scholarly journals Innovative Interventional and Imaging Registries: Precision Medicine in Cerebrovascular Disorders

2015 ◽  
Vol 4 (1-2) ◽  
pp. 5-17 ◽  
Author(s):  
David S. Liebeskind
Keyword(s):  
Clinical Research ◽  
Precision Medicine ◽  
Cerebrovascular Disorders ◽  
Added Value ◽  
Carotid Disease ◽  
Educational Value ◽  
Randomized Controlled ◽  
Intracranial Atherosclerotic Disease ◽  
History Of

Background: Precision medicine in cerebrovascular disorders may be greatly advanced by the use of innovative interventional and imaging-intensive registries. Registries have remained subsidiary to randomized controlled trials, yet vast opportunities exist to leverage big data in stroke. Summary: This overview builds upon the rationale for innovative, imaging-intensive interventional registries as a pivotal step in realizing precision medicine for several cerebrovascular disorders. Such enhanced registries may serve as a model for expansion of our translational research pipeline to fully leverage the role of phase IV investigations. The scope and role of registries in precision medicine are considered, followed by a review on the history of stroke and interventional registries, data considerations, critiques or barriers to such initiatives, and the potential modernization of registry methods into efficient, searchable, imaging-intensive resources that simultaneously offer clinical, research and educational added value. Key Messages: Recent advances in technology, informatics and endovascular stroke therapies converge to provide an exceptional opportunity for registries to catapult further progress. There is now a tremendous opportunity to deploy registries in acute stroke, intracranial atherosclerotic disease and carotid disease where other clinical trials leave questions unanswered. Unlike prior registries, imaging-intensive and modernized methods may leverage current technological capabilities around the world to efficiently address key objectives and provide added clinical, research and educational value.

Client, Therapist, and Treatment Variables

2016 ◽  
Author(s):  
Satoko Kimpara ◽  
Hannah Holt ◽  
Julianne Alsante ◽  
Larry E. Beutler
Keyword(s):  
Psychotherapy Research ◽  
Therapeutic Change ◽  
Research And Practice ◽  
Randomized Controlled ◽  
The Past ◽  
History Of Psychotherapy ◽  
History Of ◽  
Changing Practices ◽  
Health Field

Consideration of the client–therapist match as a contributor, predictor, and optimizer of therapeutic change is not new in the behavioral health field. Indeed, it has evolved from two interactive and co-acting histories: (a) changing practices in psychotherapy research and (b) corresponding changes in the way that clinicians have viewed the role of theory in their practices. In the past three and a half decades, research emphasis has changed to increasingly reflect the roles played by client diagnoses, brands of interventions, and the theories that underlie their use. This chapter reviews the history of psychotherapy research and randomized controlled trials (RCTs). It then describes a contemporary view of RCT design that attempts to incorporate contemporary research developments that are bringing together research and practice.

scholarly journals Elder law and its subject: the contextualised ageing individual

2019 ◽  
pp. 1-20
Author(s):  
Ann Numhauser-Henning
Keyword(s):  
Legal Status ◽  
Age Discrimination ◽  
Added Value ◽  
Labour Law ◽  
Social Construct ◽  
Ageing Worker ◽  
Elder Law ◽  
History Of ◽  
The Subject

AbstractElder law is often approached in terms of a ‘body’ of law. In this article, I argue for a contextualised and externalised perspective on the ageing individual as the subject of elder law. Elder law relates to the implications of law as an institutionalisation of society seen through the lens of older persons. The aged subject is a contested and differentiated social construct to be studied in relation to an externalised social ‘problem’ and properly contextualised. Whereas the ageing individual in the context of labour law and anti-discrimination regulation turns out to be remarkably young, the specific history of LGBT persons in society comes to the fore in cases where age intersects with a ground such as sexual orientation. The ‘ageing’ worker must thus be understood in relation to work as the dominant distributive order in society, and in relation to institutions and developments associated with work. Due to the role of age as a traditional social stratifier, the prohibition against age discrimination has been given a weaker format than have prohibitions against other kinds of discrimination, and the ban on ageism has failed to achieve a clear legal status. Deficiencies in the measures taken against age discrimination are also evident in their incapacity to address situations where age intersects with other grounds, resulting in a compartmentalised application and interpretation of discrimination bans, leaving vulnerable sub-groups without protection. In sum, elder law is very much a field in process and – although arguing for the added value of a contextualised perspective – it may for the time being suffice to say that ‘elder law is what elder law researchers do’.

scholarly journals The Evolving Paradigm in the Management of Intracranial Atherosclerotic Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Ali K. Ozturk ◽  
Ketan R. Bulsara
Keyword(s):  
English Literature ◽  
Treatment Options ◽  
Atherosclerotic Disease ◽  
Endovascular Techniques ◽  
Intracranial Atherosclerotic Disease ◽  
History Of ◽  
Recurrent Strokes ◽  
Rigorous Treatment ◽  
Significant Health

Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke worldwide and represents a significant health problem. The pathogenesis and natural history of ICAD are poorly understood, and rigorous treatment paradigms do not exist as they do for extracranial atherosclerosis. Currently, the best treatment for ICAD remains aspirin therapy, but many patients who are placed on aspirin continue to experience recurrent strokes. As microsurgical and endovascular techniques continue to evolve, the role of extracranial to intracranial bypass operations and stenting are increasingly being reconsidered. We performed a PubMed review of the English literature with a particular focus on treatment options for ICAD and present evidence-based data for the role of surgery and stenting in ICAD against medical therapy alone.

The Role of Management Games and Simulations in Education and Research

1990 ◽  
Vol 16 (2) ◽  
pp. 307-336 ◽  
Author(s):  
Bernard Keys ◽  
Joseph Wolfe
Keyword(s):  
Experiential Learning ◽  
Review Of The Literature ◽  
Educational Value ◽  
Future Developments ◽  
Current State ◽  
History Of ◽  
Management Games ◽  
Games And Simulations

This review takes a broad look at the management gaming movement and summarizes how the field has evolved to its current state. The article defines terms and parametersfor the management gamingfield and briefly reviews the history of business gaming. Several models of experiential learning applicable to gaming are explained. Included are studies on the educational value of management games and a review of the literature that deals with management games and simulations as research laboratories. Some of the field's trends and future developments are also projected.

scholarly journals Developing and Sustaining Sustainability-Related Academic Programming: Observations of Emerging Practices

2018 ◽  
Vol 4 (1) ◽  
pp. 27
Author(s):  
Haris Alibašić ◽  
William Crawley
Keyword(s):  
Geographic Area ◽  
Geographic Region ◽  
Academic Programs ◽  
Added Value ◽  
Universities And Colleges ◽  
Academic Level ◽  
Grand Rapids ◽  
History Of ◽  
Appointed Officials

<p>The purpose of this paper is to provide an overview and summary of selected sustainability-related academic programs and certificates delivered by universities and colleges located in the same geographic area (Grand Rapids, Michigan, U.S.).   Holistic and practical dimensions of creating and sustaining educational programs are evaluated, and emerging outcomes from universities with a history of prosperous sustainability studies programs are provided as models of applicability.  The possible effects of the level of formalizing sustainability in higher education and different aspects of academic-level sustainability programming at universities and colleges in a single geographic region were studied in a comparative perspective.  The study focused on the role of internal and external leadership, political and appointed officials, networking factors of various stakeholders, demand for sustainability in education, and the resources commitment in staffing.  We evaluated each element in the context of sustainability in education and longevity and self-support.  These findings and the concept of successfully developing and sustaining sustainability‑related academic programs in Grand Rapids (MI) are examined within a broad and holistic context encompassing educational, programmatic, socioeconomic, organizational, and leadership dimensions.  While further research is warranted, predictably, all elements performed well and added value to the conceptual framework of developing and sustaining sustainability-related academic programming with potential lessons applicable to the programmatic approaches to education domestically and abroad.</p>

scholarly journals Geoscience international: the role of scientific unions

2016 ◽  
Vol 7 (2) ◽  
pp. 103-123 ◽  
Author(s):  
Alik Ismail-Zadeh
Keyword(s):  
Future Development ◽  
Added Value ◽  
International Union ◽  
Building Capacity ◽  
Professional Societies ◽  
Scientific Disciplines ◽  
History Of ◽  
Space Sciences ◽  
Scientific Standards

Abstract. International geoscientific unions (geounions) have been coordinating and promoting international efforts in Earth and space sciences since the beginning of the 20th century. Thousands of scientists from many nations and specific scientific disciplines have developed ways of cooperation through international unions and learned how to work together to promote basic geosciences. The unions have been initiating, developing, and implementing international cooperative programmes, setting scientific standards, developing research tools, educating and building capacity, and contributing to science for policy. This paper analyses the role of geounions in and their added value to the promotion of geoscience internationally in the arena of the existing and emerging professional societies of geoscientists. The history of the geounions and the development of international cooperation in geosciences are reviewed in the paper in the context of scientific and political changes over the last century. History is considered here to be a key element in understanding and shaping the future of geounions. Scientific and organisational aspects of their activities, including cooperation with international and intergovernmental institutions, are analysed using the example of the International Union of Geodesy and Geophysics (IUGG). The geounions' activities are compared to those of professional societies. Future development of scientific unions and their role in the changing global landscape of geosciences are discussed.

Elaborating the role of reflection and individual differences in the study of folk-economic beliefs

2018 ◽  
Vol 41 ◽  
Author(s):  
Kevin Arceneaux
Keyword(s):  
Decision Making ◽  
Individual Differences ◽  
Cognitive Processes ◽  
Evolutionary History ◽  
Behavioral Responses ◽  
History Of ◽  
Economic Beliefs

AbstractIntuitions guide decision-making, and looking to the evolutionary history of humans illuminates why some behavioral responses are more intuitive than others. Yet a place remains for cognitive processes to second-guess intuitive responses – that is, to be reflective – and individual differences abound in automatic, intuitive processing as well.

The role of a family history of adenocarcinomas in patients with Barrett oesophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
P TSIBOURIS ◽  
M HENDRICKSE ◽  
P ISAACS
Keyword(s):  
Family History ◽  
History Of ◽  
Barrett Oesophagus

Protective Factors and Suicidality in Members of Arab Kindred

Crisis ◽  
2012 ◽  
Vol 33 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Sami Hamdan ◽  
Nadine Melhem ◽  
Israel Orbach ◽  
Ilana Farbstein ◽  
Mohammad El-Haib ◽  
...  
Keyword(s):  
Risk Factors ◽  
Protective Factors ◽  
Suicidal Behavior ◽  
Composite International Diagnostic Interview ◽  
Diagnostic Interview ◽  
Suicidal Risk ◽  
Arab Population ◽  
Psychiatric Interview ◽  
History Of

Background: Relatively little is known about the role of protective factors in an Arab population in the presence of suicidal risk factors. Aims: To examine the role of protective factors in a subsample of in large Arab Kindred participants in the presence of suicidal risk factors. Methods: We assessed protective and risk factors in a sample of 64 participants (16 suicidal and 48 nonsuicidal) between 15 and 55 years of age, using a comprehensive structured psychiatric interview, the Composite International Diagnostic Interview (CIDI), self-reported depression, anxiety, hopelessness, impulsivity, hostility, and suicidal behavior in first-degree and second-relatives. We also used the Religiosity Questionnaire and suicide attitude (SUIATT) and multidimensional perceived support scale. Results: Suicidal as opposed to nonsuicidal participants were more likely to have a lifetime history of major depressive disorder (MDD) (68.8% vs. 22.9% χ2 = 11.17, p = .001), an anxiety disorder (87.5% vs. 22.9, χ2 = 21.02, p < .001), or posttraumatic stress disorder (PTSD) (25% vs. 0.0%, Fisher’s, p = .003). Individuals who are otherwise at high risk for suicidality have a much lower risk when they experience higher perceived social support (3.31 ± 1.36 vs. 4.96 ± 1.40, t = 4.10, df = 62, p < .001), and they have the view that suicide is somehow unacceptable (1.83 ± .10 vs. 1.89 ± .07, t = 2.76, df = 60, p = .008). Conclusions: Taken together with other studies, these data suggest that the augmentation of protective factors could play a very important role in the prevention of incidental and recurrent suicidal behavior in Arab populations, where suicidal behavior in increasing rapidly.

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