Influence of CAPD and Residual Diuresis on the Serum Levels of Alpha-1-Microglobulin in End-Stage Renal Disease

Nephron ◽  
1989 ◽  
Vol 51 (3) ◽  
pp. 367-369 ◽  
Author(s):  
M.H. Weber ◽  
P. Reetze ◽  
F. Neumann ◽  
G. Warneke ◽  
F. Scheler
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Stage Renal Disease ◽  
End Stage ◽  
Residual Diuresis

scholarly journals CUT OFF VALUE OF PROCALCITONIN IN END STAGE RENAL DISEASE PATIENTS WITHOUT INFECTION

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Naila Asif ◽  
Samina Shamim ◽  
Shafqat Waqar Khanzada ◽  
Muhammad Rizwan
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Acute Phase Reactant ◽  
Normal Serum ◽  
Maintenance Hemodialysis ◽  
Maintenance Haemodialysis ◽  
Reactive Protein ◽  
Stage Renal Disease ◽  
End Stage

OBJECTIVE: To determine cut off value of procalciton (PCT) in aseptic end stage renal disease patients undergoing haemodialysis. BACKGROUND: Haemodialysisis considered as a proinflammatory state and therefore associated with release of inflammatory cytokines and acute phase reactant proteins. The conventional laboratory markers (C-reactive protein, erythrocyte sedimentation rate) are efficient tools for the diagnosis of infection in patients with normal kidney functions. However they can be nonspecifically elevated in patients on haemodialysis and only reflect inflammatory response not associated with infection. PCT is considered a very important biomarker in differentiating infections from inflammation. The study was undertaken to evaluate normal serum levels of PCT in patients undergoing HD.PATIENTS AND METHOD: The study included 82 end-stage renal failure patients without evidence of systemic or localized infection undergoing maintenance haemodialysis. RESULTS: In our study, the PCT concentrations showed a mean of .622ng/ml in patients on maintenance hemodialysis without signs of infection. CONCLUSION:The study suggests that serum PCT at a cutoff value of .62ng/ml should be considered normal in aseptic haemodialysis patients. KEYWORDS: Procalcitonin, haemodialysis, sepsis

Evaluation of the Role of Gabapentin and/or Omega-3 in Uremic Pruritus for Patients Undergoing Hemodialysis

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Sinan Forat Hussein ◽  
Kadhim Ali Kadhim ◽  
Ali JassimAl Sultani ◽  
Saad Abdulrahman Hussain
Keyword(s):  
Renal Disease ◽  
Fish Oil ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Efficacy And Safety ◽  
Omega 3 ◽  
Uremic Pruritus ◽  
Stage Renal Disease ◽  
End Stage

Uremic pruritus is chronic itching that occurs in patients with advanced or end-stage renal disease. It is one of common symptoms in patients with end-stage renal disease with approximately 60–90% of patients on hemodialysis (HD) suffering from this problem. This study was designed to evaluate the efficacy and safety of prescribing Gabapentin or Omega-3 alone or in combination for relieving uremic pruritus in Iraqi patients undergoing hemodialysis. The results showed that all the three involved regimens (gabapentin,omega-3,and the combination of both drugs) had significantly reduced the pruritus score. Furthermore,the combination was significantly superior to other regimens in reducing pruritus score,while no significant effect was observed by all the regimens on interleukin-6 or on parathyroid hormone serum levels. In Conclusion Gabapentin 100mg plus 1000mg omega-3 based fish oil capsules containing 120mg is superior to gabapentin 100mg capsule or 1g of omega-3 based fish oil capsule containing 120mg docosahexaenoic acid and 180mg ecosapentaenoic acid (each alone),in reducing pruritus score in a sample of Iraqi patients.

scholarly journals Serum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease

2017 ◽  
Vol 186 (8) ◽  
pp. 952-960 ◽  
Author(s):  
Casey M Rebholz ◽  
Morgan E Grams ◽  
Yuan Chen ◽  
Alden L Gross ◽  
Yingying Sang ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals THE CORRELATION OF ANEMIA AND HEPCIDIN SERUM LEVELS IN REGULAR HEMODIALYSIS PATIENTS WITH CHRONIC HEPATITIS C IN HAJI ADAM MALIK HOSPITAL MEDAN

2019 ◽  
Vol 25 (2) ◽  
pp. 218
Author(s):  
Wingsar Indrawanto ◽  
Adi Koesoema Aman ◽  
Alwi Thamrin
Keyword(s):  
Renal Failure ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Renal Disease ◽  
Chronic Hepatitis C ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Stage Renal Disease ◽  
End Stage ◽  
Regular Hemodialysis

Background : End stage renal disease patients who undergo hemodialysis therapy are the high-risk populations who are infected by hepatitis C virus. Some studies have been reported that hepcidin levels decreased in patients with chronic hepatitis C. Hepcidin serum concentrations were also reported to increase in patients with renal failure in the line with increased severity of renal failure, which can cause the accumulation of hepcidin which culminates in anemia because iron deficiency. This Study was to analyze the correlation of anemia and hepcidin serum levels in patients end stage renal disease who undergoing regular hemodialysis with chronic hepatitis C.Methods : This study was an analytic observational with cross sectional design which was conduted on 24 patients end stage renal disease (ESRD) with chronic hepatitis C and 24 patients  with ESRD without hepatitis who are undergoing regular hemodialysis theraphy in Haji Adam Malik Hospital, Medan in July – September 2016. All study subjects were examined for full blood count and hepcidin serum levels. The result of the iron status were recorded from the patient’s medical record.Result : In this study, the mean hemoglobin was 8,15±1,44 g/dL, mean hematocrit 25,42±4,53%, median hepcidin levels 29,75 (4,92-359,49) in the patients ESRD with chronic hepatitis C  and mean hemoglobin 8,21±1,50 g/dL, mean hematocrit 25,25±4,37%, median hepcidin levels 30,33 (11,65-141,53) in the patients ESRD without hepatitis. In Spearman’s rho test  was showed a positive correlation that significant between hepcidin and hemoglobin (r = 0,439, p = 0,032), hepcidin and hematocrit (r = 0,021, p = 0,024) in patients ESRD with chronic hepatitis C.Conclusion : This study showed there was a positive correlation between anemia and hepcidin serum levels in patients ESRD who undergoing regular hemodialysis with chronic hepatitis C.

Relation Between Matrix Gla Protein and Cardiac Vavular Calcifications in Haemodialysis Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Magdy Mohamed Saeed El-Sharkawy ◽  
Ahmed Hassan Mohamed El Thakaby ◽  
Reem Mohsen El Sharabasy ◽  
Mahmoud Fathy Mohamed ElBahrawy
Keyword(s):  
Heart Disease ◽  
Renal Disease ◽  
Valvular Heart Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Matrix Gla Protein ◽  
Pathologic Features ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Heart valve calcification was first described a century ago. Its pathologic features were first described by Dewitsky in 1910. Valvular heart disease is common in end-stage renal disease patients. The incidence of valvular heart disease is 5 times greater in dialysis patients than in the general population MGP plays a key role in the inhibition of tissue calcification, which was demonstrated in MGP-deficient mice Objective To detect the prevalence of cardiac valvular calcifications among end stage renal disease patients on prevalent haemodialysis and its relation to Matirx Gla protein. Patients and Methods Enrolled patients were recruited from Ain shams hospitals, divided into two groups according to the presence/absence of valvular calcifications on echocardiographic examination as follows: Group A: included patients with valvular calcifications. Group B: included patients without valvular calcifications. Results In current study, 19 (23.8%) patients showed mitral calcification, 30 (37.5%) showed aortic calcification and 44 (55.0%) had calcification in general as 5 patients had both mitral and aortic calcifications. In current study, the patient who had calcification were significantly older, heavier in weight and BMI and were had HD for longer than those who didn’t have calcification. Patient who had calcification had lower levels of both platelets and urea than those who didn’t have calcification. In current study, the mean ucMGP was 549.5 ± 160.1 and the patient who had calcification had higher levels of ucMGP than those who did not have calcification. There was a significant positive correlation between age, weight, BMI, duration of HD and ucMGP. And there was a significant negative correlation between platelet count, serum albumin and ucMGP. Conclusion In current study, MGP was able to significantly differentiate between patients with and without calcification at a cutoff point (>564 pg/mlv) with sensitivity 86.36%, specificity 97.22. Our study confirmed that older age, hypertension, diabetes mellitus low platelet, higher ucMGP and blood urea are the most predictive parameters of valvular calcifications in hemodialysis patients. Other markers were not associated with valvular calcifications. ucMGP serum levels can significantly differentiate between HD cases with valvular calcifications and those not and those who had findings in CXR.

Characterization of Free Phenytoin Concentrations in End-Stage Renal Disease Using the Winter-Tozer Equation

2017 ◽  
Vol 51 (8) ◽  
pp. 669-674 ◽  
Author(s):  
Vincent V. Soriano ◽  
Eljim P. Tesoro ◽  
Sean P. Kane
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Predictive Accuracy ◽  
Serum Levels ◽  
Percentage Error ◽  
Total Serum ◽  
Stage Renal Disease ◽  
End Stage ◽  
Free Serum

Background: The Winter-Tozer (WT) equation has been shown to reliably predict free phenytoin levels in healthy patients. In patients with end-stage renal disease (ESRD), phenytoin-albumin binding is altered and, thus, affects interpretation of total serum levels. Although an ESRD WT equation was historically proposed for this population, there is a lack of data evaluating its accuracy. Objective: The objective of this study was to determine the accuracy of the ESRD WT equation in predicting free serum phenytoin concentration in patients with ESRD on hemodialysis (HD). Methods: A retrospective analysis of adult patients with ESRD on HD and concurrent free and total phenytoin concentrations was conducted. Each patient’s true free phenytoin concentration was compared with a calculated value using the ESRD WT equation and a revised version of the ESRD WT equation. Results: A total of 21 patients were included for analysis. The ESRD WT equation produced a percentage error of 75% and a root mean square error of 1.76 µg/mL. Additionally, 67% of the samples had an error >50% when using the ESRD WT equation. A revised equation was found to have high predictive accuracy, with only 5% of the samples demonstrating >50% error. Conclusion: The ESRD WT equation was not accurate in predicting free phenytoin concentration in patients with ESRD on HD. A revised ESRD WT equation was found to be significantly more accurate. Given the small study sample, further studies are required to fully evaluate the clinical utility of the revised ESRD WT equation.

scholarly journals Serum Sclerostin But Not DKK-1 Correlated with Central Arterial Stiffness in End Stage Renal Disease Patients

2020 ◽  
Vol 17 (4) ◽  
pp. 1230 ◽  
Author(s):  
Chun-Feng Wu ◽  
Jia-Sian Hou ◽  
Chih-Hsien Wang ◽  
Yu-Li Lin ◽  
Yu-Hsien Lai ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Arterial Stiffness ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Serum Levels ◽  
Control Group ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Sclerostin and dickkopf-1 (DKK1) played a role in the development of cardiovascular diseases and arterial stiffness in chronic kidney disease (CKD) patients but with controversial results of patients in end-stage renal disease (ESRD) including hemodialysis (HD) and peritoneal dialysis (PD). This study aimed to examine the association between the mode of dialysis or the values of sclerostin or DKK1 and carotid-femoral pulse wave velocity (cfPWV) in ESRD patients. There were 122 HD and 72 PD patients enrolled in this study. By a validated tonometry system, cfPWV was measured and then segregated patients into values of >10 m/s as the high central arterial stiffness (AS) group and values ≤ 10 m/s as the control group. Serum levels of sclerostin and DKK1 were measured using a commercial enzyme-linked immunosorbent assay kit. Possible risk factors for the development of AS were analyzed by logistic regression analysis. There were 21 (29.2%) of PD and 53 (43.4%) of HD in the high AS group. Compared to patients in the control group, those in the high AS group were older, had more comorbidities, had higher systolic blood pressure, and had higher serum levels of fasting glucose, C-reactive protein, and sclerostin. Levels of sclerostin (adjusted OR 1.012, 95% CI. 1.006–1.017, p = 0.0001) was found to be an independent predictor of high AS in ESRD patients by multivariate logistic regression analysis. Furthermore, receiver operating characteristic curve analysis showed the optimal cut-off values of sclerostin for predicting AS was 208.64 pmol/L (Area under the curve 0.673, 95% CI: 0.603–0.739, p < 0.001). This study showed that serum levels of sclerostin, but not DKK1 or mode of dialysis, to be a predictor for high central AS in ESRD patients.

Sign in / Sign up

Export Citation Format

Share Document