scholarly journals Association of Chemokine (C-C Motif) Receptor 5 and Ligand 5 with Recovery from Major Depressive Disorder and Related Neurocognitive Impairment

2021 ◽  
pp. 1-11
Author(s):  
Olivia Bauer ◽  
Vladimir M. Milenkovic ◽  
Sven Hilbert ◽  
Nina Sarubin ◽  
Johannes Weigl ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Executive Functions ◽  
Neuropsychological Test ◽  
Therapy Response ◽  
Response Prediction ◽  
Neurocognitive Impairment ◽  
Mrna Levels ◽  
Major Depressive ◽  
Emotional Perception

<b><i>Introduction:</i></b> Inflammatory processes play an important role in the pathophysiology of major depressive disorder (MDD), but their relevance for specific symptoms such as neurocognitive impairment is rarely investigated. <b><i>Methods:</i></b> In this observational study, we investigated the changes of leukocyte chemokine (C-C motif) receptor 5 (CCR5) and ligand 5 (CCL5) mRNA levels and inflammatory cytokines in 60 MDD patients before (PRE) and after 5 weeks (W5) of antidepressive treatment in relation to therapy response and alterations in cognitive functions by means of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We hypothesized that elevated CCR5 and CCL5 levels in depressed patients would decrease upon treatment and could differ with regard to cognitive impairment associated with MDD. <b><i>Results:</i></b> Both CCR5 and CCL5 levels were significantly decreased in the responder group compared to nonresponders even before treatment. The cytokine IL-6 as a marker of inflammation in depression did not show a difference before treatment in future responders versus nonresponders, but decreased significantly upon antidepressive therapy. Regarding neurocognitive impairment in MDD patients, an increased misperception of the emotion “anger” after 5 weeks of treatment proved to be associated with a more pronounced change in CCR5, and the perception of the emotion “disgust” became faster along with a stronger decrease in CCL5 over the same time. Executive functions typically impaired in MDD patients were not markedly associated with alterations in CCR5/CCL5. <b><i>Discussion:</i></b> CCR5 and CCL5 are important in the targeting of immune cells by HIV. This is the first study providing valuable hints that both CCR5 and CCL5 might also serve as markers of therapy response prediction in MDD. Regarding neurocognitive impairment in depression, CCR5 and CCL5 did not reveal characteristic changes upon MDD treatment such as executive functions, which are probably delayed. However, changes of emotional perception appear to be an earlier responding feature.

scholarly journals Neurocognitive impairment in adolescent major depressive disorder: State vs. trait illness markers

2011 ◽  
Vol 133 (3) ◽  
pp. 625-632 ◽  
Author(s):  
Fadi T. Maalouf ◽  
David Brent ◽  
Luke Clark ◽  
Lucy Tavitian ◽  
Rebecca Munnell McHugh ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Neurocognitive Impairment ◽  
Major Depressive

The acute and medium-term effects of treatment with electroconvulsive therapy on memory in patients with major depressive disorder

2015 ◽  
Vol 46 (4) ◽  
pp. 797-806 ◽  
Author(s):  
N. P. Maric ◽  
Z. Stojanovic ◽  
S. Andric ◽  
I. Soldatovic ◽  
M. Dolic ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Visual Memory ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Neuropsychological Test ◽  
Medium Term ◽  
Major Depressive ◽  
Visual Spatial

BackgroundCurrent literature provides insufficient information on the degree of cognitive impairment during and after electroconvulsive therapy (ECT), mostly due to the fact that applied tests lacked sensitivity and flexibility. Our goal was to evaluate cognitive functioning in adult depressed patients treated with bi-temporal ECT, using tests sensitive for detection of possible acute and medium-term memory changes.MethodThirty adult patients with major depressive disorder, treated with a course of bi-temporal ECT, underwent clinical and cognitive measurements three times: at baseline, immediately after a course of ECT, and 1 month later. For cognition assessment, we used learning and visual, spatial and figural memory tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).ResultsBi-temporal ECT has proven to be an effective treatment. The linear mixed model, used to analyze changes in depression severity and patients’ cognitive performances over time and to assess dynamic correlations between aforementioned features, did not show any significant memory impairment as a potential acute or medium-term ECT effect. However, it yielded significant improvement on visual memory and learning at the follow-up, which positively correlated with the improvement of depression.ConclusionGood progress is being made in the search for ECT-related acute and medium-term cognitive side-effects by using the tests sensitive to detect memory dysfunction with parallel forms of the tasks (to counter practice effects on repeat testing). Our results on learning and memory in relation to ECT during treatment of depression did not bring forth any prolonged and significant bi-temporal ECT-related memory deficit.

Effects of selective serotonin reuptake and dual serotonergic–noradrenergic reuptake treatments on attention and executive functions in patients with major depressive disorder

2010 ◽  
Vol 177 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Ixchel Herrera-Guzmán ◽  
Jorge E. Herrera-Abarca ◽  
Esteve Gudayol-Ferré ◽  
Daniel Herrera-Guzmán ◽  
Lizbeth Gómez-Carbajal ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Executive Functions ◽  
Serotonin Reuptake ◽  
Selective Serotonin ◽  
Major Depressive

Predictors of neurocognitive impairment at 2years after a first-episode major depressive disorder

2016 ◽  
Vol 68 ◽  
pp. 24-33 ◽  
Author(s):  
Chuan-zheng Gu ◽  
Hui-li He ◽  
Hui-feng Duan ◽  
Zhong-hua Su ◽  
Hong Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Neurocognitive Impairment ◽  
First Episode ◽  
Major Depressive

scholarly journals Neural Network Based Response Prediction of rTMS in Major Depressive Disorder Using QEEG Cordance

2015 ◽  
Vol 12 (1) ◽  
pp. 61 ◽  
Author(s):  
Turker Tekin Erguzel ◽  
Serhat Ozekes ◽  
Selahattin Gultekin ◽  
Nevzat Tarhan ◽  
Gokben Hizli Sayar ◽  
...  
Keyword(s):  
Neural Network ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Response Prediction ◽  
Major Depressive

scholarly journals SIGIRR and TNFAIP3 Are Differentially Expressed in Both PBMC and TNF-α Secreting Cells of Patients With Major Depressive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Chin-Chuen Lin ◽  
Tiao-Lai Huang
Keyword(s):  
Immune Response ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Innate Immune ◽  
Differentially Expressed ◽  
Mrna Levels ◽  
Healthy Controls ◽  
Negative Regulators ◽  
Major Depressive ◽  
Tnf Α

Background: Major depressive disorder (MDD) is associated with the activation of the immune/inflammatory system. TNF-α is associated with MDD and poor treatment response. Toll-like receptors (TLR) are responsible in innate immune response, and is associated with MDD and antidepressant response. Some negative regulators of TLR pathway such as SOCS1, TOLLIP, SIGIRR, TNFAIP3, and MyD88s, are reported to be differentially expressed in the peripheral blood samples of patients of MDD.Methods: We recruited patients with MDD and healthy controls, collect their demographic data, and measured their mRNA levels of negative TLR regulators, using peripheral blood mononuclear cells (PBMC) and isolated TNF-α secreting cells. Clinical symptoms were evaluated using Halmiton Depression Rating Scale (Ham-D). Some patients were evaluated again after 4 weeks of antidepressant treatment.Results: Forty-seven patients with MDD and 52 healthy controls were recruited. Between the PBMC samples of 37 MDD patients and 42 controls, mRNA levels of SOCS1, SIGIRR, TNFAIP3, and MyD88s were significantly different. Between TNF-α secreting cells of 10 MDD patients and 10 controls, mRNA levels of SIGIRR and TNFAIP3 were significantly different. Change of Ham-D score only correlated significantly with TOLLIP mRNA level after treatment.Conclusion: SIGIRR and TNFAIP3, two negative regulators of TLR immune response pathways, were differentially expressed in both PBMC and TNF-α secreting cells of patients with MDD as compared to healthy controls. The negative regulations of innate immune response could contribute to the underlying mechanism of MDD.

Genetic determinants of circulating VEGF levels in major depressive disorder and electroconvulsive therapy response

2020 ◽  
Vol 81 (5) ◽  
pp. 593-599 ◽  
Author(s):  
Elisabetta Maffioletti ◽  
Massimo Gennarelli ◽  
Chiara Magri ◽  
Luisella Bocchio‐Chiavetto ◽  
Marco Bortolomasi ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Therapy Response ◽  
Genetic Determinants ◽  
Major Depressive
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