Abstract P237: Moderate and Heavy Alcohol Consumption Are Associated With Decreased Systolic Function After 8 Years of Follow-up

Introduction: Excessive alcohol consumption is an important risk factors for cardiovascular disease, however, the underlying mechanisms are not well understood. Hypothesis: We assessed the hypothesis whether alcohol consumption is prospectively associated with unfavorable measures of cardiac structure and function. Methods: We used data from the Hoorn Study, a population-based, prospective cohort study. Data on self-reported alcohol consumption were collected with a validated food frequency questionnaire in 2000/2001(baseline for the current analyses). Echocardiography was performed in 2000/2001 in 582 participants and in 2007/2009 in 339 participants. Participants were classified into 5 categories based on self-reported alcohol consumption (glasses per week): 0 (non-drinkers), 0- 3 (light-drinkers), ≥3-7 (light to moderate drinkers), ≥7-14 (moderate drinkers) and ≥14 (heavy drinkers). Light drinking was considered the reference group. We studied the association of alcohol consumption with echocardiographic measures after 8 years of follow-up using linear regression analyses, adjusting for potential confounders. Results: The mean age was 69.8±6.5 years and 50% was female. After 7.4±0.5 years follow-up, moderate and heavy alcohol consumption were associated with a decreased left ventricular ejection fraction of -5.1% (-8.7, -1.4) for moderate and -4.8% (-8.8, -0.8) for heavy drinkers (Table). Heavy drinking was also associated with a decrease in left atrial volume index: -3.9mL/m 2 (-7.6, -0.2). No longitudinal associations were found between alcohol consumption and left ventricular mass index. Conclusion: Both moderate and heavy drinking were associated with decreased systolic function after 8 years follow-up. The toxic effect of alcohol could lead to underfilling of the left atrium which could lead to lower systolic function. These findings may explain the increased cardiovascular risk among people with excessive alcohol use.

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HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER

Innovation in Aging ◽

10.1093/geroni/igz038.3324 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S911-S911

Author(s):

Riki E Slayday ◽

Carol E Franz ◽

Sean N Hatton ◽

Linda K McEvoy ◽

Michael J Lyons ◽

...

Keyword(s):

Alcohol Consumption ◽

Brain Aging ◽

Age Difference ◽

Protective Effects ◽

Heavy Alcohol ◽

Heavy Drinkers ◽

Heavy Alcohol Consumption ◽

Excessive Alcohol ◽

Brain Age ◽

Late Midlife

Abstract Excessive alcohol consumption is associated with cognitive decline, exacerbated brain atrophy, and dementia in older adults, but associations with midlife brain health are less well understood. We hypothesized that heavy drinkers would have older-looking brains in late midlife. We examined alcohol consumption at mean age 56 (range 51-59) in 364 men from the Vietnam Era Twin Study of Aging (VETSA) and their predicted brain age at mean age 62 (range 56-67). We created five midlife alcohol consumption groups based on drinks consumed over the past two weeks: never, former, light (1-14), moderate (15-28), and heavy (>28). Participants underwent structural magnetic resonance imaging at mean age 62. Predicted brain age was measured using the Brain-Age Regression Analysis and Computation Utility software (BARACUS). Models adjusted for age, scanner, race/ethnicity, SES, smoking, health, depressive symptoms, alcohol dependence, general cognitive ability at age 20, and non-independence of twins within pairs. Heavy drinkers had a significantly older predicted than chronological brain age (M= 5.93, SE= 0.88) compared to each of the other four groups (p’s < 0.05). There were no significant differences among the never (M= 2.88, SE= 0.98), former (M= 2.76, SE= 0.74), light (M= 3.00, SE= 0.94), or moderate (M= 5.93, SE= 0.88) consumption groups. Heavy alcohol consumption at age 56 was associated with an approximately 3-year greater predicted brain age difference at age 62. There was no evidence of protective effects of light/moderate drinking over non-drinking. The neurotoxic effects of excessive alcohol may exacerbate brain aging in late midlife.

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Associations between occupation and heavy alcohol consumption in UK adults aged 40–69 years: a cross-sectional study using the UK Biobank

BMC Public Health ◽

10.1186/s12889-021-10208-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Andrew Thompson ◽

Munir Pirmohamed

Keyword(s):

Alcohol Consumption ◽

Heavy Drinking ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Heavy Alcohol ◽

Heavy Drinkers ◽

Heavy Alcohol Consumption ◽

The Uk ◽

Gender Specific

Abstract Background Understanding the relationship between occupation and alcohol use offers opportunities to provide health promotion programmes based on evidence of need. We aimed to determine associations between occupation and heavy alcohol consumption in working individuals aged 40–69 years. Methods A cross-sectional study was conducted using 100,817 people from the UK Biobank: 17,907 participants categorised as heavy drinkers, defined as > 35 units/week for women and > 50 units/week for men, and 82,910 drinking controls. Prevalence ratios (PRs) and 95% CIs were calculated for gender-specific heavy drinking in 353 occupations using Standard Occupational Classification, V.2000. Results Seventy-seven occupations were associated with level of alcohol consumption in drinkers. The largest ratios for heavy drinkers were observed for publicans and managers of licenced premises (PR = 2.81, 95%CI 2.52–3.14); industrial cleaning process occupations (PR = 2.09, 1.33–3.28); and plasterers (PR = 2.07, 1.66–2.59). Clergy (PR = 0.20, 0.13–0.32); physicists, geologists and meteorologists (PR = 0.40, 0.25–0.65); and medical practitioners (PR = 0.40, 0.32–0.50) were least likely to be heavy drinkers. There was evidence of gender-specific outcomes with the proportion of jobs associated with heavy drinking accounted for by skilled trade occupations being 0.44 for males and 0.05 for females, and 0.10 for males and 0.40 for females when considering managers and senior officials. Conclusions In the largest study of its kind, we found evidence for associations between a wider variety of occupations and the risk of heavy alcohol consumption than identified previously, particularly in females, although causality cannot be assumed. These results help determine which jobs and broader employment sectors may benefit most from prevention programmes.

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Abstract P002: Heavy Alcohol Consumption Increases the Risk of Atrial Fibrillation -Circulatory Risk in Communities Study(CIRCS)

Circulation ◽

10.1161/circ.127.suppl_12.ap002 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Fumihiko Sano ◽

Tetsuya Ohira ◽

Akihiko Kitamura ◽

Hironori Imano ◽

Renzhe Cui ◽

...

Keyword(s):

Atrial Fibrillation ◽

Alcohol Consumption ◽

Medical History ◽

Moderate Alcohol Consumption ◽

Heavy Alcohol ◽

Ethanol Drinking ◽

Wide Range ◽

Detailed Medical History ◽

Heavy Alcohol Consumption

Background— Evidence on the relationship of a wide range of alcohol consumption with risk of incident atrial fibrillation has been limited. Methods— Between 1991 and 1995, 8602 Japanese men and women aged 30 to 80 years and free of clinical atrial fibrillation took part in the first examination of the Circulatory Risk in Communities Study(CIRCS)- a population based cohort study of cardiovascular risk factors, cardiovascular disease incidence, and their trends in Japanese communities. In the first examination, we checked a detailed medical history, physical examination, blood and urine examination, and electrocardiogram (ECG). An interviewer obtained histories in detail for weekly alcohol intake. In the follow-up period, incident atrial fibrillations were ascertained by annual ECG record and medical history of treatment of atrial fibrillation. ECGs were coded with the Minnesota Code by trained physician-epidemiologists. Differences in baseline characteristics between atrial fibrillation cases and controls were compared using Student t-tests or chi-squared tests. The hazard ratios (HRs) of incidence of atrial fibrillation and 95% confidence interval (CI) relative to the never-drinking group were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazard model. Results— During an average follow-up of 6.4 years, 290 incident atrial fibrillation occurred. The higher incidence rate of atrial fibrillation was observed among participants with more than 69 g of ethanol drinking per week, compared with less than 69 g of ethanol drinking per week. On the other hand, light to moderate alcohol consumption was not associated with risk of atrial fibrillation. Compared with the never drinking group, the multivariable-adjusted HRs of past, light (<23 g), light moderate (23-46 g), moderate (46-69 g), and heavy (>69 g) drinking groups were 1.20 (95% CI, 0.61-2.35), 0.85 (95% CI, 0.57-1.27), 1.05 (95% CI, 0.63-1.75), 1.34 (95% CI, 0.78-2.32), and 2.92 (95% CI, 1.61-5.28), respectively. Conclusions— Heavy alcohol consumption was associated with the higher risk of atrial fibrillation, whereas there was no association of less than moderate alcohol consumption and atrial fibrillation.

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Heavy alcohol consumption in individuals with HIV infection: Effects on neuropsychological performance

Journal of the International Neuropsychological Society ◽

10.1017/s1355617705050095 ◽

2005 ◽

Vol 11 (1) ◽

pp. 70-83 ◽

Cited By ~ 66

Author(s):

JOHANNES C. ROTHLIND ◽

TANYA M. GREENFIELD ◽

ANNE V. BRUCE ◽

DIETER J. MEYERHOFF ◽

DEREK L. FLENNIKEN ◽

...

Keyword(s):

Alcohol Consumption ◽

Alcohol Use ◽

Executive Functioning ◽

Hiv Infection ◽

Synergistic Effects ◽

Heavy Drinking ◽

Heavy Alcohol ◽

Heavy Drinkers ◽

Heavy Alcohol Use ◽

Active Alcohol

Higher rates of alcohol use have been reported in HIV+ individuals compared to the general population. Both heavy alcohol use and HIV infection are associated with increased risk of neuropsychological (NP) impairment. We examined effects of heavy active alcohol use and HIV on NP functioning in a large sample of community-residing HIV+ individuals and HIV− controls. The four main study groups included 72 HIV− light/non-drinkers, 70 HIV− heavy drinkers (>100 drinks per month), 70 HIV+ light/non-drinkers, and 56 HIV+ heavy drinkers. The heavy drinking group was further subdivided to assess effects of the heaviest levels of active alcohol use (>6 drinks per day) on NP functioning. A comprehensive NP battery was administered. Multivariate analysis of covariance was employed to examine the effect of HIV and alcohol on NP functioning after adjusting for group differences in age and estimated premorbid verbal intellectual functioning. The analyses identified main effects of heavy drinking and HIV on NP function, with greatest effects involving the contrast of HIV+ heavy drinkers and the HIV− light drinkers. Synergistic effects of heaviest current drinking and HIV infection were identified in analyses of motor and visuomotor speed. Supplementary analyses also revealed better NP function in the HIV+ group with antiretroviral treatment (ART) and lower level of viral burden, a finding that was consistent across levels of alcohol consumption. Finally, heavy alcohol use and executive functioning difficulties were associated with lower levels of self-reported medication adherence in the HIV+ group. The findings suggest that active heavy alcohol use and HIV infection have additive adverse effects on NP function, that they may show synergistic effects in circumstances of very heavy active alcohol use, and that heavy drinking and executive functioning may mediate health-related behaviors in HIV disease. (JINS, 2005, 11, 70–83.)

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Effect of alcohol consumption on patient-reported outcomes in hip arthroscopy: a matched controlled study with minimum 2-year follow-up

Hip International ◽

10.1177/1120700019853554 ◽

2019 ◽

Vol 30 (4) ◽

pp. 457-468

Author(s):

Ajay C Lall ◽

Erwin Secretov ◽

Muriel R Battaglia ◽

David R Maldonado ◽

Itay Perets ◽

...

Keyword(s):

Alcohol Consumption ◽

Total Hip Arthroplasty ◽

Hip Arthroscopy ◽

Patient Reported Outcomes ◽

Heavy Drinking ◽

Controlled Study ◽

Patient Reported ◽

Heavy Drinkers ◽

Outerbridge Grade

Introduction:There is a paucity of literature examining the effects of alcohol consumption on patient-reported outcomes (PROs) after hip arthroscopy. The purpose of this study was to report 2-year outcomes of hip arthroscopy in patients who consume alcohol compared to patients who abstain.Methods:Registry data were prospectively collected and retrospectively reviewed to identify heavy drinkers at the time of primary hip arthroscopy. Patients were matched 1:1 (heavy drinkers:non-drinkers) based on age, sex, BMI, acetabular Outerbridge grade, and capsular treatment. All patients were assessed with 4 validated PROs: mHHS, NAHS, HOS-SSS, and iHOT-12. Pain was estimated with VAS.Results:42 patients were pair matched in each group (heavy drinkers:non-drinkers). Both groups demonstrated significant improvement for all PROs and VAS. Heavy drinkers reported lesser improvement in HOS-SSS ( p = 0.0169), smaller decrease in VAS ( p = 0.0157), and lower final scores on iHOT-12 ( p = 0.0302), SF-12 mental ( p = 0.0086), and VR-12 mental ( p = 0.0151). Significantly fewer patients in the heavy-drinking group reached PASS for mHHS ( p = 0.0464). Odds of achieving PASS for mHHS was 2.5 times higher for patients who abstain from alcohol. The rates of revision hip arthroscopy and conversion to total hip arthroplasty were not statistically different between groups.Conclusion:While hip arthroscopy may still yield clinical benefit in drinkers, patients who consume heavy amounts of alcohol may ultimately achieve an inferior functional status and should be counselled on drinking cessation to optimise their results.

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Differential Effects of Moderate or Heavy Alcohol Consumption on Circulating Adhesion Molecule Levels

Thrombosis and Haemostasis ◽

10.1055/s-0037-1613153 ◽

2002 ◽

Vol 88 (07) ◽

pp. 52-55 ◽

Cited By ~ 20

Author(s):

E. Badía ◽

J. M. Nicolás ◽

J. Fernández-Solá ◽

E. Antúnez ◽

A. Urbano-Márquez ◽

...

Keyword(s):

Alcohol Consumption ◽

Adhesion Molecule ◽

Serum Levels ◽

Intercellular Adhesion Molecule ◽

Intercellular Adhesion Molecule 1 ◽

Lower Serum ◽

Heavy Alcohol ◽

Endothelial Adhesion Molecule ◽

Heavy Drinkers ◽

Heavy Alcohol Consumption

SummaryEpidemiological studies suggest that moderate but not heavy alcohol consumption provides protection against coronary heart disease. We assessed the relationship between alcohol consumption and serum levels of adhesion molecules involved in the pathogenesis of early atherosclerosis. One-hundred apparently healthy men with similar cardiovascular risk factors were divided into four groups according to ethanol intake. Moderate drinkers (20-40 g/day) showed lower serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels than abstainers (p <0.05; both), as well as lower serum ICAM-1, VCAM-1 and E-selectin levels than heavy drinkers (p = 0.01; all). The latter also showed higher serum ICAM-1 and E-selectin levels than abstainers (p <0.001; both). We conclude that moderate drinkers show a significant reduction of soluble endothelial adhesion molecule levels compared to abstainers and heavy drinkers, that may contribute to the protective effect of moderate alcohol consumption against atherosclerosis.

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“We Drink, Therefore We Are”

Group Processes & Intergroup Relations ◽

10.1177/1368430210392399 ◽

2011 ◽

Vol 14 (5) ◽

pp. 637-649 ◽

Cited By ~ 28

Author(s):

Andrew G. Livingstone ◽

Hollie Young ◽

Antony S. R. Manstead

Keyword(s):

Alcohol Consumption ◽

Social Inclusion ◽

Positive Attitude ◽

Heavy Drinking ◽

Group Norms ◽

Heavy Alcohol ◽

Complementary Pattern ◽

The Social ◽

Heavy Alcohol Consumption ◽

Ingroup Identity

We consider how ingroup norms, identification and individual attitudes interact when a behaviour (heavy alcohol consumption) is defining of an ingroup identity. We sampled 115 students at a UK university, measuring ingroup identification and attitudes to heavy drinking before manipulating the ingroup drinking norm (moderate vs. heavy). Heavy drinking intentions and tendencies to socially include/exclude two target students—one of whom drank alcohol regularly and one of whom did not—were measured. As predicted, participants with a positive attitude to heavy drinking and who identified strongly with the ingroup reported stronger intentions to drink heavily when the ingroup had a moderate, rather than a heavy drinking norm, indicating resistance to the normative information. A complementary pattern emerged for the social inclusion/exclusion measures. Implications for theory and interventions that focus on group norms are discussed.

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Chronic heavy alcohol consumption influences the association between genetic variants of GCK or INSR and the development of diabetes in men: A 12-year follow-up study

Scientific Reports ◽

10.1038/s41598-019-56011-y ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Han Byul Jang ◽

Min Jin Go ◽

Sang Ick Park ◽

Hye-Ja Lee ◽

Seong Beom Cho

Keyword(s):

Alcohol Consumption ◽

Genetic Variants ◽

Cross Sectional Study ◽

Candidate Snps ◽

Sectional Study ◽

Β Cell ◽

Cross Sectional ◽

Heavy Alcohol ◽

Heavy Drinkers ◽

Heavy Alcohol Consumption

AbstractChronic heavy alcohol consumption is a risk factor for diabetes, which is characterized by impaired β-cell function and insulin resistance. We aimed to determine whether the longitudinal associations between genetic variants of glucokinase (GCK) and insulin receptor (INSR) and the risk of developing diabetes were influenced by chronic heavy alcohol consumption. Data were obtained from the Korean Genome and Epidemiology Study. To identify candidate variants, 1,520 subjects (726 non-drinkers and 794 heavy drinkers) were included in the baseline cross-sectional study. After excluding patients with diabetes at baseline and those with insufficient data on diabetes incidence, prospective analyses were conducted in 773 subjects (353 non-drinkers and 420 heavy drinkers). In the baseline cross-sectional study, one SNP (rs758989) in GCK and four SNPs (rs7245757, rs1035942, rs1035940, and rs2042901) in INSR were selected as candidate SNPs that interact with alcohol to affect prediabetes and diabetes. We identified that these GCK and INSR polymorphisms are affected by chronic heavy alcohol consumption and have an effect on the incidence of diabetes. The incidence of diabetes was increased in chronic heavy alcohol drinkers carrying the C allele of GCK compared with never-drinkers with the C allele (HR, 2.15; 95% CI 1.30–3.57), and was increased in chronic heavy alcohol drinkers who were not carrying the INSR haplotype (−/−) compared with never-drinkers carrying the AACT haplotype (HR, 1.98; 95% CI 1.24–3.18). Moreover, we observed that the aggravating effects on the late insulin secretion (I/G120 and I/G AUC 60–120) in individuals who were chronic heavy drinkers with C allele of GCK. In the INSR haplotype, chronic heavy drinkers not carrying AACT were associated with lower disposition index. These results potentially suggest that chronic heavy alcohol consumption induce β-cell dysfunction partially mediated by decreased GCK expression or decline of insulin sensitivity via inhibition of INSR, thereby contributing to the development of diabetes.

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