scholarly journals An Unusual Case of Extranodal Rosai-Dorfman Disease Manifesting as an Epibulbar Mass

2015 ◽  
Vol 6 (3) ◽  
pp. 351-355 ◽  
Author(s):  
Hang M. Tran ◽  
Sahmon Chinichian ◽  
Kris Storkersen ◽  
Keith Tokuhara
Keyword(s):  
Unusual Case ◽  
Clinical Course ◽  
Excisional Biopsy ◽  
Incisional Biopsy ◽  
Black Race ◽  
Subcutaneous Nodules ◽  
The Past ◽  
Rosai Dorfman Disease ◽  
Histopathologic Evaluation

Purpose: To report an unusual presentation of a 48-year-old man with a salmon-colored epibulbar mass, whose pathology was consistent with extranodal Rosai-Dorfman disease (RDD). Method: We conducted a retrospective and interventional case report. Results: A 48-year-old white man presented with progressive left eye irritation, redness, and multiple large subcutaneous nodules on his arms and torso over the past year. He did not have any lymphadenopathy, lymphocytosis, or fever. Visual acuity and intraocular pressures were normal in both eyes. He had mild vertical diplopia on downward gaze. Slit lamp examination revealed a non-tender salmon-colored epibulbar mass of 1.0 × 1.2 cm. Incisional biopsy was performed. Histopathologic evaluation revealed emperipolesis, with positive CD68, positive S100, and negative CD1a staining. These findings were consistent with extranodal RDD. At the 24-month follow-up, there were no signs of recurrence, and his diplopia resolved. Conclusions: This case of RDD is rare because of the concurrent epibulbar mass with subcutaneous nodules on the torso and arms. Extranodal RDD with epibulbar mass involvement tends to be unilateral, occurring mainly in males, and evenly among people of white and black race. An epibulbar mass of any color should raise concern for systemic lymphoma and RDD. The clinical course for extranodal RDD is typically benign. Excisional biopsy is often done for diagnosis and treatment. Recurrence of the unilateral epibulbar mass after biopsy is rare, but common with bilateral epibulbar masses.

Poison Centers: An Overview of the Past, Present, and Future

2000 ◽  
Vol 13 (1) ◽  
pp. 14-26
Author(s):  
Rose Ann Gould Soloway
Keyword(s):  
Health Care Providers ◽  
Clinical Course ◽  
Future Research ◽  
Care Providers ◽  
Need For Treatment ◽  
The Past ◽  
Poison Centers ◽  
Poison Prevention

Poison centers are the source of expert treatment advice for all types of poison exposures. For this reason, health care providers and consumers are encouraged to call poison centers immediately in case of a possible poison exposure. This allows for rapid evaluation of potential toxicity, determination of the need for treatment, follow-up to the conclusion of a patient's clinical course, and data collection which can be useful in identifying unsuspected poisons, directing future research, and identifying subjects for poison prevention efforts.

Pigmented Villonodular Synovitis of the Talus in a Child

Foot & Ankle ◽  
1988 ◽  
Vol 9 (3) ◽  
pp. 139-142 ◽  
Author(s):  
Maurice K. Aghasi ◽  
Dror Robinson ◽  
Renata M. Reif ◽  
Nachum Halperin
Keyword(s):  
Unusual Case ◽  
Excisional Biopsy ◽  
Pigmented Villonodular Synovitis ◽  
Abrupt Onset ◽  
Joint Effusion ◽  
Villonodular Synovitis ◽  
Tissue Mass ◽  
Localized Pigmented Villonodular Synovitis ◽  
Pigmented Villonodular

An unusual case of localized pigmented villonodular synovitis of the ankle joint in a 3-year-old boy is described. The child was brought to the hospital because of abrupt onset of pain and joint effusion. A soft tissue mass eroding the talar dome was seen in roentgenograms. Exact diagnosis was established by excisional biopsy. Curettage of the lesion resulted in healing without recurrence at 10-year follow-up examination.

scholarly journals Oral Verrucous Carcinoma: A Study of 12 Cases

2010 ◽  
Vol 04 (02) ◽  
pp. 202-207 ◽  
Author(s):  
Alper Alkan ◽  
Emel Bulut ◽  
Omer Gunhan ◽  
Bora Ozden
Keyword(s):  
Verrucous Carcinoma ◽  
Precancerous Lesion ◽  
Excisional Biopsy ◽  
Follow Up Study ◽  
Floor Of The Mouth ◽  
The Past ◽  
Verrucous Hyperplasia ◽  
Retromolar Trigone ◽  
Diagnostic Difficulties

Objectives: The purpose of this clinical study was to identify a clinical and histopathological relationship between verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma.Methods: We evaluated 12 patients who had developed oral verrucous carcinoma in the past 10 years in a follow-up study. In this study, the diagnostic criteria included clinical and histopathological features of the lesions. Each lesion was examined by a single oral pathologist.Results: All the patients were diagnosed with verrucous carcinoma following excisional biopsy. One patient was diagnosed with verrucous hyperplasia and another with verrucous keratosis in their initial histological findings. Mandibular, posterior alveolar crest, and retromolar trigone were the most affected sites (41.6%), followed by the buccal mucosa (16.6%), the palate (16.6%), the floor of the mouth (16.6%), and the lip (8.3%). No patients had evidence of recurrence after treatment.Conclusions: Verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma may not be distinguished clinically or may coexist, resulting in diagnostic difficulties. It should be kept in mind that verrucous hyperplasia may also develop from leukoplakic lesions, and it may transform into verrucous carcinoma or squamous-cell carcinoma, acting as a potential precancerous lesion. (Eur J Dent 2010;4:202-207)

Colon Adenocarcinoma Metastasis Through Ileocolic Fistula to Small Bowel in the Setting of Crohn’s Disease

2021 ◽  
Author(s):  
Michael Tseng ◽  
Taseen Ahmed Syed ◽  
Patricija Zot ◽  
Ravi Vachhani
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Unusual Case ◽  
Colon Adenocarcinoma ◽  
Fistula Tract ◽  
Gastrointestinal Fistula ◽  
The Past ◽  
Pathology Reports

Abstract Purpose: Patients with Crohn’s disease (CD) are at higher risk of developing colorectal cancer (CRC) and gastrointestinal fistula. We report an unusual case of sigmoid colon adenocarcinoma in a CD patient that metastasized to the small bowel through an ileocolic fistula tract.Methods: This case report was written after patient was seen in the clinic and reviewing overall hospitalization including clinically relevant data including imaging and pathology reports associated to our focus and presentation. Prior cases of metastatic CRC via fistula tract were reviewed and compared as well. Results: We described an unprecedented case of a sigmoid adenocarcinoma metastasized to ileum via ileal-sigmoid fistula. Patient received surgical treatment and systemic chemotherapy and currently in remission. Conclusion: CD is associated with a higher risk of fistula development. Few cases in the past described CRC metastasized within the gastrointestinal tract through a fistula. Intriguingly in our case, sigmoid adenocarcinoma developed and further metastasized to the ileum via the ileal-sigmoid fistula in the setting of CD. In addition to presenting a unique pathological phenomenon in these patients, this case raises awareness of the importance of regular follow-up and early initiation of IBD therapies.

Subungual Exostosis of the Great Toe

2011 ◽  
Vol 4 (6) ◽  
pp. 376-378 ◽  
Author(s):  
Roop Singh ◽  
Mantu Jain ◽  
Rakesh Goel ◽  
Ramchander Siwach ◽  
Rajneesh Kalra ◽  
...  
Keyword(s):  
Benign Lesion ◽  
Plain Radiograph ◽  
Excisional Biopsy ◽  
Great Toe ◽  
Therapeutic Level ◽  
Level Of Evidence ◽  
The Past ◽  
Calcified Lesion ◽  
Nail Removal

Subungual exostosis is an acquired, benign, and solitary bone tumor of the distal phalanx occurring beneath or adjacent to nail. A 18-year-old man presented with a lump, ulceration, and pain on his right big toe. This complaint was present for the past 2 years. Initially, lump and pain were present, and since the past 6 months ulceration and superadded infection occurred. Plain radiograph showed a calcified lesion that was continuous with the phalangeal cortical surface in the distal dorsal aspect of the big toe. Excisional biopsy with complete nail removal and reconstruction of the tip of the toe were done. Histopathology confirmed the diagnosis of subungual exostosis. Clinical or radiological recurrence was not observed after 26 months of follow-up. The case is reported to present the tumor overview and to highlight that the diagnosis of this benign lesion should not be missed. Clinical and radiological features allow early diagnosis and treatment thus preventing the lesion to progress to the stage of onycholysis. Level of Evidence: Therapeutic, Level IV

scholarly journals Long-Lasting Follow-Up with Low-Dose Steroid in an 18-Year-Old Male with Rosai–Dorfman Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Volkan Karakuş ◽  
Yelda Morgül Dere ◽  
Dilek Ersil Soysal
Keyword(s):  
Lymph Nodes ◽  
Low Dose ◽  
Plasma Cells ◽  
Oral Prednisolone ◽  
Excisional Biopsy ◽  
Steroid Treatment ◽  
Unknown Etiology ◽  
Rosai Dorfman Disease ◽  
S 100

Rosai–Dorfman disease (RDD) is a rare and benign pathology of sinus histiocytosis of unknown etiology. Lymphadenopathy is the predominant clinical manifestation, but diverse organs can also be affected. Histological features involve S-100+ histiocytes with characteristic nuclear features within the enlarged sinusoids of the lymph nodes. The clinical course is unpredictable, but is often benign with spontaneous resolution of disease in most patients. We report a patient with bilateral massive enlargement of cervical, axillary, and inguinal lymph nodes, moderately enlarged spleen, and a weight loss of 15 kg. Excisional biopsy from the cervical lymph node showed that the dilated sinusoids were infiltrated by lymphocytes, plasma cells, and large histiocytes with CD 68 and S-100 protein positive. Due to the slow progression of the disease, oral prednisolone with a body weight of 1 mg/kg was started in March 2016. The steroid dosage has been adjusted many times during the clinical follow-up. After 33 months, steroid treatment resulted in partial shrinkage of lymph nodes, the spleen returned to its normal size, and the patient gained weight. After 38 months of follow-up, no systemic symptoms, sign, or extranodal involvement were detected, and the patient continued with low-dose steroid treatment.

scholarly journals Rosai-Dorfman-Destombes disease: isolated intracranial without nodal involvement presentation. Illustrative case

2021 ◽  
Vol 1 (24) ◽  
Author(s):  
César Chong ◽  
Xavier Wong-Achi ◽  
Cinthya Apolo
Keyword(s):  
Clinical Course ◽  
Excisional Biopsy ◽  
Therapeutic Management ◽  
Treatment Modalities ◽  
Pathology Report ◽  
Illustrative Case ◽  
Resonance Imaging ◽  
History Of ◽  
The Brain

BACKGROUND Rosai-Dorfman-Destombes disease is a rare and heterogeneous entity that has been associated with autoimmune, hereditary, and malignant diseases. There is controversy about its etiopathogenesis, clinical course, and therapeutic management. OBSERVATIONS The authors report a case of a 61-year-old man with a history of progressive headache without any other symptoms. Magnetic resonance imaging of the brain revealed multiple irregular lesions with an initial diagnostic impression of meningiomatosis. An excisional biopsy was performed, and the pathology report stated the finding was Rosai-Dorfman-Destombes disease. LESSONS The uniqueness of this case is its rarity. The isolated intracranial location presents many diagnostic and therapeutic challenges, with radiological and clinical characteristics similar to those of other central nervous system tumors. There is currently no clear evidence of the pathogenesis and therapeutic management of this condition. Follow-up of these patients will help elucidate the natural history of this condition and the benefits of various treatment modalities.

Risk profile associated with convexity meningioma resection in the modern neurosurgical era

2010 ◽  
Vol 112 (5) ◽  
pp. 913-919 ◽  
Author(s):  
Nader Sanai ◽  
Michael E. Sughrue ◽  
Gopal Shangari ◽  
Kenny Chung ◽  
Mitchel S. Berger ◽  
...  
Keyword(s):  
Clinical Course ◽  
Intraoperative Complications ◽  
Risk Profile ◽  
Who Grade ◽  
Vein Thrombosis ◽  
The Past ◽  
Simpson Grade ◽  
Csf Leakage ◽  
Deep Vein

Object Although meningiomas are commonly found along the supratentorial convexity, the risk profile associated with this subset of lesions in the modern neurosurgical era is unknown. Methods The authors retrospectively reviewed the clinical course of patients with supratentorial convexity meningiomas treated during the past 10 years. All patients had undergone MR imaging within 72 hours after surgery and at least 1 year of clinical follow-up. Patients with multiple meningiomas, hemangiopericytomas, malignant meningiomas, or tumor-prone syndromes were excluded from analysis. Results Between 1997 and 2007, 141 consecutive patients (median age 48 years, range 18–95 years) underwent resection of a supratentorial convexity meningioma. The most common signs or symptoms at presentation were headache (48%), seizures (34%), and weakness (21%). The mean tumor volume was 146.3 cm3 (range 1–512 cm3). There were no intraoperative complications or deaths. Medical or neurosurgical morbidity was noted in the postoperative course of 14 patients, equating to a 10% overall complication rate. Postoperative surgical complications included hematoma requiring evacuation, CSF leakage, and operative site infection. Medical complications included pulmonary embolus and deep vein thrombosis requiring treatment. A Simpson Grade 0 or 1 resection was achieved in 122 patients (87%). One hundred six tumors (75%) were WHO Grade I, whereas 35 (25%) were WHO Grade II. The median clinical follow-up was 2.9 years (range 1–10 years), and the median radiographic follow-up was 3.7 years (range 1–10 years). Six patients (4%) had radiographic evidence of tumor recurrence, with 3 (2%) undergoing repeat resection. Conclusions With the conservative recommendations for surgery for asymptomatic meningiomas and the advent of radiosurgery during the past 10 years, microsurgically treated convexity meningiomas are now typically large in size. Nevertheless, the patient's clinical course following microsurgical removal of these lesions is expected to be uncomplicated. The authors' findings provide a defined risk profile associated with the resection of supratentorial convexity meningiomas in the modern neurosurgical era.

scholarly journals Pleomorphic lipoma of the bulbar conjunctiva

2018 ◽  
Vol 11 (1) ◽  
pp. e226548
Author(s):  
Emily Li ◽  
Jonathan Silbert ◽  
John Sinard
Keyword(s):  
Excisional Biopsy ◽  
Bulbar Conjunctiva ◽  
Histopathological Analysis ◽  
The Third ◽  
The Past ◽  
Pleomorphic Lipoma ◽  
The Right ◽  
Rare Diagnosis

A 55-year-old woman presented with a painless, pink mass of the right eye bulbar conjunctiva that had been gradually increasing in size for the past 10 years. Excisional biopsy with histopathological analysis revealed a rare diagnosis of pleomorphic lipoma. There was no recurrence at last follow-up evaluation 6 months postoperatively. To the best of our knowledge, this represents the third case of pleomorphic lipoma of the bulbar conjunctiva reported to date.

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