Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study

Dermatology ◽  
2020 ◽  
pp. 1-6
Author(s):  
Stefano Caccavale ◽  
Giulia Calabrese ◽  
Emanuela Mattiello ◽  
Paolo Broganelli ◽  
Alice Ramondetta ◽  
...  
Keyword(s):  
Observational Study ◽  
Small Sample Size ◽  
Melanocytic Nevus ◽  
Small Sample ◽  
Retrospective Observational Study ◽  
Congenital Melanocytic Nevus ◽  
Single Center ◽  
Single Center Experience ◽  
The Mean ◽  
Congenital Melanocytic Nevi

<b><i>Background:</i></b> Congenital melanocytic nevi (CMN) are benign proliferations of melanocytes usually present at birth. The magnitude of the melanoma risk for CMN is controversial, generating an ongoing debate on the best approach to manage these lesions. <b><i>Objective:</i></b> To perform a retrospective, observational study with the aim to evaluate the prevalence of CMN-associated melanomas in tertiary referral centers, as well as the eventual correlation between clinical, dermoscopic, and histological features of CMN-associated melanomas. <b><i>Methods:</i></b> A single-center retrospective observational study was performed on all clinical and dermoscopic images of histologically confirmed melanomas arising on CMN over a 14-year period (January 2005 to March 2019). <b><i>Results:</i></b>Our database included 2,159 melanomas in the considered period. Of those, 27 (1.3%) were CMN-associated melanomas. The mean age of patients with CMN-associated melanoma was 33 years (range, 11–70 years). The mean diameter of CMN-associated melanoma was 18 mm (range, 6 mm to 20 cm), and 56% were located on the back. Twenty-one (77.8%) of CMN-associated melanomas arose on small CMN (&#x3c;1.5 cm), 5 (18.5%) on medium-sized CMN (1.5–19.9 cm), and 1 (3.7%) on a large/giant type (≥20 cm). The majority of CMN-associated melanomas (63%) exhibited a globular dermoscopic pattern in their benign part, while a blue-white veil and irregular blotches were the most frequent dermoscopic features in the malignant part. About three quarters of melanomas occupied 10–50% of the nevus surface. Breslow thickness was higher in melanomas involving less than 10% of nevus surface (mean thickness, 1 mm) than in those affecting 10–50 and &#x3e;50% of the nevus surface (0.8 and 0.7 mm, respectively). <b><i>Conclusions:</i></b> In our series, small CMN was the most frequent type of CMN-associated melanoma. Although the risk of melanoma is increasing by the increasing size of CMN, our finding is definitely related to the much higher prevalence of small CMN in the general population as compared to the prevalence of intermediate-sized and large CMN. <b><i>Limitations:</i></b> Small sample size, single-center experience, retrospective design.

scholarly journals P11.04 A single center experience in pediatric high grade gliomas (a retrospective observational study)

2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii92-iii92
Author(s):  
M. S. Elnaggar ◽  
K. F. Riad ◽  
A. A. Abdelhakeem ◽  
A. F. Elsherif
Keyword(s):  
Observational Study ◽  
Retrospective Observational Study ◽  
High Grade ◽  
Single Center ◽  
Single Center Experience ◽  
High Grade Gliomas

scholarly journals PROGNOSTIC FACTORS IN MYELODYSPLASTIC SYNDROMES: SINGLE-CENTER EXPERIENCE

2019 ◽  
Vol 141 (7-8) ◽  
pp. 238-246
Keyword(s):  
Prognostic Factors ◽  
Small Sample Size ◽  
Risk Groups ◽  
Small Sample ◽  
World Health ◽  
Single Center ◽  
Single Center Experience ◽  
Age Of Diagnosis ◽  
Transfusion Dependency ◽  
Health Organization

Introduction: Myelodysplastic syndrome (MDS) is one of the most common myeloid neoplasms of elderly characterized by cytopenias and limited therapeutic options. The main aim of this retrospective single-center study was to examine the value of classical prognostic factors. The main outcome of the study was overall survival (OS) defined as death from MDS or any other reason. Methods: We analyzed the medical records of patients diagnosed with MDS at single centre in the period from beginning of 2013 to the end of 2016. Results: Total of 58 patients (median age of diagnosis being 69 years) were included in the study. After median of follow-up of 12 months, median OS was 17 months and estimated 3-year OS rate 25%. Classical prognostic systems such as IPSS, WPSS and R-IPSS were statistically significant prognostic factors discriminating adequately between low and high risk groups in terms of outcome. However, due to small sample size, we were not able to distinguish the most appropriate scoring system. The cytogenetics subgroups according to IPPS and R-IPSS were significant predictors of outcomes underlying its crucial role in MDS diagnosis. Despite the statistical tendency morphological features of MDS (2008 World Health Organization subtype and number of blasts in bone marrow) were not significant predictors of OS. Among clinical features, only presence and degree of anemia and transfusion dependency were significant predictors of inferior survival. Conclusion: The majority of traditional prognostic factors were significant in our cohort in concordance with literature review.

Stillbirth Rate and Weight at Birth of Quintuplets in Japan

1989 ◽  
Vol 38 (1-2) ◽  
pp. 65-69 ◽  
Author(s):  
Yoko Imaizumi
Keyword(s):  
Sample Size ◽  
Birth Order ◽  
Gestational Age ◽  
Size Effects ◽  
Maternal Age ◽  
Small Sample Size ◽  
Small Sample ◽  
Stillbirth Rate ◽  
The Mean

AbstractNation-wide data in Japan on births and prenatal deaths of 16 sets of quintuplets during 1974-1985 were analysed. Among the 16 sets, 3 sets were liveborn, 8 were stillborn, and 5 were mixed, with a stillbirth rate of 0.64 (51/80). Effects of sex, maternal age and birth order on the stillbirth rate were not considered because of the small sample size. Effects of gestational age and birthweight on stillbirth rate were also examined. The mean weight of the 40 quintuplet individuals was 1,048 g.

A 5-year observational study of lung-protective ventilation in the operating room: A single-center experience

2013 ◽  
Vol 28 (4) ◽  
pp. 533.e9-533.e15 ◽  
Author(s):  
Dean R. Hess ◽  
Dhimiter Kondili ◽  
Edward Burns ◽  
Edward A. Bittner ◽  
Ulrich H. Schmidt
Keyword(s):  
Observational Study ◽  
Operating Room ◽  
Protective Ventilation ◽  
Lung Protective Ventilation ◽  
Single Center ◽  
Single Center Experience

scholarly journals Percutaneous Vertebroplasty Combined with Percutaneous Pediculoplasty for Lytic Vertebral Body and Pedicle Lesions of Metastatic Tumors

2015 ◽  
Vol 3;18 (3;5) ◽  
pp. E347-E353
Author(s):  
Zhong-Liang Deng
Keyword(s):  
Observational Study ◽  
Vertebral Body ◽  
Percutaneous Vertebroplasty ◽  
Management Practice ◽  
Medical Center ◽  
Therapeutic Option ◽  
Retrospective Observational Study ◽  
Symptom Duration ◽  
Single Center ◽  
Metastatic Tumors

Background: Percutaneous pediculoplasty (PP) consists of the injection of Poly(methyl methacrylate) (PMMA) into the fractured pedicle or lytic vertebral pedicle lesions, as a technique derived from vertebroplasty. Objectives: To evaluate the short-term analgesic effect of percutaneous vertebroplasty (PV) and percutaneous pediculoplasty (PP) in patients with lytic vertebral body and pedicle lesions of metastatic tumors. Study Design: Single-center retrospective observational study. Setting: An interventional pain management practice, a medical center, major metropolitan city, China. Methods: Single-center retrospective observational study of all patients managed with PV and PP for painful vertebral body and pedicle metastatic tumors between 2007 and 2013. For each patient, symptom duration and pain intensity were recorded. PP was performed under local analgesia, in the prone position, with C-arm fluoroscopy guidance. The mixture of PMMA and Doxorubicin was delivered into the vertebral body with a non-beveled needle for the initial treatment followed by the mixture delivery into the lytic pedicle during needle withdrawal. Results: Nine patients (5 women, 4 men) were enrolled in the study with a mean age of 65.9 years (range 57 – 75). Technical success was defined as the ability to access the lesion using the approach. A positive clinical response for pain relief was achieved in these patients in whom vertebroplasty and pediculoplasty had been performed. Pain level was not significantly reduced in 3 patients in whom just vertebroplasty has been performed because the medial wall of the pedicle was destroyed by the metastatic lesion. Limitations: This study is limited by its sample size. Conclusions: PV and PP via the transpedicular approach for infiltrated vertebral bodies and infiltrated pedicles of metastatic tumors may be considered a valid therapeutic option. Key words: Percutaneous pediculoplasty, percutaneous vertebroplasty, lytic pedicular lesions, bone cement

scholarly journals Congenital Melanocytic Hairy Nevi in a Child from North-Western Nigeria

2020 ◽  
pp. 28-34
Author(s):  
Fatima Bello Jiya ◽  
Maryam Amodu- Sanni ◽  
Nma Muhammed Jiya ◽  
Dada Muhammed Aquib ◽  
Muhammed Umar ◽  
...  
Keyword(s):  
Melanocytic Nevus ◽  
Temporal Region ◽  
Healthy Children ◽  
Congenital Melanocytic Nevus ◽  
Melanocytic Nevi ◽  
Lower Back ◽  
The Face ◽  
Congenital Melanocytic Nevi ◽  
North Western ◽  
Apparently Healthy

Aim: To present the first report of a large congenital melanocytic nevus with satellite nevi in an apparently healthy child from Sokoto, North-Western Nigeria. Presentation of Case: A three year old girl was brought to the paediatric out-patient clinic of Paediatrics department of Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto with complaints of darkened skin colour on the left side of the face and scalp, the left arm, lower back, buttocks, and thighs, and excessive hair growth over the same side of the face since birth. There were no neurological symptoms Physical examination findings revealed a well-nourished, not ill looking child. She had a hyper pigmented patch on the left side of the face extending from the lower jaw to the scalp, measuring 21 cm in its longest length, with hypertrichosis on the same site, and two distinct, firm, painless nodular lesions on the left temporal region measuring 3 mm and 4mm respectively. On the lower one-third of the left arm was a hairy, velvety area of hyperpigmentation measuring 2X3 cm in diameter. Other affected sites were the lower back, the gluteal region and the thighs. Her neurologic and other systemic examinations were normal. A diagnosis of large congenital facial melanocytic hairy nevus with multiple satellite nevi was made. Discussion: Congenital melanocytic nevi are benign proliferations of melanocytic cells said to be present at birth or in the first two years of life. Large lesions are rare, they measure 20 cm or more and are said to occur more commonly on the trunk and thighs. The exact pathogenesis of congenital melanocytic nevi is yet, unknown. It is thought to occur as a result of a morphological error in the neuroectoderm during embryogenesis. Treatment of patients with large congenital melanocytic nevus may include surgical or non-surgical procedures as well as psychological interventions. Large lesions, multiple satellite lesions or paravertebral and axial locations are sometimes associated with the risk of neurological complications and malignant transformation. Conclusion: Large congenital melanocytic nevi are uncommon skin lesions that can occur in apparently healthy children. Individualization of the patients with regards to treatment options and long term monitoring are imperative.

The use of frequency distributions in an attempt to detect host mortality induced by infections of diplostomatid metacercariae

Parasitology ◽  
1984 ◽  
Vol 89 (2) ◽  
pp. 209-220 ◽  
Author(s):  
C. R. Kennedy
Keyword(s):  
Small Sample Size ◽  
Parasite Burden ◽  
Fish Host ◽  
Small Sample ◽  
Host Age ◽  
Parasite Abundance ◽  
Frequency Distributions ◽  
Host Mortality ◽  
The Mean ◽  
Over Dispersion

SummaryFollowing recent suggestions that a peaked host age–parasite abundance curve, concomitant with a decline in the degree of dispersion of parasites in the older age classes of hosts, can provide evidence of parasite-induced host mortality, the changes in mean abundance and over-dispersion of metacercarial stages of Diplostomum spathaceum, D. gasterostei, Tylodelphys clavata and T. podicipina in relation to fish age were studied in a field locality. The mean parasite burden of D. spathaceum, D. gasterostei and T. clavata increased with host age and the maximum mean burden was found in the oldest hosts. The variance to mean ratio also increased in D. gasterostei, but decreased in the oldest hosts in D. spathaceum and T. clavata. It is concluded that this decrease could be due to parasite-induced host mortality but could equally be due to death of parasites within the host or to changes in infection rate or could be a reflection of the small sample size of the oldest fish. The mean burden of T. podicipina declined gradually with host age, but the variance to mean ratio remained constant and it is concluded that this could be explained by death of the parasites within the host. None of these data or data from other localities provided clear and unambiguous evidence of host mortality induced by heavy infections of any of the four species, although they are consistent with such mortality and do not refute such a possibility. It is concluded that it may be just as difficult to detect and unequivocally demonstrate parasite-induced host mortality in metacercarial digenean–fish host systems as in any other parasite–host systems.

Predictors of severe postoperative hyperglycemia after cardiac surgery in infants: a single-center, retrospective, observational study

2018 ◽  
Vol 32 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Natsuhiro Yamamoto ◽  
Tomoya Irie ◽  
Shunsuke Takaki ◽  
Osamu Yamaguchi ◽  
Takahisa Goto
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Single Center
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