Abstract B19: Colonic transcriptional response to 1,25(OH)2 vitamin D in African and European Americans

2016 ◽  
Author(s):  
Sonia Kupfer ◽  
Brandon Mapes ◽  
Shigeki Nakagome ◽  
David Witonsky ◽  
Anna Di Rienzo
Keyword(s):  
Vitamin D ◽  
Transcriptional Response ◽  
European Americans

scholarly journals Colonic transcriptional response to 1α,25(OH) 2 vitamin D 3 in African- and European-Americans

2017 ◽  
Vol 168 ◽  
pp. 49-59 ◽  
Author(s):  
Dereck Alleyne ◽  
David B. Witonsky ◽  
Brandon Mapes ◽  
Shigeki Nakagome ◽  
Meredith Sommars ◽  
...  
Keyword(s):  
Vitamin D ◽  
Transcriptional Response ◽  
European Americans ◽  
Vitamin D 3

Abstract PO-143: Differences in vitamin D genomic and epigenomic responses in colonic organoids from African- and European-Americans

2022 ◽  
Author(s):  
Sonia Kupfer ◽  
David Witonsky ◽  
Jinchao Li ◽  
Margaret Bielski ◽  
Kristi Lawrence
Keyword(s):  
Vitamin D ◽  
European Americans

Mo2008 CD14 Transcriptional Response to Vitamin D Differs Between Proximal and Distal Colon

2015 ◽  
Vol 148 (4) ◽  
pp. S-766-S-767
Author(s):  
Brandon Mapes ◽  
Candace M. Cham ◽  
Sonia Kupfer
Keyword(s):  
Vitamin D ◽  
Transcriptional Response ◽  
Distal Colon

scholarly journals Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans

2014 ◽  
Vol 133 (11) ◽  
pp. 1395-1405 ◽  
Author(s):  
Ken Batai ◽  
Adam B. Murphy ◽  
Ebony Shah ◽  
Maria Ruden ◽  
Jennifer Newsome ◽  
...  
Keyword(s):  
Vitamin D ◽  
African Americans ◽  
Serum Vitamin ◽  
Gene Variants ◽  
Serum Vitamin D ◽  
European Americans ◽  
Pathway Gene ◽  
Vitamin D Levels

Sa1969 Inter-Ethnic Differences in Genome-Wide Transcriptional Response to Vitamin D in the Colon

2013 ◽  
Vol 144 (5) ◽  
pp. S-347
Author(s):  
Sonia Kupfer ◽  
Katy Ceryes ◽  
Meredith Chase ◽  
Ellie Hong ◽  
Shaneen Baxter ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ethnic Differences ◽  
Transcriptional Response ◽  
Genome Wide

scholarly journals A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Timothy Warwick ◽  
Marcel H. Schulz ◽  
Stefan Günther ◽  
Ralf Gilsbach ◽  
Antonio Neme ◽  
...  
Keyword(s):  
Vitamin D ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Target Genes ◽  
Active Form ◽  
Transcriptional Response ◽  
Biologically Active ◽  
Open Chromatin ◽  
Monocytic Cell ◽  
Monocytic Cell Line

AbstractThe transcription factor vitamin D receptor (VDR) is the high affinity nuclear target of the biologically active form of vitamin D3 (1,25(OH)2D3). In order to identify pure genomic transcriptional effects of 1,25(OH)2D3, we used VDR cistrome, transcriptome and open chromatin data, obtained from the human monocytic cell line THP-1, for a novel hierarchical analysis applying three bioinformatics approaches. We predicted 75.6% of all early 1,25(OH)2D3-responding (2.5 or 4 h) and 57.4% of the late differentially expressed genes (24 h) to be primary VDR target genes. VDR knockout led to a complete loss of 1,25(OH)2D3–induced genome-wide gene regulation. Thus, there was no indication of any VDR-independent non-genomic actions of 1,25(OH)2D3 modulating its transcriptional response. Among the predicted primary VDR target genes, 47 were coding for transcription factors and thus may mediate secondary 1,25(OH)2D3 responses. CEBPA and ETS1 ChIP-seq data and RNA-seq following CEBPA knockdown were used to validate the predicted regulation of secondary vitamin D target genes by both transcription factors. In conclusion, a directional network containing 47 partly novel primary VDR target transcription factors describes secondary responses in a highly complex vitamin D signaling cascade. The central transcription factor VDR is indispensable for all transcriptome-wide effects of the nuclear hormone.

1024 Transcriptional Response to 1,25(OH)2 Vitamin D in the Human Colon: Differences by Ethnicity and Colorectal Cancer Affection

2014 ◽  
Vol 146 (5) ◽  
pp. S-181
Author(s):  
Sonia Kupfer ◽  
David Witonsky ◽  
Meredith Chase ◽  
Katy Ceryes ◽  
Anna DiRienzo
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Transcriptional Response ◽  
Human Colon
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