cancer there was no procedure related mortality differences between various races. However, for some reason Asian/Pacific Islanders had a significantly higher mortality for non-procedure related colorectal cancer admissions. Further studies are warranted to understand the above findings.

scholarly journals Colorectal Cancer Incidence Rates in the Louisiana Acadian Parishes Demonstrated to be Among the Highest in the United States

2014 ◽  
Vol 5 (10) ◽  
pp. e60 ◽  
Author(s):  
Jordan J Karlitz ◽  
Christine Blanton ◽  
Patricia Andrews ◽  
Vivien W Chen ◽  
Xiao-Cheng Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
United States ◽  
Cancer Incidence ◽  
The United States ◽  
Incidence Rates ◽  
Colorectal Cancer Incidence ◽  
Cancer Incidence Rates

Community Assessment of Colorectal Cancer Screening Compliance in Northwest Louisiana

2019 ◽  
Vol 40 (4) ◽  
pp. 273-279
Author(s):  
Stephanie Holden
Keyword(s):  
Colorectal Cancer ◽  
United States ◽  
Rural Areas ◽  
Knowledge Score ◽  
The United States ◽  
Incidence Rates ◽  
Cluster Sampling ◽  
Crc Screening ◽  
Residence Location ◽  
Crc Knowledge

Background In the United States, colorectal cancer (CRC) screening rates have steadily increased. The state of Louisiana has persistent lower screening rates compared to the United States and other states, and with African Americans experiencing the highest CRC incidence rates. Aggregate national and state data can be problematic in isolating key health issues and data in rural areas. Study Purpose: At the Louisiana parish-level, which is comparable to county municipalities in other U.S. states, the research study examined endoscopy CRC screening among African American Medicare beneficiaries. Method Using cluster sampling, survey-based data from two neighboring parishes in northwest Louisiana were collected. The survey instrument was adapted from the Medicare Current Beneficiary Survey. Results The key study variables were CRC screening compliance, residence location, self-reported CRC knowledge, and physician recommendation. The findings showed significant differences in CRC screening compliance between the two parishes. Participants with CRC knowledge score of at least 3 out of 5 were more likely to be compliant with CRC screening. The findings demonstrated the importance of isolating geo-specific data, especially in rural areas, to plan effective health education or intervention strategies.

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