Skin Lesions as Another Possible Clinical Manifestation of Mitochondrial Toxicity in an HIV-Infected Patient

Dermatology ◽  
2007 ◽  
Vol 214 (2) ◽  
pp. 189-190
Author(s):  
C. Bachmeyer ◽  
V. Orlandini ◽  
D. Grimaldi ◽  
P. Bonnard ◽  
P. Moguelet ◽  
...  
Keyword(s):  
Clinical Manifestation ◽  
Infected Patient ◽  
Skin Lesions ◽  
Mitochondrial Toxicity

scholarly journals Cutaneous Disease as Sole Clinical Manifestation of Protothecosis in a Boxer Dog

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Emmanouil I. Papadogiannakis ◽  
Emmanouil N. Velonakis ◽  
Gregory K. Spanakos ◽  
Alexander F. Koutinas
Keyword(s):  
Clinical Manifestation ◽  
Systemic Therapy ◽  
Opportunistic Infections ◽  
Skin Lesions ◽  
Causal Organism ◽  
Cutaneous Disease ◽  
Prototheca Wickerhamii ◽  
Skin Nodules ◽  
Uncommon Case ◽  
Disseminated Disease

Prototheca wickerhamiiis ubiquitous, saprophytic achlorophyllous algae that cause opportunistic infections in the dog and cat and disseminated disease usually in immunocompromised animals. In this report an uncommon case of canine cutaneous protothecosis is presented. A 6-year-old female boxer was brought in with skin lesions that consisted of nodules and generalized footpad hyperkeratosis, depigmentation, and erosion. Cytology and histopathology showed pyogranulomatous inflammation along with organisms containing round sporangia with spherical sporangiospores. PCR and sequencing identified the causal organism asPrototheca wickerhamii. Therapy applied in this patient with either fluconazole alone or combination of amphotericin B and itraconazole proved effective only for footpad lesions but not for skin nodules. Systemic therapy seems to be ineffective for skin nodules, at least in chronic cases of canine cutaneous protothecosis. Although canine protothecosis usually presents with the disseminated form, cutaneous disease as sole clinical manifestation of the infection may also be witnessed.

scholarly journals The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

2016 ◽  
Vol 60 (9) ◽  
pp. 5608-5611 ◽  
Author(s):  
Min Li ◽  
Andrea C. Mislak ◽  
Yram Foli ◽  
Esinam Agbosu ◽  
Vivek Bose ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Dna Polymerase ◽  
Infected Patient ◽  
Polymerase Activity ◽  
Mitochondrial Toxicity ◽  
Wild Type ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Deoxynucleoside Triphosphate ◽  
Dntp Binding

ABSTRACTWe found a heterozygous C2857T mutation (R953C) in polymerase gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less than that of the wild type. The R953C mutant shows a 4-fold decrease in discrimination of analog nucleotides relative to the wild type. R953 is located on the “O-helix” that forms the substrate deoxynucleoside triphosphate (dNTP) binding site; the interactions of R953 with E1056 and Y986 may stabilize the O-helix and affect polymerase activity.

HISTOPLASMOSIS IN AN HIV-INFECTED PATIENT: REPORT OF AN UNUSUAL CLINICAL MANIFESTATION

2017 ◽  
Vol 124 (2) ◽  
pp. e53
Author(s):  
FELIPE MARTINS SILVEIRA ◽  
ANA PAULA NEUTZLING GOMES ◽  
SANDRA BEATRIZ CHAVES TARQUÍNIO ◽  
THAÍSE GOMES E NÓBREGA ◽  
KARINE DUARTE DA SILVA ◽  
...  
Keyword(s):  
Clinical Manifestation ◽  
Infected Patient ◽  
Patient Report

Foot ischaemia and toe skin necrosis associated with interleukin-2 infusion in an HIV-infected patient

2009 ◽  
Vol 20 (8) ◽  
pp. 577-579 ◽  
Author(s):  
A Belda ◽  
J Borrás-Blasco ◽  
L Lopez-Montes ◽  
D Rosique-Robles ◽  
E Casterá ◽  
...  
Keyword(s):  
Infected Patient ◽  
Skin Necrosis ◽  
Ultrasound Examination ◽  
Interleukin 2 ◽  
Skin Lesions ◽  
Posterior Tibial Artery ◽  
Probability Scale ◽  
Posterior Tibial ◽  
Digital Pulse ◽  
Possible Cause

A 39-year-old white man developed a severe left toe foot ischaemia and toe skin necrosis following his 12 courses of interleukin (IL)-2 (4.5 MIU twice a day, subcutaneously) for five days every two months. He had no known general risk factors for thrombosis other than HIV infection. An arterial Doppler ultrasound examination of the leg confirmed the permeability of the posterior tibial artery and its digital pulse. A diagnosis of foot ischaemia and toe skin necrosis was made. The suspected causative agent was IL-2 since this was the only drug that the patient was taking before the symptoms appeared. The patient was empirically treated with an aspirin and pentoxifylline in order to improve local microcirculation. We observed a satisfactory response with a quick resolve of skin lesions. The most possible cause of foot ischaemia and toe skin necrosis was considered to be IL-2 because of the temporal relationship between the exposure to the drug and onset of symptoms. Based on the Naranjo probability scale, IL-2 could be considered the probable cause of the foot ischaemia and toe skin necrosis. If clinical evaluation leads to the suspicion of ischaemic process, therapy with IL-2 should be discontinued immediately.

Atypical disseminated leishmaniasis resembling post-kala-azar dermal leishmaniasis in an HIV-infected patient

2006 ◽  
Vol 17 (5) ◽  
pp. 351-353 ◽  
Author(s):  
E Boumis ◽  
P Chinello ◽  
C Della Rocca ◽  
M G Paglia ◽  
M F Proietti ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Leishmania Infantum ◽  
Infected Patient ◽  
Skin Lesions ◽  
Positive Patient ◽  
Hiv Positive ◽  
Chain Reaction ◽  
Kala Azar ◽  
Polymerase Chain

Post-kala-azar dermal leishmaniasis (PKDL) is very uncommon among HIV-positive patients, and very few cases have so far been documented. A case of atypical disseminated leishmaniasis resembling PKDL in an HIV-positive patient successfully treated with N-methylglucamine antimoniate is reported. The polymerase chain reaction performed on the skin lesions was positive for Leishmania infantum.

scholarly journals Clinical Manifestation, Dermoscopy, and Scanning Electron Microscopy in Two Cases of Contagious Ecthyma (Orf Nodule)

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Ana Laura Rosifini Alves Rezende ◽  
Fred Bernardes Filho ◽  
Natália Aparecida de Paula ◽  
Loan Towersey ◽  
Roderick Hay ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Clinical Manifestation ◽  
Skin Disease ◽  
Direct Contact ◽  
Specific Treatment ◽  
Skin Lesions ◽  
Contagious Ecthyma ◽  
Scanning Electron

Orf is a highly contagious skin disease commonly seen in goats and sheep that can be transmitted to people who have direct contact with infected animals. Here, we report the clinical manifestation, dermoscopy, and scanning electron microscopy in two women who developed skin lesions on their hands after handling goats with wounds in the udders. Human orf is usually self-limiting and no specific treatment is needed.

scholarly journals PECULIARITIES OF CLINICAL MANIFESTATION OF INFECTED ECZEMA AND APPROACHES TO CHOOSING ANTIBIOTIC THERAPY

2015 ◽  
pp. 38-41
Author(s):  
L. A. Poroshina
Keyword(s):  
Antibiotic Therapy ◽  
Clinical Features ◽  
Clinical Manifestation ◽  
Skin Disease ◽  
Severe Disease ◽  
Antibiotic Sensitivity ◽  
Skin Lesions ◽  
Disease Course ◽  
Resistance To Therapy ◽  
Frequent Relapse

Infected eczema is considered to be a widespread skin disease. Recently it has had a tendency for severe disease course, resistance to therapy and frequent relapse. This article describes clinical features of manifestations of the disease, studies microflora of patient's skin lesions, antibiotic sensitivity of these microorganisms.

scholarly journals Lues maligna in an HIV-infected patient

2005 ◽  
Vol 38 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Luiz Fernando Cabral Passoni ◽  
Jacqueline Anita de Menezes ◽  
Sayonara Rocha Ribeiro ◽  
Érica Coutinho O. Sampaio
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Infected Patient ◽  
Skin Lesions ◽  
Successful Therapy ◽  
B Virus

We report such a case of malignant syphilis in a 42-year-old HIV-infected man, co-infected with hepatitis B virus, who presented neurolues and the classical skin lesions of lues maligna. The serum VDRL titer, which was 1:64 at presentation, increased to 1:2,048 three months after successful therapy with penicillin, decreasing 15 months later to 1:8.

scholarly journals Malignant syphilis as the first manifestation of HIV infection

2012 ◽  
Vol 4 (1) ◽  
pp. 15 ◽  
Author(s):  
Efstathios Rallis ◽  
Vasileios Paparizos
Keyword(s):  
Hiv Infection ◽  
Clinical Manifestation ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Penicillin G ◽  
Homosexual Male ◽  
Ulcerative Lesions ◽  
Thick Crust

Malignant syphilis is a rare and severe variant of secondary syphilis. It is clinically characterized by large papular, nodular and ulcerative lesions affecting the trunk and the extremities and covered with thick crust. We present a case of 52-year-old homosexual male who developed malignant syphilis and this was the first clinical manifestation of HIV infection. The patient was treated successfully with intravenous aqueous crystalline penicillin G. Physicians should recognize malignant syphilis and considered it in all HIV-infected individuals with ulceronodular skin lesions.

scholarly journals Acrodermatitis Enteropathica: A Case Report

2020 ◽  
Vol 35 (6) ◽  
pp. e201-e201
Author(s):  
Asma Al Naamani ◽  
Tuqa Al Lawati
Keyword(s):  
Case Report ◽  
Clinical Diagnosis ◽  
Zinc Deficiency ◽  
Clinical Manifestation ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Skin Lesions ◽  
Genetic Mutation ◽  
Acrodermatitis Enteropathica ◽  
Rare Autosomal Recessive Disease

Acrodermatitis enteropathica is a rare autosomal recessive disease caused by a genetic mutation leading to zinc deficiency. Clinical manifestation includes skin lesions, diarrhea, and alopecia. We report the case of a two-month-old girl, admitted with erythematous scaly lesions in the neck and vesiculopustular lesions in the perioral region, associated with alopecia and diarrhea. Clinical diagnosis of the disease was made from her first presentation. She was started on zinc therapy and her lesions resolved entirely after one month of treatment.

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