scholarly journals Role of Oxidative Stress and Severity of Diabetic Retinopathy in Type 1 & Type 2 Diabetes

2021 ◽  
Author(s):  
Kholoud Albokhary ◽  
Feda Aljaser ◽  
Manal Abudawood ◽  
Hajera Tabassum ◽  
Afnan Bakhsh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Cross Sectional Study ◽  
Antioxidant Defenses ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
The Status ◽  
Type 1 Dm

Background: Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus (DM). Oxidative stress generated on account of hyperglycemic state may lead to retinal abnormalities including DR. Objectives : To evaluate the status of antioxidant enzymes -superoxide dismutase (SOD) and catalase (CAT); with different stages of DR severity in subjects with type 1 and type 2 DM. Methods: The cross-sectional study enrolled 148 subjects with type 1 DM (n=17); type 2 DM (n=96) and non-diabetes controls (n=35). Subjects with DM were divided into two subgroups based on DR severity (mild-to-severe non-proliferative DR and proliferative DR [PDR]) and Serum glycated hemoglobin (HbA1c), lipid profile, SOD and CAT were estimated. Results: Both SOD and CAT levels were lower in diabetes subjects than non-diabetic controls. A significant positive correlation was found between HbA1C level and severity of DR (P<0.0001). Levels of SOD and CAT varied significantly with DR severity in both diabetic groups at p<0.05. Furthermore, levels of SOD and CAT was found to decrease significantly (P<0.001) in DR (+) compared to DR (-) patients. Also, increased levels of HbA1c was significantly associated (P<0.001) with decreased SOD in both subgroups (NPDR and PDR). DR severity was significantly associated with SOD and CAT in the NPDR and PDR subgroups (P<0.05). Conclusion: Oxidative stress and decreased antioxidant defenses are associated with DR progression to its PDR stage.

scholarly journals Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jin Ook Chung ◽  
Seon-Young Park ◽  
Dong Hyeok Cho ◽  
Dong Jin Chung ◽  
Min Young Chung
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Growth Differentiation Factor 15 ◽  
Type 2 Dm ◽  
Differentiation Factor ◽  
Significant Difference ◽  
The Relationship

AbstractThe purpose of our study was to investigate the relationship between plasma growth differentiation factor-15 (GDF-15) concentrations and diabetic retinopathy in patients with type 2 diabetes mellitus (DM). We evaluated 235 patients with type 2 DM in a cross-sectional study. Significantly increased levels of the plasma GDF-15 were found in individuals with diabetic retinopathy versus those without. According to the degree of diabetic retinopathy, there was a significant difference in the average plasma GDF-15 levels (no diabetic retinopathy, 1114 ng/L; nonproliferative diabetic retinopathy, 1327 ng/L; proliferative diabetic retinopathy, 1445 ng/L; p for trend = 0.035) after adjustments for confounders. Logistic regression analyses indicated that plasma GDF-15 concentrations were significantly associated with diabetic retinopathy (odds ratio per 1 standard deviation increment in the log-transformed value, 1.78; 95% confidence interval, 1.05–3.03, p = 0.032). Our study showed a significant positive relationship between plasma GDF-15 concentrations and diabetic retinopathy in type 2 DM patients.

scholarly journals PREVALENCE OF DIABETIC RETINOPATHY AMONG CHILDREN WITH TYPE 1 DIABETES MELLITUS

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Shakti Krishan Rajguru ◽  
Jasraj Bohra
Keyword(s):  
Diabetic Retinopathy ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Moderate Degree ◽  
Cross Sectional ◽  
Mild Degree ◽  
Diabetic Children ◽  
Type 1 Dm

Background: This study to find out the prevalence of diabetic retinopathy (DR) among diabetic children with type 1 DM treated with insulin. Methods: This is a cross-sectional study conducted on 50 children with type 1 DM from 1 to 14  years of age. All patients were subjected to full fundus examination and were then classified according to its results into patients with DR and patients without DR. Results: A total of 6 (12.0%) patients were found to have DR. 5 patients had retinopathy in one eye and 1 patients had retinopathy in both eyes. Thus, the total number of eyes with retinopathy was 7 of 100 screened eyes (7.00% of all eyes). Most eyes with retinopathy had a mild degree of NPDR, as it was present in 6 eyes. The other 1eyes had moderate degree of retinopathy Conclusion: The prevalence of DR was 12.0% among all studied patients and 7.00% among all studied eyes. The grade of retinopathy was directly related to the duration of DM, fasting blood glucose, and glycosylated hemoglobin levels. Keywords: DM, DR, Hb1Ac

PREVALENCE OF DIABETIC RETINOPATHY AMONG CHILDREN WITH TYPE 1 DIABETES MELLITUS TREATED BY INSULIN

2021 ◽  
pp. 64-65
Author(s):  
Dinesh Kumar ◽  
Chanchal Gupta ◽  
Mahesh Kumar Gupta ◽  
Vishnu Agarwal
Keyword(s):  
Diabetic Retinopathy ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Children ◽  
The Mean ◽  
Type 1 Dm

BACKGROUND- This study to nd out the prevalence of diabetic retinopathy (DR) among diabetic children with type 1 DM treated with insulin. METHODS -This is a cross-sectional study conducted on 100 children with type 1 DM from 1 to 16 years of age. All patients were subjected to full fundus examination and were then classied according to its results into patients with DR and patients without DR. RESULTS- The mean age of the patients was 9.42±1.31 years and 56.00% were males. DR was found in 10 (10.00%) patients, seven of whom had retinopathy in one eye and three had retinopathy in both eyes. Mild nonproliferative DR was found in 11 eyes and moderate DR was found in 2 eyes. CONCLUSION- The prevalence of DR was 10.0% among all studied patients and 6.50% among all studied eyes. The grade of retinopathy was directly related to the duration of DM, fasting blood glucose, and glycosylated hemoglobin levels.

scholarly journals Diabetic kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Randa I. Farah ◽  
Mohammed Q. Al-Sabbagh ◽  
Munther S. Momani ◽  
Asma Albtoosh ◽  
Majd Arabiat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Laboratory Data ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Kidney ◽  
Type 2 Dm

Abstract Aim Diabetic kidney disease (DKD) is a major long-term complication of diabetes mellitus (DM). Given the paucity of data on DKD in Jordan, we aimed to evaluate the prevalence, characteristics and correlates of DKD in Jordanian patients with type 2 DM. Methods This cross-sectional study included 1398 adult patients with type 2 DM who sought medical advice in the endocrinology clinic between March and September 2019. Demographic, clinical and laboratory data were reviewed. DKD was defined as reduced eGFR, and/or albuminuria. Three regression models were constructed to identify factors associated with CKD stages, albuminuria and DKD. Results Overall, 701 (50.14%) patients had DKD, with a median age of 59.71 ± 11.36  years. Older age, high triglycerides, and low high-density lipoprotein were associated with DKD (multivariable odds ratio [OR]: 1.02, 95% confidence interval [CI]: 1.01–1.03, p < 0.01; OR: 1.1, 95% CI: 1.01–1.2; and OR: 0.98, 95% CI: 0.97–0.99, p < 0.01 respectively). Metformin and renin-angiotensin system blockers were negatively associated with albuminuria and chronic kidney disease stages (p < 0.01). Conclusion Our study demonstrated that approximately one half of patients with type 2 DM had DKD. Further studies are necessary to understand this high prevalence and the underlying factors. Future research are needed to assess implementing targeted community-based intervention.

scholarly journals Thyroid hormones profile of patients with type 2 diabetes mellitus in Kano, Nigeria

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Mustapha Zainab Abubakar ◽  
Kabiru Abdulsalam ◽  
Isah A. Yahaya
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Endocrine Disorders ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Type 2 Diabetics ◽  
Patients With Diabetes ◽  
Considerable Impact

Diabetes mellitus (DM) and thyroid disease are the two most common endocrine disorders in the general population. Several Studies have shown that thyroid dysfunction is common in patients with DM, and thyroid dysfunction have been found to have a considerable impact on the glycaemic control and often increases the risk of development of long-term complications in patients with diabetes mellitus. This study determined the prevalence of thyroid dysfunction in patients with type 2 DM in Kano, North-Western Nigeria. The study was a descriptive cross-sectional study conducted on 250 participants made up of 130 patients with type 2 DM and 120 apparently healthy non-diabetic controls. Questionnaires were used to collect information on bio data, medical history, duration of diagnosis of diabetes and type of treatment. Also, blood samples of the participants were collected and analyzed for fasting plasma glucose, fT3, fT4, and TSH. The results were interpreted using American Thyroid Associations’ criteria and the data was analyzed using the statistical software package, STATA version 20. Two hundred and thirty-four (93.6%) of the participants were euthyroid while sixteen (6.4%) were found to have various forms of thyroid dysfunction. The prevalence of thyroid dysfunction was 10% and 2.5% among type 2 diabetics and controls respectively. Among the type 2 DM patients with thyroid dysfunction, 38.5% had hypothyroidism. Thyroid dysfunction was found to be commoner among type 2 DM patients than non-diabetic individuals with hypothyroidism being the commonest disorder.

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