Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis

We have previously shown nutritional intervention with fish oil (n-3 PUFA) to reduce numerous complications associated with the metabolic syndrome (MetS) in the JCR:LA-corpulent (cp) rat. In the present study, we sought to explore the potential role of fish oil to prevent glomerulosclerosis in JCR:LA-cp rats via renal eicosanoid metabolism and lipidomic analysis. Male lean and MetS JCR:LA-cp rats were fed a lipid-balanced diet supplemented with fish oil (5 or 10 % of total fat). After 16 weeks of feeding, albuminuria was significantly reduced in MetS rats supplemented with 5 or 10 % fish oil ( − 53 and − 70 %, respectively, compared with the untreated MetS rats). The 5 % fish oil diet resulted in markedly lower glomerulosclerosis ( − 43 %) in MetS rats and to a lesser extent in those supplemented with 10 % fish oil. Interestingly, untreated MetS rats had higher levels of 11- and 12-hydroxyeicosatetraenoic acids (HETE) v. lean rats. Dietary fish oil reduced these levels, as well as other (5-, 9- and 15-) HETE. Whilst genotype did not alter prostanoid levels, fish oil reduced endogenous renal levels of 6-keto PGF1α (PGI2 metabolite), thromboxane B2 (TxB2), PGF2α and PGD2 by approximately 60 % in rats fed 10 % fish oil, and TxB2 ( − 50 %) and PGF2α ( − 41 %) in rats fed 5 % fish oil. In conclusion, dietary fish oil prevented glomerular damage in MetS rats and mitigated the elevation in renal HETE levels. These results suggest a potential role for dietary fish oil to improve dysfunctional renal eicosanoid metabolism associated with kidney damage during conditions of the MetS.

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Blood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: role of adiponectin and nitric oxide

British Journal Of Nutrition ◽

10.1017/s0007114511006921 ◽

2012 ◽

Vol 108 (8) ◽

pp. 1435-1442 ◽

Cited By ~ 30

Author(s):

Andréa Name Colado Simão ◽

Marcell Alysson Batisti Lozovoy ◽

Larissa Danielle Bahls ◽

Helena Kaminami Morimoto ◽

Tathiana Name Colado Simão ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Fish Oil ◽

Inflammatory Markers ◽

Inflammatory Marker ◽

Control Group ◽

Treatment Groups ◽

The Metabolic Syndrome ◽

Baseline Values

The aim of the present study was to verify the effects of fish oil and a soya-based product on inflammatory markers and endothelial function measured by NO in women with the metabolic syndrome (MetS). A total of sixty-five women (mean age: 47·9 (sd9·98) years) were studied in a 90-d parallel, randomised design. A control group maintained their usual diet; the second group received 29 g/d of soyabean (kinako); the third group received 3 g/d of fish oiln-3 fatty acids; and the fourth group received fish oil (3 g/d) and kinako (29 g/d). Anthropometric, blood pressure (BP), inflammatory markers, anti-inflammatory marker (adiponectin) and NO concentrations were evaluated. In relation to the baseline values, the group that received fish oil and kinako concomitantly presented a statistically significant decrease in systolic BP (SBP;P < 0·05), whereas there was a significant decrease in diastolic BP (DBP) in the control group (P < 0·05), kinako group (P < 0·01) and fish oil group (P < 0·01) after 90 d. There was a significant increase in adiponectin (P < 0·01) and NO values (P < 0·05) after 90 d in the kinako and fish oil groups. Differences between treatment groups verified a significant decrease (P < 0·05) in DBP in the kinako group after 90 d when compared to the results obtained from the fish oil and kinako groups. In conclusion, the findings of increased serum adiponectin and NO metabolite levels after 90 d, both in the fish oil and soya groups, reinforce the importance of the influence of adiponectin and NO levels on BP decrease in patients with the MetS.

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W09.208 Effect of atorvastatin and fish oil on HDL apolipoprotein A-I kinetics in the metabolic syndrome

Atherosclerosis ◽

10.1016/s0021-9150(04)90207-9 ◽

2004 ◽

Vol 5 (1) ◽

pp. 48

Author(s):

P BOLITHO

Keyword(s):

Metabolic Syndrome ◽

Fish Oil ◽

The Metabolic Syndrome ◽

Apolipoprotein A

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Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice

The Journal of Lipid Research ◽

10.1194/jlr.m700478-jlr200 ◽

2007 ◽

Vol 49 (1) ◽

pp. 217-229 ◽

Cited By ~ 44

Author(s):

Marcia L. E. MacDonald ◽

Roshni R. Singaraja ◽

Nagat Bissada ◽

Piers Ruddle ◽

Russell Watts ◽

...

Keyword(s):

Metabolic Syndrome ◽

The Metabolic Syndrome ◽

Stearoyl Coa Desaturase ◽

Deficient Mice

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Stearoyl-CoA Desaturase-1 and the Metabolic Syndrome

Current Drug Targets - Immune Endocrine & Metabolic Disorders ◽

10.2174/1568008033340117 ◽

2003 ◽

Vol 3 (4) ◽

pp. 271-280 ◽

Cited By ~ 66

Author(s):

Paul Cohen ◽

James M. Ntambi ◽

Jeffrey M. Friedman

Keyword(s):

Metabolic Syndrome ◽

The Metabolic Syndrome ◽

Stearoyl Coa Desaturase

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Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice

Journal of Agricultural and Food Chemistry ◽

10.1021/jf201496h ◽

2011 ◽

Vol 59 (13) ◽

pp. 7482-7489 ◽

Cited By ~ 33

Author(s):

Zhi-Hong Yang ◽

Hiroko Miyahara ◽

Tetsu Mori ◽

Nobushige Doisaki ◽

Akimasa Hatanaka

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Fatty Acids ◽

Fish Oil ◽

Monounsaturated Fatty Acids ◽

Beneficial Effects ◽

Dietary Fish

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Fish and Dietary Fish Oil Are Associated with a Risk of Metabolic Syndrome in Korean Adults (P08-024-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz044.p08-024-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Eunhee Choi ◽

Seoeun Ahn ◽

Kyungho Ha ◽

Hyojee Joung

Keyword(s):

Metabolic Syndrome ◽

Fish Oil ◽

Science Research ◽

Epidemiological Studies ◽

Dietary Intakes ◽

Dietary Recall ◽

Fisheries Science ◽

Funding Sources ◽

Dietary Fish ◽

Using Data

Abstract Objectives Several epidemiological studies have examined the association between fish and dietary fish oil intake and metabolic syndrome in a population. However, few studies have investigated fish and dietary fish oil intake and its association with the risk of metabolic syndrome in the Korean population. Methods Using data from the 2013–2016 Korea National Health and Nutrition Examination Survey, a total of 14,519 adults (6,135 men and 8,384 women) aged ≥ 19 years were involved in this study. Dietary intakes of fish and fish oil including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were estimated by a 24-h dietary recall. Metabolic syndrome was diagnosed using the National Cholesterol Education Program Adult Treatment Panel III criteria. The odds ratios (ORs) for the presence of metabolic syndrome according to the tertile of fish and fish oil intakes were calculated using a multiple logistic regression model. Results The prevalence of metabolic syndrome among the participants was 9.18%. The mean intake (standard error, SE) of fish, EPA and DHA was 123.35 (2.67) g/day, 103.43 (2.48) mg/day and 179.21 (4.75) mg/day for the study participants, respectively. Dietary intakes of fish and fish oil were not associated with the prevalence of metabolic syndrome, however, they were associated with the prevalence of several metabolic abnormalities. Men in the highest tertile of energy adjusted DHA intake from fish showed a 20% decreased risk of hypertriglyceridemia (OR, 0.80; 95% CI, 0.67–0.96, p for trend, 0.0274), compared with those in the lowest tertile. However, Women in the highest tertile of fish intake showed a higher prevalence of impaired fasting glucose (OR, 1.70; 95% CI, 1.24–2.33) than those in the lowest tertile. Conclusions Our findings suggest that a higher intake of dietary fish oil might be associated with a lower risk of hypertriglyceridemia in Korean men. Thus, further prospective studies are needed to examine the association of fish and fish oil with metabolic syndrome. Funding Sources This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2018R1A2B6007070) and the National Institute of Fisheries Science (R2019051).

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