scholarly journals Endophthalmitis Caused by Agrobacterium radiobacter following Intravitreal Aflibercept for Diabetic Retinopathy

2020 ◽  
Vol 11 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Landon J. Rohowetz ◽  
Nicolas A. Yannuzzi ◽  
Sunil Gupta ◽  
Nimesh A. Patel ◽  
Darlene Miller ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Intravitreal Injection ◽  
Post Injection ◽  
Agrobacterium Radiobacter ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Intravitreal Aflibercept ◽  
Gram Negative Bacillus ◽  
Baseline Visual Acuity

Agrobacterium (Rhizobium) radiobacter is a gram-negative bacillus rarely implicated in ocular disease. A 79-year-old male who performed extensive yardwork following intravitreal injection with aflibercept for diabetic macular edema developed endophthalmitis caused by Agrobacterium radiobacter on post-injection day 7. The patient was treated with vitreous tap and intravitreal injection of vancomycin and ceftazidime with clearance of the infection and restoration of his baseline visual acuity at 20/80.

scholarly journals Intraocular lipopolysaccharide examination for early diagnosis of Stenotrophomonas maltophilia endophthalmitis: a case report

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052092986
Author(s):  
Li Chen ◽  
Zhuo Zai Xu ◽  
Yong Tao
Keyword(s):  
Visual Acuity ◽  
Case Report ◽  
Early Diagnosis ◽  
Stenotrophomonas Maltophilia ◽  
Gram Negative ◽  
Hand Motion ◽  
Bacterial Endophthalmitis ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
Intraocular Fluid

This report describes the presence of Stenotrophomonas maltophilia endophthalmitis after phacoemulsification in a 66-year-old woman. The patient presented with ocular redness and pain, as well as hypopyon in the anterior chamber and reduction of visual acuity to hand motion. Intraocular fluid examination revealed a lipopolysaccharide level of >2.5, which suggested bacterial endophthalmitis. The patient was promptly treated with intravitreal ceftazidime 2 mg and vancomycin 1 mg, as well as intravenous infusion of cefuroxime 750 mg, all administered simultaneously at 12-hour intervals. She also received topical levofloxacin eyedrops, once per hour. Subsequently, pathology culture confirmed the presence of the Gram-negative bacillus, S. maltophilia. The presence of lipopolysaccharide in intraocular fluid is an important early indicator of bacterial endophthalmitis, which can provide guidance for clinical treatment.

scholarly journals Multifocal Electroretinogram, Central Macula Thickness and Visual Acuity in Diabetic Macular Edema Following Intravitreal Injection of anti-VEGF

2021 ◽  
Vol 4 (2) ◽  
pp. 150
Author(s):  
Syntia Nusanti ◽  
Kirana Sampurna ◽  
Ari Djatikusumo ◽  
Anggun Rama Yudantha ◽  
Joedo Prihartono
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Intravitreal Injection ◽  
Diabetic Macular Edema ◽  
Proliferative Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Post Injection ◽  
Anti Vegf ◽  
Sd Oct

Introduction :  Diabetic Retinopathy (DR) is one of the major cause of visual acuity deterioration in diabetic patients. The loss of central visual acuity in diabetic patients are mainly due to macula edema, which is found in 29% diabetic patients with the over 20 years duration of disease. The aim of this study is to evaluate and investigate the possible correlation among changes of visual acuity (VA), central macular thickness (CMT) using Spectral Domain Optical Coherence Tomography (SD-OCT). Electrophysiological responses using multifocal electroretinography (MfERG) in diabetic macular edema (DME) following intravitreal injection of bevacizumab. Methods: Single arm clinical trial. Thirty-three eyes of 33 DME patients (16 non-proliferative diabetic retinopathy and 17 non-high-risk proliferative diabetic retinopathy), receives intravitreal bevacizumab 1,25mg. All patients underwent complete ophthalmic examination including ETDRS VA testing, Sixty-one scaled hexagon MfERG and SD-OCT scan at baseline, 1-week and 1-month post-injection. Components of the first order kernel (N1, N2 and P1) in central 2o were measured. Result : MfERG showed reduced P1 amplitude (P<0.05) at 1-week after injection followed by increased P1 amplitude (P>0.05) at 1-month after treatment as compared to the baseline in all subjects. There was 19% improvement CMT and 0.2Logmar VA improvement in 1-month post-injection compared to the baseline (P<005). This study showed no serious ocular adverse effects. There was no significant correlation between changes in visual acuity with changes in CMT or other MfERG parameters. Conclusion: Intravitreal injection bevacizumab resulting in improved VA, reduction in CMT and mild improvement in the MfERG responses. Although VA changes did not correlate with reduced CMT nor with improved responses of MfERG, the combined use of SD-OCT and MfERG may be used to evaluate macular function in DME patient with worsened visual acuity post anti-VEGF injection.

scholarly journals Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sung Uk Baek ◽  
Min Seon Park ◽  
Bum-Joo Cho ◽  
In Won Park ◽  
Soonil Kwon
Keyword(s):  
Risk Factors ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Platelet Count ◽  
Multivariate Logistic Regression Analysis ◽  
Panretinal Photocoagulation ◽  
Lower Baseline ◽  
Uncontrolled Diabetes ◽  
High Platelet Count ◽  
Baseline Visual Acuity

AbstractUncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed DR patients who had completed PRP in at least one eye with a 3-year follow-up. A total of 243 eyes of 243 subjects (mean age 52.6 ± 11.6 years) were enrolled. Among them, 52 patients (21.4%) showed progression of DR after PRP (progression group), and the other 191 (78.6%) patients had stable DR (non-progression group). The progression group had higher proportion of proliferative DR (P = 0.019); lower baseline visual acuity (P < 0.001); and higher platelet count (P = 0.048), hemoglobin (P = 0.044), and hematocrit, (P = 0.042) than the non-progression group. In the multivariate logistic regression analysis for progression of DR, baseline visual acuity (HR: 0.053, P < 0.001) and platelet count (HR: 1.215, P = 0.031) were identified as risk factors for progression. Consequently, we propose that patients with low visual acuity or high platelet count are more likely to have progressive DR despite PRP and require careful observation. Also, the evaluation of hemorheological factors including platelet counts before PRP can be considered useful in predicting the prognosis of DR.

scholarly journals Bipolar staining of gram-negative bacillus in cerebrospinal fluid

Blood ◽  
2014 ◽  
Vol 124 (18) ◽  
pp. 2892-2892
Author(s):  
Lori D. Racsa ◽  
Eileen M. Burd
Keyword(s):  
Cerebrospinal Fluid ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus

scholarly journals Meningitis Caused by Salmonella Newport in a Five-Year-Old Child

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Ana De Malet ◽  
Sheila Ingerto ◽  
Israel Gañán
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Disorders ◽  
Invasive Disease ◽  
Salmonella Typhi ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Salmonella Newport ◽  
Gram Negative Bacillus ◽  
The Central Nervous System

Salmonella Newport is a Gram-negative bacillus belonging to the Enterobacteria family and the nontyphi Salmonella (NTS), usually related to gastroenteritis. Main difference between NTS and Salmonella typhi is that the last one evolves to an invasive disease easier than NTS. These can progress to bacteremias in around 5% of cases and secondary focuses can appear occasionally, as in meningitis. An infection of the central nervous system is uncommon, considering its incidence in 0.6–8% of the cases; most of them are described in developing countries and mainly in childhood, especially neonates. Bacterial meningitis by NTS mostly affects immunosuppressed people in Europe. Prognosis is adverse, with a 50% mortality rate, mainly due to complications of infection: hydrocephalus, ventriculitis, abscesses, subdural empyema, or stroke. Choice antibiotic treatments are cefotaxime, ceftriaxone, or ceftazidime. The aim of this paper is to present a case of meningitis caused by Salmonella Newport diagnosed in a five-year-old girl living in a rural area of the province of Ourense (Spain), with favorable evolution and without neurological disorders.

Melioidosis and glanders

2010 ◽  
pp. 768-772
Author(s):  
S.J. Peacock
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Northern Australia ◽  
Gram Negative ◽  
Negative Bacillus ◽  
North East ◽  
Serious Infection ◽  
The World ◽  
Gram Negative Bacillus ◽  
Sixth Decade

Melioidosis is a serious infection caused by the soil-dwelling Gram-negative bacillus Burkholderia pseudomallei. It is most commonly reported in north-east Thailand and northern Australia, but is increasingly recognized around the world. Infection is predominantly acquired through bacterial inoculation, often related to occupation, and mostly affects adults between the fourth and sixth decade who have risk factors such as diabetes mellitus and renal impairment....

scholarly journals Melioidosis with Septic Shock and Disseminated Infection in a Neutropenic Patient Receiving Chemotherapy

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Sitthi Sukauichai ◽  
Chantana Pattarowas
Keyword(s):  
Septic Shock ◽  
Mortality Rate ◽  
Burkholderia Pseudomallei ◽  
Neutropenic Patient ◽  
Pulmonary Nodules ◽  
Severe Infection ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus ◽  
Chemotherapy Induced Neutropenia

Melioidosis is a bacterial infection, caused by Gram-negative bacillus, Burkholderia pseudomallei, widespread in Southeast Asia and the northern part of Australia, resulting in a high mortality rate in severe infection. However, it has rarely been reported in patients with chemotherapy-induced neutropenia. The authors described a case of melioidosis in a neutropenic patient presenting with septic shock after receiving chemotherapy. Blood and urine cultures were positive for Burkholderia pseudomallei, and CT scan showed multiple pulmonary nodules and hepatosplenic abscesses. The patient was successfully treated with antibiotics for the infection and with combined modalities for a malignancy.

A Gram-negative Bacillus Infection Causing Gill Lesions in Cultured Rockfish Sebastes schlegeli

2005 ◽  
Vol 40 (3) ◽  
pp. 143-145 ◽  
Author(s):  
Tatsuya Kobayashi ◽  
Makoto Imai ◽  
Yoshifumi Kawaguchi
Keyword(s):  
Sebastes Schlegeli ◽  
Gram Negative ◽  
Negative Bacillus ◽  
Gram Negative Bacillus
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