Vegetable Freshness Perception in Dementia with Lewy Bodies and Alzheimer’s Disease

Introduction: Although various visual function deficits have been reported in patients with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), vegetable freshness perception has not been thoroughly examined. Objective: To investigate vegetable freshness perception in patients with AD and DLB and to clarify the relationship between vegetable freshness perception and various visuoperceptual functions. Methods: We enrolled 37 patients with probable DLB, 58 patients with probable AD, and 32 age-matched healthy controls. We assessed vegetable freshness perception and visuoperceptual functions, including vegetable brightness perception, contrast sensitivity, color perception, and stereopsis. Patients with DLB showed disproportionate deficits in vegetable freshness perception and vegetable luminance perception compared to patients with AD and controls. Analyses of the groups with higher and lower vegetable freshness perceptions revealed significant differences in contrast sensitivity and visual texture recognition. Results: In the vegetable freshness test, we found significant differences among the 3 groups (F = 30.029, p < 0.0001); the extent of impairment in patients with DLB was greater than that in patients with AD. In patients with DLB, the vegetable freshness judgments were significantly correlated with texture judgment scores and contrast sensitivity. Conclusion: Our findings revealed significantly impaired vegetable freshness perception in patients with DLB. Vegetable freshness perception may be related to visual texture recognition in patients with DLB.

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Visual texture agnosia in dementia with lewy bodies and Alzheimer’s disease

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.2171 ◽

2017 ◽

Vol 381 ◽

pp. 769

Author(s):

Y. Oishi ◽

T. Imamura ◽

T. Shimomura ◽

K. Suzuki

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Visual Texture

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Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer’s Disease

Biomedicines ◽

10.3390/biomedicines9091272 ◽

2021 ◽

Vol 9 (9) ◽

pp. 1272

Author(s):

Ana Gámez-Valero ◽

Jaume Campdelacreu ◽

Dolores Vilas ◽

Lourdes Ispierto ◽

Jordi Gascón-Bayarri ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Cross Sectional Study ◽

Healthy Controls ◽

Cross Sectional ◽

Diagnostic Potential ◽

Degenerative Dementia ◽

Mirna Deregulation

Dementia with Lewy bodies (DLB) is one of the most common causes of degenerative dementia, after Alzheimer’s disease (AD), and presents pathological and clinical overlap with both AD and Parkinson’s disease (PD). Consequently, only one in three DLB cases is diagnosed correctly. Platelets, previously related to neurodegeneration, contain microRNAs (miRNAs) whose analysis may provide disease biomarkers. Here, we profiled the whole platelet miRNA transcriptome from DLB patients and healthy controls. Differentially expressed miRNAs were further validated in three consecutive studies from 2017 to 2019 enrolling 162 individuals, including DLB, AD, and PD patients, and healthy controls. Results comprised a seven-miRNA biosignature, showing the highest diagnostic potential for the differentiation between DLB and AD. Additionally, compared to controls, two miRNAs were down-regulated in DLB, four miRNAs were up-regulated in AD, and two miRNAs were down-regulated in PD. Predictive target analysis identified three disease-specific clusters of pathways as a result of platelet-miRNA deregulation. Our cross-sectional study assesses the identification of a novel, highly specific and sensitive platelet-associated miRNA-based biosignature, which distinguishes DLB from AD.

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Visual texture agnosia influences object identification in dementia with Lewy bodies and Alzheimer's disease

Cortex ◽

10.1016/j.cortex.2020.04.008 ◽

2020 ◽

Vol 129 ◽

pp. 23-32

Author(s):

Yuka Oishi ◽

Toru Imamura ◽

Tatsuo Shimomura ◽

Kyoko Suzuki

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Object Identification ◽

Visual Texture

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Visual texture agnosia in dementia with Lewy bodies and Alzheimer's disease

Cortex ◽

10.1016/j.cortex.2018.03.018 ◽

2018 ◽

Vol 103 ◽

pp. 277-290 ◽

Cited By ~ 3

Author(s):

Yuka Oishi ◽

Toru Imamura ◽

Tatsuo Shimomura ◽

Kyoko Suzuki

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Visual Texture

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Comparing Cognitive Profiles of Licensed Drivers with Mild Alzheimer’s Disease and Mild Dementia with Lewy Bodies

International Journal of Alzheimer s Disease ◽

10.1155/2016/6542962 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11

Author(s):

Stephanie Yamin ◽

Arne Stinchcombe ◽

Sylvain Gagnon

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Future Research ◽

Healthy Controls ◽

Neuropsychological Measures ◽

Visuospatial Perception ◽

Primary Means ◽

Almost All

Purpose. Alzheimer’s disease (AD) and dementia with Lewy Bodies (DLB) constitute two of the most common forms of dementia in North America. Driving is a primary means of mobility among older adults and the risk of dementia increases with advanced age. The purpose of this paper is to describe the cognitive profile of licensed drivers with mild AD and mild DLB.Method. Licensed drivers with mild AD, mild DLB, and healthy controls completed neuropsychological tests measuring general cognition, attention, visuospatial/perception, language, and cognitive fluctuations.Results. The results showed differences between healthy controls and demented participants on almost all neuropsychological measures. Participants with early DLB were found to perform significantly worse on some measures of attention and visuospatial functioning in comparison with early AD.Discussion. Future research should examine the relationship between neuropsychological measures and driving outcomes among individuals with mild AD and mild DLB.

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Generalized Rhythmic Delta Activity Frontally Predominant Differentiates Dementia With Lewy Bodies From Alzheimer's Disease and Parkinson's Disease Dementia: A Conventional Electroencephalography Visual Analysis

Clinical EEG and Neuroscience ◽

10.1177/1550059421997147 ◽

2021 ◽

pp. 155005942199714

Author(s):

Lucia Zinno ◽

Anna Negrotti ◽

Chiara Falzoi ◽

Giovanni Messa ◽

Matteo Goldoni ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Parkinson’S Disease ◽

Alzheimer's Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Dementia With Lewy Bodies ◽

Visual Analysis ◽

Lewy Bodies ◽

Delta Activity ◽

Rhythmic Delta Activity

Introduction. An easily accessible and inexpensive neurophysiological technique such as conventional electroencephalography may provide an accurate and generally applicable biomarker capable of differentiating dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) and Parkinson’s disease-associated dementia (PDD). Method. We carried out a retrospective visual analysis of resting-state electroencephalography (EEG) recording of 22 patients with a clinical diagnosis of 19 probable and 3 possible DLB, 22 patients with probable AD and 21 with PDD, matched for age, duration, and severity of cognitive impairment. Results. By using the grand total EEG scoring method, the total score and generalized rhythmic delta activity frontally predominant (GRDAfp) alone or, even better, coupled with a slowing of frequency of background activity (FBA) and its reduced reactivity differentiated DLB from AD at an individual level with an high accuracy similar to that obtained with quantitative EEG (qEEG). GRDAfp alone could also differentiate DLB from PDD with a similar level of diagnostic accuracy. AD differed from PDD only for a slowing of FBA. The duration and severity of cognitive impairment did not differ between DLB patients with and without GRDAfp, indicating that this abnormal EEG pattern should not be regarded as a disease progression marker. Conclusions. The findings of this investigation revalorize the role of conventional EEG in the diagnostic workup of degenerative dementias suggesting the potential inclusion of GRDAfp alone or better coupled with the slowing of FBA and its reduced reactivity, in the list of supportive diagnostic biomarkers of DLB.

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