Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion

2021 ◽  
pp. 1-5
Author(s):  
Reshma Pujari ◽  
Marsali Ruth Newman ◽  
Karen L. Talia ◽  
Adam Pendlebury ◽  
David Hawkes ◽  
...  
Keyword(s):  
Cervical Screening ◽  
Low Risk ◽  
Low Grade ◽  
Seborrheic Keratosis ◽  
Transformation Zone ◽  
Large Loop ◽  
Cytological Features ◽  
Intraepithelial Lesion ◽  
Rare Lesion

<b><i>Introduction:</i></b> Seborrheic keratosis-like lesion of the cervix and vagina is a rare lesion and shows similar morphology to vulvar seborrheic keratosis; 3 of the 7 previously reported cases were associated with low-risk human papillomavirus (HPV) type 42. We report a case of seborrheic keratosis-like lesion of the cervix and provide the first description of the cytological features of this lesion. <b><i>Case Presentation:</i></b> A woman in her late forties presented with postcoital bleeding. She had a cervical screening test following which she underwent cervical biopsy, endocervical and endometrial curettage, large loop excision of the transformation zone of the cervix, and hysterectomy. <b><i>Results:</i></b> The liquid-based cytology preparation showed cohesive groups of mildly atypical squamoid cells with a spindle cell morphology, mildly increased nuclear to cytoplasmic ratio, prominent nucleoli, and occasional nuclear grooves. No koilocytes were identified. Molecular genotyping revealed positivity for HPV type 42. <b><i>Discussion/Conclusion:</i></b> This represents the first description of the cytological features of a seborrheic keratosis-like lesion of the cervix, which are distinctive and unusual. Whilst the mild squamous atypia raised the possibility of a low-grade squamous intraepithelial lesion, no koilocytes were identified. The association in our case with a low-risk HPV type, HPV 42, provides further evidence for a role of this HPV type in the pathogenesis of these lesions.

Liquid-Based Cytology: Evaluation of Effectiveness, Cost-Effectiveness, and Application to Present Practice

2004 ◽  
Vol 2 (6) ◽  
pp. 597-611 ◽  
Author(s):  
J. Thomas Cox
Keyword(s):  
Cost Effectiveness ◽  
Cervical Screening ◽  
Pap Test ◽  
Representative Specimen ◽  
Low Grade ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Split Sample ◽  
Intraepithelial Lesion ◽  
Liquid Based Cytology

This article reviews the data available as of 2004 on the effectiveness and cost-effectiveness of cervical screening with the two available cytologic methods, the conventional Papanicolaou (Pap; CP) smear and liquid-based cytology (LBC), and discusses the application of LBC to current practice. The majority of LBC studies are on the ThinPrep Pap Test (CYTYC, Boxsborough, MA) and the remainder are on SurePath (TriPath, Burlington, NC), which was previously known as AutoCyte Prep. LBC identified more low-grade squamous intraepithelial lesion (LSIL) Pap test results compared with paired conventional cytology in 17 of 21 ThinPrep and 9 of 12 SurePath “split-sample” studies considered to fulfill the criteria for inclusion in the British NHS Health Technology Assessment (HTA) evaluation of cervical cytology. In four of the six recent ThinPrep and one of two SurePath split-sample studies, more high-grade squamous intraepithelial lesion-positive (HSIL+) results were identified by LBC than by CP. All 15 “direct-to vial studies” meeting HTA criteria reported more LSIL+ results for LBC compared with CP, and all eight of the direct-to-vial studies reporting HSIL+ results separately showed increased detection of high-grade cytology interpretations. Fifteen studies met the criteria for evaluating sensitivity and specificity. Aggregate sensitivity for the CP was 71.5% and for LBC was 80.1%. Indirect comparisons of the two LBC methods did not detect a difference in sensitivity, and a meta-analysis of the six studies comparing specificity between CP and LBC found no difference. Other capabilities of LBC are improved specimen adequacy and the ability to do ancillary testing out of the liquid-based vial. In cost-effective analyses based on models of disease natural history and/or the clinical effectiveness of each screening modality, screening with CP was always dominated by screening with LBC. Primary cervical screening guidelines issued by the American Cancer Society in 2002 recommend repeating the cytology biannually if liquid-based and annually if conventional. The gain in sensitivity, apparent cost-effectiveness, and advantage of having a representative specimen for ancillary testing, support the use of LBC.

scholarly journals Limited Role of Promoter Methylation of MGMT and C13ORF18 in Triage of Low-Grade Squamous Intraepithelial Lesion

2018 ◽  
Vol 131 (8) ◽  
pp. 939-944 ◽  
Author(s):  
Lu-Lu Sun ◽  
Yuan Liu ◽  
Xiao Sun ◽  
Lei Pan ◽  
Dan Wu ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Limited Role ◽  
Intraepithelial Lesion

scholarly journals Immunohistochemical Expression of p16INK4a and bcl-2 According to HPV Type and to the Progression of Cervical Squamous Intraepithelial Lesions

2005 ◽  
Vol 53 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Márcia C.M. Guimarães ◽  
Maria Alice G. Gonçalves ◽  
Christiane P. Soares ◽  
Jussara S.R. Bettini ◽  
Roberta A. Duarte ◽  
...  
Keyword(s):  
Low Grade ◽  
Immunoperoxidase Method ◽  
Squamous Intraepithelial Lesion ◽  
Immunohistochemical Expression ◽  
Quantitative Expression ◽  
Cervical Squamous Intraepithelial Lesions ◽  
Intraepithelial Lesion ◽  
E6 And E7 ◽  
Intraepithelial Lesions

Inactivation of the cell cycle inhibitor gene p16MTS1 seems to be involved in human papillomavirus (HPV)-related carcinogenesis because E6 and E7 oncoproteins may impair p16INK4a and, indirectly, bcl-2 functions. In this study, we analyzed the role of immunohistochemical expression of p16INK4a and bcl-2 in HPV-infected cervical biopsies as prognostic markers of the progression of squamous intraepithelial lesion (SIL). Sixty-five cervical biopsies were stratified into two subgroups according to the second biopsy: 27 of them maintained a low-grade (LG)-SIL diagnosis, and 38 progressed from LG-SIL to high-grade (HG)-SIL. p16INK4a and bcl-2 quantitative expression levels were measured by the immunoperoxidase method. PCR-DNA techniques were used to detect and type HPV. The Wilcoxon and Fisher exact tests were employed for the statistical analysis. In the group with an LG-SIL diagnosis at the second biopsy, no significant associations were found between p16INK4a and bcl-2 expression and presence of HPV16/18. In the group that progressed to HG-SIL, a significant association was observed between p16INK4a overexpression and HPV16/18 presence ( p=0.021), but none with bcl-2 levels. It is concluded that immunohistochemical bcl-2 expression may not be useful for predicting the progression of HPV-related SIL. In contrast, p16INK4a overexpression seemed to be associated with HPV 16 and 18, suggesting that it may be a good marker for predicting SIL progression.

Risk Factors of Post-Large Loop Excision of the Transformation Zone Recurrent High-Grade Cervical Intraepithelial Lesion

2019 ◽  
Vol 23 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Emilie Demarquet ◽  
Julien Mancini ◽  
Lise Preaubert ◽  
Jean Gondry ◽  
Julien Chevreau ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Grade ◽  
Transformation Zone ◽  
Large Loop ◽  
Cervical Intraepithelial Lesion ◽  
Intraepithelial Lesion

scholarly journals The impact of HPV cervical screening on negative large loop excision of the transformation zone (LLETZ): A comparative cohort study

2016 ◽  
Vol 141 (3) ◽  
pp. 485-491 ◽  
Author(s):  
K.M. Manley ◽  
A.K. Wills ◽  
G.C. Morris ◽  
J.L. Hogg ◽  
A. López Bernal ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cervical Screening ◽  
Transformation Zone ◽  
Large Loop ◽  
Comparative Cohort Study ◽  
The Impact

scholarly journals Human Papillomavirus Infection of the Skin

2018 ◽  
Vol 142 (6) ◽  
pp. 700-705 ◽  
Author(s):  
Patrick Bacaj ◽  
David Burch
Keyword(s):  
Human Papillomavirus ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Papillomavirus Infections ◽  
Review Of The Literature ◽  
Squamous Intraepithelial Lesion ◽  
Papillomavirus Infection ◽  
Appropriate Treatment ◽  
Intraepithelial Lesion

Context.— Human papillomavirus is implicated in the pathogenesis of benign and malignant neoplasms of the skin. Objective.— To review the role of human papillomavirus in the development of malignancies and their precursor lesions in skin. Data Sources.— The study comprised a review of the literature. Conclusions.— The use of low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion terminology brings order and simplicity to these lesions, correlates with the current understanding of the biology of human papillomavirus infections, and helps to promote accurate diagnosis of and appropriate treatment for these lesions.

scholarly journals Human Papilloma Virus Persistence after Cone Excision in Women with Cervical High Grade Squamous Intraepithelial Lesion: A Prospective Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Laurențiu Pirtea ◽  
Dorin Grigoraş ◽  
Petru Matusz ◽  
Marilena Pirtea ◽  
Lavinia Moleriu ◽  
...  
Keyword(s):  
Prospective Study ◽  
Pap Smear ◽  
Hpv Infection ◽  
High Grade ◽  
Transformation Zone ◽  
Large Loop ◽  
Persistence Rate ◽  
Intraepithelial Lesion ◽  
A Prospective Study ◽  
Intraepithelial Lesions

Background. Persistent human papillomavirus (HPV) infection is a necessary event in cervical cancer tumorigenesis. Our objectives were to estimate the rate of HPV infection persistence after large loop excision of the transformation zone (LEEP) in patients with high grade squamous intraepithelial lesions (HSIL) and to investigate if HPV persistence is type related.Methods. We conducted a prospective study on 89 patients with HSIL treated with LEEP. DNA HPV was performed before surgery and at 6, 12, and 18 months after LEEP.Results. Four patients were excluded from the study. The HPV persistence in the remaining 85 patients was 32.95% (6 months), 14.12% (12 months), and 10.59% (18 months). Type 16 had the highest persistence rate, 23.5% (6 months), 11.8% (12 months), and 8.2% (18 months). Coinfection was found to be 54.12% before LEEP and 18.8% (6 months), 4.7% (12 months), and 3.5% (18 months) after LEEP. The rate of coinfections including type 16 was 46.83% of all coinfections. Coinfection including type 16 was not correlated with higher persistence rate compared to infection with type 16 only.Conclusions. HPV infection is not completely eradicated by LEEP in patients with HSIL lesion on PAP smear. HPV persistence after LEEP is influenced by HPV type. HPV type 16 has the highest persistence rate.

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