Abstract B55: Peritoneal tumor spread in high-grade serous ovarian cancer: Differences in the immune response.

2016 ◽  
Author(s):  
Katharina Auer ◽  
Anna Bachmayr-Heyda ◽  
Nyamdelger Sukhbaatar ◽  
Stefanie Aust ◽  
Christoph Grimm ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Tumor Spread ◽  
Peritoneal Tumor

scholarly journals Neutrophil Extracellular Trap Formation Correlates with Favorable Overall Survival in High Grade Ovarian Cancer

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 505 ◽  
Author(s):  
Besnik Muqaku ◽  
Dietmar Pils ◽  
Johanna C. Mader ◽  
Stefanie Aust ◽  
Andreas Mangold ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Ovarian Cancer ◽  
Abundance Ratio ◽  
Neutrophil Extracellular Trap ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Association Network ◽  
Tumor Spread ◽  
Peritoneal Tumor ◽  
Extracellular Trap

It is still a question of debate whether neutrophils, often found in the tumor microenvironment, mediate tumor-promoting or rather tumor-inhibiting activities. The present study focuses on the involvement of neutrophils in high grade serous ovarian cancer (HGSOC). Macroscopic features classify two types of peritoneal tumor spread in HGSOC. Widespread and millet sized lesions characterize the miliary type, while non-miliary metastases are larger and associated with better prognosis. Multi-omics and FACS data were generated from ascites samples. Integrated data analysis demonstrates a significant increase of neutrophil extracellular trap (NET)-associated molecules in non-miliary ascites samples. A co-association network analysis performed with the ascites data further revealed a striking correlation between NETosis-associated metabolites and several eicosanoids. The congruence of data generated from primary neutrophils with ascites analyses indicates the predominance of NADPH oxidase 2 (NOX)-independent NETosis. NETosis is associated with protein S100A8/A9 release. An increase of the S100A8/CRP abundance ratio was found to correlate with favorable survival of HGSOC patients. The analysis of additional five independent proteome studies with regard to S100A8/CRP ratios confirmed this observation. In conclusion, NET formation seems to relate with better cancer patient outcome.

scholarly journals Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (38) ◽  
pp. 61336-61354 ◽  
Author(s):  
Katharina Auer ◽  
Anna Bachmayr-Heyda ◽  
Nyamdelger Sukhbaatar ◽  
Stefanie Aust ◽  
Klaus G. Schmetterer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune System ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Tumor Spread ◽  
Peritoneal Tumor

scholarly journals Impact of humoral immune response against p53 on clinical outcome of High-Grade Serous Ovarian Cancer (HGSOC) patients

2016 ◽  
Vol 27 ◽  
pp. viii8
Author(s):  
M. Garziera ◽  
E. Cecchin ◽  
M. Montico ◽  
R. Roncato ◽  
S. Gagno ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
Clinical Outcome ◽  
Humoral Immune Response ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Humoral Immune

scholarly journals Molecular Profiling and Clinical Outcome of High-Grade Serous Ovarian Cancer Presenting with Low- versus High-Volume Ascites

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Tomer Feigenberg ◽  
Blaise Clarke ◽  
Carl Virtanen ◽  
Anna Plotkin ◽  
Michelle Letarte ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
Clinical Outcome ◽  
Expression Profiles ◽  
High Volume ◽  
High Grade ◽  
Advanced Stage ◽  
Serous Ovarian Cancer ◽  
Immune Response Genes ◽  
Low Volume

Epithelial ovarian cancer consists of multiple histotypes differing in etiology and clinical course. The most prevalent histotype is high-grade serous ovarian cancer (HGSOC), which often presents at an advanced stage frequently accompanied with high-volume ascites. While some studies suggest that ascites is associated with poor clinical outcome, most reports have not differentiated between histological subtypes or tumor grade. We compared genome-wide gene expression profiles from a discovery cohort of ten patients diagnosed with stages III-IV HGSOC with high-volume ascites and nine patients with low-volume ascites. An upregulation of immune response genes was detected in tumors from patients presenting with low-volume ascites relative to those with high-volume ascites. Immunohistochemical studies performed on tissue microarrays confirmed higher expression of proteins encoded by immune response genes and increased tumorinfiltrating cells in tumors associated with low-volume ascites. Comparison of 149 advanced-stage HGSOC cases with differential ascites volume at time of primary surgery indicated low-volume ascites correlated with better surgical outcome and longer overall survival. These findings suggest that advanced stage HGSOC presenting with low-volume ascites reflects a unique subgroup of HGSOC, which is associated with upregulation of immune related genes, more abundant tumor infiltrating cells and better clinical outcomes.

Abstract 455: B cells actively participate to the anti-cancer immune response in high grade serous ovarian cancer metastases

2015 ◽  
Author(s):  
Anne Montfort ◽  
Steffen Boehm ◽  
Thomas Dowe ◽  
Joanne Topping ◽  
Michelle Lockley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune Response ◽  
B Cells ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cancer Metastases ◽  
Anti Cancer

scholarly journals Targeting the Microenvironment in High Grade Serous Ovarian Cancer

Cancers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 266 ◽  
Author(s):  
Nkechiyere Nwani ◽  
Livia Sima ◽  
Wilberto Nieves-Neira ◽  
Daniela Matei
Keyword(s):  
Ovarian Cancer ◽  
Cancer Progression ◽  
Malignant Ascites ◽  
Cancer Cell Proliferation ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Secreted Factors ◽  
Peritoneal Tumor ◽  
Tumor Dissemination ◽  
Cellular Components

Cancer–stroma interactions play a key role in cancer progression and response to standard chemotherapy. Here, we provide a summary of the mechanisms by which the major cellular components of the ovarian cancer (OC) tumor microenvironment (TME) including cancer-associated fibroblasts (CAFs), myeloid, immune, endothelial, and mesothelial cells potentiate cancer progression. High-grade serous ovarian cancer (HGSOC) is characterized by a pro-inflammatory and angiogenic signature. This profile is correlated with clinical outcomes and can be a target for therapy. Accumulation of malignant ascites in the peritoneal cavity allows for secreted factors to fuel paracrine and autocrine circuits that augment cancer cell proliferation and invasiveness. Adhesion of cancer cells to the mesothelial matrix promotes peritoneal tumor dissemination and represents another attractive target to prevent metastasis. The immunosuppressed tumor milieu of HGSOC is permissive for tumor growth and can be modulated therapeutically. Results of emerging preclinical and clinical trials testing TME-modulating therapeutics for the treatment of OC are highlighted.

scholarly journals Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39640-39653 ◽  
Author(s):  
Anna Bachmayr-Heyda ◽  
Katharina Auer ◽  
Nyamdelger Sukhbaatar ◽  
Stefanie Aust ◽  
Simon Deycmar ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Small Rnas ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Competing Endogenous Rna ◽  
Tumor Spread ◽  
Competing Endogenous Rna Network ◽  
Cancer Tumor
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