Metachronous and Synchronous Occurrence of 5 Primary Malignancies in a Female Patient between 1997 and 2013: A Case Report with Germline and Somatic Genetic Analysis

The number of patients with multiple primary malignancies has been increasing steadily in recent years. In the present study, we describe a unique case of an 81-year-old woman with 5 metachronous and synchronous primary malignant neoplasms. The patient was first diagnosed with an endometrium adenocarcinoma in 1997 and a colon adenocarcinoma in 2002. Eleven years after her colon surgery, in 2013, the patient presented with 3 other primary malignancies within a 4-month time span: an invasive malignant melanoma on the lower leg, an invasive mucinous breast carcinoma in the right breast, and a pleomorphic spindle cell sarcoma on the left upper arm. Subsequent routine medical checkups in 2013–2017 revealed no metastases of the primary malignancies. The patient mentioned a familial aggregation of malignant tumors, including 2 sisters with breast cancer and a brother with lung cancer. Interestingly, next-generation sequencing analysis of the patient’s blood sample detected no mutations in the BRCA1, BRCA2, TP53, PTEN, CDH1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, STK11, BMPR1A, SMAD4, PTEN, POLE, POLD1, GREM1, and GALNT12 genes. Therefore, whole genome sequencing is warranted to identify cancer-related genetic alterations in this patient with quintuple primary malignancies.

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Inherited Thyroid Tumors With Oncocytic Change

Frontiers in Endocrinology ◽

10.3389/fendo.2021.691979 ◽

2021 ◽

Vol 12 ◽

Author(s):

Marcelo Correia ◽

Ana Rita Lima ◽

Rui Batista ◽

Valdemar Máximo ◽

Manuel Sobrinho-Simões

Keyword(s):

Malignant Tumors ◽

Familial Aggregation ◽

Genetic Alterations ◽

Incomplete Penetrance ◽

Thyroid Tumors ◽

Medullary Thyroid ◽

Additional Layer ◽

Malignant Lesions ◽

Pathological Behavior ◽

Familial Context

Familial non-medullary thyroid carcinoma (FNMTC) corresponds to 5-10% of all follicular cell-derived carcinoma (FCDTC). Oncocytic thyroid tumors have an increased incidence in the familial context in comparison with sporadic FCDTC, encompassing benign and malignant tumors in the same family presenting with some extent of cell oxyphilia. This has triggered the interest of our and other groups to clarify the oncocytic change, looking for genetic markers that could explain the emergence of this phenotype in thyroid benign and malignant lesions, focusing on familial aggregation. Despite some advances regarding the identification of the gene associated with retinoic and interferon-induced mortality 19 (GRIM-19), as one of the key candidate genes affected in the “Tumor with Cell Oxyphilia” (TCO) locus, most of the mutations follow a pattern of “private mutations”, almost exclusive to one family. Moreover, no causative genetic alterations were identified so far in most families. The incomplete penetrance of the disease, the diverse benign and malignant phenotypes in the affected familial members and the variable syndromic associations create an additional layer of complexity for studying the genetic alterations in oncocytic tumors. In the present review, we summarized the available evidence supporting genomic-based mechanisms for the oncocytic change, particularly in the context of FNMTC. We have also addressed the challenges and gaps in the aforementioned mechanisms, as well as molecular clues that can explain, at least partially, the phenotype of oncocytic tumors and the respective clinico-pathological behavior. Finally, we pointed to areas of further investigation in the field of oncocytic (F)NMTC with translational potential in terms of therapy.

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Germline mutations in MSH2 and ATM gene in patients with GIST (gastrointestinal stromal tumor) and second epitelial tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e23520 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e23520-e23520

Author(s):

Silvia Gasperoni ◽

Laura Papi ◽

Francesca Castiglione ◽

Francesca Gensini ◽

Roberta Sestini ◽

...

Keyword(s):

Genetic Counseling ◽

Lynch Syndrome ◽

Colon Adenocarcinoma ◽

Germline Mutations ◽

Genetic Alterations ◽

Second Primary ◽

Sequencing Analysis ◽

Msh2 Gene ◽

Primary Tumors ◽

Therapeutic Implications

e23520 Background: In adult GISTs are frequently sporadic, while rarely GISTs are linked to Carney Triad and Carney-Stratakis Syndrome and NF1. GISTs with second primary tumors are reported in 4-33% of patients in literature and genetic counseling is suggested to explore an underlying germline mutations pathway. Methods: In our Academic Hospital Centre (EURACAN member) in Florence, Italy, we are following patients with GIST and multiple primary tumors with genetic counseling (72 GISTs with second tumors/185 patients with GIST) and germline analysis of the following genetic panel is performed as clinically indicated: BRCA1, BRCA2, MUTYH, MLH1, MSH2, MSH6, CDH1, ATM, TP53, PTEN, CHECK2, PALB2, BARD1, BRIP1, BLM, RAD51C, RAD51D, XRCC2, PMS2, MRE11A, RAD50, NBN, FAM175A, EPKAM, TSK1, MEN1 by sequencing analysis with Illumina MiSeq by kit multiplicom BRCA Hereditary cancer Mastr plus, and bioinformatic analysis by software SOPHIADDM (Sophia genetics) for point genetic alterations of BRCA1 NM_007294.3, BRCA2 NM_000059.3, MUTYH NM_000249, MSH2 NM_000251, MSH6 NM_000179, CDH1 NM_00444360, ATM NM_000051, TP53 NM_000546, PTEN NM_000314, CHEK2 NM_001005735, PALB2 NM_024675, BARD1 NM_000465, BRIP1 NM_032043, BLM NM_000057, RAD51C NM_002876, RAD51D NM_001142571, XRCC2 NM_005431, PMS2 NM_000535, MRE11A NM_005590, RAD50 NM_006732, NBN NM_002485, FAM175A NM_139076, EPCAM NM_002354, STK1 NM_000455, MEN1 NM_000244 and MLPA (Multiplex Ligation-dependent Probe Amplification) test analysis for patients with kit P087-BRCA1,P045-BRCA2(CHEK2, P248-MLH1-MSH2, P003-MLH1/MSH2, P072-MSH6-MUTYH (MRC-Holland). Results: In 3 patients germline mutations have been observed: 1 patient showed the c.1192dupG, p.(Ala398Glyfs*19) pathogenic mutation in exon 7 of MSH2 gene, confirmed by Sanger Sequencing, 1 patient showed c.565-?_1130+?del mutation consisting in heterozygous 3-4-5-6 exons deletion of MSH2 gene, confirmed by MLPA analysis, and in 1 patient the following ATM alteration has been identified in heterozygosis: ATM c.5319+2T > C, p.(?). In the 2 patients with Lynch syndrome with colon adenocarcinoma (MSI-H), synchronous GISTs (1 patient quadruple WT and 1 patient kit ex 11 mutated ) were diagnosed; in the patient with ATM mutation, the diagnosis of GIST (kit ex 11 mutated) occurred after prostate adenocarcinoma and before colon adenocarcinoma (MSI-H). Conclusions: Our analysis suggests that GIST diagnosis could be tumor-related to multiple hereditary tumor syndromes as Lynch Syndrome and Ataxia-Teleangectasia syndrome, the latter being linked in eterozygosis to tumor susceptibility to breast in female. This report represents a high value in terms of genetic counseling for relatives and in terms of therapeutic implications for the patients.

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Malignant tumors of the pharynx: etiological factors and epidemiological indicators in Ukraine

OTORHINOLARYNGOLOGY 2-3(2) 2019 - OTORHINOLARYNGOLOGY ◽

10.37219/2528-8253-2019-4-58 ◽

2020 ◽

pp. 58-66

Author(s):

Erwin V. Lukach ◽

Marina B. Sambur ◽

Zoya P. Fedorenko ◽

Yuri O. Serezhko

Keyword(s):

Genetic Factors ◽

Malignant Tumors ◽

Relative Number ◽

Malignant Neoplasms ◽

Pharyngeal Cancer ◽

Papilloma Virus ◽

Etiological Factors ◽

Number Of Patients ◽

World Standard

The authors analyze the epidemiological indicators of morbidity, mortality, age structure, relative number of patients detecting during prophylactic examination and contingent of patients with malignant neoplasms (MN) of the throat in Ukraine and regions according to the Bulletin of National Cancer Registry of Ukraine in 2014-2018. The highest incidence rate per 100,000 population in the regions of Ukraine was found in Transcarpathian (both sexes – 9.6; males – 17.9; females – 2.0), Kirovograd (8.8; 16.9; 1.9) and Khmelnitsky (7.7; 15.9; 0.7) regions. Very low rates of detection of patients with MN of the throat as a whole in Ukraine were observed at the prophylactic examinations: in 2015 – 10.0%, in 2016 – 11.0%. Annually in Ukraine, about 44.0% of patients with visually detectable cancer of the pharynx die within 1 year of diagnosis The mortality rate of patients with MN of the throat in 2017 per 100 thousand population of Ukraine is twice higher (4.5) than the world standard (2.0). The etiological factors that cause cancer and the role of human papilloma virus (HPV) of high oncogenic risk (16; 18 and other types) in the carcinogenesis of squamous cell carcinoma of the throat are considered. The data on genetic factors, features of gene mutation, clinical course, treatment and prognosis in patients with HPV-associated and HPV-negative malignancies of the pharynx are presented. For the prevention of pharyngeal cancer in Ukraine, the feasibility of immunization of children and young women aged 9-25 years with vaccines against HPV "Cervarix" and "Gardasil" is discussed. The authors have proposed suggestions for the early detection and improvement of the effectiveness of treatment of patients with pharyngeal throat.

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Contents of HSP60 and HSP70 in tumor tissues of patients with bladder cancer

Bulletin of Taras Shevchenko National University of Kyiv Series Biology ◽

10.17721/1728_2748.2019.77.79-82 ◽

2019 ◽

Vol 77 (1) ◽

pp. 79-82

Author(s):

V. Dmytryk ◽

Y. Zinkova ◽

O. Savchuk

Keyword(s):

Bladder Cancer ◽

Cell Differentiation ◽

Malignant Tumors ◽

Tnm Classification ◽

Developed Countries ◽

Prognostic Indicators ◽

Malignant Neoplasms ◽

Treatment And Prevention ◽

Number Of Patients ◽

High Level

Bladder cancer (BC) continues to be a disease with a high mortality rate. BC is the 9th most frequently diagnosed cancer in the world. According to statistics, the largest number of patients with BC patients in developed countries. About 75 % of patients are men. Various molecules have been identified as potential prognostic indicators and/or targets for a given disease. However, the search for targets for the treatment and prevention of BC remains relevant. Recently, studies have been conducted on the participation of heat shock proteins (HSPs) in malignant neoplasms. In which high expression of HSPs is associated with the protection of transformed cells and the blocking of apoptosis. Data on overexpression of HSPs have been published for a number of oncological diseases, including breast, cervical, colon, lung and prostate cancers. Recent studies have closely linked the level of HSPs expression with the subsequent prognosis of the disease. The aim of the work was to identify the dynamics of HSP70 and HSP60 in tumors and walls of a healthy bladder in BC patients, depending on the stage of cancer with the TNM classification, and also on the degree of cell differentiation. In our study, an increase in HSPs content in homogenates of tumors was found in comparison with samples of healthy bladder walls, that is, an increase in HSPs content may be associated with BC. An increase in the content HSP60 and HSP70 was noted, depending on the BC stage, as well as on the degree of cell differentiation. A high level of HSP expression can ensure the correct folding and membrane transport of products of oncogenes and anti-oncogenes. On the other hand, high synthesis of HSPs can regulate the process of protein degradation and quickly normalize protein metabolism in cancer cells, ensuring the rapid growth of malignant tumors.

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Ultrasonic differential diagnostics of cyst and cystic tumors of the spleen

Medical Visualization ◽

10.24835/1607-0763-2020-3-63-75 ◽

2020 ◽

Vol 24 (3) ◽

pp. 63-75

Author(s):

Yu. A. Stepanova ◽

M. Z. Alimurzaeva ◽

D. A. Ionkin

Keyword(s):

Differential Diagnosis ◽

Cancer Metastasis ◽

Malignant Tumors ◽

Dynamic Control ◽

Differential Diagnostics ◽

Epithelial Lining ◽

Focal Lesions ◽

Morphological Form ◽

Cystic Tumors ◽

Number Of Patients

The incidence of focal lesions in the spleen is 3.2–4.2% per 100,000 population. Spleen cysts are rare (incidence 0.75 per 100,000). These are single or multiple, thin- and smooth-walled cavities filled with a transparent liquid. Distinguish between primary (or true) cysts, lined with epithelium, and secondary (or false), devoid of epithelial lining. Among the primary cysts, there are congenital cysts formed in the embryonic period due to the migration of peritoneal cells into the spleen tissue, dermoid and epidermoid cysts. A special group of primary cysts are parasitic cysts. Cystic tumors of the spleen include lymphangioma and lymphoma.The main difficulties in the diagnosis and differential diagnosis of cysts and cystic tumors of the spleen are associated with the rarity of this pathology and, as a consequence, a small number of works, including a significant number of the cases. However, in those works where a large number of the cases are described, most often this is one morphological form and an analysis of its various characteristics.Purpose. Based on the analysis of our own examination data of a significant number of patients with cysts and cystic tumors of the spleen, to assess the possibility of differential diagnosis of individual morphological forms according to ultrasound data.Materials and methods. 323 patients with cysts and cystic tumors of the spleen from 15 to 77 years old (men – 105 (32.5%); women – 218 (67.5%) were treated at A.V. Vishnevsky National Medical Research Center of Surgery for the period from 1980 to 2020. All patients underwent ultrasound during examination. Surgical treatment was carried out in various ways – (85.1%), when making a preoperative diagnosis of an uncomplicated spleen cyst of small size, dynamic observation was carried out (verification by puncture biopsy data).Results. Morphological verification of cysts and cystic tumors of the spleen was presented as follows (taking into account possible difficulties in identifying the epithelial lining): true cyst – 182 (56.4%); dermoid cyst – 3 (0.9%) (malignant – in 1 case); pseudocyst – 16 (5.0%); pancreatogenic – 34 (10.5%); echinococcus – 52 (16.1%); lymphangioma – 24 (7.4%); lymphoma – 10 (3.1%); ovarian cancer metastasis – 2 (0.6%). The article describes the ultrasound signs of the above forms of the lesions with an emphasis on the complexity of diagnosis.Conclusions. Primary and parasitic spleen cysts are well differentiated according to ultrasound; false cysts of the spleen, depending on the cause of their occurrence, can create difficulties in their identification and differentiation (they require careful dynamic control); cystic tumors of the spleen should be differentiated from malignant tumors and metastases of a cystic structure, as a result of which such vigilance should always be present when they are detected.

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The possibility of using tantalum oxide microparticles in phosphate glass for radiation therapy of malignant neoplasms

Pacific Medical Journal ◽

10.34215/1609-1175-2020-4-85-87 ◽

2020 ◽

pp. 85-87

Author(s):

O. S. Plotnikova ◽

V. I. Apanasevich ◽

M. A. Medkov ◽

A. A. Polezhaev ◽

V. I. Nevozhai ◽

...

Keyword(s):

Phosphate Glass ◽

Linear Accelerator ◽

Malignant Tumors ◽

Video Recording ◽

Tantalum Oxide ◽

Vertical Plane ◽

Secondary Radiation ◽

Semiconductor Diode ◽

Malignant Neoplasms ◽

Diode Detector

Objective: The creation of the medicine for a local radiomodification of tumors.Methods: The level of the secondary radiation on the surface of the phosphate glass powder with the inclusion of tantalum oxide processed by 6 MeV deceleration emission was studied. Medical linear accelerator TrueBeam (Varian, USA), and Semiconductor diode detector PDI 2.0 (Sun Nuclear Corp., USA) having the system of moving in vertical plane and the system of position video recording were used.Results: The presence of the phosphate glass (containing 20% Та2О5) on the surface gave a 63.7% increase to the secondary radiation. It’s around two thirds of the overall level.Conclusion: An opportunity to create a medicine on the basis of phosphate glass, containing tantalum oxide, for local radiomodification of malignant tumors.

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Aspartame and cancer – new evidence for causation

Environmental Health ◽

10.1186/s12940-021-00725-y ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Philip J. Landrigan ◽

Kurt Straif

Keyword(s):

Public Health ◽

Cancer Risk ◽

Malignant Tumors ◽

Daily Intake ◽

Immunohistochemical Analysis ◽

International Agency ◽

Advisory Group ◽

Malignant Neoplasms ◽

Acceptable Daily Intake ◽

New Findings

Abstract Background Aspartame is one of the world’s most widely used artificial sweeteners and is an ingredient in more than 5000 food products globally. A particularly important use is in low-calorie beverages consumed by children and pregnant women. The Ramazzini Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice. Increased cancer risk was seen even at low exposure levels approaching the Acceptable Daily Intake (ADI). Prenatal exposures caused increased malignancies in rodent offspring at lower doses than in adults. These findings generated intense controversy focused on the accuracy of RI’s diagnoses of hematopoietic and lymphoid tissue tumors (HLTs). Critics made the claim that pulmonary lesions observed in aspartame-exposed animals were inflammatory lesions caused by Mycoplasma infection rather than malignant neoplasms. Methods To address this question, RI subjected all HLTs from aspartame-exposed animals to immunohistochemical analysis using a battery of markers and to morphological reassessment using the most recent Internationally Harmonized Nomenclature and Diagnostic (INHAND) criteria. Findings This immunohistochemical and morphological re-evaluation confirmed the original diagnoses of malignancy in 92.3% of cases. Six lesions originally diagnosed as lymphoma (8% of all HLTs) were reclassified: 3 to lymphoid hyperplasia, and 3 to chronic inflammation with fibrosis. There was no evidence of Mycoplasma infection. Interpretation These new findings confirm that aspartame is a chemical carcinogen in rodents. They confirm the very worrisome finding that prenatal exposure to aspartame increases cancer risk in rodent offspring. They validate the conclusions of the original RI studies. These findings are of great importance for public health. In light of them, we encourage all national and international public health agencies to urgently reexamine their assessments of aspartame’s health risks - especially the risks of prenatal and early postnatal exposures. We call upon food agencies to reassess Acceptable Daily Intake (ADI) levels for aspartame. We note that an Advisory Group to the International Agency for Research on Cancer has recommended high-priority reevaluation of aspartame’s carcinogenicity to humans.

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Establishing Adrenocortical Carcinoma Specific Prognostic Genes Signature

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqaa161.324 ◽

2020 ◽

Vol 154 (Supplement_1) ◽

pp. S148-S149

Author(s):

A R Patil ◽

D S Dabrowski ◽

J Cotelingam ◽

D Veillon ◽

M Ong ◽

...

Keyword(s):

Median Survival ◽

Poor Prognosis ◽

Cancer Genomics ◽

Disease Free Survival ◽

Genetic Alterations ◽

Malignant Neoplasms ◽

Free Survival ◽

Signature Genes ◽

Disease Free ◽

Disease Specific

Abstract Introduction/Objective Adrenal Cortical Carcinoma (ACC) is a rare malignant neoplasms originating from adrenal cortical tissue with an annual incidence rate of 1 to 2 cases per million individuals. These tumors have poor prognosis with 5-year disease free survival being 30% after complete resection in Stage I to Stage III patients. Hence, there is a need for identifying prognostic markers for effective management of disease in these patients. Methods We analyzed the data in The Cancer Genome Atlas of 1141 ACC individuals, using cbioportal.org, a web- based platform for analysis of large-scale cancer genomics data sets, and derived correlation between prognosis and genetic alterations in approximately 51,309 genes. Results We identified 15 signature genes (NOTCH1, TP53, ZNRF3, LRP1, KIF5A, MDM2, LETMD1, MTOR, NOTCH3, RERE, SMARCC2, LDLR, HRNR, AVPR1A and PCDH15), alterations in which indicated a poor prognosis for ACC individuals. Analysis of 15 signature genes demonstrated that disease specific median survival for the patients with ACC, was reduced to 39.5 months (p value < 8 x 10 -9 and sensitivity of 93%) when any one or more of these genes was altered. Whereas, disease specific median survival was greater than 180 months (90% survival being 180 months) with no alteration in our signature genes. In addition, our analysis of our signature genes demonstrates reduced overall survival, disease free survival and progression free survival in individuals having alterations in our signature genes. Moreover, our set of 15 genes belonged mainly to MDM2-TP53, NOTCH and mTOR pathways, and small molecule modulators of these pathways are in process of development. Conclusion Our 15 gene signature was not only able to predict poor prognosis in ACC, but also has the potential to serve as a molecular marker set for initiation of NOTCH and mTOR specific targeted therapies in these patients.

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Risk of Metastatic Ovarian Involvement in Nongynecologic Malignancies

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e3182332cd1 ◽

2012 ◽

Vol 22 (1) ◽

pp. 3-8 ◽

Cited By ~ 4

Author(s):

Kidong Kim ◽

Soo Youn Cho ◽

Sang-Il Park ◽

Hye Jin Kang ◽

Beob-Jong Kim ◽

...

Keyword(s):

Overall Survival ◽

Malignant Tumors ◽

Rank Test ◽

Benign Tumors ◽

Binary Logistic Regression Analysis ◽

Fisher Exact Test ◽

Tumor Type ◽

Metastatic Tumors ◽

Number Of Patients ◽

Adnexal Tumors

ObjectiveThe objectives were to evaluate the risk of malignant adnexal tumors in women with nongynecologic malignancies and to identify variables associated with the risk of malignant adnexal tumors.MethodsThe eligibility criteria included the diagnosis of a nongynecologic malignancy and adnexal tumors, which were resected or subjected to biopsy at our institute between 1999 and 2010. The risk of malignant adnexal tumors was assessed by dividing the number of patients with metastatic tumors to the adnexa or primary adnexal cancers by the total number of patients. The association of clinicopathologic variables with the risk of malignant adnexal tumors was evaluated using the Fisher exact test and binary logistic regression analysis. In patients with metastatic tumors to the adnexa, the association of clinicopathologic variables with overall survival after adnexal surgery was examined using the log-rank test.ResultsIn 166 patients with adnexal tumors, 41 benign tumors, 113 metastatic tumors to the adnexa, and 12 primary adnexal cancers were diagnosed. Age older than 46 years, a tumor type associated with a high risk for malignant adnexal tumors, and bilateral tumors significantly increased the risk of malignant adnexal tumors. The overall survival of the patients with stomach cancer was significantly worse than the patients with colorectal or breast cancers.ConclusionOne hundred twenty-five of the 166 patients with nongynecologic malignancies who had adnexal tumors managed surgically were shown to have malignant tumors, and most of the tumors were metastatic from primary sites. The risk of malignant adnexal tumors was associated with age, nongynecologic malignancy, and bilaterality.

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The working of the urology department during the COVID-19 epidemic

Urologicheskie vedomosti ◽

10.17816/uroved52792 ◽

2020 ◽

Vol 10 (4) ◽

pp. 301-307

Author(s):

Ekaterina V. Kul’chavenya ◽

Denis P. Kholtobin ◽

Alexander I. Neymark

Keyword(s):

Medical Center ◽

Total Duration ◽

World Health ◽

Medical Attention ◽

Malignant Neoplasms ◽

City Hospital ◽

Strict Adherence ◽

Number Of Patients ◽

Coronavirus Infection ◽

Research Institute

Introduction. In March 2020, the World Health Organization declared the outbreak of the novel coronavirus infection (COVID-19) a pandemic. The pandemic also significantly affected all academic, scientific and educational activities. Material and methods. We compared the work of the urological departments of the private (Medical Center Avicenna, Novosibisk) and municipal (City Clinical Hospital No. 11, Barnaul) clinics, as well as the urogenital department of the Novosibirsk Research Institute of Tuberculosis of the Ministry of Healthcare of Russia for 6 months of calm 2019, and the first half of 2020, which coincided with the start of the COVID-19 coronavirus pandemic. Results. In March 2020, the urogenital department of the Novosibirsk Research Institute of Tuberculosis of the Ministry of Healthcare of Russia was redesigned into an observational one. In the first half of 2020, patients with malignant neoplasms, varicocele, chronic pyelonephritis, hydronephrosis, dropsy of the testicular membranes and with phimosis/paraphimosis were admitted to the urology department of the City Hospital No. 11 in Barnaul in the first half of 2020. On the contrary, statistically significant in 2020 the number of patients admitted for kidney abscess and acute prostatitis prevailed. It can be assumed that, due to the tense epidemic situation, patients postponed seeking medical attention until their condition required emergency intervention. In the Medical Center Avicenna (Novosibirsk) in the first half of 2020 the number of visits to the pediatric urologist significantly decreased, the inpatient and average bed-day decreased. On the contrary the total duration of the patients' stay in the day hospital has significantly increased, which is logically explained by the epidemic situation; there was a statistically significant decrease in the number of most operations and outpatient procedures. Conclusion. The new coronavirus infection has affected all spheres of human life, to a maximum extent on medicine. In the first six months, no unified approaches to the management of urological patients in epidemic conditions were developed; clinics worked according to internal standards. Our analysis showed that strict adherence to sanitary and hygienic standards and the implementation of anti-epidemic measures allows us to provide urological care to patients in full-even in such unfavorable conditions.

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