scholarly journals Increased Expression of P-Selectin on Platelets Is a Risk Factor for Silent Cerebral Infarction in Patients With Atrial Fibrillation

Circulation ◽  
1998 ◽  
Vol 98 (17) ◽  
pp. 1721-1727 ◽  
Author(s):  
Tetsuo Minamino ◽  
Masafumi Kitakaze ◽  
Shoji Sanada ◽  
Hiroshi Asanuama ◽  
Toshiya Kurotobi ◽  
...  
Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5234
Author(s):  
Chika Shichijo ◽  
Keita Kai ◽  
Kazuki Jinnouchi ◽  
Masashi Nishihara ◽  
Hideo Hara ◽  
...  

Cerebral infarction (CI) severely affects the prognosis of patients with malignancy. The aim of the study was to compare the pathology of CI between cases with and without malignancy focusing on intracranial Mönckeberg’s atherosclerosis. Among 778 autopsy cases of craniotomy, 53 cases of “cerebral infarction without malignancy group” (CI group), 50 cases of “malignant tumor without CI group” (MT group), and 39 cases of “cerebral infarction with malignancy group” (CM group) were identified. Mönckeberg’s atherosclerosis was mainly found in the basal ganglia and its prevalence in the CM group (38.5%) was significantly higher than in the MT group (12.0%, p = 0.005), and apparently higher than in the CI group (18.9%, p = 0.057). The CI group was significantly older, had higher BMIs, and a greater prevalence of hypertension and atrial fibrillation compared to the CM group. In addition, the prevalence of chronic renal disease was significantly lower in the CM group (2.6%, p = 0.012) than in the CI group (20.8%). Our results indicated that Mönckeberg’s atherosclerosis was often found in the basal ganglia of CM cases and that intracranial Mönckeberg’s atherosclerosis is a potential risk factor for CI in patients with advanced stage malignancy.


2018 ◽  
Vol 82 (3) ◽  
pp. 672-676 ◽  
Author(s):  
Keitaro Senoo ◽  
Yusuke Kondo ◽  
Yoshio Kobayashi ◽  
Gregory YH Lip

2013 ◽  
Vol 22 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Eo Rin Cho ◽  
Hyun Kim ◽  
Hyung Suk Seo ◽  
Sooyeon Suh ◽  
Seung Ku Lee ◽  
...  

Metabolism ◽  
2008 ◽  
Vol 57 (10) ◽  
pp. 1323-1327 ◽  
Author(s):  
Naoya Fukunaga ◽  
Futoshi Anan ◽  
Koji Kaneda ◽  
Tomoko Nawata ◽  
Tetsunori Saikawa ◽  
...  

Heart Rhythm ◽  
2019 ◽  
Vol 16 (9) ◽  
pp. 1305-1313 ◽  
Author(s):  
Keita Miki ◽  
Makoto Nakano ◽  
Kentaro Aizawa ◽  
Yuhi Hasebe ◽  
Yoshitaka Kimura ◽  
...  

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Yakabe ◽  
A Aso ◽  
Y Fukuyama ◽  
M Araki ◽  
T Nakamura

Abstract Aims Cryoballoon ablation (CBA) is effective for atrial fibrillation (AF), however acute silent cerebral infarction (SCI) is not uncommon after CBA. This study aimed to clarify the relationship between the morphology of LAA and SCI. Methods and results From 2015 to 2019, 207 consecutive patients (65.1±11.4 years, 26.6% of female, 31.4% of persistent AF) who underwent CBA for AF at our hospital were enrolled. All patients were evaluated with computed tomography for LAA before CBA and divided into two groups as chicken wing (CW) group and non-CW group. SCI was evaluated with magnetic resonance imaging at the following day after CBA. As a result, 18.4% of patients have occurred SCI after CBA. Although the patients' background didn't differ between the two groups, the Hounsfield scale (LAA/Aorta ratio) was lower (non-CW vs. CW = 0.68±0.12 vs. 0.73±0.11, p=0.004), and LAA orifice size tended to be larger (16.9±4.6 vs. 15.8±4.1, p=0.053) in non-CW group. SCI significantly occurred in non-CW group (29.5% vs. 11.6%, p=0.003), especially in cauliflower shape of 45.0%. In multivariate analysis, non-CW (p=0.002, Odds ratio 3.2, 95% of CI 1.5–7.0), skipped DOAC before CBA (p=0.04, Odds ratio 6.1, 95% of CI 1.1–115.4), and touch-up ablation in left atrium (p=0.02, Odds ratio 2.8, 95% CI 1.2–6.5) were independent predictors of SCI. Conclusions SCI was not rare after CBA for AF. Morphology of LAA was strongly associated with SCI. Funding Acknowledgement Type of funding source: None


2017 ◽  
Vol 24 (10) ◽  
pp. 1484-1488
Author(s):  
Muhammad Adnan Sarwar ◽  
Huma Muzaffar ◽  
Shakeel Ahmad

Objectives: To determine the frequency of different risk factors among patientsof stroke due to cerebral infarction. Study Design: Descriptive cross sectional survey. Setting:Punjab Medical College and affiliated hospitals (Allied Hospital and DHQ), Faisalabad. Durationwith Dates: Six months from June 2006 to November 2006. Methods: This was a crosssectional survey that included 195 patients with stroke due to cerebral infarction. The mainoutcome variable was frequency of different risk factors which were described as frequencydistribution table. Results: Hypertension was seen among 142 (73%) patients, followed bydiabetes mellitus in 83 42.5% patients, ischemic heart disease in 74 (38%) patients, smokingin 59 (30.3%) patients, obesity in 53(27%) patients, atrial fibrillation in 43 (22%) patients anddyslipidemia in 23 (11.8%). Conclusion: Hypertension is the most common risk factor followedby diabetes mellitus associated with stroke due to cerebral infarction.


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