scholarly journals Changes in MIDAS, Perceived Stress, Frontalis Muscle Activity and Non-Steroidal Anti-Inflammatory Drugs Usage in Patients with Migraine Headache without Aura following Ayurveda and Yoga Compared to Controls: An Open Labeled Non-Randomized Study

2018 ◽  
Vol 25 (4) ◽  
pp. 250-260 ◽  
Author(s):  
M.S. Vasudha ◽  
N.K. Manjunath ◽  
H.R. Nagendra
Keyword(s):  
Perceived Stress ◽  
Muscle Activity ◽  
Migraine Headache ◽  
Randomized Study ◽  
Frontalis Muscle ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Comparison of the Effects on Rib Fracture between the Traditional Japanese Medicine Jidabokuippo and Nonsteroidal Anti-Inflammatory Drugs: A Randomized Controlled Trial

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hajime Nakae ◽  
Aya Yokoi ◽  
Hiroyuki Kodama ◽  
Akira Horikawa
Keyword(s):  
Treatment Duration ◽  
Injury Severity ◽  
Healthcare Expenditure ◽  
Controlled Trial ◽  
Randomized Study ◽  
Rib Fracture ◽  
Duration Of Treatment ◽  
Traditional Japanese Medicine ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Jidabokuippo is a traditional Japanese medicine used for contusion-induced swelling and pain. This open multicenter randomized study was designed to compare the efficacies of jidabokuippo and nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rib fracture by analyzing the treatment duration. Our study involved 170 rib fracture patients capable of oral ingestion divided randomly into 2 groups: the jidabokuippo and NSAID groups. We compared the duration of treatment and healthcare expenditure between these 2 groups. Medication was continued in both groups until the visual analogue scale score decreased to less than 50% of the pretreatment score. We excluded the patients in whom medication was prematurely discontinued. We analyzed 81 patients belonging to the jidabokuippo and NSAIDs groups. No significant intergroup differences were observed in age, gender, severity (injury severity score), and presence/absence of underlying disease. The treatment duration was significantly shorter in the jidabokuippo group than in the NSAIDs group (P=0.0003). Healthcare expenditure was significantly lower in the jidabokuippo group than in the NSAIDs group (P<0.0001). Our results suggest that compared to NSAIDs, jidabokuippo can shorten the duration of treatment in patients with rib fracture and is a promising analgesic agent based on the medical economic viewpoint.

scholarly journals Risk Evaluation for the Formation of Gastroduodenal Erosion and Ulceration Induced by Meloxicam in Patients with Seropositive and Seronegative Rheumatoid Arthritis

2019 ◽  
Vol 29 (2) ◽  
pp. 45-52
Author(s):  
R. A. Pavlyukov ◽  
M. R. Konorev
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factor ◽  
Rheumatoid Factor ◽  
Risk Evaluation ◽  
Prognostic Value ◽  
Patient Monitoring ◽  
Randomized Study ◽  
Gastroduodenal Erosion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Aim. In this paper, the authors set out toascertain the prognostic value of the rheumatoid factor for the formation of gastroduodenal erosions and ulcers in patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs (meloxicam).Materials and methods. A prospective, randomized study of 138 patients with rheumatoid arthritis taking methotrexate (12.5 mg per week) and meloxicam — nonsteroidal anti-inflammatory drug — (15 mg per day) was conducted. The formation of gastroduodenal erosions and ulcers was recorded for 4–8 years during esophagogastroduo-denoscopy (at study entry, following three months, then once a year). The groups of seropositive and seronegative patients comprised 69 people each.Results. During the period of patient monitoring, significant differences were found (P < 0.01) in the frequency of the formation of gastric and duodenal erosions and ulcers in patients with seropositive (79.7 %; 95 % CI: 70.2–89.2 %) and seronegative (4.4 %; 95 % CI: 0.01–9.2 %) rheumatoid arthritis (τ = 0.763; P < 0.01), taking meloxicam. In the course of monitoring patients (for 4–8 years) with rheumatoid arthritis who took meloxicam, the authors established high rates of the prognostic (rheumatoid) factor for predicting the formation of gastric and duodenal erosions and ulcers: forecast sensitivity — 94.8 %, forecast specificity — 82.5 %, the proportion of correct forecasts — 87.7 %.Conclusions. The rheumatoid factor is found to be a significant (P < 0.01) risk factor for gastroduodenal erosions and ulcers in patients with rheumatoid arthritis, who take non-steroidal anti-inflammatory drugs (meloxicam). 

La sindrome “Cefalea e deficit neurologici transitori con linfocitosi liquorale”: un’altra encefalopatia autoimmune?

2021 ◽  
Vol 24 (8) ◽  
pp. 241
Author(s):  
Maria Elisa Morelli ◽  
Marco Carrozzi
Keyword(s):  
Cerebrospinal Fluid ◽  
Migraine Headache ◽  
Neurological Deficits ◽  
Age Group ◽  
Impaired Consciousness ◽  
Neurologic Deficits ◽  
Paediatric Age ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Autoimmune Pathogenesis

Headache and neurologic deficits with cerebrospinal fluid lymphocytosis syndrome (HaNDL) is a rare nosographic entity, which mainly affects adults but can also occur in the paediatric age. In the literature, 31 cases in this age group are described. Symptomatology typically lasts about three months with episodes that tend to relapse. An autoimmune pathogenesis has been hypothesized. The paper describes the case of an adolescent who presented with three acute and transient episodes of migraine headache in three days associated with impaired consciousness, focal neurological deficits and CSF lymphocytosis. After treatment with steroidal and non-steroidal anti-inflammatory drugs, the patient did not relapse in the following four months. The treatment indicated in the literature is only supportive (analgesics, antiemetics), however in this case the anti-inflammatory therapy reduced the duration of the episode and the recurrence of further episodes.

Triptan persistency among newly initiated users in a pharmacy claims database

Cephalalgia ◽  
2010 ◽  
Vol 31 (4) ◽  
pp. 488-500 ◽  
Author(s):  
Božena J Katić ◽  
Srini Rajagopalan ◽  
Tony W Ho ◽  
Ya-Ting Chen ◽  
X Henry Hu
Keyword(s):  
Migraine Headache ◽  
Migraine Therapy ◽  
Claims Database ◽  
Pharmacy Claims ◽  
Prescription Refill ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Migraine Medication

Objective Our study was conducted to describe prescription refill patterns among patients newly treated with triptans. Background Although triptans are efficacious in treating migraine headache, the persistency of triptan use among newly initiated users has not been well described. Methods From a US pharmacy claims database, we identified patients receiving new triptan monotherapy prescriptions from 2001 to 2005. Prescription refill information was gathered for two years for each patient. Persistency was defined as sustained refills of the index triptan prescription, regardless of duration between refills. Results Of 40,892 patients receiving a new triptan prescription, 53.8% (N=22031) did not persistently refill their index triptan. Of these, 25.5% discontinued prescription migraine therapy, 7.4% switched to a different triptan, and 67.1% switched to a non-triptan migraine medication at the time of their first refill. Only 46.2% of patients received at least one persistent refill. Conclusions Migraine patients were more likely to discontinue their triptan after their index prescription than at any other time in their prescription refill history. The majority of patients did not persistently refill triptans, but filled prescriptions for non-specific migraine therapies such as opioids and non-steroidal anti-inflammatory drugs. Reasons for triptan discontinuation warrant further investigation.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Therapeutic use of lowmolecular weight heparin for capillaritis alba

Phlebologie ◽  
2008 ◽  
Vol 37 (05) ◽  
pp. 259-265 ◽  
Author(s):  
H. Kutzner ◽  
G. Hesse
Keyword(s):  
Case Studies ◽  
Randomized Study ◽  
Compression Therapy ◽  
Venous Hypertension ◽  
Therapeutic Use ◽  
Prospective Randomized Study ◽  
Anti Inflammatory ◽  
Positive Effect ◽  
Inflammatory Effect

SummaryThe reason of the so called ulcerated capillaritis alba or idiopathic atrophie blanche is vasculopathy caused by severe venous hypertension. Thrombosed and rarificated vessels worsen the oxygenation, increase permanent inflammation and impede the necessary compression therapy. The anti-inflammatory effects of heparin alleviate pain and being independent from the antithrombotic ones it needs much lower doses for treatment. This anti-inflammatory effect is now becoming more important in clinical phlebology. Case studies of more than 50 patients and one prospective randomized study of 87 patients clearly demonstrate the ameliorated healing of ulcerated atrophie blanche. In our office we could document this positive effect with 22 patients. We present the pathophysiology of low molecular heparins for ulcerated capillaritis alba and our own experiences with it.

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

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