Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study

This case report describes a 38-year-old male who was hospitalized for further clarification of clinically mild hyperthyroidism. His increased total hormone levels, the elevated free thyroid hormones and the elevated basal TSH with blunted response to TRH strongly suggested a pituitary adenoma with inappropriate TSH incretion. Transmission computed tomography showed an intrasellar expansion, 16 mm in diameter. The neoplastic TSH production was confirmed by an elevated alpha-subunit and a raised molar alpha-sub/ATSH ratio. However, T4 distribution on prealbumin (PA, TTR), albumin (A) and thyroxine binding globulin (TBG) showed a clearly increased binding to PA (39%), indicating additional prealbumin-associated hyperthyroxinemia. The absolute values of PA, A and TBG were within the normal range. After removal of the TSH-producing adenoma, basal TSH, the free thyroid hormones and T4 binding to prealbumin returned to normal. Therefore, the prealbumin-associated hyperthyroxinemia had to be interpreted as a transitory phenomenon related to secondary hyperthyroidism (T4 shift from thyroxine binding globulin to prealbumin) rather than a genetically conditioned anomaly of protein binding.

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Association of thyroid hormones with blood pressure and arterial stiffness in the general population: The Dali study

Journal of Clinical Hypertension ◽

10.1111/jch.14154 ◽

2020 ◽

Author(s):

Md Tasneem Jamal ◽

Qing‐Lu Li ◽

Qi‐Yan Li ◽

Wan‐Ying Liang ◽

Li‐Hong Wang ◽

...

Keyword(s):

Blood Pressure ◽

General Population ◽

Arterial Stiffness ◽

Thyroid Hormones

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Parasympathetic function during deep breathing in the general population: relation to coronary risk factors and normal range

Journal of Internal Medicine ◽

10.1046/j.1365-2796.1999.00446.x ◽

1999 ◽

Vol 245 (3) ◽

pp. 287-294 ◽

Cited By ~ 11

Author(s):

O. May ◽

H. Arildsen ◽

M. Møller

Keyword(s):

Risk Factors ◽

General Population ◽

Coronary Risk Factors ◽

Coronary Risk ◽

Deep Breathing ◽

Normal Range ◽

Parasympathetic Function

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Effect of vitamin B6 supplementation, in combination with magnesium, on severe stress and magnesium status: secondary analysis from an RCT

Proceedings of The Nutrition Society ◽

10.1017/s0029665120004395 ◽

2020 ◽

Vol 79 (OCE2) ◽

Author(s):

Lionel Noah ◽

Gisèle Pickering ◽

Claude Dubray ◽

Andre Mazur ◽

Simon Hitier ◽

...

Keyword(s):

General Population ◽

Vitamin B6 ◽

Controlled Trial ◽

Secondary Analysis ◽

Subscale Score ◽

Normal Range ◽

Parallel Group ◽

Stress Score ◽

Randomised Controlled ◽

The Relationship

AbstractIntroductionEvidence from a recent randomised controlled trial1 suggests that in severely stressed subjects with low magnesemia, supplementation with magnesium (Mg) in combination with vitamin B6 (B6) provides greater benefits than Mg alone. B6 was reported to facilitate Mg absorption and its cellular uptake and to exert synergistic effect with Mg. The current secondary analysis explored the relationship between Mg-B6 combination and erythrocyte Mg concentration, used as a biomarker of body Mg status.Material and MethodsAn 8-week, Phase IV, controlled, single-blinded, parallel-group trial (EudraCT Number 2015-003749-24) stratified by sex was conducted in adults (n = 264) with a Depression Anxiety Stress Scales - stress subscale score (DASS-42SS) > 18 and serum Mg of 0.5–0.85mmol/L, randomised 1:1 to daily oral Mg-B6 (Magne B6®, Mg 300 mg; B6 30mg) or oral Mg alone (Magnespasmyl®, Mg 300mg). Outcomes were stress score, serum Mg (mmol/L), erythrocytes Mg (mmol/L), and serum B6 (nmol/L) from baseline to Week4 and Week8. Data are given as mean(SD) values.Results & DiscussionBaseline characteristics. Baseline magnesemia was 0.80(0.04) for both groups. Erythrocyte Mg concentration for the lower quintile of the studied population (n = 53) was 0.73–1.62, below the normal range of 1.65–2.65 in general population. The mean stress score in this subgroup was higher [29.5(6.3)], but not significantly different from that in other quintiles [lowest value: 26.1(7.6)]. Baseline B6 serum level for the lower B6 quintile (5–23), below the normal range for general population, was suggestive of possible B6 deficiency.Treatment effects. Both treatments increased slightly but not significantly erythrocyte Mg level from baseline to Week8 [1.84(0.03) to 1.86(0.03), and 1.86(0.03) to 188(0.03), respectively for Mg + B6 and Mg groups]. Significant changes were observed in subjects with low erythrocyte Mg level at baseline (< 1.6), namely an increase of + 0.13(0.04–0.22) for Mg + B6 and + 0.17(0.08–0.25) for Mg groups, but with no difference between treatments. Moreover, Mg + B6 supplementation led to a significant change (p < 0.0001) in serum B6 level between baseline and Wk8 [55.9(4.8) to 370.9(11.3)], as compared to Mg alone [51.9(4.8) to 51.5(11.3)].In conclusion, both treatments significantly increased erythrocyte Mg in subjects with low Mg status. B6 supplementation did not lead to further increase in erythrocyte Mg level. We have previously shown that severely stressed population benefits from B6 supplementation in combination with Mg, however, the mechanism of the interaction between Mg and B6 remains to be elucidated.1Sponsored by Sanofi

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Thyroid hormones improve cardiac function and decrease expression of pro-apoptotic proteins in the heart of rats 14 days after infarction

APOPTOSIS ◽

10.1007/s10495-015-1204-3 ◽

2015 ◽

Vol 21 (2) ◽

pp. 184-194 ◽

Cited By ~ 17

Author(s):

Alexandre Luz de Castro ◽

Rafael Oliveira Fernandes ◽

Vanessa D. Ortiz ◽

Cristina Campos ◽

Jéssica H. P. Bonetto ◽

...

Keyword(s):

Thyroid Hormones ◽

Cardiac Function ◽

Apoptotic Proteins

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Synthesis and Metabolism of Thyroid Hormones Is Preferentially Maintained in Selenium-Deficient Transgenic Mice

Endocrinology ◽

10.1210/en.2005-1089 ◽

2006 ◽

Vol 147 (3) ◽

pp. 1306-1313 ◽

Cited By ~ 55

Author(s):

Lutz Schomburg ◽

Cornelia Riese ◽

Marten Michaelis ◽

Emine Griebert ◽

Marc O. Klein ◽

...

Keyword(s):

Thyroid Gland ◽

Thyroid Hormones ◽

Knockout Mice ◽

Serum Levels ◽

Mrna Levels ◽

Normal Range ◽

Growth Defects ◽

Low Levels

The thyroid gland is rich in selenium (Se) and expresses a variety of selenoproteins that are involved in antioxidative defense and metabolism of thyroid hormones (TH). Se deficiency impairs regular synthesis of selenoproteins and adequate TH metabolism. We recently generated mice that lack the plasma Se carrier, selenoprotein P (SePP). SePP-knockout mice display decreased serum Se levels and manifest growth defects and neurological abnormalities partly reminiscent of thyroid gland dysfunction or profound hypothyroidism. Thus, we probed the TH axis in developing and adult SePP-knockout mice. Surprisingly, expression of Se-dependent 5′-deiodinase type 1 was only slightly altered in liver, kidney, or thyroid at postnatal d 60, and 5′-deiodinase type 2 activity in brain was normal in SePP-knockout mice. Thyroid gland morphology, thyroid glutathione peroxidase activity, thyroid Se concentration, and serum levels of TSH, T4, or T3 were within normal range. Pituitary TSHβ transcripts and hepatic 5′-deiodinase type 1 mRNA levels were unchanged, indicating regular T3 bioactivity in thyrotropes and hepatocytes. Cerebellar granule cell migration as a sensitive indicator of local T3 action during development was undisturbed. Collectively, these findings demonstrate that low levels of serum Se or SePP in the absence of other challenges do not necessarily interfere with regular functioning of the TH axis. 5′-deiodinase isozymes are preferentially supplied, and Se-dependent enzymes in the thyroid are even less-dependent on serum levels of Se or SePP than in brain. This indicates a top priority of the thyroid gland and its selenoenzymes with respect to the hierarchical Se supply within the organism.

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Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeaa004 ◽

2020 ◽

Vol 21 (5) ◽

pp. 501-507 ◽

Cited By ~ 3

Author(s):

Peter Selmer Rønningen ◽

Trygve Berge ◽

Magnar Gangås Solberg ◽

Steve Enger ◽

Ståle Nygård ◽

...

Keyword(s):

Sex Differences ◽

General Population ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Left Atrial ◽

Normal Range ◽

Healthy Group ◽

Systolic Volume ◽

Normal Limits

Abstract Aims The current study aimed to describe normal values of left atrial (LA) volumes and LA emptying fraction (LAEF) in a large sample in their mid-60s from the general population and to explore sex differences. Methods and results In the Akershus Cardiac Examination (ACE) 1950 Study, body surface area-indexed LA maximum (LAVimax) and minimum (LAVimin) volumes and LAEF were measured in 3489 individuals aged 63.9 ± 0.6 years from the general population. A healthy group of 832 individuals was defined. Data are presented as mean ± standard deviation (SD) and a normal range of mean ± 2 SD. T-tests were used for comparisons. In the healthy group, mean LAVimax was 25.5 ± 6.2 mL/m2 and the normal range was 13.1–37.9 mL/m2. Men had significantly larger body surface area-indexed volumes than women, but there was no difference in LAEF. The mean LAVimax for healthy men was 26.4 ± 6.5 mL/m2, for healthy women 24.9 ± 5.8 mL/m2 (P < 0.001) and the upper normal limits were 39.4 and 36.5 mL/m2, respectively. In the healthy group, 13.0% of all men and 5.4% of all women had LAVimax above the current upper normal limit of 34 mL/m2. Conclusion A large proportion of healthy individuals, in particular men, had LAVimax >34 mL/m2. Our findings suggest that the recommended cut-off may be too low at the age of 65 years and above and that sex-specific cut-offs should be considered.

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The Association of Normal Range Glycated Hemoglobin with Restrictive Lung Pattern in the General Population

PLoS ONE ◽

10.1371/journal.pone.0117725 ◽

2015 ◽

Vol 10 (2) ◽

pp. e0117725 ◽

Cited By ~ 8

Author(s):

Il Hwan Oh ◽

Jung Hwan Park ◽

Chang Hwa Lee ◽

Joon-Sung Park

Keyword(s):

General Population ◽

Glycated Hemoglobin ◽

Normal Range

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A slight decrease in serum albumin level is associated with rapid progression of kidney dysfunction even within the normal range: The Yuport Health Checkup Center Cohort Study

10.1101/655563 ◽

2019 ◽

Author(s):

Hoichi Amano ◽

Kazunobu Yoshimura ◽

Ryutaro Iijima ◽

Kaito Waki ◽

Keisei Matsumoto ◽

...

Keyword(s):

General Population ◽

Serum Albumin ◽

Kidney Function ◽

Serum Albumin Level ◽

Continuous Variable ◽

Albumin Level ◽

Rapid Decline ◽

Rapid Progression ◽

Normal Range ◽

Health Checkup

AbstractObjectiveA low-normal albumin level is associated with a high risk of cardiovascular disease and mortality in the general population. However, the relationship between serum albumin level and future decline of kidney function is unclear. We aimed to clarify the effect of serum albumin level on the decline of kidney function in the general population.MethodsThe data used were from 11,000 participants of a voluntary health checkup program between 1998 and 2006 conducted in Japan. The primary outcome for kidney function was a difference in estimated glomerular filtration rate (ΔeGFR) of ≥3 mL/min/1.73 m2/year. The association of the risk of decreased kidney function with albumin level was determined using a logistic regression analysis. We fit separate multivariable logistic regressions for serum albumin levels (g/dL) as a continuous variable and as categorical data, classified as ≤4.3 (n=2,530), 4.4– 4.6 (n=5,427), and ≥4.7 (n=3,043).ResultsOf 11,000 participants, 346 had a ΔeGFR/year of ≥3. As compared with the participants with albumin levels of ≥4.7 g/dL, the risk of decline in kidney function was higher not only in those with albumin levels of ≤4.3 g/dL (adjusted OR = 2,29, 95% CI: 1.65–3.18) but also in 4.4-4.6 g/dL (adjusted OR = 1.60, 95% CI: 1.20–2.14).ConclusionDecreased albumin level is an independent risk factor for rapid decline in kidney function even within the normal range.

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