Lung Cancer Presenting as a Soft-Tissue Metastasis

Soft-tissue metastasis refers to the growth of cancer cells, originating from internal cancer, in soft tissues. In most cases, soft-tissue metastases develop after initial diagnosis of the primary internal malignancy and late in the course of the disease. In very rare cases, they may occur at the same time or before the primary cancer has been detected. In our cases, the soft-tissue metastases and the primary lung cancer were diagnosed at the same time.

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An Unusual Presentation of Lung Cancer

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1708702 ◽

2017 ◽

Vol 07 (01) ◽

pp. 078-079

Author(s):

Likith Rai ◽

Amol Dilip Amonkar

Keyword(s):

Lung Cancer ◽

Soft Tissue ◽

Abdominal Wall ◽

Soft Tissues ◽

Anterior Abdominal Wall ◽

Primary Lung Cancer ◽

Rare Condition ◽

Unknown Primary ◽

Soft Tissue Metastasis ◽

Internal Malignancy

AbstractSoft-tissue metastasis refers to the growth of cancer cells originating from internal cancer in the soft tissues. In most cases, soft-tissue metastasis develops after initial diagnosis of the primary internal malignancy and late in the course of the disease. In very rare cases, they may occur at the same time or before the primary cancer has been detected. In our case, the soft-tissue metastasis and the primary lung cancer were diagnosed at the same time. To the best of our knowledge soft tissue metastasis on the anterior abdominal wall of unknown primary lung cancer is an extremely rare condition and only a handful of cases have been reported till date .We report a case of unsuspected soft tissue metastasis on the anterior abdominal wall of an unknown primary lung cancer with relevant discussion on the same.

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Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization

Cell Death Discovery ◽

10.1038/s41420-021-00453-9 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Onsurang Wattanathamsan ◽

Rawikorn Thararattanobon ◽

Ratchanee Rodsiri ◽

Pithi Chanvorachote ◽

Chanida Vinayanuwattikun ◽

...

Keyword(s):

Lung Cancer ◽

Cell Death ◽

Cancer Cells ◽

Trichostatin A ◽

Primary Lung Cancer ◽

Lung Cancer Cells ◽

Cancer Resistance ◽

Apoptosis Resistance ◽

Tubulin Acetylation ◽

Cancer Aggressiveness

AbstractThe posttranslational modifications (PTMs) of microtubules have been reported to play an important role in cancer aggressiveness, including apoptosis resistance. In this study, we aimed to investigate the biological role of microtubule PTMs in the regulation of paclitaxel responsiveness. The acetylated tubulin (Ace-tub) level was strongly associated with paclitaxel sensitivity, as observed in patient-derived primary lung cancer cells and xenografted immunodeficient mice. We showed that paclitaxel-resistant H460 lung cancer cells, generated by a stepwise increase in paclitaxel, exhibited markedly increased tubulin acetylation and consequently acquired paclitaxel resistance. Upregulation of tubulin acetylation by overexpression of α-tubulin acetyltransferase 1 wild-type (αTAT1wt), an enzyme required for acetylation, or by treatment with trichostatin A (TSA), a histone deacetylase 6 (HDAC6) inhibitor, significantly attenuated paclitaxel-induced apoptosis. Investigation of the underlying mechanism revealed that the levels of antiapoptotic Mcl-1 appeared to increase in αTAT1wt-overexpressing and TSA-treated cells compared to control cells, whereas the levels of other antiapoptotic regulatory proteins were unchanged. On the other hand, decreased tubulin acetylation by αTAT1 RNA interference downregulated Mcl-1 expression in patient-derived primary lung cancer and paclitaxel-resistant lung cancer cells. A microtubule sedimentation assay demonstrated that Mcl-1 binds to microtubules preferentially at Ace-type, which prolongs the Mcl-1 half-life (T1/2). Furthermore, immunoprecipitation analysis revealed that polyubiquitination of Mcl-1 was extensively decreased in response to TSA treatment. These data indicate that tubulin acetylation enhances the resistance to paclitaxel-induced cell death by stabilizing Mcl-1 and protecting it from ubiquitin–proteasome-mediated degradation.

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Imaging features and prognostic value of 18F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study

BMC Cancer ◽

10.1186/s12885-020-07080-0 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Tingting Xu ◽

Xinyi Zhang ◽

Shumao Zhang ◽

Chunfeng Liu ◽

Wenhui Fu ◽

...

Keyword(s):

Lung Cancer ◽

Retrospective Study ◽

Soft Tissue ◽

Fdg Pet ◽

Prognostic Value ◽

Imaging Features ◽

Soft Tissue Metastasis ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer

Genes & Development ◽

10.1101/gad.304162.117 ◽

2017 ◽

Vol 31 (20) ◽

pp. 2099-2112 ◽

Cited By ~ 18

Author(s):

Shuan Rao ◽

Verena Sigl ◽

Reiner Alois Wimmer ◽

Maria Novatchkova ◽

Alexander Jais ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Cells ◽

Energy Homeostasis ◽

Primary Lung Cancer ◽

Lung Cancer Cells

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Abstract 5780: 3Dex-vivoassay platform using primary lung cancer cells in malignant pleural effusions as predictor for clinical outcome of personalized chemotherapy

10.1158/1538-7445.am2017-5780 ◽

2017 ◽

Author(s):

Cheng-guang Wu ◽

Francesca Chiovaro ◽

Tamara Tanos ◽

Alex Soltermann ◽

Sumeer Dhar

Keyword(s):

Lung Cancer ◽

Clinical Outcome ◽

Cancer Cells ◽

Primary Lung Cancer ◽

Lung Cancer Cells ◽

Pleural Effusions ◽

Malignant Pleural Effusions ◽

Personalized Chemotherapy

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Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study

PLoS ONE ◽

10.1371/journal.pone.0250531 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0250531

Author(s):

Li-Ju Ho ◽

Hung-Yi Yang ◽

Chi-Hsiang Chung ◽

Wei-Chin Chang ◽

Sung-Sen Yang ◽

...

Keyword(s):

Lung Cancer ◽

Cohort Study ◽

Large Scale ◽

Primary Lung Cancer ◽

Significant Risk ◽

Population Based ◽

Chronic Obstructive ◽

Primary Cancer ◽

Increased Risk ◽

Subsequent Risk

Background Tuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Thus, we evaluated the risk of secondary lung cancer in patients with or without tuberculosis (TB) using a nationwide population-based dataset. Methods In a cohort study of 1,936,512 individuals, we selected 6934 patients among patients with primary cancer and TB infection, based on the International Classification of Disease (ICD-p-CM) codes 010–011 from 2000 to 2015. The control cohort comprised 13,868 randomly selected, propensity-matched patients (by age, gender, and index date) without TB exposure. Using this adjusted date, a possible association between TB and the risk of developing secondary lung cancer was estimated using a Cox proportional hazards regression model. Results During the follow-up period, secondary lung cancer was diagnosed in 761 (10.97%) patients with TB and 1263 (9.11%) patients without TB. After adjusting for covariates, the risk of secondary lung cancer was 1.67 times greater among primary cancer in the cohort with TB than in the cohort without TB. Stratification revealed that every comorbidity (including diabetes, hypertension, cirrhosis, congestive heart failure, cardiovascular accident, chronic kidney disease, chronic obstructive pulmonary disease) significantly increased the risk of secondary lung cancer when comparing the TB cohort with the non-TB cohort. Moreover, the primary cancer types (including head and neck, colorectal cancer, soft tissue sarcoma, breast, kidney, and thyroid cancer) had a more significant risk of becoming secondary lung cancer. Conclusion A significant association exists between TB and the subsequent risk for metastasis among primary cancers and comorbidities. Therefore, TB patients should be evaluated for the subsequent risk of secondary lung cancer.

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Upper limb soft tissue metastasis in post mastectomy patient

International Surgery Journal ◽

10.18203/2349-2902.isj20184105 ◽

2018 ◽

Vol 5 (10) ◽

pp. 3433

Author(s):

Janani S. Reddy ◽

Surya Rao Rao Venkata Mahipathy ◽

Alagar Raja Durairaj ◽

Narayanamurthy Sundaramurthy

Keyword(s):

Soft Tissue ◽

Breast Carcinoma ◽

World Literature ◽

Soft Tissues ◽

Case Series ◽

Anterior Chest Wall ◽

Clinicopathological Characteristics ◽

Soft Tissue Metastasis ◽

Primary Malignancy ◽

Chest Wall Recurrence

Soft tissue metastasis from any primary malignancy is considered very rare and a breast carcinoma metastasizing to soft tissue is still rarer. To the best of our knowledge, carcinoma breast with soft tissue metastasis to upper extremity is very uncommon with only seven cases been reported in world literature till date and our case is the eighth such case in an elderly female, a known case of carcinoma left breast operated 7 years back. Only few case series and isolated cases reports have been published regarding any primary malignancy or breast carcinoma metastasizing to soft tissues. PET CT done showed features suggestive of left anterior chest wall recurrence with contralateral axillary lymphnodal metastasis and with soft tissue metastases in the left arm. We hereby present this case with review of literature to highlight its extreme rarity, unusual presentation, clinicopathological characteristics and its overall prognosis.

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Proximity proteomics identifies cancer cell membrane cis-molecular complex as a potential cancer target

10.1101/455501 ◽

2018 ◽

Author(s):

Norihiro Kotani ◽

Arisa Yamaguchi ◽

Tomoko Ohnishi ◽

Ryusuke Kuwahara ◽

Takanari Nakano ◽

...

Keyword(s):

Lung Cancer ◽

Cell Membrane ◽

Cancer Cells ◽

Cancer Cell ◽

Primary Lung Cancer ◽

Lung Squamous Cell Carcinoma ◽

Multiple Drug ◽

Cancer Treatments ◽

Lung Cancer Patients

ABSTRACTCancer-specific antigens expressed in the cell membrane have been used as targets for several molecular targeted strategies in recent years with remarkable success. To develop more effective cancer treatments, novel targets and strategies for targeted therapies are needed. Here, we examined the cancer cell membrane-resident “cis-bimolecular complex” as a possible cancer target (cis-bimolecular cancer target: BiCAT) using proximity proteomics, a technique that has attracted attention in recent years. BiCATs were detected using a previously developed method, termed the enzyme-mediated activation of radical source (EMARS), to label the components proximal to a given cell membrane molecule. EMARS analysis identified some BiCATs, such as close homolog of L1 (CHL1), fibroblast growth factor 3 (FGFR3) and α2 integrin, which are commonly expressed in mouse primary lung cancer cells and human lung squamous cell carcinoma cells. Analysis of cancer specimens from 55 lung cancer patients revealed that approximately half of patients were positive for these BiCATs. In vitro simulation of effective drug combinations used for multiple drug treatment strategy was performed using reagents targeted to BiCAT molecules. The combination treatment based on BiCAT information moderately suppressed cancer cell proliferation compared with single administration, suggesting that the information about BiCATs in cancer cells is profitable for the appropriate selection of the combination among molecular targeted reagents. Thus, BiCAT has the possibility to make a contribution to several molecular targeted strategies in future.

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